Compounds > chloroquine

chloroquine and trichostatin a

chloroquine has been researched along with trichostatin a in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.53)18.2507
2000's8 (42.11)29.6817
2010's9 (47.37)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrews, KT; Boyle, GM; Fairlie, DP; Gardiner, DL; Kahnberg, P; Le, GT; Lucke, AJ; Skinner-Adams, TS; Tran, TN1
Avery, MA; Mukherjee, P; Pradhan, A; Shah, F; Tekwani, BL1
Billadeau, DD; Chen, Y; Dow, GS; Kozikowski, AP; Lopez-Sanchez, M; Savoy, DN1
Adrián, F; Anderson, P; Brinker, A; Caldwell, JS; Chatterjee, A; Gray, NS; Henson, K; Janes, J; Kato, N; Kuhen, K; Matzen, JT; McNamara, C; Nagle, A; Nam, TG; Plouffe, D; Schultz, PG; Trager, R; Winzeler, EA; Yan, SF; Zhou, Y1
Andrews, KT; Caridha, D; Chen, Y; Dow, GS; Gerena, L; Gettayacamin, M; Johnson, J; Kozikowski, AP; Li, Q; Melendez, V; Obaldia, N; Tran, TN1
Benicewicz, DB; Chen, PC; Gryder, B; Guerrant, W; Khan, SI; Oyelere, AK; Patil, V; Tekwani, BL1
Andrews, KT; Avery, VM; Duffy, S; Hamacher, A; Hansen, FK; Kassack, MU; Kuna, K; Kurz, T; Marek, L; Meister, S; Mordmüller, B; Schmetter, R; Stenzel, K; Sumanadasa, SD; Winzeler, EA1
Andrews, KT; Antonova-Koch, Y; Avery, VM; Diedrich, D; Duffy, S; Fisher, G; Gebru, T; Hansen, FK; Held, J; Hesping, E; Kurz, T; Meister, S; Schöler, A; Stenzel, K; Winzeler, EA1
Andrews, KT; Arimondo, PB; Bouchut, A; Chua, MJ; Fabrizi, G; Hoglund, U; Khalife, J; Lafitte, S; Lucidi, A; Mai, A; Mazzone, R; Pechalrieu, D; Pierrot, C; Rotili, D; Schultz, J; Skinner-Adams, TS; Valente, S1
Chng, WJ; Dymock, BW; Fang Nee, AH; Haider, S; Mustafa, N; Ramanujulu, PM; Soumyanarayanan, U; Tan, KSW; Tong, JX1
Krajewski, WA1
Kraevskiĭ, VA; Prasolov, VS1
Amor-Guéret, M; Bayart, E; Grigorieva, O; Leibovitch, S; Onclercq-Delic, R1
Chavez, A; Johnson, FB; Lebel, M; Massip, L; Turaga, RV1
Rahim, R; Strobl, JS1
Beeson, JG; Goodman, CD; Langer, C; McFadden, GI; Wilson, DW1
Chen, Q; Deitsch, KW; Heinberg, AR; Ukaegbu, UE; Wele, M; Zhang, X1
Chen, X; Gao, L; Hong, Y; Lu, L; Sun, X; Zhang, J; Zhang, Q; Zhao, T1
Dong, G; Dong, Z; Liu, J; Livingston, MJ; Su, Y; Tang, C; Wu, G; Yin, XM1

Other Studies

19 other study(ies) available for chloroquine and trichostatin a

ArticleYear
Potent antimalarial activity of histone deacetylase inhibitor analogues.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4

    Topics: Amino Acids, Dicarboxylic; Animals; Antimalarials; Cysteine; Drug Resistance; Enzyme Inhibitors; Erythrocytes; Histone Deacetylase Inhibitors; Humans; Models, Molecular; Parasitic Sensitivity Tests; Plasmodium falciparum; Sequence Homology, Amino Acid

2008
Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy.
    Bioorganic & medicinal chemistry, 2008, May-01, Volume: 16, Issue:9

    Topics: Algorithms; Animals; Antimalarials; Binding Sites; Computer Simulation; Crystallography, X-Ray; Enzyme Inhibitors; Histone Deacetylases; Humans; Ligands; Models, Chemical; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Predictive Value of Tests; Structure-Activity Relationship

2008
A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.
    Journal of medicinal chemistry, 2008, Jun-26, Volume: 51, Issue:12

    Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Isoenzymes; Pancreatic Neoplasms; Parasitic Sensitivity Tests; Plasmodium falciparum; Triazoles

2008
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Jul-01, Volume: 105, Issue:26

    Topics: Animals; Antimalarials; Cluster Analysis; Computational Biology; Drug Evaluation, Preclinical; Drug Resistance; Folic Acid Antagonists; Malaria; Models, Molecular; Parasites; Plasmodium falciparum; Reproducibility of Results; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase

2008
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10

    Topics: Animals; Antimalarials; Aotidae; Drug Resistance; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Hydroxamic Acids; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Mice, Inbred ICR; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship; Thiazoles

2008
Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.
    Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1

    Topics: Antimalarials; Antiprotozoal Agents; Histone Deacetylase Inhibitors; Histone Deacetylases; Leishmania donovani; Leishmaniasis; Malaria; Plasmodium falciparum; Structure-Activity Relationship; Triazoles

2010
Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages.
    European journal of medicinal chemistry, 2014, Jul-23, Volume: 82

    Topics: Antimalarials; Dose-Response Relationship, Drug; Drug Discovery; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Repressor Proteins; Structure-Activity Relationship

2014
One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.
    European journal of medicinal chemistry, 2018, Oct-05, Volume: 158

    Topics: Acetylation; Antimalarials; Hep G2 Cells; Histone Deacetylase Inhibitors; Histones; Humans; Malaria, Falciparum; Peptoids; Plasmodium falciparum; Protozoan Proteins

2018
Identification of novel quinazoline derivatives as potent antiplasmodial agents.
    European journal of medicinal chemistry, 2019, Jan-01, Volume: 161

    Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Fibroblasts; Humans; Mice; Mice, Inbred BALB C; Molecular Conformation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship

2019
Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.
    European journal of medicinal chemistry, 2019, Dec-15, Volume: 184

    Topics: Animals; Antimalarials; Apoptosis; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mice; Microsomes, Liver; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship

2019
Effect of in vivo histone hyperacetylation on the state of chromatin fibers.
    Journal of biomolecular structure & dynamics, 1999, Volume: 16, Issue:5

    Topics: Acetylation; Animals; Cells, Cultured; Chloroquine; Chromatin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Haplorhini; Histones; Hydroxamic Acids; Intercalating Agents; Kidney; Models, Biological; Peptide Hydrolases; Trypsin

1999
[Comparative analysis of higher levels of organization of normal and hyperacetylated chromatin].
    Doklady Akademii nauk, 1999, Volume: 366, Issue:4

    Topics: Acetylation; Animals; Cell Line; Chlorocebus aethiops; Chloroquine; Chromatin; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Hydroxamic Acids; Intercalating Agents; Nucleic Acid Conformation

1999
A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint.
    Cancer research, 2004, Dec-15, Volume: 64, Issue:24

    Topics: Adenosine Triphosphatases; CDC2 Protein Kinase; Cell Division; Chloroquine; DNA; DNA Damage; DNA Helicases; Enzyme Activation; G1 Phase; HeLa Cells; Humans; Hydroxamic Acids; Mitosis; Phosphorylation; Purines; RecQ Helicases; Roscovitine; Subcellular Fractions

2004
Werner syndrome protein prevents DNA breaks upon chromatin structure alteration.
    Aging cell, 2007, Volume: 6, Issue:4

    Topics: Animals; Bloom Syndrome; Cell Line; Cell Line, Tumor; Cellular Senescence; Chloroquine; Chromatin; DNA Breaks; DNA Topoisomerases, Type I; DNA-Binding Proteins; Exodeoxyribonucleases; Genomic Instability; Humans; Hydroxamic Acids; Mice; Oxidative Stress; Reactive Oxygen Species; RecQ Helicases; Topoisomerase I Inhibitors; Transfection; Werner Syndrome; Werner Syndrome Helicase

2007
Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells.
    Anti-cancer drugs, 2009, Volume: 20, Issue:8

    Topics: Acetylation; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Cellular Senescence; Chloroquine; Enzyme Inhibitors; Female; HeLa Cells; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Hydroxychloroquine; Ki-67 Antigen; Mass Spectrometry; Tretinoin; Tumor Stem Cell Assay

2009
Defining the timing of action of antimalarial drugs against Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:3

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Erythrocytes; Flow Cytometry; High-Throughput Screening Assays; Hydroxamic Acids; Inhibitory Concentration 50; Mefloquine; Merozoites; Plasmodium falciparum; Quinine; Quinolines; Schizonts; Time Factors

2013
A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum.
    PLoS genetics, 2015, Volume: 11, Issue:5

    Topics: Antigenic Variation; Antigens, Protozoan; Azepines; Chloroquine; Gene Expression Regulation; Genetic Loci; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Hydroxamic Acids; Immune Evasion; Inhibitory Concentration 50; Malaria, Falciparum; Models, Theoretical; Piperazines; Plasmodium falciparum; Promoter Regions, Genetic; Protozoan Proteins; Quinazolines; RNA Polymerase II; Terpenes; Transcriptional Activation; Transcriptome

2015
Histone deacetylase inhibitor trichostatin A and autophagy inhibitor chloroquine synergistically exert anti-tumor activity in H-ras transformed breast epithelial cells.
    Molecular medicine reports, 2018, Volume: 17, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Transformed; Chloroquine; Drug Combinations; Drug Synergism; Epithelial Cells; Forkhead Box Protein O1; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mammary Glands, Human; Proto-Oncogene Proteins p21(ras); RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases

2018
Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells.
    Cell death & disease, 2018, 02-23, Volume: 9, Issue:3

    Topics: Acute Kidney Injury; Adenylate Kinase; Animals; Autophagy; Autophagy-Related Protein 7; Chloroquine; Cisplatin; Cytoprotection; Histone Deacetylase Inhibitors; Hydroxamic Acids; Kidney Tubules, Proximal; Mice, Inbred C57BL; Mice, Knockout; Protective Agents; TOR Serine-Threonine Kinases; Vorinostat

2018