chlorpheniramine and azelastine

chlorpheniramine has been researched along with azelastine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19902 (14.29)18.7374
1990's4 (28.57)18.2507
2000's4 (28.57)29.6817
2010's3 (21.43)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Carrupt, PA; Jolliet, P; Morin, C; Morin, D; Pagliara, A; Rihoux, JP; Testa, B; Tillement, JP; Urien, S1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Browning, C; Buckley, JM; Clark, KL; Fechner, L; Gore, PM; Hancock, AP; Hodgson, ST; Holmes, DS; Kranz, M; Looker, BE; Morriss, KM; Parton, DL; Procopiou, PA; Russell, LJ; Slack, RJ; Sollis, SL; Vile, S; Watts, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Campbell, BH; Connell, JT; Diamond, L; Donnelly, A; Hamilton, LH; Hemsworth, GR; Perhach, JL; Rosenthal, RR; Weiler, JM1
Kai, H; Katayama, K; Katayama, S; Sakuma, Y; Tanaka, I; Tsunoda, H1
Benson, PM; Freitag, J; Meltzer, EO; Weiler, JM; Weiler, K; Widlitz, MD1
Berkebile, C; Friedman, BS; Metcalfe, DD; Santiago, ML1
Kelso, JM1
Asano, K; Furuta, A; Hirano, K; Shoji, N; Suzaki, H1
Baek, SY; Kim, HI; Kim, JH; Kim, YK; Shin, DW; Woo, IS1

Trials

4 trial(s) available for chlorpheniramine and azelastine

ArticleYear
Multicenter, double-blind, multiple-dose, parallel-groups efficacy and safety trial of azelastine, chlorpheniramine, and placebo in the treatment of spring allergic rhinitis.
    The Journal of allergy and clinical immunology, 1988, Volume: 82, Issue:5 Pt 1

    Topics: Adolescent; Adult; Chlorpheniramine; Circadian Rhythm; Clinical Trials as Topic; Dizziness; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Phthalazines; Placebos; Pyridazines; Rhinitis, Allergic, Seasonal; Seasons; Sleep Stages; Taste

1988
A dose-ranging study of the efficacy and safety of azelastine nasal spray in the treatment of seasonal allergic rhinitis with an acute model.
    The Journal of allergy and clinical immunology, 1994, Volume: 94, Issue:6 Pt 1

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Child; Chlorpheniramine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Phthalazines; Rhinitis, Allergic, Seasonal

1994
Comparison of azelastine and chlorpheniramine in the treatment of mastocytosis.
    The Journal of allergy and clinical immunology, 1993, Volume: 92, Issue:4

    Topics: Adult; Aged; Chlorpheniramine; Double-Blind Method; Drug Administration Schedule; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Mastocytosis; Middle Aged; Phthalazines; Skin Tests; Urticaria

1993
Study protocol on azelastine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 78, Issue:2

    Topics: Anti-Allergic Agents; Chlorpheniramine; Data Interpretation, Statistical; Double-Blind Method; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Histamine H1 Antagonists; Humans; Phthalazines; Research Design; Rhinitis, Allergic, Perennial; Sample Size; United States; United States Food and Drug Administration

1997

Other Studies

10 other study(ies) available for chlorpheniramine and azelastine

ArticleYear
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist.
    Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6

    Topics: Alkanes; Animals; Biological Transport; Blood Proteins; Brain; Cetirizine; Histamine H1 Antagonists; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxyzine; Isomerism; Models, Molecular; Molecular Conformation; Octanols; Rats; Water

1998
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis.
    Journal of medicinal chemistry, 2011, Apr-14, Volume: 54, Issue:7

    Topics: Administration, Intranasal; Administration, Oral; Drug Discovery; Histamine H1 Antagonists; Histamine H3 Antagonists; Humans; Models, Molecular; Phthalazines; Protein Conformation; Receptors, Histamine H1; Receptors, Histamine H3; Rhinitis

2011
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Effect of azelastine on the release and action of leukotriene C4 and D4.
    International archives of allergy and applied immunology, 1987, Volume: 83, Issue:3

    Topics: Animals; Arachidonate 5-Lipoxygenase; Chlorpheniramine; Guinea Pigs; Ileum; In Vitro Techniques; Ketotifen; Lung; Phthalazines; Pyridazines; SRS-A

1987
Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro.
    International archives of allergy and immunology, 2011, Volume: 155, Issue:1

    Topics: Adult; Antigens, Plant; Cell Proliferation; Chemokine CCL17; Chemokine CCL22; Chlorpheniramine; Extracellular Signal-Regulated MAP Kinases; GATA1 Transcription Factor; Gene Expression; Histamine; Histamine H1 Antagonists; Humans; Ketotifen; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Macrophages; Male; Middle Aged; NF-kappa B; Phosphorylation; Phthalazines; Piperazines; Plant Proteins; Rhinitis, Allergic, Seasonal; Signal Transduction; Terfenadine; Tuberculin; Young Adult

2011
Development and validation of a simultaneous analytical method for non-steroidal therapeutic compounds in cosmetics using liquid chromatography-tandem mass spectrometry.
    Journal of separation science, 2021, Volume: 44, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bufexamac; Chlorpheniramine; Chromatography, High Pressure Liquid; Clotrimazole; Cosmetics; Doxepin; Fusidic Acid; Ketotifen; ortho-Aminobenzoates; Phthalazines; Tacrolimus; Tandem Mass Spectrometry

2021