chlorpromazine and amantadine

chlorpromazine has been researched along with amantadine in 45 studies

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (44.44)	18.7374
1990's	3 (6.67)	18.2507
2000's	11 (24.44)	29.6817
2010's	10 (22.22)	24.3611
2020's	1 (2.22)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Bednarczyk, D; Ekins, S; Wikel, JH; Wright, SH	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Glen, RC; Lowe, R; Mitchell, JB	1
Gozalbes, R; Pineda-Lucena, A	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Goldberg, LI	1
Borsy, J; Dunai-Kovács, Z; Székely, JI	1
Pakszys, W	1
Messiha, FS	3
Donath, E; Egger, M; Glaser, R; Ziemer, S	1
Berencsi, K; Földeák, S; Mándi, Y; Molnár, J; Prágai, B	1
Kamianov, IM; Katsen, IZ; Kupisk, AG	1
Schergna, E	1
Lahti, RA; McAllister, B; Wozniak, J	1
Andrews, C; Lance, JW	1
Eigeman, L; Vaatstra, WJ	1
Abuzzahab, FS; Kelly, JT; Schiele, BC; Zimmermann, RL	1
Rivera-Calimlim, L	1
Clark, WG; Fleming, RM; Menon, MK	1
Hackman, R; Neuvonen, PJ; Pentikainen, P; Vapaatalo, H	1
Baran, L; Maj, J; Sarnek, J; Sowińska, H	1
Baran, L; Maj, J; Sowińska, H	1
Craddock, G; Fahn, S; Kumin, G	1
Florio, V	1
Kleinrok, Z; Szurska, G	1
Hostetler, KY; Matsuzawa, Y	1
Cornelissen, E; Dewerchin, HL; Nauwynck, HJ; Van Hamme, E; Verhasselt, B	1

Reviews

1 review(s) available for chlorpromazine and amantadine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for chlorpromazine and amantadine

Article	Year
A double-blind study of amantadine hydrochloride versus benztropine mesylate in drug-induced parkinsonism. Pharmacology, 1974, Volume: 12, Issue:2 Topics: Administration, Oral; Amantadine; Antiparkinson Agents; Benztropine; Capsules; Chlorpromazine; Clinical Trials as Topic; Humans; Parkinson Disease; Parkinson Disease, Secondary; Placebos; Schizophrenia; Time Factors	1974

Other Studies

43 other study(ies) available for chlorpromazine and amantadine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Molecular pharmacology, 2003, Volume: 63, Issue:3 Topics: Computational Biology; HeLa Cells; Humans; Models, Molecular; Organic Cation Transporter 1; Pyridinium Compounds; Quinolinium Compounds; Structure-Activity Relationship; Transfection	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Comparison of putative dopamine receptors in blood vessels and the central nervous system. Advances in neurology, 1975, Volume: 9 Topics: Amantadine; Amphetamine; Animals; Aporphines; Arteries; Brain; Chlorpromazine; Dogs; Dopamine; Dopamine Antagonists; Drug Synergism; Haloperidol; Kidney; Piribedil; Receptors, Drug; Thioridazine; Trifluoperazine; Tyramine	1975
The effect of anti-parkinsonian drugs on chlorpromazine-induced depression of operant behaviour. Pharmacology, 1976, Volume: 14, Issue:3 Topics: Amantadine; Animals; Antiparkinson Agents; Apomorphine; Atropine; Behavior, Animal; Chlorpromazine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Phenothiazines; Rats; Trihexyphenidyl	1976
[Interaction between L-dopa and other drugs]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1976, Nov-22, Volume: 31, Issue:47 Topics: Amantadine; Anti-Arrhythmia Agents; Apomorphine; Chlorpromazine; Drug Antagonism; Drug Interactions; Drug Synergism; Humans; Levodopa; Parkinson Disease; Tranquilizing Agents	1976
Genotype-treatment interaction between amantadine and chlorpromazine in the mouse. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1991, Volume: 99, Issue:3 Topics: Amantadine; Animals; Biogenic Amines; Brain; Chlorpromazine; Dopamine; Drug Interactions; Genotype; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Motor Activity; Normetanephrine; Serotonin; Time Factors	1991
Neurotoxicity of chlorpromazine and modulation by amantadine as a function of mouse strain. Neurotoxicology, 1991,Fall, Volume: 12, Issue:3 Topics: Amantadine; Animals; Basal Ganglia Diseases; Chlorpromazine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Rats; Rats, Inbred Strains; Species Specificity	1991
Gonadal alcohol and aldehyde dehydrogenase: in vivo and in vitro effects of psychoactive and endocrine agents. Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:1 Topics: Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Amantadine; Animals; Chlorpromazine; Enkephalin, Leucine; Epididymis; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Papaverine; Psychotropic Drugs; Rats; Rats, Inbred Strains; Reserpine; Scopolamine; Species Specificity; Testis	1990
Electrorotation--a new method for investigating membrane events during thrombocyte activation. Influence of drugs and osmotic pressure. Biochimica et biophysica acta, 1986, Sep-25, Volume: 861, Issue:1 Topics: Adamantane; Amantadine; Blood Platelets; Calcimycin; Cell Membrane; Chlorpromazine; Electrochemistry; Humans; Light; Mathematics; Osmotic Pressure; Platelet Aggregation; Rimantadine; Scattering, Radiation; Thrombin	1986
Comparative study of antiproliferative effects of chlorpromazine, 7,8-dioxochlorpromazine, amantadine-N-mustard, rutin-N-mustard and alpha, beta and gamma interferon on K-562 cells in vitro. Acta microbiologica Hungarica, 1985, Volume: 32, Issue:4 Topics: Amantadine; Antineoplastic Agents, Phytogenic; Cell Division; Cell Line; Chlorpromazine; Cytotoxicity, Immunologic; DNA Replication; Humans; Interferon Type I; Interferon-gamma; Leukemia, Myeloid; Monocytes; Nitrogen Mustard Compounds; Protein Biosynthesis; Rutin; Transcription, Genetic	1985
[Experience with the use of midantan for treatment and prevention of the neuroleptic syndrome]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1973, Volume: 73, Issue:8 Topics: Adult; Amantadine; Antiparkinson Agents; Antipsychotic Agents; Catatonia; Chlorpromazine; Facial Muscles; Female; Humans; Hyperkinesis; Male; Middle Aged; Movement Disorders; Muscle Cramp; Neck; Parasympatholytics; Parkinson Disease, Secondary; Pharyngeal Diseases; Respiratory Insufficiency; Schizophrenia; Schizophrenia, Paranoid; Speech Disorders; Tachycardia; Tranquilizing Agents	1973
[Recent therapeutic conquests in extrapyramidal syndromes]. Minerva medica, 1970, Dec-19, Volume: 61, Issue:101 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Amantadine; Athetosis; Brain Diseases; Central Nervous System Diseases; Chlorpromazine; Chorea; Creutzfeldt-Jakob Syndrome; Dibenzazepines; Dimercaprol; Humans; Huntington Disease	1970
Apomorphine antagonism of the elevation of homovanillic acid induced by antipsychotic drugs. Life sciences. Pt. 1: Physiology and pharmacology, 1972, Jul-01, Volume: 11, Issue:13 Topics: Amantadine; Animals; Apomorphine; Brain; Chlorpromazine; Dopamine; Dose-Response Relationship, Drug; Drug Antagonism; Haloperidol; Homovanillic Acid; Mice; Morphine; Phenylacetates; Receptors, Adrenergic; Structure-Activity Relationship; Synaptic Transmission; Thiothixene; Tranquilizing Agents; Trifluoperazine	1972
Dysaesthesia-dyskinesia: a syndrome of painful legs and moving toes. Proceedings of the Australian Association of Neurologists, 1973, Volume: 9 Topics: Aged; Amantadine; Amitriptyline; Chlorpromazine; Dihydroxyphenylalanine; Female; Humans; Leg; Movement Disorders; Peripheral Nervous System Diseases; Sensation; Syndrome; Toes	1973
Dopamine turnover in the rat corpus striatum: in vivo and in vitro studies on the action of amantadine. European journal of pharmacology, 1974, Volume: 25, Issue:2 Topics: Amantadine; Amphetamine; Animals; Apomorphine; Body Temperature; Chlorpromazine; Corpus Striatum; Dopamine; Male; Rats; Time Factors; Tritium; Tyrosine	1974
Effect of chronic drug treatment on intestinal membrane transport of 14 C-L-dopa. British journal of pharmacology, 1972, Volume: 46, Issue:4 Topics: Amantadine; Animals; Biological Transport; Carbon Isotopes; Chlorpromazine; Dihydroxyphenylalanine; Drug Interactions; In Vitro Techniques; Intestinal Absorption; Jejunum; Male; Neomycin; Phenobarbital; Rats	1972
Blockade of the central effects of d-amphetamine sulfate by amantadine hydrochloride. European journal of pharmacology, 1973, Volume: 21, Issue:3 Topics: Amantadine; Animals; Behavior, Animal; Caudate Nucleus; Chlorpromazine; Dextroamphetamine; Male; Mice; Phenylacetates; Time Factors	1973
Inhibition of the apomorphine gnawing compulsion by amantadine. Experientia, 1973, Volume: 29, Issue:12 Topics: Amantadine; Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Synergism; Male; Metoclopramide; Rats	1973
Pharmacological effects of 1,3-dimethyl-5-aminoadamantane, a new adamantane derivative. European journal of pharmacology, 1974, Volume: 26, Issue:1 Topics: Amantadine; Animals; Apomorphine; Blood Pressure; Body Temperature; Brain Chemistry; Catalepsy; Chlorpromazine; Dextroamphetamine; Disulfides; Dopamine; Female; Fluphenazine; Haloperidol; Humans; Imidazoles; Male; Methyltyrosines; Motor Activity; Norepinephrine; Oxotremorine; Parasympatholytics; Rats; Reflex; Reserpine; Spiro Compounds; Stereotyped Behavior	1974
The effect of amantadine on motor activity and catalepsy in rats. Psychopharmacologia, 1972, Volume: 24, Issue:2 Topics: Amantadine; Animals; Brain; Catalepsy; Catecholamines; Chlorpromazine; Cocaine; Desipramine; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Male; Methyltyrosines; Motor Activity; Nialamide; Rats; Rats, Inbred Strains; Reserpine; Spiro Compounds; Thiocarbamates	1972
Acute toxic psychosis from suicidal overdosage of amantadine. Archives of neurology, 1971, Volume: 25, Issue:1 Topics: Acute Disease; Amantadine; Blood-Brain Barrier; Chlorpromazine; Humans; Male; Middle Aged; Parkinson Disease, Postencephalitic; Phenytoin; Psychoses, Substance-Induced; Suicide; Sympathetic Nervous System	1971
[Study of the central action of amantadine]. Il Farmaco; edizione pratica, 1971, Volume: 26, Issue:11 Topics: Amantadine; Animals; Butyrophenones; Central Nervous System; Chlorpromazine; Dihydroxyphenylalanine; Drug Antagonism; Drug Synergism; Electroencephalography; Epilepsy; Motor Activity; Rabbits; Rats; Reserpine	1971
[Effect of the stimulators and inhibitors of the central dopaminergic structures on the kininogen level and kallikrein activity in the rat plasma]. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 1980, Volume: 35 Topics: Amantadine; Amphetamine; Animals; Apomorphine; Chlorpromazine; Haloperidol; Kallikreins; Kininogens; Male; Rats; Receptors, Dopamine; Reserpine	1980
Studies on the mechanism of drug-induced lipidosis. Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C. Biochemical pharmacology, 1981, May-15, Volume: 30, Issue:10 Topics: Amantadine; Aniline Compounds; Animals; Chlorphentermine; Chlorpromazine; Heptanes; Imipramine; Lipidoses; Liver; Lysosomes; Male; Pharmacology; Phospholipases; Phospholipases A; Propranolol; Rats; Tripelennamine; Type C Phospholipases	1981
Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin. The Journal of general virology, 2008, Volume: 89, Issue:Pt 9 Topics: Amantadine; Animals; beta-Cyclodextrins; Cats; Caveolae; Caveolin 1; Chlorpromazine; Clathrin; Coronavirus, Feline; Dynamins; Endocytosis; Genistein; In Vitro Techniques; Monocytes; Nystatin; rho GTP-Binding Proteins; Virus Internalization	2008