Page last updated: 2024-08-22

chlorproguanil and proguanil

chlorproguanil has been researched along with proguanil in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (24.59)	18.7374
1990's	14 (22.95)	18.2507
2000's	28 (45.90)	29.6817
2010's	4 (6.56)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Björkman, A; Rooth, I; Sinani, HM	1
González-Ruiz, A; Haworth, SJ; O'Neil, AB; Warhurst, DC	1
Björkman, A; Flachs, H; Hanson, AP; Hvidberg, EF; Høgh, B; Petersen, E	1
Bjorkman, A; Flacks, H; Hanson, AP; Hogh, B; Petersen, E	1
Breckenridge, AM; Helsby, NA; Howells, RE; Ward, SA	1
Bates, CJ; Bradley, AK; Fuller, NJ; Greenwood, AM; Greenwood, BM; Hayes, RJ; Tulloch, S	1
Flachs, H; Havermann, K; Le Bras, J; Ringwald, P	1
Brandling-Bennett, AD; Gilles, HM; Howells, RE; Koech, DK; Oloo, AJ; Watkins, WM	1
Haworth, SJ; Law, B; O'Neil, AB; Tuersley, LV	1
Chulay, JD; Howells, RE; Sixsmith, DG; Spencer, HC; Watkins, WM	1
Boriga, DA; Brandling-Bennett, AD; Carter, JY; Howells, RE; Koech, DK; Nevill, CG; Watkins, WM	1
Da Costa, F; Schapira, A	1
Flachs, H; Hanson, AP; Høgh, B; Petersen, E	1
Edstein, MD; Rieckmann, KH; Veenendaal, JR	1
Barutwanayo, M; Coosemans, MH; Gryseels, B; Onori, E; Otoul, C; Wéry, M	1
Edstein, MD; Veenendaal, JR	1
Alestig, K; Bengtsson, E; Björkman, A; Brohult, J; Hanson, A; Hedman, P; Kollie, E; Pehrson, PO; Rombo, L; Willcox, M	1
Bengtsson, E; Björkman, A; Brohult, J; Hanson, AP; Hedman, P; Hetland, G; Kollie, E; Pehrson, PO; Rombo, L; Willcox, M	1
Bengtsson, E; Björkman, A; Brohult, J; Sirleaf, V; Willcox, M	1
Helsby, NA; Ward, SA; Wright, JD	1
Breckenridge, AM; Mberu, EK; Szwandt, IS; Watkins, WM; Winstanley, PA	1
Abdul-Aguye, I; Kolawole, JA; Mustapha, A; Ochekpe, N	1
Chambo, O; Curtis, CF; Hills, E; Mbwana, H; Trigg, JK; Watkins, W	1
Amradee, S; Chinwongprom, K; Kyle, DE; Looareesuwan, S; Watkins, WM; White, NJ; Wilairatana, P	1
Amukoye, E; Hatcher, J; Lowe, B; Marsh, K; Minyiri, G; Mosobo, M; Ngumbao, E; Snow, RW; Ton, M; Watkins, WM; Winstanley, PA	1
Curtis, J; Duraisingh, MT; Warhurst, DC	1
Breckenridge, AM; Winstanley, PA	1
Curtis, J; Maxwell, CA; Ortelli, F; Watkins, WM	1
Hopkins Sibley, C; Mberu, EK; Monks, SA; Nduati, E; Nzila, AM; Watkins, WM; Winstanley, PA	1
Hills, E; Mberu, E; Mutabingwa, T; Nduati, E; Nzila, A; Watkins, W; Winstanley, P	1
Winstanley, P	1
Chimpeni, P; Cortese, JF; Dzinjalamala, FK; Kamwendo, DD; Kublin, JG; Lescano, AG; Malkin, EM; Martino, LM; Molyneux, ME; Mukadam, RA; Plowe, CV; Rogerson, SJ; Taylor, TE; Winstanley, PA	1
Chimpeni, P; Hatcher, J; Kublin, JG; Marsh, K; Molyneux, ME; Plowe, CV; Sulo, J; Taylor, TE; Watkins, WM; Winstanley, PA	1
Greenwood, B; Lang, T	1
CHARLES, LJ	1
Carneiro, IA; Chambo, W; Curtis, CF; Magogo, F; Maxwell, CA; Mwaimu, M	1
Zimmerman, PA	1
Imwong, M; Looareesuwan, S; Wilairatana, P	1
Alloueche, A; Bailey, W; Barton, S; Bwika, J; Chimpeni, P; Falade, CO; Fehintola, FA; Horton, J; Jaffar, S; Kanyok, T; Kremsner, PG; Kublin, JG; Lang, T; Missinou, MA; Mkandala, C; Oduola, AM; Premji, Z; Robertson, L; Sowunmi, A; Ward, SA; Winstanley, PA	1
Bukirwa, H; Critchley, J; Garner, P	1
Alloueche, A; Bates, SJ; Bwika, J; Happi, TC; Kremsner, PG; Kublin, JG; Premji, Z; Sibley, CH; Watkins, WM; Winstanley, PA	1
A Clode, S; Clark, RL; Gaunt, I; Ward, SA; White, TE; Winstanley, P	1
Peters, W; Robinson, BL; Stewart, LB	2
Alker, AP; Chaluluka, E; Kamwendo, DD; Meshnick, SR; Molyneux, ME; Mwapasa, V; Purfield, A; Rogerson, SJ; Tadesse, E	1
Garner, P; Jones, K; Taylor-Robinson, D	1
Kamau, EM; Nduati, EW	1
Aarons, L; Bojang, K; Edwards, G; Hughes, D; Manyando, C; Simpson, JA; Ward, S; Watkins, WA; Winstanley, P	1
Biagini, GA; Edwards, G	1
Hasan, MA; Klinkenberg, E; Leslie, T; Mayan, MI; Rowland, M; Safi, MH; Whitty, CJ	1
Nyunt, MM; Plowe, CV	1
Curtis, J; D'Alessandro, U; Fanello, CI; Karema, C; Ndahindwa, V; Ngamije, D; Uwimana, A; Van Doren, W; Van Overmeir, C	1
Adjuik, M; Amenga-Etego, S; Asante, KP; Chandramohan, D; Dosoo, DK; Greenwood, B; Gyapong, J; Owusu, R; Owusu-Agyei, S	1
Avellino, P; Bancone, G; d'Alessandro, U; Fanello, CI; Karema, C; Lee, SJ; Modiano, D; Uwimana, A	1
Bandyopadhyay, N; Duparc, S; Kirby, PL; Miller, AK; Ward, SA; Winstanley, PA; Wootton, DG	1
Borrmann, S; Duparc, S; Esamai, F; Ezedinachi, EU; Greenwood, B; Guiguemdé, R; Kellam, L; Kirby, PL; Oguche, S; Owusu-Agyei, S; Pamba, A; Premji, Z; Sowunmi, A; Umeh, RE; Ward, SA; Winstanley, PA	1
Agbenyega, T; Awobusuyi, J; Carter, N; Dicko, A; Duparc, S; Goh, LE; Greenwood, B; Harrell, E; Ndububa, DA; Pamba, A; Pitmang, S; Tiono, AB; Ward, SA; Winstanley, PA	1
Clark, RL; Gristwood, WE; Harrell, AW; Lewsley, R; Wilson, R	1
Bardsley, B; Barry, SJ; Drozdz, MA; Hancock, SA; Okafo, GN; Szafran, MM	1
Björkman, A; Jovel, IT; Mårtensson, A; Roper, C; Ursing, J	1

Reviews

5 review(s) available for chlorproguanil and proguanil

Article	Year
Clinical pharmacology and malaria. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:7 Topics: Amodiaquine; Antimalarials; Cost-Benefit Analysis; Humans; Malaria, Falciparum; Proguanil; Quinine; Risk Assessment	1997
Studies on anti-folate antimalarials in east Africa. Parassitologia, 1999, Volume: 41, Issue:1-3 Topics: Africa, Eastern; Animals; Antimalarials; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Half-Life; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	1999
Chlorproguanil-dapsone for treating uncomplicated malaria. The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4 Topics: Adult; Antimalarials; Child; Dapsone; Drug Combinations; Humans; Malaria; Proguanil; Randomized Controlled Trials as Topic	2004
Malaria: uncomplicated, caused by Plasmodium falciparum. Clinical evidence, 2005, Issue:13 Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Mefloquine; Proguanil; Pyrimethamine; Sesquiterpenes; Sulfadoxine	2005
Resisting resistance: dealing with the irrepressible problem of malaria. British journal of clinical pharmacology, 2006, Volume: 61, Issue:6 Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria; Proguanil; Sesquiterpenes	2006

Trials

19 trial(s) available for chlorproguanil and proguanil

Article	Year
Proguanil daily or chlorproguanil twice weekly are efficacious against falciparum malaria in a holoendemic area of Tanzania. The Journal of tropical medicine and hygiene, 1991, Volume: 94, Issue:1 Topics: Adolescent; Animals; Child; Drug Administration Schedule; Humans; Malaria; Mefloquine; Plasmodium falciparum; Proguanil; Random Allocation; Tanzania	1991
The effects of antimalarials and folate supplements on haematological indices and red cell folate levels in Gambian children. Annals of tropical paediatrics, 1988, Volume: 8, Issue:2 Topics: Antimalarials; Child, Preschool; Dapsone; Drug Combinations; Erythrocyte Indices; Erythrocytes; Folic Acid; Gambia; Hematocrit; Humans; Infant; Leukocyte Count; Placebos; Proguanil; Pyrimethamine	1988
Inadequacy of chlorproguanil 20 mg per week as chemoprophylaxis for falciparum malaria in Kenya. Lancet (London, England), 1987, Jan-17, Volume: 1, Issue:8525 Topics: Adolescent; Child; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; In Vitro Techniques; Kenya; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Random Allocation; Sulfadoxine	1987
Chlorproguanil/dapsone for the treatment of non-severe Plasmodium falciparum malaria in Kenya: a pilot study. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:3 Topics: Animals; Dapsone; Drug Therapy, Combination; Humans; Kenya; Malaria; Pilot Projects; Plasmodium falciparum; Proguanil	1988
Studies on malaria prophylaxis with chlorproguanil or chloroquine in Mozambique. The Central African journal of medicine, 1988, Volume: 34, Issue:3 Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Humans; Malaria; Mozambique; Plasmodium falciparum; Proguanil; Random Allocation	1988
Double-blind study to assess the efficacy of chlorproguanil given alone or in combination with chloroquine for malaria chemoprophylaxis in an area with Plasmodium falciparum resistance to chloroquine, pyrimethamine and cycloguanil. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:1 Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines	1987
Monthly antimalarial chemotherapy to children in a holoendemic area of Liberia. Annals of tropical medicine and parasitology, 1986, Volume: 80, Issue:2 Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Hematocrit; Humans; Immunoglobulin G; Liberia; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Spleen; Time Factors	1986
Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:10 Topics: Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Proguanil; Pyrimethamine; Sulfadoxine	1997
In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. The Journal of infectious diseases, 1998, Volume: 177, Issue:5 Topics: Amino Acid Sequence; Animals; Antimalarials; Arginine; Asparagine; Child; Dapsone; Dihydropteroate Synthase; Drug Therapy, Combination; Genes, Protozoan; Genetic Variation; Genotype; Humans; Isoleucine; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sulfadoxine	1998
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. The Journal of infectious diseases, 2002, Feb-01, Volume: 185, Issue:3 Topics: Antimalarials; Biomarkers; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Double-Blind Method; Drug Combinations; Drug Resistance, Bacterial; Humans; Infant; Malaria, Falciparum; Mutation; Proguanil; Prospective Studies; Pyrimethamine; Sensitivity and Specificity; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Treatment Failure	2002
Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial. Lancet (London, England), 2002, Oct-12, Volume: 360, Issue:9340 Topics: Antimalarials; Cause of Death; Child, Preschool; Dapsone; Developing Countries; Drug Combinations; Drug Therapy, Combination; Female; Hemoglobinometry; Humans; Infant; Kenya; Malaria, Falciparum; Malawi; Male; Proguanil; Pyrimethamine; Recurrence; Retreatment; Sulfadoxine; Survival Rate	2002
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial. Lancet (London, England), 2004, Jun-05, Volume: 363, Issue:9424 Topics: Africa; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Methemoglobin; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome	2004
Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial. JAMA, 2007, May-23, Volume: 297, Issue:20 Topics: Adolescent; Adult; Afghanistan; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Female; Folic Acid Antagonists; Humans; Malaria, Vivax; Male; Middle Aged; Pakistan; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome	2007
A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2008, Volume: 102, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Humans; Infant; Malaria, Falciparum; Male; Proguanil; Rural Health; Rwanda; Treatment Outcome	2008
An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria. PloS one, 2008, Jun-25, Volume: 3, Issue:6 Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Infant; Lumefantrine; Malaria; Male; Polymerase Chain Reaction; Proguanil; Treatment Outcome	2008
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. PloS one, 2008, Volume: 3, Issue:12 Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Malaria, Falciparum; Male; Oxidants; Polymorphism, Genetic; Proguanil; Pyrimethamine; Sulfadoxine	2008
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria. European journal of clinical pharmacology, 2009, Volume: 65, Issue:10 Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Dapsone; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Gambia; Humans; Malaria, Falciparum; Malawi; Male; Middle Aged; Parasitic Sensitivity Tests; Proguanil; Time Factors	2009
Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria. PloS one, 2009, Aug-19, Volume: 4, Issue:8 Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Dapsone; Double-Blind Method; Ethanolamines; Female; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Male; Patient Compliance; Proguanil; Treatment Outcome	2009
Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria. The American journal of tropical medicine and hygiene, 2009, Volume: 81, Issue:6 Topics: Adolescent; Adult; Africa South of the Sahara; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Therapy, Combination; Female; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria, Falciparum; Male; Plasmodium falciparum; Proguanil; Time Factors	2009

Other Studies

37 other study(ies) available for chlorproguanil and proguanil

Article	Year
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Dapsone in low doses prevents Pneumocystis carinii pneumonia in the rat model. The Journal of infection, 1991, Volume: 22, Issue:2 Topics: Administration, Oral; Animals; Dapsone; Diet; Disease Models, Animal; Immune Tolerance; Male; Pneumonia, Pneumocystis; Proguanil; Random Allocation; Rats; Rats, Inbred Strains; Triazines	1991
Plasma, erythrocyte and urine concentrations of chlorproguanil and two metabolites in man after different doses. The Journal of tropical medicine and hygiene, 1991, Volume: 94, Issue:3 Topics: Adult; Aged; Antimalarials; Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Male; Middle Aged; Proguanil; Triazines	1991
In vitro and in vivo susceptibility of Plasmodium falciparum isolates from Liberia to pyrimethamine, cycloguanil and chlorcycloguanil. Annals of tropical medicine and parasitology, 1990, Volume: 84, Issue:6 Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Resistance; Humans; In Vitro Techniques; Liberia; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines	1990
In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme. British journal of clinical pharmacology, 1990, Volume: 30, Issue:2 Topics: Antimalarials; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Proguanil; Sparteine; Tolbutamide	1990
[A study of the efficacy of the chemoprevention of malaria using chlorproguanil alone or in combination with chloroquine in French expatriates in Dar-es-Salaam, Tanzania]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1989, Volume: 82, Issue:1 Topics: Adolescent; Adult; Child; Chloroquine; Drug Therapy, Combination; Female; France; Humans; Malaria; Male; Middle Aged; Proguanil; Tanzania	1989
Chlorproguanil chemoprophylaxis for falciparum malaria in Kenya. Lancet (London, England), 1987, Mar-07, Volume: 1, Issue:8532 Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Kenya; Malaria; Male; Pilot Projects; Plasmodium falciparum; Proguanil	1987
A preliminary pharmacokinetic study of the antimalarial drugs, proguanil and chlorproguanil. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:4 Topics: Adult; Biological Assay; Humans; Kinetics; Proguanil	1987
Malaria breakthrough despite chlorproguanil chemoprophylaxis in an area without antifol resistance. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:5 Topics: Animals; Antimalarials; Drug Resistance; Folic Acid Antagonists; Humans; Malaria; Plasmodium falciparum; Proguanil; Triazines	1988
Pharmacokinetics of chlorproguanil in man after a single oral dose of Lapudrine. Chemotherapy, 1988, Volume: 34, Issue:4 Topics: Administration, Oral; Adult; Half-Life; Humans; Male; Metabolic Clearance Rate; Proguanil; Triazines	1988
Chlorproguanil and chlorcycloguanil concentrations in human plasma and urine after Lapudrine administration. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:1 Topics: Adult; Antimalarials; Chromatography, High Pressure Liquid; Half-Life; Humans; Male; Proguanil; Triazines	1987
Malaria control by chlorproguanil. I. Clinical effects and susceptibility of Plasmodium falciparum in vivo after seven years of monthly chlorproguanil administration to children in a Liberian village. Annals of tropical medicine and parasitology, 1985, Volume: 79, Issue:6 Topics: Adolescent; Child; Child, Preschool; Disease Susceptibility; Humans; Leukocytes; Liberia; Malaria; Plasmodium falciparum; Plasmodium malariae; Proguanil; Splenomegaly	1985
Plasmodium falciparum resistance to pyrimethamine and chlorproguanil -- host or parasite dependent? Annals of tropical medicine and parasitology, 1980, Volume: 74, Issue:2 Topics: Child; Child, Preschool; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine	1980
The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides. British journal of clinical pharmacology, 1995, Volume: 39, Issue:4 Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Mephenytoin; Mephobarbital; Microsomes, Liver; Mixed Function Oxygenases; Proguanil; Substrate Specificity; Succinimides	1995
In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:4 Topics: Animals; Dapsone; Dihydropteroate Synthase; Drug Combinations; Drug Synergism; Folic Acid Antagonists; Granulocytes; Hematopoietic Stem Cells; Humans; Plasmodium falciparum; Proguanil	1995
Effect of temperature on chlorproguanil and proguanil hydrochloride solutions: a chemical stability study. Journal of pharmaceutical and biomedical analysis, 1996, Volume: 14, Issue:6 Topics: Ammonium Hydroxide; Antimalarials; Drug Stability; Half-Life; Hydrochloric Acid; Hydrogen-Ion Concentration; Hydroxides; Proguanil; Solutions; Temperature	1996
Resistance to pyrimethamine/sulfadoxine in Plasmodium falciparum in 12 villages in north east Tanzania and a test of chlorproguanil/dapsone. Acta tropica, 1997, Volume: 63, Issue:2-3 Topics: Anti-Infective Agents; Antimalarials; Child; Child, Preschool; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Infant; Malaria, Falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania	1997
Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:2 Topics: Adolescent; Adult; Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Female; Folic Acid Antagonists; Follow-Up Studies; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Pilot Projects; Plasmodium falciparum; Proguanil; Thailand; Treatment Outcome	1997
Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum. The Journal of infectious diseases, 2000, Volume: 181, Issue:6 Topics: Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Peptide Synthases; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase	2000
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania. Lancet (London, England), 2001, Oct-13, Volume: 358, Issue:9289 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Resistance; Genotype; Humans; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania	2001
Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria. Tropical medicine & international health : TM & IH, 2001, Volume: 6, Issue:11 Topics: Antimalarials; Artemisinins; Clinical Trials, Phase III as Topic; Dapsone; Drug Approval; Drug Combinations; Drug Therapy, Combination; Health Services Accessibility; Humans; Malaria, Falciparum; Proguanil; Sesquiterpenes	2001
The development of Lapdap, an affordable new treatment for malaria. The Lancet. Infectious diseases, 2003, Volume: 3, Issue:3 Topics: Animals; Antimalarials; Child; Clinical Trials as Topic; Dapsone; Drug Approval; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Proguanil; Time Factors; United Kingdom	2003
Field trials with chlorproguanil in the prophylaxis of malaria in Ghana. Bulletin of the World Health Organization, 1961, Volume: 24 Topics: Africa; Antimalarials; Child; Drug Resistance; Ghana; Humans; Infant; Malaria; Malaria, Falciparum; Proguanil; Pyrimethamine	1961
Variation of malaria transmission and morbidity with altitude in Tanzania and with introduction of alphacypermethrin treated nets. Malaria journal, 2003, Sep-10, Volume: 2 Topics: Altitude; Animals; Anopheles; Antigens, Protozoan; Child; Child, Preschool; Dapsone; Drug Therapy, Combination; Humans; Incidence; Infant; Insecticides; Malaria, Falciparum; Plasmodium falciparum; Prevalence; Proguanil; Protective Devices; Pyrethrins; Secondary Prevention; Tanzania	2003
Roll back of Plasmodium falciparum antifolate resistance by insecticide-treated nets. The American journal of tropical medicine and hygiene, 2003, Volume: 69, Issue:3 Topics: Animals; Antimalarials; Bedding and Linens; Culicidae; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Insecticides; Malaria, Falciparum; Mosquito Control; Mutation; Plants; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	2003
Chlorproguanil-dapsone for malaria in Africa. Lancet (London, England), 2004, Jun-05, Volume: 363, Issue:9424 Topics: Africa; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	2004
Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites. The Journal of infectious diseases, 2004, Nov-15, Volume: 190, Issue:10 Topics: Alleles; Amino Acid Substitution; Animals; Antimalarials; Dapsone; Drug Resistance; Gabon; Genes, Protozoan; Humans; Kenya; Malaria, Falciparum; Malawi; Molecular Epidemiology; Mutation, Missense; Nigeria; Parasitic Sensitivity Tests; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania; Tetrahydrofolate Dehydrogenase	2004
Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit. Birth defects research. Part B, Developmental and reproductive toxicology, 2004, Volume: 71, Issue:6 Topics: Abnormalities, Drug-Induced; Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Combinations; Embryonic Development; Female; Fetal Development; Pregnancy; Proguanil; Rabbits; Rats; Rats, Sprague-Dawley; Sesquiterpenes	2004
The chemotherapy of rodent malaria. LXII. Drug combinations to impede the selection of drug resistance, part 5: rates of development of resistance to some inhibitors of folate metabolism and to artesunate. Annals of tropical medicine and parasitology, 2004, Volume: 98, Issue:8 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Therapy, Combination; Folic Acid Antagonists; Malaria, Falciparum; Male; Mice; Parasitemia; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Proguanil; Sesquiterpenes; Triazines	2004
The chemotherapy of rodent malaria. LXIII. Drug combinations to impede the selection of drug resistance, part 6: the potential value of chlorproguanil and dapsone in combination, and with the addition of artesunate. Annals of tropical medicine and parasitology, 2005, Volume: 99, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Malaria; Male; Mice; Parasitemia; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Proguanil; Rodent Diseases; Sesquiterpenes	2005
Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:9 Topics: Animals; Antimalarials; DNA Primers; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Malawi; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Reverse Transcriptase Polymerase Chain Reaction; Sulfadoxine; Tetrahydrofolate Dehydrogenase	2005
Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy. Acta tropica, 2006, Volume: 97, Issue:3 Topics: Animals; Antimalarials; Atovaquone; Dapsone; Drug Synergism; Drug Therapy, Combination; Folic Acid Antagonists; Naphthoquinones; Plasmodium falciparum; Proguanil; Triazines	2006
Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone. British journal of clinical pharmacology, 2006, Volume: 61, Issue:3 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Humans; Infant; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Proguanil; Prospective Studies; Triazines	2006
Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance. Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:5 Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Design; Drug Resistance; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Global Health; Half-Life; Humans; Lumefantrine; Malaria; Mefloquine; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Sulfadoxine	2007
Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity. Birth defects research. Part B, Developmental and reproductive toxicology, 2010, Volume: 89, Issue:5 Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Artesunate; Autoradiography; Dapsone; Female; Fetus; Male; Pregnancy; Proguanil; Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Distribution	2010
Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacart™) tablets. Journal of pharmaceutical and biomedical analysis, 2011, Feb-20, Volume: 54, Issue:3 Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dapsone; Drug Combinations; Drug Stability; Drug Therapy, Combination; Hot Temperature; Humans; Humidity; Magnetic Resonance Spectroscopy; Malaria, Falciparum; Mass Spectrometry; Proguanil; Tablets	2011
Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976-78. Malaria journal, 2017, 03-13, Volume: 16, Issue:1 Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Liberia; Malaria, Falciparum; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Proguanil; Protozoan Proteins; Pyrimethamine; Selection, Genetic	2017