chlorpromazine and caffeine

chlorpromazine has been researched along with caffeine in 175 studies

Research

Studies (175)

TimeframeStudies, this research(%)All Research%
pre-1990123 (70.29)18.7374
1990's5 (2.86)18.2507
2000's19 (10.86)29.6817
2010's25 (14.29)24.3611
2020's3 (1.71)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Butler, DE; L'Italien, YJ; Marriott, JG; Nordin, IC; Poschel, PH; Zweisler, L1
Butler, DE; Marriott, JG; Poschel, BP1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Ahman, M; Holmén, AG; Wan, H1
Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Rodríguez-Franco, MI1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M1
Conradi, R; Lee, PH; Shanmugasundaram, V1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F1
Sen, S; Sinha, N1
Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, ZF; Huang, SL; Huang, ZS; Liang, H; Qin, JK; Tang, H; Zhao, HT; Zhao, LZ; Zhong, SM1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Chen, ZF; Liang, H; Tang, H; Wang, ZY; Zhao, HT; Zhong, SM1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Jiang, N; Kong, LY; Lan, JS; Li, ZR; Wang, KD; Wang, X; Xie, SS; Yu, W1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Chen, W; Huangli, Y; Qin, J; Shen, Y; Tang, H; Wang, L; Wei, S1
Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M1
Cheng, M; Guo, J; Jiang, N; Li, Q; Liang, N; Liu, J; Nong, X; Pang, C; Qin, Y; Tang, C; Tang, W; Xie, SS; Zhang, Z1
Cheng, M; Fang, Y; Guo, J; Jin, Y; Liu, J; Wan, Y; Wang, R; Xie, SS; Zhang, Z; Zhou, W1
Hanson, HM; Ivester, CA; Morton, BR1
Fujiwara, M; Oishi, R; Razzak, A; Ueki, S1
Jones, DJ; Medina, MA; Palmer, GC; Stavinoha, WB1
Gourevitch, A; Yanev, S1
Jhamandas, K; Sawynok, J; Sutak, M1
Dykes, DJ; Laster, WR; Rose, WC; Schabel, FM; Trader, MW1
Feller, K; Graupner, K; Kálmán, E; von Littrow, C1
Kalachev, BP1
Bolden, TE; Lemeh, DH; Seibert, W; Stewart, EB1
Buczko, W; Moniuszko-Jakoniuk, J1
Fukushima, M; Shibata, M1
Matkó, I; Petri, G; Szenohradszky, J; Tárnoky, K1
Kenunen, OG; Kozlovskiĭ, VL1
Lialiaris, T; Mourelatos, D; Pantazaki, A; Sivridis, E1
Rudas, N; Tondo, L1
Grigorus, AG; Navakatikjan, AO1
Adamantidis, MM; Adnet, PJ; Adnet-Bonte, CA; Dupuis, BA; Haudecoeur, G; Krivosic-Horber, RM; Saulnier, F1
Glatte, P; Osieka, R; Schmidt, CG1
Kurebayashi, N; Ogawa, Y1
Jauchem, JR1
Phillis, JW1
Dozi-Vassiliades, J; Lialiaris, T; Mourelatos, D1
Goldberg, SR; Katz, JL1
Glatte, P; Osieka, R; Pannenbäcker, R; Schmidt, CG1
Ashoori, F; Takai, A; Tomita, T1
Matsubara, S; Omori, T1
Bounameaux, Y1
Ferrini, R; Miragoli, G1
Färber, G; Fraling, F; Herz, A; Niedner, I1
Molnár, J; Prágai, B1
Amiragova, MG; Arkhangel'skaia, MI; Svirskaia, RI1
Bînzaru, T; Mihalaş, GI; Nagy, I; Plauchithiu, M; Rottenberg, F1
Carvalho, AP; Madeira, VM1
Bishun, NP; Lloyd, N; Mills, J; Parke, DV; Raven, RW; Williams, DC1
Greengard, P; Quinn, GP; Reid, MB1
Gibson, W; Jessup, S; Ramwell, P; Shaw, J1
Giurgea, CE; Moyersoons, FE1
Galzigna, L1
Mlejnkova, M; Rysánek, K; Spánkova, H; Synek, P1
Beyrich, T; Schleuder, M1
Takaori, S; Tanabe, K1
Boissier, JR; Larousse, C; Simon, P; Villeneuve, A1
Chiba, S; Nagawa, Y; Yui, T1
Frank, GB; Jhamandas, K1
Hata, T; Kita, T; Murakami, T1
Ditzler, W; Plotnikoff, N; Will, F1
Izquierdo, I1
Doctor, RB; Jindal, MN; Kelkar, VV1
Andersson, KE1
Batra, S1
Kulikov, MA; Zlatin, RS1
Borowitz, JL; Miya, TS; Rahwan, RG1
Billets, S; Carruth, J; Einolf, N; Fenselau, C; Ward, R1
Cohen, MH1
Antunes-Madeira, MC; Madeira, VM1
Gordon, JL1
Endo, T1
Bass, WC; Brown, H1
Deneau, G; Seevers, MH; Yanagita, T1
Mason, RG; Read, MS; Saba, SR; Shermer, RW1
Nakano, M1
Ban, TA; Lehmann, HE1
Hecht, K; Treptow, K1
Hecht, K; Peschel, M; Treptow, K1
Filipescu, A; Spirescu, J1
Bapat, SK; Dhawn, BN; Saxena, VC1
Saito, H; Takagi, K; Watanabe, M1
Hecht, K; Hecht, T; Treptow, K1
Balwani, JH; Mardikar, BR; Srinivasan, S1
von Albert, HH1
Fairhurst, AS; Hasselbach, W1
Markovich, VV; Ostrovskaia, RU1
Nieschulz, O2
Shliafer, TP1
Molinengo, L; Ricci-Gamalero, S1
Senault, B1
Barbaz, BS; Bernard, PS; Chernov, HI; DeStevens, G; Partyka, DA; Wilson, DE1
Dítĕ, P; Krízala, JF; Krupar, V; Sita, F1
Schubert, B1
Laplace, JP; Ruckebusch, Y1
Preibisch-Effenberger, R; Schmidt, V1
Lugovskiĭ, BK1
Burgison, RM; Dietz, AJ1
Hecht, K; Hecht, T; Poppei, M; Treptow, K1
Birzis, L; Tachibana, S1
Bättig, K; Wanner, HU1
Knothe, J; Preibischèffenberger, R1
Gen, MC; Valdman, AV1
Collins, RJ; Simonton, VR1
Babbini, M; Cestari, A; De Marchi, F; Graziani, G1
Caldwell, P; Emmett-Oglesby, MW; Spencer, DG1
Hagiwara, Y; Suzuki, Y; Taguchi, K1
Cassone, MC; Fundarò, A; Molinengo, L1
Emley, GS; Hutchinson, RR1
Jones, RS; Olpe, HR; Steinmann, MW1
Sporn, P1
Cohen, MH; Schoenfeld, D; Wolter, J1
Chaput de Saintonge, DM; Hong, CY; Turner, P1
Kuribara, H1
BLOUGH, DS1
BARRY, H; ZIMBARDO, PG1
HIRASHIMA, T1
HIMWICH, HE; STEINER, WG1
FRUTTERO, F; HAHN, R; SCARZELLA, R1
BARGIEL, Z; KADZIELA, W1
BOHDANECKY, Z; NECINA, J1
STAIB, AH1
HUGGINS, CG; SMITH, CM; WALASZEK, EJ1
LYNN, R1
GRUNDMAN, M; LENFELD, J; SLADKOVA, O1
WHITE, RP1
YAMAMOTO, H1
GUSHANSKII, EL1
TURI, P1
BESSIN, P; BOISSIER, JR; DUMONT, C1
TEUCHMANN, JK; WIGLUSZ, Z1
FORNEY, RB; HUGHES, FW; KHAN, AU1
CROMLEY, WH; EBY, RZ; FELLOWS, EJ; FOWLER, PJ; PAULS, JF; TEDESCHI, DH1
BARRY, H; MILLER, NE1
GOLDSTEIN, L; MURPHREE, HB; PFEIFFER, CC; SUGERMAN, AA1
RUDOLPH, AS; SEWELL, HH; WHITE, RP1
KURYSHEVA, KA; POLUSHCHEV, FN1
HIRASHIMA, T; HIROTA, K; MAKINO, H; NAKAMURA, T; TAKAHASHI, Y; YAMAMOTO, K1
Lialiaris, TS; Mourelatos, C; Papachristou, F; Simopoulou, M1
Nakagawa, T; Nishi, K; Takase, I; Yamamoto, Y1
Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W1
Harris, G; Landesmann, B; Mennecozzi, M; Palosaari, T; Whelan, M1
Kobayashi, K; Matsushita, S; Murata, T; Shimizu, N1

Reviews

4 review(s) available for chlorpromazine and caffeine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Effects of drugs on thermal responses to microwaves.
    General pharmacology, 1985, Volume: 16, Issue:4

    Topics: Adrenergic beta-Antagonists; Analgesics; Anesthetics; Animals; Bemegride; Body Temperature; Caffeine; Cardiac Glycosides; Chlorpromazine; Cholinesterase Inhibitors; Doxapram; Glucocorticoids; Hexamethonium; Hexamethonium Compounds; Microwaves; Nicotine; Nikethamide; Parasympatholytics; Parasympathomimetics; Pentylenetetrazole; Serotonin; Sympathomimetics; Vitamins

1985
Chromosome damage induced by chemicals.
    Chemico-biological interactions, 1973, Volume: 6, Issue:6

    Topics: Antineoplastic Agents; Aspirin; Benzene; Caffeine; Chloramphenicol; Chlorine; Chlorpromazine; Chromosome Aberrations; Chromosomes; Colchicine; Contraceptives, Oral; Cyclamates; Diazepam; Dibenzazepines; Drug Evaluation; Ethanol; Humans; Hydroxylamines; Lithium; Lymphocyte Culture Test, Mixed; Lysergic Acid Diethylamide; Nicotine; Organophosphorus Compounds; Ozone; Pesticides; Phenylbutazone

1973
RUSSIAN THEORY AND RESEARCH ON SCHIZOPHRENIA.
    Psychological bulletin, 1963, Volume: 60

    Topics: Amobarbital; Bromides; Caffeine; Cerebral Cortex; Chlorpromazine; Conditioning, Psychological; Convulsive Therapy; Electroconvulsive Therapy; Electroencephalography; Humans; Insulin; Orientation; Psychological Tests; Research; Russia; Schizophrenia; Sleep; Sodium; Sympathetic Nervous System; USSR

1963

Trials

3 trial(s) available for chlorpromazine and caffeine

ArticleYear
Effects of psychoactive drugs on conflict avoidance behavior in human subjects.
    Activitas nervosa superior, 1971, Volume: 13, Issue:2

    Topics: Adolescent; Adult; Amobarbital; Avoidance Learning; Caffeine; Child; Chlordiazepoxide; Chlorpromazine; Conflict, Psychological; Electroshock; Female; Haloperidol; Humans; Male; Meprobamate; Methamphetamine; Neurotic Disorders; Pentylenetetrazole; Perphenazine; Placebos; Tranquilizing Agents

1971
Effect of four centrally acting drugs on handwriting.
    Japanese journal of pharmacology, 1969, Volume: 19, Issue:1

    Topics: Caffeine; Chlorpromazine; Female; Handwriting; Humans; Male; Methamphetamine; Phenobarbital; Placebos

1969
Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma.
    Cancer treatment reports, 1980, Volume: 64, Issue:1

    Topics: Caffeine; Chlorpromazine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Melanoma; Nitrosourea Compounds; Semustine; Time Factors; Vomiting

1980

Other Studies

168 other study(ies) available for chlorpromazine and caffeine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl] -2-oxo-1-pyrrolidineacetamides, including pramiracetam.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:5

    Topics: Amnesia; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Humans; Male; Mice; Mice, Inbred Strains; Pyrrolidines; Structure-Activity Relationship

1984
Cognition-activating properties of 3-(Aryloxy)pyridines.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:3

    Topics: Animals; Cognition; Dose-Response Relationship, Drug; Male; Mice; Psychotropic Drugs; Pyridines; Structure-Activity Relationship

1981
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
    Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
    Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Drug Design; Humans; Isomerism; Membranes, Artificial; Mice; Models, Molecular; Molecular Conformation; Permeability; Protein Binding; Tacrine

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
    Journal of medicinal chemistry, 2009, Nov-26, Volume: 52, Issue:22

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding

2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
    Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption

2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution

2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:10

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Biological; Tacrine

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
    Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Membranes, Artificial; Models, Molecular; Molecular Structure; Permeability; Protein Binding

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
    European journal of medicinal chemistry, 2015, May-05, Volume: 95

    Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Coumarins; Drug Design; Erythrocytes; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Piperazines; Tacrine

2015
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Autophagy; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Aggregates; Structure-Activity Relationship; Tumor Cells, Cultured

2016
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
    European journal of medicinal chemistry, 2017, Apr-21, Volume: 130

    Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques

2017
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
    European journal of medicinal chemistry, 2020, Sep-15, Volume: 202

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Clorgyline; Dose-Response Relationship, Drug; Drug Design; Humans; Indans; Male; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2020
Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2021, Mar-05, Volume: 213

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzothiazoles; Benzylamines; Biphenyl Compounds; Butyrylcholinesterase; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Horses; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neuroprotective Agents; Picrates; Rats; Structure-Activity Relationship; Sulfonic Acids; Xanthones

2021
Nicotine self-administration in rats.
    NIDA research monograph, 1979, Issue:23

    Topics: Amphetamine; Animals; Caffeine; Chlordiazepoxide; Chlorpromazine; Drug Interactions; Drug Tolerance; Ethanol; Humans; Male; Mecamylamine; Nicotine; Pentolinium Tartrate; Phenobarbital; Phenytoin; Rats; Reinforcement, Psychology; Self Administration; Substance-Related Disorders

1979
Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice.
    Japanese journal of pharmacology, 1977, Volume: 27, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Caffeine; Catecholamines; Chlorpromazine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Fenclonine; Humans; Levodopa; Male; Methamphetamine; Methyltyrosines; Mice; Phenoxybenzamine; Phentolamine; Reserpine; Self Mutilation; Sympathetic Nervous System; Theophylline

1977
Influence of injected psychoactive drugs on cyclic AMP levels in mouse brain and lung following microwave irradiation.
    Neuropharmacology, 1977, Volume: 16, Issue:6

    Topics: Adenylyl Cyclases; Amitriptyline; Animals; Brain Chemistry; Caffeine; Chlorpromazine; Cyclic AMP; Dextroamphetamine; Lung; Lysergic Acid Diethylamide; Male; Methyltyrosines; Mice; Microwaves; p-Hydroxyamphetamine; Papaverine; Pargyline; Phosphoric Diester Hydrolases; Psychotropic Drugs; Reserpine

1977
Motor estimation of short time intervals under the effect of some psychotropic drugs.
    Acta physiologica et pharmacologica Bulgarica, 1979, Volume: 5, Issue:1

    Topics: Adult; Amphetamine; Caffeine; Chlorpromazine; Diazepam; Humans; Phenobarbital; Psychotropic Drugs; Reaction Time; Task Performance and Analysis; Time Perception

1979
Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium.
    European journal of pharmacology, 1978, Jun-01, Volume: 49, Issue:3

    Topics: Acetylcholine; Animals; Brain; Caffeine; Calcium; Chlorpromazine; Morphine; Rats; Theophylline; Xanthines

1978
Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors.
    Cancer treatment reports, 1978, Volume: 62, Issue:12

    Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Female; Leukemia L1210; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Semustine

1978
[The influence of centrally acting drugs on flicker fusion frequency].
    Psychiatrie, Neurologie und medizinische Psychologie. Beihefte, 1975, Volume: 20-21

    Topics: Caffeine; Chlorpromazine; Diazepam; Dose-Response Relationship, Drug; Flicker Fusion; Humans; Meprobamate; Psychotropic Drugs

1975
Interactions of alcohol with drugs.
    The Medical letter on drugs and therapeutics, 1977, Jun-03, Volume: 19, Issue:11

    Topics: Amphetamines; Caffeine; Chlorpromazine; Diazepam; Disulfiram; Drug Interactions; Ethanol; Humans

1977
[Assessment of the effectiveness of autogenic training in the complex treatment of neurotic and psychopathic states].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1976, Volume: 76, Issue:11

    Topics: Adolescent; Adult; Amitriptyline; Amobarbital; Antisocial Personality Disorder; Autogenic Training; Caffeine; Chlorpromazine; Drug Combinations; Female; Humans; Hysteria; Male; Middle Aged; Neurotic Disorders

1976
Effect of prolonged use of analgesics on pulpal response: a preliminary investigation.
    Journal of dental research, 1975, Volume: 54 Spec No B

    Topics: Adult; Aged; Analgesics; Aspirin; Caffeine; Chlorpromazine; Dental Pulp; Dental Pulp Test; Dextropropoxyphene; Electric Stimulation; Female; Humans; Male; Middle Aged; Phenacetin; Time Factors; Toothbrushing

1975
Influence of fibrinogen degradation products (FDP) on the central nervous system and on the effects of centrally acting drugs.
    Pharmacology, 1975, Volume: 13, Issue:3

    Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Central Nervous System; Chlorpromazine; Depression, Chemical; Fibrin; Fibrinogen; Male; Rats; Stimulation, Chemical; Thiopental; Time Factors

1975
[Acute toxicity and sedative action of zizyphus seeds (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1975, Volume: 95, Issue:4

    Topics: Anesthesia, Intravenous; Animals; Caffeine; Chlorpromazine; Drug Evaluation, Preclinical; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Male; Mice; Plant Extracts; Seeds

1975
[Sympatholytic therapy of paralytic ileus].
    Minerva medica, 1975, Jun-09, Volume: 66, Issue:42

    Topics: Caffeine; Catecholamines; Chlorpromazine; Drug Therapy, Combination; Humans; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Parasympathomimetics; Propranolol; Sympatholytics; Trifluperidol

1975
[The "structure of the motor behavior" of laboratory animals--new possibilities of the "open-field" method].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1992, Volume: 78, Issue:1

    Topics: Amphetamine; Animals; Animals, Laboratory; Caffeine; Chlorpromazine; Female; Male; Motor Activity; Physiology; Rats; Research Design

1992
Chlorpromazine-induced damage on nucleic acids: a combined cytogenetic and biochemical study.
    Mutation research, 1992, Volume: 265, Issue:2

    Topics: Animals; Bacteriophage lambda; Caffeine; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chlorpromazine; DNA Damage; DNA, Viral; Doxorubicin; Drug Synergism; Escherichia coli; Humans; Intercalating Agents; Lymphocytes; Mice; Mice, Inbred BALB C; Mitotic Index; Plasmids; RNA; Sister Chromatid Exchange; Tumor Cells, Cultured

1992
The course of a seasonal bipolar disorder influenced by caffeine.
    Journal of affective disorders, 1991, Volume: 22, Issue:4

    Topics: Bipolar Disorder; Caffeine; Chlorpromazine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Haloperidol; Humans; Lithium; Middle Aged; Recurrence; Seasons

1991
[Combined effects of pharmacological activation of the CNS and the complexity of mental tasks on the function of the cardiovascular and the vegetative nervous system and the work performance of operators].
    Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete, 1990, Volume: 36, Issue:9

    Topics: Caffeine; Central Nervous System; Chlorpromazine; Efficiency; Humans; Occupational Medicine; Reaction Time; Work

1990
The association between the neuroleptic malignant syndrome and malignant hyperthermia.
    Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:8

    Topics: Adult; Caffeine; Chlorpromazine; Contracture; Disease Susceptibility; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Neuroleptic Malignant Syndrome

1989
Chemosensitization by chlorpromazine (CPZ) and caffeine (C) in human melanoma xenografts sensitive or resistant to methyl-CCNU (semustine).
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1989, Volume: 165, Issue:7

    Topics: Animals; Caffeine; Chlorpromazine; Drug Resistance; Humans; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Nitrosourea Compounds; Semustine; Stimulation, Chemical; Transplantation, Heterologous

1989
Modulations by drugs of the relationship between calcium binding to troponin C and tension.
    Progress in clinical and biological research, 1989, Volume: 315

    Topics: Animals; Caffeine; Calcium; Calmodulin; Chlorpromazine; In Vitro Techniques; Isometric Contraction; Melitten; Muscle Contraction; Myofibrils; Protein Binding; Quercetin; Sulfonamides; Trifluoperazine; Troponin; Troponin C

1989
Chlorpromazine and trifluoperazine potentiate the action of adenosine on rat cerebral cortical neurons.
    General pharmacology, 1985, Volume: 16, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cerebral Cortex; Chlorpromazine; Depression, Chemical; Drug Synergism; Iontophoresis; Male; Rats; Rats, Inbred Strains; Synaptic Transmission; Synaptosomes; Trifluoperazine; Vasodilator Agents

1985
Enhancement of cytogenetic damage by chlorpromazine in human lymphocytes treated with alkylating antineoplastics and caffeine.
    Mutation research, 1988, Volume: 206, Issue:3

    Topics: Alkylating Agents; Caffeine; Cell Division; Cell Membrane; Chlorpromazine; Drug Synergism; Humans; In Vitro Techniques; Lymphocytes; Mitotic Index; Sister Chromatid Exchange

1988
Psychomotor stimulant effects of caffeine alone and in combination with an adenosine analog in the squirrel monkey.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1

    Topics: Adenosine; Amphetamine; Animals; Behavior, Animal; Caffeine; Chlorpromazine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Food; Male; Motor Activity; Saimiri

1987
Enhancement of semustine-induced cytotoxicity by chlorpromazine and caffeine in a human melanoma xenograft.
    Cancer treatment reports, 1986, Volume: 70, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Caffeine; Chlorpromazine; DNA Damage; Drug Synergism; Humans; Male; Melanoma; Mice; Mice, Nude; Nitrosourea Compounds; Semustine; Tissue Distribution

1986
The response of non-pregnant rat myometrium to oxytocin in Ca-free solution.
    British journal of pharmacology, 1985, Volume: 84, Issue:1

    Topics: Animals; Caffeine; Calcium; Chlorpromazine; Female; Fluphenazine; In Vitro Techniques; Myometrium; Oxytocin; Rats; Rats, Inbred Strains; Sulfonamides; Trifluoperazine; Uterine Contraction

1985
Rapid cooling contracture in frog striated muscles treated with chlorpromazine and haloperidol.
    The Japanese journal of physiology, 1985, Volume: 35, Issue:2

    Topics: Animals; Caffeine; Chlorpromazine; Cold Temperature; Dantrolene; Haloperidol; Muscle Contraction; Muscles; Procaine; Ranidae; Time Factors; Toes

1985
[Studies on the effect of various substances on platelet function with several methods].
    Die Medizinische Welt, 1973, Feb-02, Volume: 24, Issue:5

    Topics: Amphetamine; Anti-Anxiety Agents; Blood Platelets; Caffeine; Chlorpromazine; Debrisoquin; Dibenzazepines; Flurazepam; Guanethidine; Humans; Oxazoles; Papaverine; Phenytoin; Platelet Aggregation; Pyridines; Theophylline

1973
[The effect of glaziovine on exploratory behavior of normal mice in the so-called "holey board" test].
    Bollettino della Societa italiana di biologia sperimentale, 1974, Oct-15, Volume: 50, Issue:19

    Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Aporphines; Behavior, Animal; Caffeine; Chlordiazepoxide; Chlorpromazine; Exploratory Behavior; Female; Mice

1974
Pharmacologically induced alterations of cortical and subcortical evoked potentials compared with physiological changes during the awake-sleep cycle in cats.
    Electroencephalography and clinical neurophysiology, 1967

    Topics: Amphetamine; Anesthetics; Animals; Atropine; Auditory Cortex; Caffeine; Cats; Central Nervous System Stimulants; Cerebral Cortex; Chloralose; Chlorpromazine; Computers; Dihydroxyphenylalanine; Electroencephalography; Evoked Potentials; Hippocampus; Imipramine; Lysergic Acid Diethylamide; Pentobarbital; Perphenazine; Physostigmine; Sleep; Thalamus; Tranquilizing Agents; Visual Cortex; Wakefulness

1967
Repression of alkaline phosphatase synthesis by adenine, adenosine and adenine nucleotides in an adenine auxotroph of Bacillus anthracis.
    Acta microbiologica Academiae Scientiarum Hungaricae, 1973, Volume: 20, Issue:3

    Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Alkaline Phosphatase; Bacillus anthracis; Caffeine; Chlorpromazine; Culture Media; Dinitrophenols; Enzyme Repression; Inosine Nucleotides; Lyases; Mutation; Phosphates; Theophylline

1973
[Role of hypothalamic nonspecific structures in regulation of the pituitary-thyroid system].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1974, Volume: 60, Issue:1

    Topics: Animals; Blood Proteins; Caffeine; Cats; Chlorpromazine; Electroencephalography; Hypothalamus; Iodine; Pituitary Gland; Protein Binding; Succinylcholine; Thyroid Gland; Thyroid Hormones; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine; Urethane

1974
[Study of the uptake of Ca45 in various experimental conditions].
    Fiziologia normala si patologica, 1971, Volume: 17, Issue:2

    Topics: Abdominal Muscles; Animals; Brain; Caffeine; Calcium; Chlorpromazine; Muscles; Physical Exertion; Rats

1971
Interaction of cations and local anesthetics with isolated sarcolemma.
    Biochimica et biophysica acta, 1972, Jun-20, Volume: 266, Issue:3

    Topics: Actomyosin; Adenosine Triphosphatases; Anesthetics, Local; Animals; Binding Sites; Caffeine; Calcium; Chlorpromazine; Enzyme Activation; Lipids; Magnesium; Mathematics; Procaine; Protein Binding; Protons; Quinine; Rabbits; Sarcolemma; Spectrophotometry, Atomic; Tetracaine; Zinc

1972
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism.
    Molecular pharmacology, 1966, Volume: 2, Issue:4

    Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine

1966
The effect of PGE-1 on cyclic AMP and ion movements in turkey erythrocytes.
    Annals of the New York Academy of Sciences, 1971, Apr-30, Volume: 180

    Topics: Animals; Biological Transport; Caffeine; Calcium; Calcium Chloride; Calcium Isotopes; Cattle; Chlorpromazine; Cyclic AMP; Depression, Chemical; Drug Synergism; Epinephrine; Erythrocytes; Guinea Pigs; Half-Life; Humans; Metabolism; Propranolol; Prostaglandins; Rabbits; Rats; Sodium; Sodium Isotopes; Stimulation, Chemical; Time Factors; Turkeys

1971
On the pharmacology of cortical evoked potentials.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 199, Issue:1

    Topics: Acetamides; Animals; Caffeine; Cats; Cerebral Cortex; Chlordiazepoxide; Chlorpromazine; Corpus Callosum; Dextroamphetamine; Electric Stimulation; Evoked Potentials; Phenobarbital; Pyrrolidinones; Reflex, Monosynaptic; Sciatic Nerve; Stereotaxic Techniques; Synaptic Transmission; Thiopental

1972
Interaction of chloropromazine with adrenochrome and interference of a possible endogenous psychotogenic agent with some synaptic enzyme activities.
    Biochemical pharmacology, 1972, Jan-15, Volume: 21, Issue:2

    Topics: Adrenochrome; Animals; Ascorbic Acid; Brain; Caffeine; Chlorpromazine; Cholinesterase Inhibitors; Chromatography; Cyclic AMP; Drug Interactions; Hallucinogens; Haplorhini; Lithium; Monoamine Oxidase Inhibitors; Oxygen Consumption; Papio; Spectrophotometry; Synapses; Synaptosomes

1972
Effect of drugs on the activity of thrombocytes 3,5-cyclic AMP phosphodiesterase.
    International journal of clinical pharmacology, therapy and toxicology, 1974, Volume: 10, Issue:1

    Topics: 1-Propanol; Adenosine Diphosphate; Adenosine Monophosphate; Aminophylline; Blood Platelets; Caffeine; Chlorpromazine; Cyclic AMP; Desipramine; Dibenzothiepins; Epinephrine; Imipramine; Nortriptyline; Phosphoric Diester Hydrolases; Piperazines; Platelet Adhesiveness

1974
[Comparative study on quantitative determination of mixtures of analgesics. 1. Studies on selectivity of volumetric analysis procedures].
    Die Pharmazie, 1974, Volume: 29, Issue:7

    Topics: Acetaminophen; Aminopyrine; Analgesics; Ascorbic Acid; Aspirin; Barbiturates; Caffeine; Chlorpromazine; Codeine; Conductometry; Electrochemistry; Meprobamate; Mesylates; Methods; Papaverine; Phenacetin; Phenobarbital; Phenylbutazone; Potentiometry; Quinine; Salicylamides; Salicylates; Theobromine

1974
Effects of central depressants and stimulants on EEG alterations induced by carotid cooling and warming.
    Japanese journal of pharmacology, 1965, Volume: 15, Issue:2

    Topics: Aminopyrine; Antidepressive Agents; Atropine; Caffeine; Carotid Arteries; Central Nervous System Stimulants; Chlorpromazine; Electroencephalography; Hot Temperature; Hypnotics and Sedatives; Hypothermia, Induced; Methamphetamine; Pentobarbital; Physostigmine; Reserpine

1965
Flurothyl in mice: seizure, post-convulsive behavior, and interactions with psychotropic drugs.
    Canadian journal of physiology and pharmacology, 1968, Volume: 46, Issue:1

    Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Biperiden; Caffeine; Catalepsy; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Electroshock; Haloperidol; Humans; Imipramine; Iproniazid; Meprobamate; Monoamine Oxidase Inhibitors; Motor Activity; Parasympatholytics; Pargyline; Prenylamine; Procyclidine; Rats; Reflex; Reserpine; Seizures; Tranylcypromine

1968
[Pharmacological studies on 2-methyl-4-amino-6-methoxy-s-triazine (CV399); with special reference to its central effects].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1970, Volume: 66, Issue:1

    Topics: Amphetamine; Analgesics; Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Body Temperature; Brain Chemistry; Caffeine; Cats; Central Nervous System; Chlordiazepoxide; Chlorpromazine; Drug Synergism; Ethanol; Haplorhini; Indoleacetic Acids; Male; Meprobamate; Methylphenidate; Mice; Morphine; Motor Activity; Pentobarbital; Piperidines; Rats; Reserpine; Respiration; Salivation; Seizures; Serotonin; Triazines

1970
Effects of drugs acting alone and in combination on the motor activity of intact mice.
    British journal of pharmacology, 1970, Volume: 39, Issue:4

    Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central Nervous System Stimulants; Chlorpromazine; Diazepam; Diphenhydramine; Female; Glutamates; Hydroxybutyrates; Lactones; Meperidine; Meprobamate; Mice; Motor Activity; Nikethamide; Phenobarbital; Picrotoxin; Promethazine; Reflex; Scopolamine; Seizures; Strychnine; Tranquilizing Agents

1970
[Introduction of mass psychology in animals to pharmacology. 6. Mutural relation in simultaneity convulsion and non-convulsin in E1-mice].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1970, Jul-20, Volume: 66, Issue:4

    Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Camphor; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diphenhydramine; Imipramine; Mice; Nikethamide; Pentylenetetrazole; Rodent Diseases; Seizures; Tranquilizing Agents

1970
Stimulant activity of pemoline and magnesium hydroxide.
    Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 181, Issue:2

    Topics: Animals; Antacids; Ataxia; Caffeine; Cats; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Coma; Diazepam; Dogs; Drug Antagonism; Haplorhini; Hydroxides; Magnesium; Methamphetamine; Methylphenidate; Mice; Motor Activity; Pemoline; Pupil; Resins, Plant; Stimulation, Chemical; Tetrabenazine; Vomiting

1969
Effect on pseudoconditioning of drugs with known central nervous activity.
    Psychopharmacologia, 1974, Volume: 38, Issue:3

    Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione

1974
Chlorpromazine-induced contracture of frog rectus abdominis muscle.
    Pharmacology, 1974, Volume: 12, Issue:1

    Topics: Acetylcholine; Adenosine; Animals; Arsenic; Atropine; Caffeine; Chlorpromazine; Choline; Cocaine; Cyanides; Electric Stimulation; Fluorides; Hexamethonium Compounds; In Vitro Techniques; Iodoacetates; Muscle Contraction; Ouabain; Physostigmine; Potassium Chloride; Procaine; Quinine; Sparteine; Stimulation, Chemical; Tubocurarine

1974
Effects of chlorpromazine, imipramine, and quinidine on the mechanical activity of single skeletal muscle fibres of the frog.
    Acta physiologica Scandinavica, 1972, Volume: 85, Issue:4

    Topics: Animals; Anura; Caffeine; Chlorpromazine; Drug Synergism; Electric Stimulation; Imipramine; Methods; Muscle Contraction; Myofibrils; Potassium; Quinidine; Rana temporaria; Tendons

1972
The effects of drugs on calcium uptake and calcium release by mitochondria and sarcoplasmic reticulum of frog skeletal muscle.
    Biochemical pharmacology, 1974, Jan-01, Volume: 23, Issue:1

    Topics: Animals; Anura; Biological Transport; Brain; Caffeine; Calcium; Chlorpromazine; Imidazoles; In Vitro Techniques; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Muscles; Myocardium; Quinidine; Rana temporaria; Sarcoplasmic Reticulum; Time Factors

1974
[Correlations and characteristics of the changes in electrical activity of the posterior hypothalamus and the motor cortex due to different pharmacological agents].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1973, Volume: 59, Issue:1

    Topics: Animals; Caffeine; Carbachol; Chloral Hydrate; Chlorpromazine; Electroencephalography; Electrophysiology; Epinephrine; Hypothalamus; Motor Cortex; Rabbits; Scopolamine

1973
The role of intracellular calcium in catecholamine secretion from the bovine adrenal medulla.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 184, Issue:1

    Topics: Adrenal Medulla; Animals; Caffeine; Calcium; Calcium Isotopes; Catecholamines; Cattle; Centrifugation, Density Gradient; Chlorpromazine; Chromaffin System; Colorimetry; Dextroamphetamine; Epinephrine; In Vitro Techniques; Magnesium; Mitochondria; Norepinephrine; Procaine; Subcellular Fractions; Sucrose

1973
Rapid identification of acute drug intoxications.
    The Johns Hopkins medical journal, 1973, Volume: 133, Issue:3

    Topics: Acute Disease; Caffeine; Chlorpromazine; Gastric Lavage; Glutethimide; Humans; Mass Spectrometry; Methods; Poisoning; Spectrum Analysis; Substance-Related Disorders; Time Factors

1973
Brief communication: Enhancement of the antitumor effect of 1,-3-bis(2-chloroethyl)-1-nitrosourea by chlorpromazine and caffeine.
    Journal of the National Cancer Institute, 1973, Volume: 51, Issue:4

    Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Leukemia L1210; Male; Mice

1973
Interaction of Ca2+ and Mg2+ with synaptic plasma membranes.
    Biochimica et biophysica acta, 1973, Oct-25, Volume: 323, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Anilino Naphthalenesulfonates; Animals; Caffeine; Calcium; Cations, Divalent; Centrifugation, Density Gradient; Chlorpromazine; Fluorometry; Magnesium; Procaine; Sheep; Succinate Dehydrogenase; Synaptic Membranes; Synaptosomes; Tetracaine

1973
Differential changes in potency of platelet-aggregation inhibitors after preincubation in platelet-rich plasma.
    Research communications in chemical pathology and pharmacology, 1974, Volume: 7, Issue:1

    Topics: Adenosine Diphosphate; Amitriptyline; Animals; Caffeine; Chlorpromazine; Diphenhydramine; Dipyridamole; Imipramine; Papaverine; Plasma; Platelet Adhesiveness; Swine; Time Factors; Trifluoperazine

1974
[Experimental study on analysis of animal behavior and its quantification].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1974, Volume: 70, Issue:2

    Topics: Animals; Behavior, Animal; Caffeine; Chlorpromazine; Computers; Male; Methamphetamine; Methods; Motor Activity; Rats; Reserpine

1974
Effect of drugs on visually controlled avoidance behavior in rhesus monkeys: a psychophysical analysis.
    Psychopharmacologia, 1967, Volume: 11, Issue:2

    Topics: Anesthetics; Animals; Avoidance Learning; Caffeine; Chlorpromazine; Dextroamphetamine; Escape Reaction; Hallucinogens; Haloperidol; Haplorhini; Lysergic Acid Diethylamide; Male; Morphine; Parasympatholytics; Pentobarbital; Phencyclidine; Piperidines; Psychopharmacology; Size Perception; Strychnine; Visual Perception

1967
Self-administration of psychoactive substances by the monkey.
    Psychopharmacologia, 1969, Volume: 16, Issue:1

    Topics: Animals; Behavior, Animal; Caffeine; Catheterization; Chlorpromazine; Cocaine; Codeine; Dextroamphetamine; Ethanol; Haplorhini; Humans; Mescaline; Morphinans; Morphine; Morphine Dependence; Pentobarbital; Substance-Related Disorders

1969
Apparent similarity of mechanisms of platelet adhesion and aggregation. Differentiation of these functions from clot retraction.
    Thrombosis et diathesis haemorrhagica, 1972, Feb-29, Volume: 27, Issue:1

    Topics: Amitriptyline; Aspirin; Blood Coagulation Tests; Caffeine; Chloromercuribenzoates; Chlorpromazine; Clot Retraction; Cocaine; Diphenhydramine; Ethacrynic Acid; Guanidines; Humans; Phenothiazines; Phentolamine; Phenylbutazone; Platelet Adhesiveness; Promethazine; Quinacrine; Quinidine; Reserpine; Sulfinpyrazone; Sulfones; Tosyl Compounds

1972
Effects of interaction with surfactants, adsorbents, and other substances on the permeation of chlorpromazine through a dimethyl polysiloxane membrane.
    Journal of pharmaceutical sciences, 1971, Volume: 60, Issue:4

    Topics: Bile Acids and Salts; Caffeine; Charcoal; Chlorpromazine; Diffusion; Drug Interactions; Gelatin; Glycolates; Hydrogen-Ion Concentration; Kinetics; Lactose; Membranes, Artificial; Mucins; Permeability; Riboflavin; Saccharin; Silicones; Surface-Active Agents; Tablets; Talc; Time Factors

1971
A study of pharmaco-dynamics in periodic conditional processes in albino rats.
    Activitas nervosa superior, 1971, Volume: 13, Issue:2

    Topics: Animals; Avoidance Learning; Barbiturates; Caffeine; Chlorpromazine; Conditioning, Classical; Electroshock; Locomotion; Rats; Reaction Time

1971
[Entropy dependent responses in two-dimensional conditional reflex controlled decision situations and their possible modelling].
    Acta biologica et medica Germanica, 1971, Volume: 27, Issue:5

    Topics: Acoustic Stimulation; Animals; Caffeine; Chlorpromazine; Conditioning, Classical; Decision Making; Electric Stimulation; Learning; Male; Models, Psychological; Rats; Rats, Inbred Strains; Reaction Time

1971
[The pain syndrome of the edentulous alveolar crest and its treatment].
    Revue de stomatologie et de chirurgie maxillo-faciale, 1969, Volume: 70, Issue:2

    Topics: Administration, Topical; Alveolar Process; Aminopyrine; Anti-Inflammatory Agents; Aspirin; Caffeine; Chlorpromazine; Codeine; Humans; Hyaluronoglucosaminidase; Hydrocortisone; Mouth, Edentulous; Pain; Phenobarbital; Procaine; Promethazine

1969
Studies of the spontaneous movement of animals by the hole cross test; effect of 2-dimethyl-aminoethanol and its acyl esters on the central nervous system.
    Japanese journal of pharmacology, 1971, Volume: 21, Issue:6

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Central Nervous System; Chlorpromazine; Deanol; Depression, Chemical; Esters; Ethanol; Ethylamines; Male; Methamphetamine; Methods; Mice; Motor Activity; Reserpine; Stimulation, Chemical

1971
[Dependence of pharmacologic effects on the noise level].
    Acta biologica et medica Germanica, 1969, Volume: 23, Issue:1

    Topics: Animals; Autonomic Agents; Barbiturates; Benactyzine; Caffeine; Central Nervous System; Chlorpromazine; Conditioning, Classical; Escape Reaction; Male; Noise; Rats; Reserpine; Sodium Chloride; Statistics as Topic

1969
On the phenomenon of caffeine induced automutilation.
    Indian journal of physiology and pharmacology, 1969, Volume: 13, Issue:4

    Topics: Animals; Caffeine; Central Nervous System; Chlorpromazine; Female; Humans; Male; Methamphetamine; Mice; Rats; Self Mutilation; Stimulation, Chemical

1969
[Detection of sedative effect by electronystagmography].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:9

    Topics: Amphetamine; Antihypertensive Agents; Caffeine; Chlorpromazine; Dibenzazepines; Electric Stimulation; Humans; Hypnotics and Sedatives; Imidazoles; Methods; Pentobarbital; Phenmetrazine; Phenothiazines; Phenytoin; Promethazine; Thiethylperazine; Vestibular Function Tests

1969
Calcium efflux from a heavy sarcotubular fraction. Effects of ryanodine, caffeine and magnesium.
    European journal of biochemistry, 1970, Volume: 13, Issue:3

    Topics: Alkaloids; Animals; Biological Transport; Caffeine; Calcium; Chlorpromazine; Magnesium; Metabolism; Muscles; Oxalates; Quinidine; Rabbits; Uranium; Zinc

1970
[The effect of several depriming substances on the evoked reflex pyramidal response].
    Biulleten' eksperimental'noi biologii i meditsiny, 1970, Volume: 69, Issue:5

    Topics: Animals; Bemegride; Caffeine; Cats; Cerebral Cortex; Chlorpromazine; Electric Stimulation; Hydroxybutyrates; Motor Neurons; Pyramidal Tracts; Reflex; Sensation; Skin; Sodium; Thiopental; Trifluoperazine

1970
[Pharmacology of the active substances in betel. 3. Experiments with arecaidine].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:2

    Topics: Animals; Areca; Behavior, Animal; Bile; Blood Glucose; Blood Pressure; Caffeine; Chlorpromazine; Depression, Chemical; Diuresis; Dogs; Drug Synergism; Efficiency; Glutamates; Hexobarbital; Imipramine; Learning; Mice; Nicotinic Acids; Parasympathomimetics; Perception; Phenothiazines; Plant Extracts; Plants, Medicinal; Psychopharmacology; Rats; Reserpine; Stimulation, Chemical

1970
[A comparative study of the neuronal reactions of the paleo- and neo-cortex of the guinea pig brain].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1970, Volume: 56, Issue:3

    Topics: Animals; Caffeine; Cerebral Cortex; Chlorpromazine; Electrophysiology; Guinea Pigs; Hearing; Hippocampus; Neurons; Pain; Sensation; Smell; Somatosensory Cortex

1970
[Action of some stimulants and depressants on simple extinction].
    Bollettino della Societa italiana di biologia sperimentale, 1970, Jul-15, Volume: 46, Issue:13

    Topics: Amphetamine; Animals; Caffeine; Chlorpromazine; Conditioning, Classical; Extinction, Psychological; Meprobamate; Morphine; Motivation; Pentobarbital; Psychopharmacology; Rats

1970
[Intraspecific aggressive behavior induced by apomorphine in the rat].
    Psychopharmacologia, 1970, Volume: 18, Issue:3

    Topics: Acepromazine; Age Factors; Aggression; Amitriptyline; Animals; Apomorphine; Atropine; Behavior, Animal; Caffeine; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Diazepam; Drug Antagonism; Electroshock; Environment; Haloperidol; Humans; Hydroxyzine; Imipramine; Male; Meprobamate; Morphine; Rats; Reserpine; Sex Factors; Sound; Species Specificity; Thiazines; Thioridazine

1970
Neuropharmacological properties of Su17595A a chlorpromazine-like central nervous system depressant.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 191, Issue:1

    Topics: Animals; Blood Pressure; Brain Stem; Caffeine; Cats; Chlordiazepoxide; Chlorpromazine; Cocaine; Depression, Chemical; Dextroamphetamine; Drug Antagonism; Hypnotics and Sedatives; Male; Mice; Morphine; Morpholines; Motor Activity; Pentylenetetrazole; Piperazines; Propiophenones; Rats; Reflex; Respiration; Seizures; Strychnine; Tranquilizing Agents

1971
[Detection of drugs in knee joint synovia].
    Archiv fur Toxikologie, 1971, Volume: 27, Issue:3

    Topics: Albumins; Aspirin; Binding Sites; Biological Transport; Caffeine; Chlorpromazine; Chromatography, Gas; Chromatography, Thin Layer; Codeine; Diazepam; Ephedrine; Forensic Medicine; Humans; Knee Joint; Meprobamate; Methods; Molecular Weight; Morphine; Phenacetin; Phenylbutazone; Procaine; Synovial Fluid; Synovial Membrane

1971
Identification and metabolism of some doping substances in horses.
    Acta veterinaria Scandinavica, 1967

    Topics: Amphetamine; Animals; Caffeine; Chlorpromazine; Chromatography; Gentisates; Horses; Methods; Pharmaceutical Preparations; Phenylbutazone; Salicylates; Spectrophotometry; Sports; Time Factors; Veterinary Medicine

1967
[Behavioral dissociation at the level of the relation of ingestion and the number of merycism cycles in sheep].
    Journal de physiologie, 1967, Volume: 59, Issue:4 Suppl

    Topics: Abomasum; Amphetamine; Animals; Antineoplastic Agents; Caffeine; Chlorpromazine; Circadian Rhythm; Depression, Chemical; Digitalis Glycosides; Ephedrine; Feeding Behavior; Imipramine; Iproniazid; Lanatosides; Mescaline; Pentobarbital; Reserpine; Sheep; Stimulation, Chemical; Stomach, Ruminant

1967
[On the pharmacology of the active substances of betel. 1. Central effect of arecoline].
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:10

    Topics: Amphetamine; Analgesics; Animals; Areca; Atropine; Barbiturates; Caffeine; Central Nervous System; Chlorpromazine; Cocaine; Conditioning, Classical; Depression, Chemical; Exploratory Behavior; Mice; Movement; Mydriatics; Nicotinic Acids; Pentylenetetrazole; Phenothiazines; Plants, Medicinal; Reserpine

1967
[The influence of centrally acting drugs on directional hearing of normal subjects in a free acoustic field].
    Zeitschrift fur Laryngologie, Rhinologie, Otologie und ihre Grenzgebiete, 1968, Volume: 47, Issue:5

    Topics: Aged; Audiometry; Auditory Perception; Benactyzine; Caffeine; Chlorpromazine; Female; Humans; Male; Meprobamate; Middle Aged; Phenobarbital; Strychnine

1968
[Kulenkampf-Tarnow syndrome, problems of its pathogenesis and treatment].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1968, Volume: 68, Issue:2

    Topics: Adolescent; Adult; Atropine; Brain Stem; Caffeine; Chlorpromazine; Ephedrine; Humans; Male; Masticatory Muscles; Mesencephalon; Muscle Cramp; Reticular Formation; Schizophrenia; Seizures; Trismus

1968
The hypnotic properties of 8-ethylthio-6-thiotheophylline sodium.
    Toxicology and applied pharmacology, 1968, Volume: 12, Issue:2

    Topics: Amphetamine; Animals; Caffeine; Chloral Hydrate; Chlorpromazine; Dogs; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Male; Meprobamate; Methylphenidate; Mice; Morphine; Nalorphine; Nikethamide; Pentobarbital; Pentylenetetrazole; Phenobarbital; Rabbits; Rats; Reserpine; Sleep; Theophylline; Thiopental

1968
[On the dependence of pharmacologic effects on the ambient brightness].
    Acta biologica et medica Germanica, 1968, Volume: 20, Issue:6

    Topics: Animals; Barbiturates; Benactyzine; Caffeine; Central Nervous System; Chlorpromazine; Conditioning, Classical; Environmental Exposure; Escape Reaction; Injections, Subcutaneous; Light; Male; Rats; Reserpine

1968
The action of stimulant and depressant agents on local cerebral impedance and circulation.
    Psychopharmacologia, 1964, Oct-14, Volume: 6, Issue:4

    Topics: Amphetamine; Animals; Blood Flow Velocity; Blood Pressure; Caffeine; Cats; Cerebral Cortex; Cerebrovascular Circulation; Chlorpromazine; Electrocardiography; Electroencephalography; Ethyl Ethers; Heart; Hippocampus; Hypothalamus; Pentobarbital; Reticular Formation; Thalamus

1964
[Pharmacological effects on running performance of rats in different performance reward and different performance conditions].
    Psychopharmacologia, 1965, Mar-15, Volume: 7, Issue:3

    Topics: Amphetamine; Animals; Barbiturates; Behavior, Animal; Caffeine; Chlordiazepoxide; Chlorpromazine; Imipramine; Meprobamate; Physical Exertion; Rats; Reward

1965
[The influence of centrally active drugs on sound perception in normally hearing subjects using a binaural speech test].
    Zeitschrift fur Laryngologie, Rhinologie, Otologie und ihre Grenzgebiete, 1965, Volume: 44, Issue:9

    Topics: Benactyzine; Caffeine; Chlorpromazine; Hearing; Hearing Tests; Humans; Meprobamate; Phenobarbital; Psychopharmacology; Strychnine

1965
Experimental observations on the pharmacology of the pontine respiration center.
    Progress in brain research, 1967, Volume: 20

    Topics: Animals; Caffeine; Cats; Chlorpromazine; Morphine; Pentobarbital; Pentylenetetrazole; Piperidines; Respiration; Reticular Formation; Urethane

1967
Inhibition of evoked potentials by caudate stimulation and its antagonism by centrally acting drugs.
    International journal of neuropharmacology, 1967, Volume: 6, Issue:5

    Topics: Amphetamine; Amygdala; Animals; Bemegride; Caffeine; Cats; Caudate Nucleus; Cerebral Cortex; Chlorpromazine; Electric Stimulation; Electrophysiology; Evoked Potentials; Forelimb; Hippocampus; Hypothalamus; Imipramine; Medulla Oblongata; Mephenesin; Morphine; Neurons; Pentobarbital; Pentylenetetrazole; Picrotoxin; Reticular Formation; Strychnine; Thalamus

1967
Central nervous system activity of 1-(3-methoxypropylamino)-2-hydroxy-2-(1,4-benzodioxan-2-yl)-ethane hydrochloride.
    Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 165, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Central Nervous System; Chlorpromazine; Desipramine; Drug Synergism; Electroencephalography; Humans; Methamphetamine; Phenelzine; Rats; Reserpine; Reticular Formation; Sympatholytics; Thiopental

1967
Tolerance to N6-(L-phenylisopropyl) adenosine. Contribution of behavioral mechanisms and cross-tolerance profile.
    Neuropharmacology, 1984, Volume: 23, Issue:6

    Topics: Adenosine; Animals; Behavior, Animal; Caffeine; Chlorpromazine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Phenylisopropyladenosine; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Purinergic

1984
Influences on drugs on evoked potentials in the cat cerebellum: I. Effects of CNS depressants and stimulants on the cerebellar afferent pathways.
    Japanese journal of pharmacology, 1982, Volume: 32, Issue:3

    Topics: Animals; Caffeine; Cats; Central Nervous System Depressants; Central Nervous System Stimulants; Cerebellum; Chlorpromazine; Evoked Potentials; Female; Male; Meprobamate; Neural Pathways; Pentobarbital; Picrotoxin; Strychnine

1982
Action of antidepressants, stimulants and depressants in the transition from a fixed ratio to a fixed interval schedule of reinforcement.
    Progress in neuro-psychopharmacology & biological psychiatry, 1983, Volume: 7, Issue:1

    Topics: Amitriptyline; Amphetamine; Animals; Caffeine; Chlorpromazine; Conditioning, Operant; Diazepam; Doxepin; Imipramine; Male; Psychotropic Drugs; Rats; Rats, Inbred Strains; Reinforcement Schedule

1983
Unique influences of ten drugs upon post-shock biting attack and pre-shock manual responding.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:1

    Topics: Aggression; Animals; Bites and Stings; Caffeine; Chlordiazepoxide; Chlorpromazine; Cocaine; Conditioning, Operant; Dextroamphetamine; Diazepam; Electroshock; Ethanol; Female; Humans; Male; Morphine; Nicotine; Phenobarbital; Saimiri

1983
The locus coeruleus: actions of psychoactive drugs.
    Experientia, 1983, Mar-15, Volume: 39, Issue:3

    Topics: Action Potentials; Animals; Atropine; Caffeine; Chlorpromazine; Desipramine; Haloperidol; Locus Coeruleus; Male; Neurons; Nicotine; Norepinephrine; Physostigmine; Psychotropic Drugs; Rats; Scopolamine

1983
[Malignant hyperthermia-results of familial investigations in Austria (author's transl)].
    Wiener klinische Wochenschrift. Supplementum, 1981, Volume: 132

    Topics: Adenosine Triphosphate; Austria; Caffeine; Calcium; Chlorpromazine; Creatine Kinase; Halothane; Humans; In Vitro Techniques; Isoenzymes; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride

1981
Effects of chlorpromazine and other drugs acting on the central nervous system on human sperm motility.
    European journal of clinical pharmacology, 1982, Volume: 22, Issue:5

    Topics: Caffeine; Central Nervous System; Chlorpromazine; Diazepam; Humans; In Vitro Techniques; Male; Phenobarbital; Phenytoin; Sperm Motility

1982
Effects of psychotropic drugs on impairment of acquisition of shuttle avoidance produced by pretreatment with pairs of tone signal and shock in mice.
    The Japanese journal of psychiatry and neurology, 1994, Volume: 48, Issue:3

    Topics: Animals; Avoidance Learning; Caffeine; Chlorpromazine; Diazepam; Electroshock; Imipramine; Male; Mice; Morphine; Nicotine; Psychotropic Drugs; Signal Detection, Psychological

1994
Some effects of drugs on visual discrimination in the pigeon.
    Annals of the New York Academy of Sciences, 1957, Mar-14, Volume: 66, Issue:3

    Topics: Animals; Caffeine; Chlorpromazine; Columbidae; Humans; Learning; Lysergic Acid Diethylamide; Meperidine; Pentobarbital; Visual Perception

1957
Effects of caffeine and chlorpromazine on the sexual behavior of male rats.
    Science (New York, N.Y.), 1958, Jan-10, Volume: 127, Issue:3289

    Topics: Animals; Caffeine; Chlorpromazine; Male; Rats; Sexual Behavior

1958
[Pharmacological studies on the central nervous system by means of experimental perfusion of the cerebral ventricles and subarachnoid space. III. With special reference to the excretion of irrigation fluids and changes in the blood pressure during the use
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1962, Mar-20, Volume: 58

    Topics: Acetylcholine; Blood Pressure; Brain; Caffeine; Cerebral Ventricles; Chlorpromazine; Curare; Epinephrine; Histamine; Humans; Perfusion; Subarachnoid Space

1962
Central cholinolytic action of chlorpromazine.
    Science (New York, N.Y.), 1962, Jun-08, Volume: 136, Issue:3519

    Topics: Acetylcholine; Animals; Brain; Caffeine; Chlorpromazine; Cholinergic Antagonists; Electroencephalography; Parasympatholytics; Physostigmine; Rabbits

1962
[Changes in auditory adaptation caused by drugs acting on the central nervous system].
    Minerva otorinolaringologica, 1963, Volume: 13

    Topics: Acclimatization; Bromine; Caffeine; Central Nervous System; Chlorpromazine; Hearing; Hearing Tests; Humans

1963
[Vasomotor reactions of the vascular network of the rabbit ear during acute fatigue under the influence of certain neurovasotropic substances].
    Journal de physiologie, 1963, Volume: 55

    Topics: Acetylcholine; Animals; Blood Vessels; Caffeine; Chlorpromazine; Epinephrine; Fatigue; Rabbits; Serotonin; Vasomotor System

1963
Course of some pharmacological tests in functionally decorticated animals.
    Physiologia bohemoslovenica, 1963, Volume: 12

    Topics: Amphetamine; Amphetamines; Animals; Caffeine; Cerebral Cortex; Cerebral Decortication; Chlorpromazine; Ethers; Magnesium Sulfate; Meperidine; Morphine; Pentylenetetrazole; Phenylbutazone; Pregnanediones; Strychnine; Thiopental

1963
[The influence of drugs with central active components on oxygen consumption in carp].
    Acta biologica et medica Germanica, 1963, Volume: 10

    Topics: Animals; Barbiturates; Caffeine; Carps; Central Nervous System; Chlorpromazine; Energy Metabolism; Ethanol; Metabolism; Oxygen Consumption; Strychnine; Urethane

1963
Drugs that modify actions of pharmacologically active polypeptides.
    Annals of the New York Academy of Sciences, 1963, Feb-04, Volume: 104

    Topics: Atropine; Bradykinin; Caffeine; Chlorpromazine; Dibucaine; Ergot Alkaloids; Humans; Hypertension; Lysergic Acid Diethylamide; Morphine; Oxytocin; Peptides; Phenoxybenzamine; Reserpine; Tripelennamine; Vasopressins; Vitamin B 12

1963
[ON THE MECHANISM OF INHIBITION OF INFLAMMATORY EDEMA WITH CAFFEINE, WITH REFERENCE TO SEROTONIN].
    Casopis lekaru ceskych, 1963, May-17, Volume: 102

    Topics: Caffeine; Chlorpromazine; Dextrans; Edema; Epinephrine; Formaldehyde; Inflammation; Rats; Research; Selective Serotonin Reuptake Inhibitors; Serotonin

1963
RELATIONSHIP BETWEEN CHOLINERGIC DRUGS AND EEG ACTIVATION.
    Archives internationales de pharmacodynamie et de therapie, 1963, Sep-01, Volume: 145

    Topics: Atropine; Bemegride; Caffeine; Chlordiazepoxide; Chlorpromazine; Cholinergic Agents; Dextroamphetamine; Electroencephalography; Lysergic Acid Diethylamide; Methylphenidate; Morphine; Parasympathomimetics; Pentobarbital; Pentylenetetrazole; Pharmacology; Phenoxybenzamine; Physostigmine; Rabbits; Research

1963
THE CENTRAL EFFECTS OF XYLOPININE IN MICE.
    Japanese journal of pharmacology, 1963, Volume: 13

    Topics: Amobarbital; Berberine Alkaloids; Caffeine; Central Nervous System; Chlorpromazine; Hypnotics and Sedatives; Methamphetamine; Mice; Nervous System; Pharmacology; Quinolizines; Research; Tetrabenazine; Toxicology; Tranquilizing Agents

1963
[DYNAMICS OF SUBORDINATION AND ADAPTATION IN PATIENTS WITH THE CATATONIC FORM OF SCHIZOPHRENIA WITH CHRONIC UNFAVORABLE DEVELOPMENT].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1963, Volume: 63

    Topics: Acclimatization; Adaptation, Physiological; Caffeine; Catatonia; Central Nervous System; Chlorpromazine; Epinephrine; Humans; Schizophrenia; Schizophrenic Psychology

1963
ASSAY PROCEDURE FOR PHARMACEUTICAL COMBINATIONS OF ASPIRIN, PHENACETIN, CAFFEINE, AND ITOBARBITAL WITH PHENOTHIAZINE DERIVATIVES. I.
    Journal of pharmaceutical sciences, 1964, Volume: 53

    Topics: Anti-Bacterial Agents; Antipsychotic Agents; Aspirin; Barbiturates; Caffeine; Chemistry, Pharmaceutical; Chlorpromazine; Phenacetin; Phenothiazines; Promethazine; Research; Thiethylperazine; Thioridazine

1964
[ON A NEW METHOD OF RECORDING MOVEMENT IN THE LABORATORY ANIMAL MAINTAINED IN ITS REARING ENVIRONMENT--ITS APPLICATION TO THE STUDY OF SOME BEHAVIOR-MODIFYING AGENTS].
    Archives internationales de pharmacodynamie et de therapie, 1964, Sep-01, Volume: 151

    Topics: Amphetamine; Amphetamines; Animals; Animals, Laboratory; Barbiturates; Behavior, Animal; Caffeine; Chlorpromazine; Cinnamates; Cyanides; Heterocyclic Compounds; Hypnotics and Sedatives; Injections, Intraperitoneal; Mice; Morphine; Movement; Pharmacology; Phenobarbital; Research; Reserpine

1964
[EXPERIMENTAL STUDIES ON THE EFFECT OF SOME PHARMACOLOGICAL PREPARATIONS ON THE ANESTHETIC ACTIVITY OF COCAINE].
    Klinika oczna, 1964, Volume: 34

    Topics: Adjuvants, Anesthesia; Anesthetics; Anura; Caffeine; Chlorpromazine; Cocaine; Ephedrine; Epinephrine; Guinea Pigs; Humans; Nitrates; Pentylenetetrazole; Pharmacology; Phenobarbital; Rabbits; Research; Reserpine

1964
PLASMA FREE FATTY ACIDS IN RATS AFTER SHOCK AS MODIFIED BY CENTRALLY ACTIVE DRUGS.
    Archives internationales de pharmacodynamie et de therapie, 1964, Oct-01, Volume: 151

    Topics: Amphetamine; Amphetamines; Blood; Caffeine; Chlordiazepoxide; Chlorpromazine; Electroshock; Ethanol; Fatty Acids; Fatty Acids, Nonesterified; Hydroxyzine; Meprobamate; Pentobarbital; Pharmacology; Rats; Research; Reserpine; Stress, Physiological; Tranquilizing Agents

1964
EFFECTS OF CENTRALLY ACTING DRUGS ON CONFINEMENT MOTOR ACTIVITY.
    Journal of pharmaceutical sciences, 1964, Volume: 53

    Topics: Behavior, Animal; Caffeine; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Methylphenidate; Motor Activity; Movement; Pharmacology; Phenmetrazine; Piperidines; Prochlorperazine; Rats; Research; Tranylcypromine; Trifluoperazine

1964
COMPARISON OF DRUG EFFECTS ON APPROACH, AVOIDANCE, AND ESCAPE MOTIVATION.
    Journal of comparative and physiological psychology, 1965, Volume: 59

    Topics: Amobarbital; Avoidance Learning; Caffeine; Chlordiazepoxide; Chlorpromazine; Ethanol; Methamphetamine; Motivation; Psychopharmacology; Rats; Research; Reward

1965
TIME-SERIES, FREQUENCY ANALYSIS, AND ELECTROGENESIS OF THE EEGS OF NORMALS AND PSYCHOTICS BEFORE AND AFTER DRUGS.
    The American journal of psychiatry, 1965, Volume: 121

    Topics: Amphetamine; Antidepressive Agents; Barbiturates; Biomedical Research; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Deanol; Drug Therapy; Electroencephalography; Lysergic Acid Diethylamide; Meprobamate; Orphenadrine; Pentobarbital; Perphenazine; Pharmacology; Phenobarbital; Placebos; Schizophrenia; Statistics as Topic; Tranquilizing Agents

1965
DRUG-INDUCED DISSOCIATION BETWEEN EVOKED RETICULAR POTENTIALS AND THE EEG.
    Electroencephalography and clinical neurophysiology, 1965, Volume: 19

    Topics: Amphetamine; Amphetamines; Animals; Antidepressive Agents; Atropine; Brain; Caffeine; Catechols; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Electroencephalography; Electrophysiology; Hallucinogens; Humans; Imipramine; Methamphetamine; Methylphenidate; Paraldehyde; Pentobarbital; Pentylenetetrazole; Phenoxybenzamine; Rabbits; Research; Reticular Formation; Scopolamine; Thioridazine; Tranquilizing Agents

1965
[Comparative results in the treatment of early pregnancy toxemias with bromine, caffeine and aminazin].
    Sovetskaia meditsina, 1962, Volume: 25

    Topics: Bromides; Bromine; Caffeine; Chlorpromazine; Female; Pre-Eclampsia; Pregnancy; Toxemia

1962
[Influence of the gastrointestinal motility by injection of various pharmaceutical agents into the cisternal space].
    No to shinkei = Brain and nerve, 1962, Volume: 14

    Topics: Caffeine; Chlorpromazine; Cisterna Magna; Gastrointestinal Motility; Humans; Injections; Thiopental

1962
Antineoplastic and cytogenetic effects of chlorpromazine on human lymphocytes in vitro and on Ehrlich ascites tumor cells in vivo.
    Anti-cancer drugs, 2009, Volume: 20, Issue:8

    Topics: Animals; Antineoplastic Agents; Caffeine; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Proliferation; Cells, Cultured; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Humans; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Mitomycin; Sister Chromatid Exchange; Survival Analysis

2009
A fatal case of potential chronic overdoses of prescribed and proprietary remedies.
    Human & experimental toxicology, 2010, Volume: 29, Issue:8

    Topics: Adult; Analgesics; Caffeine; Chlorpromazine; Clomipramine; Drug Overdose; Fatal Outcome; Heart Arrest; Humans; Liver; Lung; Male; Pulmonary Edema; Substance Abuse Detection

2010
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
    Neurotoxicology, 2012, Volume: 33, Issue:1

    Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Electroshock; Male; Pentylenetetrazole; Phenobarbital; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reaction Time; Seizures; Theophylline; Time Factors; Tramadol

2012
Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro?
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Calcium; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Chlorpromazine; Diclofenac; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Hepatocytes; Humans; Male; Membrane Potential, Mitochondrial; Omeprazole; Primary Cell Culture; Sex Characteristics; Verapamil

2015
The assessment of mouse spontaneous locomotor activity using motion picture.
    Journal of pharmacological sciences, 2020, Volume: 143, Issue:2

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Hypnotics and Sedatives; Locomotion; Male; Mice, Inbred C57BL; Motion Pictures; Motor Activity

2020