Page last updated: 2024-08-22

chlorproguanil and pyrimethamine

chlorproguanil has been researched along with pyrimethamine in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (22.22)	18.7374
1990's	5 (18.52)	18.2507
2000's	13 (48.15)	29.6817
2010's	2 (7.41)	24.3611
2020's	1 (3.70)	2.80

Authors

Authors	Studies
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Cheong, SL; Ng, CH; Tibon, NS	1
Bjorkman, A; Flacks, H; Hanson, AP; Hogh, B; Petersen, E	1
Bates, CJ; Bradley, AK; Fuller, NJ; Greenwood, AM; Greenwood, BM; Hayes, RJ; Tulloch, S	1
Brandling-Bennett, AD; Gilles, HM; Howells, RE; Koech, DK; Oloo, AJ; Watkins, WM	1
Barutwanayo, M; Coosemans, MH; Gryseels, B; Onori, E; Otoul, C; Wéry, M	1
Alestig, K; Bengtsson, E; Björkman, A; Brohult, J; Hanson, A; Hedman, P; Kollie, E; Pehrson, PO; Rombo, L; Willcox, M	1
Bengtsson, E; Björkman, A; Brohult, J; Sirleaf, V; Willcox, M	1
Chambo, O; Curtis, CF; Hills, E; Mbwana, H; Trigg, JK; Watkins, W	1
Amukoye, E; Hatcher, J; Lowe, B; Marsh, K; Minyiri, G; Mosobo, M; Ngumbao, E; Snow, RW; Ton, M; Watkins, WM; Winstanley, PA	1
Curtis, J; Duraisingh, MT; Warhurst, DC	1
Curtis, J; Maxwell, CA; Ortelli, F; Watkins, WM	1
Hopkins Sibley, C; Mberu, EK; Monks, SA; Nduati, E; Nzila, AM; Watkins, WM; Winstanley, PA	1
Hills, E; Mberu, E; Mutabingwa, T; Nduati, E; Nzila, A; Watkins, W; Winstanley, P	1
Chimpeni, P; Cortese, JF; Dzinjalamala, FK; Kamwendo, DD; Kublin, JG; Lescano, AG; Malkin, EM; Martino, LM; Molyneux, ME; Mukadam, RA; Plowe, CV; Rogerson, SJ; Taylor, TE; Winstanley, PA	1
Chimpeni, P; Hatcher, J; Kublin, JG; Marsh, K; Molyneux, ME; Plowe, CV; Sulo, J; Taylor, TE; Watkins, WM; Winstanley, PA	1
CHARLES, LJ	1
Zimmerman, PA	1
Imwong, M; Looareesuwan, S; Wilairatana, P	1
Alloueche, A; Bailey, W; Barton, S; Bwika, J; Chimpeni, P; Falade, CO; Fehintola, FA; Horton, J; Jaffar, S; Kanyok, T; Kremsner, PG; Kublin, JG; Lang, T; Missinou, MA; Mkandala, C; Oduola, AM; Premji, Z; Robertson, L; Sowunmi, A; Ward, SA; Winstanley, PA	1
Alloueche, A; Bates, SJ; Bwika, J; Happi, TC; Kremsner, PG; Kublin, JG; Premji, Z; Sibley, CH; Watkins, WM; Winstanley, PA	1
Alker, AP; Chaluluka, E; Kamwendo, DD; Meshnick, SR; Molyneux, ME; Mwapasa, V; Purfield, A; Rogerson, SJ; Tadesse, E	1
Garner, P; Jones, K; Taylor-Robinson, D	1
Hasan, MA; Klinkenberg, E; Leslie, T; Mayan, MI; Rowland, M; Safi, MH; Whitty, CJ	1
Nyunt, MM; Plowe, CV	1
Avellino, P; Bancone, G; d'Alessandro, U; Fanello, CI; Karema, C; Lee, SJ; Modiano, D; Uwimana, A	1
Björkman, A; Jovel, IT; Mårtensson, A; Roper, C; Ursing, J	1

Reviews

3 review(s) available for chlorproguanil and pyrimethamine

Article	Year
Current progress in antimalarial pharmacotherapy and multi-target drug discovery. European journal of medicinal chemistry, 2020, Feb-15, Volume: 188 Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular Structure; Paclitaxel; Quinolines	2020
Studies on anti-folate antimalarials in east Africa. Parassitologia, 1999, Volume: 41, Issue:1-3 Topics: Africa, Eastern; Animals; Antimalarials; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Half-Life; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	1999
Malaria: uncomplicated, caused by Plasmodium falciparum. Clinical evidence, 2005, Issue:13 Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Mefloquine; Proguanil; Pyrimethamine; Sesquiterpenes; Sulfadoxine	2005

Trials

11 trial(s) available for chlorproguanil and pyrimethamine

Article	Year
The effects of antimalarials and folate supplements on haematological indices and red cell folate levels in Gambian children. Annals of tropical paediatrics, 1988, Volume: 8, Issue:2 Topics: Antimalarials; Child, Preschool; Dapsone; Drug Combinations; Erythrocyte Indices; Erythrocytes; Folic Acid; Gambia; Hematocrit; Humans; Infant; Leukocyte Count; Placebos; Proguanil; Pyrimethamine	1988
Inadequacy of chlorproguanil 20 mg per week as chemoprophylaxis for falciparum malaria in Kenya. Lancet (London, England), 1987, Jan-17, Volume: 1, Issue:8525 Topics: Adolescent; Child; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; In Vitro Techniques; Kenya; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Random Allocation; Sulfadoxine	1987
Double-blind study to assess the efficacy of chlorproguanil given alone or in combination with chloroquine for malaria chemoprophylaxis in an area with Plasmodium falciparum resistance to chloroquine, pyrimethamine and cycloguanil. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:1 Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines	1987
Monthly antimalarial chemotherapy to children in a holoendemic area of Liberia. Annals of tropical medicine and parasitology, 1986, Volume: 80, Issue:2 Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Hematocrit; Humans; Immunoglobulin G; Liberia; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Spleen; Time Factors	1986
Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:10 Topics: Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Proguanil; Pyrimethamine; Sulfadoxine	1997
In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. The Journal of infectious diseases, 1998, Volume: 177, Issue:5 Topics: Amino Acid Sequence; Animals; Antimalarials; Arginine; Asparagine; Child; Dapsone; Dihydropteroate Synthase; Drug Therapy, Combination; Genes, Protozoan; Genetic Variation; Genotype; Humans; Isoleucine; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sulfadoxine	1998
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. The Journal of infectious diseases, 2002, Feb-01, Volume: 185, Issue:3 Topics: Antimalarials; Biomarkers; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Double-Blind Method; Drug Combinations; Drug Resistance, Bacterial; Humans; Infant; Malaria, Falciparum; Mutation; Proguanil; Prospective Studies; Pyrimethamine; Sensitivity and Specificity; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Treatment Failure	2002
Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial. Lancet (London, England), 2002, Oct-12, Volume: 360, Issue:9340 Topics: Antimalarials; Cause of Death; Child, Preschool; Dapsone; Developing Countries; Drug Combinations; Drug Therapy, Combination; Female; Hemoglobinometry; Humans; Infant; Kenya; Malaria, Falciparum; Malawi; Male; Proguanil; Pyrimethamine; Recurrence; Retreatment; Sulfadoxine; Survival Rate	2002
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial. Lancet (London, England), 2004, Jun-05, Volume: 363, Issue:9424 Topics: Africa; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Methemoglobin; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome	2004
Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial. JAMA, 2007, May-23, Volume: 297, Issue:20 Topics: Adolescent; Adult; Afghanistan; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Female; Folic Acid Antagonists; Humans; Malaria, Vivax; Male; Middle Aged; Pakistan; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome	2007
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. PloS one, 2008, Volume: 3, Issue:12 Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Malaria, Falciparum; Male; Oxidants; Polymorphism, Genetic; Proguanil; Pyrimethamine; Sulfadoxine	2008

Other Studies

13 other study(ies) available for chlorproguanil and pyrimethamine

Article	Year
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
In vitro and in vivo susceptibility of Plasmodium falciparum isolates from Liberia to pyrimethamine, cycloguanil and chlorcycloguanil. Annals of tropical medicine and parasitology, 1990, Volume: 84, Issue:6 Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Resistance; Humans; In Vitro Techniques; Liberia; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines	1990
Plasmodium falciparum resistance to pyrimethamine and chlorproguanil -- host or parasite dependent? Annals of tropical medicine and parasitology, 1980, Volume: 74, Issue:2 Topics: Child; Child, Preschool; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine	1980
Resistance to pyrimethamine/sulfadoxine in Plasmodium falciparum in 12 villages in north east Tanzania and a test of chlorproguanil/dapsone. Acta tropica, 1997, Volume: 63, Issue:2-3 Topics: Anti-Infective Agents; Antimalarials; Child; Child, Preschool; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Infant; Malaria, Falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania	1997
Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum. The Journal of infectious diseases, 2000, Volume: 181, Issue:6 Topics: Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Peptide Synthases; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase	2000
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania. Lancet (London, England), 2001, Oct-13, Volume: 358, Issue:9289 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Resistance; Genotype; Humans; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania	2001
Field trials with chlorproguanil in the prophylaxis of malaria in Ghana. Bulletin of the World Health Organization, 1961, Volume: 24 Topics: Africa; Antimalarials; Child; Drug Resistance; Ghana; Humans; Infant; Malaria; Malaria, Falciparum; Proguanil; Pyrimethamine	1961
Roll back of Plasmodium falciparum antifolate resistance by insecticide-treated nets. The American journal of tropical medicine and hygiene, 2003, Volume: 69, Issue:3 Topics: Animals; Antimalarials; Bedding and Linens; Culicidae; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Insecticides; Malaria, Falciparum; Mosquito Control; Mutation; Plants; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	2003
Chlorproguanil-dapsone for malaria in Africa. Lancet (London, England), 2004, Jun-05, Volume: 363, Issue:9424 Topics: Africa; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	2004
Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites. The Journal of infectious diseases, 2004, Nov-15, Volume: 190, Issue:10 Topics: Alleles; Amino Acid Substitution; Animals; Antimalarials; Dapsone; Drug Resistance; Gabon; Genes, Protozoan; Humans; Kenya; Malaria, Falciparum; Malawi; Molecular Epidemiology; Mutation, Missense; Nigeria; Parasitic Sensitivity Tests; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania; Tetrahydrofolate Dehydrogenase	2004
Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:9 Topics: Animals; Antimalarials; DNA Primers; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Malawi; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Reverse Transcriptase Polymerase Chain Reaction; Sulfadoxine; Tetrahydrofolate Dehydrogenase	2005
Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance. Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:5 Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Design; Drug Resistance; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Global Health; Half-Life; Humans; Lumefantrine; Malaria; Mefloquine; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Sulfadoxine	2007
Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976-78. Malaria journal, 2017, 03-13, Volume: 16, Issue:1 Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Liberia; Malaria, Falciparum; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Proguanil; Protozoan Proteins; Pyrimethamine; Selection, Genetic	2017