chloroquine and vorinostat

chloroquine has been researched along with vorinostat in 29 studies

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (17.24)	29.6817
2010's	22 (75.86)	24.3611
2020's	2 (6.90)	2.80

Authors

Authors	Studies
Andrews, KT; Boyle, GM; Fairlie, DP; Gardiner, DL; Kahnberg, P; Le, GT; Lucke, AJ; Skinner-Adams, TS; Tran, TN	1
Lombardo, F; Obach, RS; Waters, NJ	1
Billadeau, DD; Chen, Y; Dow, GS; Kozikowski, AP; Lopez-Sanchez, M; Savoy, DN	1
Andrews, KT; Caridha, D; Chen, Y; Dow, GS; Gerena, L; Gettayacamin, M; Johnson, J; Kozikowski, AP; Li, Q; Melendez, V; Obaldia, N; Tran, TN	1
Benicewicz, DB; Chen, PC; Gryder, B; Guerrant, W; Khan, SI; Oyelere, AK; Patil, V; Tekwani, BL	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Guerrant, W; Gurard-Levin, ZA; Khan, SI; Mrksich, M; Mwakwari, SC; Oyelere, AK; Patil, V; Tekwani, BL	1
Andrews, KT; Anstey, NM; Chalfein, F; Fairlie, DP; Kenangalem, E; Marfurt, J; Piera, KA; Prayoga, P; Price, RN; Tjitra, E; Wabiser, F	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Andrews, KT; Avery, VM; Duffy, S; Hamacher, A; Hansen, FK; Kassack, MU; Kuna, K; Kurz, T; Marek, L; Meister, S; Mordmüller, B; Schmetter, R; Stenzel, K; Sumanadasa, SD; Winzeler, EA	1
Battistuzzi, G; Giannini, G; Vignola, D	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Andrews, KT; Bouchut, A; Chua, MJ; Erdmann, F; Khalife, J; Pierrot, C; Robaa, D; Sauer, B; Schmidt, M; Sippl, W; Skinner-Adams, TS	1
Androphy, EJ; Boaler, PJ; Burnett, BG; Calder, AN; Cherry, JJ; Choi, S; Cuny, GD; Fritsche, M; Glicksman, MA; Hodgetts, KJ; Kern, NL; Li, H; Lorson, CL; Lusic, H; Quist, KM; Rietz, A; Xing, X	1
Andrews, KT; Antonova-Koch, Y; Avery, VM; Diedrich, D; Duffy, S; Fisher, G; Gebru, T; Hansen, FK; Held, J; Hesping, E; Kurz, T; Meister, S; Schöler, A; Stenzel, K; Winzeler, EA	1
Chng, WJ; Dymock, BW; Fang Nee, AH; Haider, S; Mustafa, N; Ramanujulu, PM; Soumyanarayanan, U; Tan, KSW; Tong, JX	1
Chan, SSL; Chou, CJ; Dolloff, N; Halene, S; Himes, RA; Inks, ES; Jiang, Y; Li, X; Luo, X; Peterson, YK; Xu, T; Yin, G	1
Carew, JS; Chung, L; Cleveland, JL; Giles, FJ; Houghton, JA; Huang, P; Kahue, CN; Nawrocki, ST; Yang, C; Zhang, H	1
Carew, JS; Esquivel, JA; Giles, FJ; Huang, P; Kelly, K; Mahalingam, D; Medina, EC; Mita, AC; Mita, MM; Nawrocki, ST; Swords, R; Zhang, H	1
Goodson, H; Helquist, P; Huegel, KL; Hulett, TW; Vaughan, KT; Wehrmann, ZT; Wiest, O	1
Del Rincon, S; Dupéré-Richer, D; Kinal, M; Ménasché, V; Miller, WH; Nielsen, TH; Pettersson, F	1
Bøe, SO; Engedal, N; Hokland, P; Simonsen, A; Torgersen, ML	1
Alquezar, C; de la Encarnación, A; Esteras, N; López de Munain, A; Martín-Requero, Á; Moreno, F	1
Classen, CF; Fiedler, T; Hering, S; Kreikemeyer, B; Linnebacher, M; Maletzki, C; Redanz, U; Rosche, Y; Strauss, M; William, D	1
Anchoori, R; Bazzaro, M; Coughlin, K; Iizuka, Y; Marastoni, M; Roden, RB; Scotti, A; Vogel, RI	1
Dong, G; Dong, Z; Liu, J; Livingston, MJ; Su, Y; Tang, C; Wu, G; Yin, XM	1
Chowdhury, R; Lohitesh, K; Mukherjee, S; Roy, A; Saini, H; Srivastava, A	1
Agnes, JP; de Souza, PO; Delgobo, M; Gonçalves, RM; Heimfarth, L; Lenz, G; Moreira, JCF; Thomé, MP; Zanotto-Filho, A	1
Frese, K; Gerloff, XF; Körholz, K; Krunic, D; Meder, B; Najafi, S; Oehme, I; Peterziel, H; Ridinger, J; Vega-Rubin-de-Celis, S; Witt, O	1

Reviews

1 review(s) available for chloroquine and vorinostat

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

28 other study(ies) available for chloroquine and vorinostat

Article	Year
Potent antimalarial activity of histone deacetylase inhibitor analogues. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4 Topics: Amino Acids, Dicarboxylic; Animals; Antimalarials; Cysteine; Drug Resistance; Enzyme Inhibitors; Erythrocytes; Histone Deacetylase Inhibitors; Humans; Models, Molecular; Parasitic Sensitivity Tests; Plasmodium falciparum; Sequence Homology, Amino Acid	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. Journal of medicinal chemistry, 2008, Jun-26, Volume: 51, Issue:12 Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Isoenzymes; Pancreatic Neoplasms; Parasitic Sensitivity Tests; Plasmodium falciparum; Triazoles	2008
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10 Topics: Animals; Antimalarials; Aotidae; Drug Resistance; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Hydroxamic Acids; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Mice, Inbred ICR; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship; Thiazoles	2008
Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group. Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1 Topics: Antimalarials; Antiprotozoal Agents; Histone Deacetylase Inhibitors; Histone Deacetylases; Leishmania donovani; Leishmaniasis; Malaria; Plasmodium falciparum; Structure-Activity Relationship; Triazoles	2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton. Journal of medicinal chemistry, 2010, Aug-26, Volume: 53, Issue:16 Topics: Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Isoenzymes; Ketolides; Leishmania donovani; Models, Molecular; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents	2010
Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:3 Topics: Drug Resistance, Multiple, Bacterial; Histone Deacetylase Inhibitors; Hydroxamic Acids; Microbial Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Vorinostat	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. European journal of medicinal chemistry, 2014, Jul-23, Volume: 82 Topics: Antimalarials; Dose-Response Relationship, Drug; Drug Discovery; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Repressor Proteins; Structure-Activity Relationship	2014
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite. Bioorganic & medicinal chemistry letters, 2015, Feb-01, Volume: 25, Issue:3 Topics: Animals; Antimalarials; Cell Line, Tumor; Dipeptides; Disease Models, Animal; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Malaria; Mice; Parasites; Plasmodium falciparum; Protein Isoforms	2015
Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum. European journal of medicinal chemistry, 2017, Feb-15, Volume: 127 Topics: Antimalarials; Caco-2 Cells; Chemistry Techniques, Synthetic; Drug Design; Furans; HEK293 Cells; Humans; Plasmodium falciparum; Structure-Activity Relationship	2017
Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. Journal of medicinal chemistry, 2017, 06-08, Volume: 60, Issue:11 Topics: Anilides; Area Under Curve; Benzamides; Cell Line; Drug Discovery; Half-Life; Humans; Isoxazoles; Molecular Probes; Muscular Atrophy, Spinal; Protein Processing, Post-Translational; Protein Stability; Quinolones; Structure-Activity Relationship; Survival of Motor Neuron 1 Protein; Thiazoles	2017
One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites. European journal of medicinal chemistry, 2018, Oct-05, Volume: 158 Topics: Acetylation; Antimalarials; Hep G2 Cells; Histone Deacetylase Inhibitors; Histones; Humans; Malaria, Falciparum; Peptoids; Plasmodium falciparum; Protozoan Proteins	2018
Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor. European journal of medicinal chemistry, 2019, Dec-15, Volume: 184 Topics: Animals; Antimalarials; Apoptosis; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mice; Microsomes, Liver; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship	2019
Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity. Journal of medicinal chemistry, 2020, 05-28, Volume: 63, Issue:10 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; fms-Like Tyrosine Kinase 3; Histone Deacetylase Inhibitors; Leukemia, Myeloid, Acute; Male; Mice; Panobinostat; Tumor Suppressor Protein p53	2020
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood, 2007, Jul-01, Volume: 110, Issue:1 Topics: Antineoplastic Agents; Autophagy; Cathepsin D; Cell Line, Tumor; Chloroquine; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Vorinostat	2007
Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation. Journal of cellular and molecular medicine, 2010, Volume: 14, Issue:10 Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Boronic Acids; Bortezomib; Carcinoma; Cell Line, Tumor; Cell Survival; Chloroquine; Colonic Neoplasms; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; HT29 Cells; Humans; Hydroxamic Acids; Lysosomes; Mice; Mice, Inbred BALB C; Mice, Nude; Proteasome Endopeptidase Complex; Pyrazines; Superoxides; Ubiquitinated Proteins; Vorinostat; Xenograft Model Antitumor Assays	2010
Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts. PloS one, 2012, Volume: 7, Issue:10 Topics: Azacitidine; beta-Cyclodextrins; Cells, Cultured; Child; Child, Preschool; Chloroquine; Chlorpromazine; Cholesterol; Decitabine; Dose-Response Relationship, Drug; Drug Synergism; Female; Fibroblasts; Humans; Hydroxamic Acids; Indoles; Intracellular Space; Male; Microscopy, Fluorescence; Mutation; Niemann-Pick Disease, Type C; Panobinostat; Sirolimus; Vorinostat	2012
Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance. Cell death & disease, 2013, Feb-07, Volume: 4 Topics: Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Chloroquine; Drug Resistance, Neoplasm; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysosomal-Associated Membrane Protein 2; Membrane Proteins; Protective Agents; RNA Interference; RNA, Small Interfering; TOR Serine-Threonine Kinases; U937 Cells; Vorinostat	2013
Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells. Blood, 2013, Oct-03, Volume: 122, Issue:14 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; Chromosomes, Human, Pair 8; Core Binding Factor Alpha 2 Subunit; Flow Cytometry; Fluorescent Antibody Technique; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoblotting; Leukemia, Myeloid, Acute; Oncogene Proteins, Fusion; RUNX1 Translocation Partner 1 Protein; Transfection; Valproic Acid; Vorinostat	2013
Increasing progranulin levels and blockade of the ERK1/2 pathway: upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:3 Topics: Aged; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chloroquine; DNA-Binding Proteins; Enzyme Inhibitors; Female; Frontotemporal Dementia; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Lymphocytes; Male; MAP Kinase Signaling System; Middle Aged; Mutation; Neuroblastoma; Progranulins; Time Factors; Vorinostat	2015
Arginine deprivation by arginine deiminase of Streptococcus pyogenes controls primary glioblastoma growth in vitro and in vivo. Cancer biology & therapy, 2015, Volume: 16, Issue:7 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Benzopyrans; Cell Line, Tumor; Cell Proliferation; Chloroquine; DNA Methylation; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hydrolases; Hydroxamic Acids; Male; Mice, Inbred Strains; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Streptococcus pyogenes; Treatment Outcome; Tumor Burden; Vorinostat; Xenograft Model Antitumor Assays	2015
Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells. Oncotarget, 2015, Feb-28, Volume: 6, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; Drug Synergism; Female; Humans; Hydroxamic Acids; MCF-7 Cells; Protease Inhibitors; Proteasome Endopeptidase Complex; Triple Negative Breast Neoplasms; Ubiquitin-Specific Proteases; Vorinostat	2015
Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells. Cell death & disease, 2018, 02-23, Volume: 9, Issue:3 Topics: Acute Kidney Injury; Adenylate Kinase; Animals; Autophagy; Autophagy-Related Protein 7; Chloroquine; Cisplatin; Cytoprotection; Histone Deacetylase Inhibitors; Hydroxamic Acids; Kidney Tubules, Proximal; Mice, Inbred C57BL; Mice, Knockout; Protective Agents; TOR Serine-Threonine Kinases; Vorinostat	2018
Autophagy inhibition potentiates SAHA‑mediated apoptosis in glioblastoma cells by accumulation of damaged mitochondria. Oncology reports, 2018, Volume: 39, Issue:6 Topics: Autophagosomes; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Synergism; Glioblastoma; Humans; Hydroxamic Acids; Membrane Potential, Mitochondrial; Mitochondria; Reactive Oxygen Species; Vorinostat	2018
Late autophagy inhibitor chloroquine improves efficacy of the histone deacetylase inhibitor SAHA and temozolomide in gliomas. Biochemical pharmacology, 2019, Volume: 163 Topics: Animals; Antimalarials; Antineoplastic Agents; Astrocytes; Autophagy; Beclin-1; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Therapy, Combination; Gene Knockdown Techniques; Humans; Rats; Rats, Wistar; Temozolomide; Vorinostat	2019
Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma. Cells, 2021, 04-24, Volume: 10, Issue:5 Topics: Animals; Antimalarials; Autophagy; Chloroquine; Forkhead Box Protein O1; Forkhead Box Protein O3; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Mechanistic Target of Rapamycin Complex 1; Neuroblastoma; Tumor Cells, Cultured; Vorinostat; Xenograft Model Antitumor Assays; Zebrafish	2021