chlorpheniramine has been researched along with cocaine in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (45.16) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 3 (9.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sen, S; Sinha, N | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Keserü, GM | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Cooper, RA; Dodean, RA; Hinrichs, DJ; Janowsky, A; Johnson, RA; Kelly, JX; Lane, KD; Riscoe, M; Smilkstein, MJ; Winter, R | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Fantozzi, R; Franconi, F; Mannaioni, PF; Masini, E; Moroni, F | 1 |
| Summers, RJ; Tillman, J | 1 |
| Anestis, DK; Gruetter, CA; Lemke, SM; Szarek, JL; Valentovic, MA | 1 |
| Bergman, J | 1 |
| Bergman, J; Spealman, RD | 1 |
| Strauss, A | 1 |
| Davis, RS; McNeill, JH | 1 |
| Goth, A; Isaac, L | 2 |
| Johnson, GL; Kahn, JB | 1 |
| Schrold, J | 1 |
| el-Asmar, MF; Ibrahim, SA; Ismail, M; Osman, OH | 1 |
| Kalsner, S | 1 |
| Koppanyi, T; Osterberg, RE | 1 |
| Blattberg, B; Levy, MN; Masuda, Y; Matsuda, Y | 1 |
| Masukawa, Y; Misawa, M; Suzuki, T | 1 |
| Misawa, M; Mori, T; Onodera, K; Suzuki, T; Tsuji, M | 1 |
| Katz, JL; Kopajtic, TA; Tanda, G | 1 |
31 other study(ies) available for chlorpheniramine and cocaine
| Article | Year |
|---|---|
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.
Topics: Acridones; Animals; Antimalarials; Cell Survival; Cells, Cultured; Drug Design; Drug Interactions; Drug Resistance, Multiple; Lymphocytes; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Molecular Structure; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Interaction of histamine H1-and H2-receptor antagonists with histamine uptake and metabolism by guinea-pig isolated atrium and mouse neoplastic mast cells cells in vitro.
Topics: Animals; Burimamide; Chlorpheniramine; Cocaine; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Mast Cells; Mast-Cell Sarcoma; Metiamide; Mice; Neoplasms, Experimental; Receptors, Drug; Triprolidine | 1975 |
Investigation of the role of calcium in the supersensitivity produced by cocaine in cat spleen strips.
Topics: Angiotensin II; Animals; Calcium; Cats; Chlorpheniramine; Cocaine; Desipramine; Drug Interactions; Female; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Oxymetazoline; Potassium; Proadifen; Spleen | 1979 |
Potentiation of 5-hydroxytryptamine-induced contraction in rat aorta by chlorpheniramine, citalopram and fluoxetine.
Topics: Animals; Aorta, Thoracic; Chlorpheniramine; Citalopram; Cocaine; Dose-Response Relationship, Drug; Fluoxetine; Histamine H1 Antagonists; Imipramine; In Vitro Techniques; Male; Pargyline; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction | 1992 |
Psychomotor stimulant effects of the stereoisomers of chlorpheniramine.
Topics: Animals; Binding, Competitive; Central Nervous System Stimulants; Chlorpheniramine; Cocaine; Dose-Response Relationship, Drug; Male; Pyrilamine; Reinforcement Schedule; Saimiri; Stereoisomerism | 1990 |
Some behavioral effects of histamine H1 antagonists in squirrel monkeys.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Chlorpheniramine; Cimetidine; Clozapine; Cocaine; Conditioning, Operant; Dextroamphetamine; Diphenhydramine; Electroshock; Feeding Behavior; Histamine H1 Antagonists; Male; Promethazine; Saimiri; Self Administration; Tripelennamine | 1986 |
Homicidal psychosis during the combined use of cocaine and an over-the-counter cold preparation.
Topics: Adult; Aspirin; Bicarbonates; Chlorpheniramine; Citrates; Cocaine; Drug Combinations; Homicide; Humans; Male; Nonprescription Drugs; Phenylpropanolamine; Psychoses, Substance-Induced; Sodium Bicarbonate; Substance-Related Disorders | 1989 |
The cardiac effects of cocaine and certain antihistamines and antidepressants.
Topics: Animals; Antidepressive Agents; Brompheniramine; Chlorpheniramine; Cocaine; Desipramine; Guinea Pigs; Heart; Histamine H1 Antagonists; Imipramine; Nerve Endings; Norepinephrine; Tripelennamine; Triprolidine; Tyramine | 1973 |
Interaction of antihistaminics with norepinephrine uptake: a cocaine-like effect.
Topics: Animals; Chlorpheniramine; Cocaine; Heart; Histamine H1 Antagonists; In Vitro Techniques; Norepinephrine; Promethazine; Rats; Tripelennamine | 1965 |
Cocaine and antihistaminic compounds: comparison of effects of some cardiovascular actions of norepinephrine, tyramine and bretylium.
Topics: Animals; Blood Pressure; Bretylium Compounds; Cardiovascular System; Chlorpheniramine; Cocaine; Dogs; Drug Synergism; Heart; Histamine H1 Antagonists; Norepinephrine; Sympathetic Nervous System; Tripelennamine; Triprolidine; Tyramine | 1966 |
The mechanism of the potentiation of norepinephrine by antihistaminics.
Topics: Animals; Blood Pressure; Chlorpheniramine; Cocaine; Drug Synergism; Female; Heart; Heart Atria; Histamine H1 Antagonists; Isoproterenol; Norepinephrine; Pressoreceptors; Promethazine; Rats; Sympathetic Nervous System; Tripelennamine; Tritium | 1967 |
Behavioural effects od d-amphetamine alone and in combination with antidepressants, antihistamines or other psychotropic drugs in young chicks.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Chickens; Chlorpheniramine; Cocaine; Desipramine; Dextroamphetamine; Diphenhydramine; Drug Antagonism; Drug Interactions; Histamine H1 Antagonists; Imipramine; Male; Nortriptyline; Promethazine | 1972 |
Effect on the rat uterus of the venom from the scorpion Leiurus quinquestriatus.
Topics: Animals; Atropine; Chlorpheniramine; Cocaine; Diphenhydramine; Estrus; Female; Hexamethonium Compounds; Kinins; Lysergic Acid Diethylamide; Methysergide; Muscle Contraction; ortho-Aminobenzoates; Papaverine; Pregnancy; Promethazine; Rats; Scorpions; Toluene; Tripelennamine; Uterus; Venoms | 1972 |
Effects of tyramine on responses to and inactivation of histamine in aortic strips.
Topics: Amine Oxidase (Copper-Containing); Amodiaquine; Animals; Aorta; Catecholamines; Chlorpheniramine; Cocaine; Diffusion; Histamine; Imidazoles; In Vitro Techniques; Iproniazid; Methylation; Muscle Contraction; Muscles; Oils; Phentolamine; Quinidine; Rabbits; Reserpine; Semicarbazides; Tranylcypromine; Tyramine | 1970 |
Effects of chlorpheniramine and pyrilamine on the atrial actions of acetylcholine, tyramine, and ephedrine.
Topics: Acetylcholine; Animals; Atropine; Chlorpheniramine; Cocaine; Ephedrine; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Physostigmine; Procaine; Pyrroles; Rabbits; Receptors, Drug; Time Factors; Tyramine | 1969 |
The effects of cocaine, chlorpheniramine and tripelennamine on the cardiac responses to sympathetic nerve stimulation.
Topics: Animals; Blood Pressure; Chlorpheniramine; Cocaine; Dogs; Electric Stimulation; Heart; Heart Rate; Myocardial Contraction; Sympathetic Nervous System; Tripelennamine | 1980 |
Differential modification of the rewarding effects of methamphetamine and cocaine by opioids and antihistamines.
Topics: Animals; Appetite; Chlorpheniramine; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Histamine Antagonists; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Methamphetamine; Morphine; Narcotics; Rats; Rats, Sprague-Dawley; Reward | 1993 |
Generalization of D-, L- and DL-chlorpheniramine and zolantidine to the discriminative stimulus effects of cocaine and methamphetamine.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzothiazoles; Chlorpheniramine; Clomipramine; Cocaine; Desipramine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Generalization, Stimulus; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Methamphetamine; Middle Aged; Phenoxypropanolamines; Piperazines; Piperidines; Rats; Rats, Inbred F344; Thiazoles | 1997 |
Cocaine-like neurochemical effects of antihistaminic medications.
Topics: Animals; Central Nervous System Stimulants; Chlorpheniramine; Cocaine; Diphenhydramine; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Histamine H1 Antagonists; Male; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Reward; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Substance-Related Disorders; Synaptic Transmission; Synaptosomes; Triprolidine | 2008 |