chloroquine has been researched along with sirolimus in 96 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (10.42) | 29.6817 |
| 2010's | 60 (62.50) | 24.3611 |
| 2020's | 26 (27.08) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dong, G; Liu, N; Sheng, C; Wang, Y; Wu, S | 1 |
| Agard, DA; Ashworth, A; Barrio-Hernandez, I; Batra, J; Beltrao, P; Bennett, MJ; Bohn, M; Bouhaddou, M; Braberg, H; Broadhurst, DJ; Cai, Y; Cakir, M; Calviello, L; Cavero, DA; Chang, JCJ; Chorba, JS; Craik, CS; d'Enfert, C; Dai, SA; Eckhardt, M; Emerman, M; Fabius, JM; Fletcher, SJ; Floor, SN; Foussard, H; Frankel, AD; Fraser, JS; Fujimori, DG; Ganesan, SJ; García-Sastre, A; Gordon, DE; Gross, JD; Guo, JZ; Haas, K; Haas, P; Hernandez-Armenta, C; Hiatt, J; Huang, XP; Hubert, M; Hüttenhain, R; Ideker, T; Jacobson, M; Jang, GM; Jura, N; Kaake, RM; Kim, M; Kirby, IT; Klippsten, S; Koh, C; Kortemme, T; Krogan, NJ; Kuzuoglu-Ozturk, D; Li, Q; Liboy-Lugo, J; Lin, Y; Liu, X; Liu, Y; Lou, K; Lyu, J; Mac Kain, A; Malik, HS; Mathy, CJP; McGregor, MJ; Melnyk, JE; Memon, D; Meyer, B; Miorin, L; Modak, M; Moreno, E; Mukherjee, S; Naing, ZZC; Noack, J; O'Meara, MJ; O'Neal, MC; Obernier, K; Ott, M; Peng, S; Perica, T; Pilla, KB; Polacco, BJ; Rakesh, R; Rathore, U; Rezelj, VV; Richards, AL; Roesch, F; Rosenberg, OS; Rosenthal, SB; Roth, BL; Roth, TL; Ruggero, D; Safari, M; Sali, A; Saltzberg, DJ; Savar, NS; Schwartz, O; Sharp, PP; Shen, W; Shengjuler, D; Shi, Y; Shoichet, BK; Shokat, KM; Soucheray, M; Stroud, RM; Subramanian, A; Swaney, DL; Taunton, J; Tran, QD; Trenker, R; Tummino, TA; Tutuncuoglu, B; Ugur, FS; Vallet, T; Venkataramanan, S; Verba, KA; Verdin, E; Vignuzzi, M; von Zastrow, M; Wang, HY; Wankowicz, SA; Wenzell, NA; White, KM; Xu, J; Young, JM; Zhang, Z; Zhou, Y | 1 |
| Chida, N; Kawano, S; Miura, K; Sato, T; Simizu, S; Suto, T | 1 |
| Bader, S; Forooghian, F; Gilman, A; HayGlass, KT; Hsiao, CC; Rempel, J; Schultz, KR; Su, WN | 1 |
| Marx, J | 1 |
| Connolly, FP; Gaikwad, A; Gutterman, JU; Haridas, V; Liang, J; Mills, GB; Xu, ZX | 1 |
| Huang, Q; Kim, YS; Liu, ZG; Ong, CN; Ong, WY; Pan, N; Shen, HM; Tan, HL; Wu, YT | 1 |
| Bae, D; Lu, S; Mercurio, AM; Taglienti, CA | 1 |
| Amaravadi, RK | 1 |
| Bast, RC; Khare, S; Kondo, S; Kondo, Y; Liao, WS; Lu, Y; Lu, Z; Luo, RZ; Mills, GB; Yu, Q; Yu, Y; Zhang, X | 1 |
| Peng, C; Shi, H; Wang, JZ; Wang, Q; Wang, S; Zhang, JY | 1 |
| Benavides, A; Frost, P; Hoang, B; Lichtenstein, A; Shi, Y | 1 |
| Hirota, Y; Tanaka, Y | 1 |
| Fan, Z; Li, X; Lu, Y; Pan, T | 1 |
| Cheng, C; Debnath, J; Fan, QW; Feldman, M; Haas-Kogan, D; Hackett, C; Houseman, BT; James, CD; Nicolaides, T; Oakes, SA; Shokat, KM; Weiss, WA | 1 |
| Bockus, A; Ding, WX; Jones, K; Ni, HM; Weinman, S; Wozniak, AL; Yin, XM | 1 |
| Henderson, P; Hupp, T; Lin, Y; Pettersson, S; Satsangi, J; Stevens, C | 1 |
| Beckmann, MW; Brandt, I; Dittmer, A; Dittmer, J; Dittrich, R; Fabry, B; Fasching, PA; Groh, N; Hoffmann, I; Kalender, WA; Koch, T; Koppitz, F; Loehberg, CR; Lotz, L; Lux, MP; Mueller, A; Oeser, S; Polier, A; Schrauder, MG; Strick, R; Strissel, PL; Wachter, DL | 1 |
| Bisicchia, E; Cavallucci, V; Cecconi, F; D'Amelio, M; Fanelli, F; Latini, L; Maccarrone, M; Molinari, M; Moreno, S; Nazio, F; Viscomi, MT | 1 |
| Aryal, S; Cummings, CT; Maycotte, P; Morgan, MJ; Thorburn, A; Thorburn, J | 1 |
| Baranowski, M; Cahová, M; Daňková, H; Kazdová, L; Páleníčková, E; Papáčková, Z; Skop, V; Zabielski, P; Zdychová, J; Zídková, J | 1 |
| Bao, JK; Cheng, Y; Liu, B; Yang, JM | 1 |
| Dong, G; Dong, Z; Jiang, M; Komatsu, M; Su, Y; Wei, Q | 1 |
| Goodson, H; Helquist, P; Huegel, KL; Hulett, TW; Vaughan, KT; Wehrmann, ZT; Wiest, O | 1 |
| Chen, X; Dong, XC; Li, M; Lin, CW; Xiong, X; Yin, XM; Zhang, H | 1 |
| Huang, ST; Li, XY; Ma, JL; Qu, S; Su, F; Zhao, W; Zhou, ZR; Zhu, XD | 1 |
| Chikte, S; Panchal, N; Warnes, G | 1 |
| Hong, SK; Kim, JH; Park, JI; Starenki, D | 1 |
| Boidot, R; Bouzin, C; Feron, O; Gallez, B; Jordan, BF; Karroum, O; Machiels, JP; Seront, E | 1 |
| Hill, JA; Li, L; Lin, F; Wang, ZV | 1 |
| Balestrieri, ML; Caraglia, M; D'Onofrio, N; Di Domenico, G; Grimaldi, A; Lamberti, M; Nocera, C; Pantano, F; Santini, D; Tonini, G; Zoccoli, A | 1 |
| Chen, W; Huang, LZ; Li, B; Liu, HF; Liu, WJ; Luo, MN; Pan, Q; Tan, J; Yang, C | 1 |
| Chang, J; Cheng, L; Ji, D; Li, J; Liu, R; Liu, X; Sun, Z; Wang, C; Wang, S; Wang, X; Zhang, X; Zhang, Z; Zheng, B; Zheng, R | 1 |
| Emoto, S; Hiyoshi, M; Iida, Y; Kaneko, M; Kishikawa, J; Kitayama, J; Murono, K; Nirei, T; Nozawa, H; Sunami, E; Tada, N; Takahashi, K; Tsuno, NH; Watanabe, T | 1 |
| Deng, W; Jiang, K; Li, Y; Liu, Q; Meng, S; Wang, Y; Xu, J; Zhang, G; Zhu, Q | 1 |
| Cho, HI; Choi, JW; Lee, SM | 1 |
| Atherton, S; Covar, J; Marshall, B; Mo, J; Smith, S; Zhang, M | 1 |
| Fan, N; Gu, L; Ma, Y; Peng, Y; Wang, Y; Yin, J | 1 |
| Nieuwenhuis, J; Perrimon, N; Samsonova, A; Tao, R; Zirin, J | 1 |
| Kimonis, VE; Llewellyn, KJ; Nalbandian, A; Nguyen, C; Yazdi, PG | 1 |
| Dai, S; Gong, Z; Qian, L; Sun, L; Xu, Z; Yan, Y | 1 |
| Duan, J; Liu, Q; Mu, H; Niu, H; Tang, J; Wang, D | 1 |
| Bespalko, A; Frenkel, D; Holtzman, DM; Iram, T; Masliah, E; Michaelson, DM; Pinkas-Kramarski, R; Schmukler, E; Simonovitch, S | 1 |
| Chen, Z; Pei, F; Wang, HS; Zhang, L | 1 |
| Hase, N; Hiyama, T; Kawai, R; Matsumoto, T; Mogi, M; Nakata, K; Ozeki, N; Yamaguchi, H | 1 |
| Chi, CH; Chi, KH; Chi, MS; Chiang, HC; Huang, YC; Kao, SJ; Wang, HE; Wang, YS | 1 |
| Bi, J; Gao, F; He, W; Huang, H; Lan, Y; Song, D; Wang, G; Zhang, D; Zhao, K | 1 |
| Aparicio, IM; Bejarano, I; Campo, ML; Espino, J; Gallardo-Soler, A; Pariente, JA; Peña, FJ; Salido, GM; Tapia, JA | 1 |
| Cao, XF; Fang, XS; Guan, MM; Li, BX; Liu, GL; Mao, HB; Weng, CY | 1 |
| Chen, JT; Chen, RM; Cheng, BC; Chio, CC; Liu, SH; Yang, ST | 1 |
| Gu, HF; Li, HZ; Liao, DF; Nie, YX; Tang, XQ; Tang, YL; Xie, XJ | 1 |
| Chen, S; Chen, Y; Lai, B; Liang, H; Liu, J; Song, L; Tang, H; Xu, L; Yang, H; Yun, L; Zhou, K | 1 |
| Li, J; Mu, Y; Yan, WJ; Yang, J; Yin, TL; Zhang, Y | 1 |
| Ding, N; Gao, F; He, W; Lan, Y; Li, Z; Lu, H; Lv, X; Su, J; Zhao, K | 1 |
| Chen, GJ; Hu, LT; Hu, XT; Lai, YJ; Long, Y; Zha, JS; Zhang, JH; Zhu, BL | 1 |
| Cao, X; Dong, G; Qu, X; Yang, S; Yu, J; Yu, N | 1 |
| An, HJ; Choi, YJ; Chung, HY; Chung, KW; Im, DS; Im, E; Kim, DH; Kim, KM; Lee, B; Lee, EK; Lee, J; Yu, BP | 1 |
| Bhattacharyya, S; Singla, M | 1 |
| Bian, XW; Chen, Q; Fu, WJ; Niu, Q; Ping, YF; Wang, JM; Weng, HY; Wu, HB; Yang, S; Yao, XH; Zhang, X; Zhao, XL | 1 |
| Hu, LK; Sun, YL; Wang, HJ; Zhao, T; Zhao, WW | 1 |
| Deng, Y; Guan, X; He, Z; Li, D; Liu, Q; Liu, Y; Tao, Z; Wang, X | 1 |
| He, XX; Li, PY; Liao, JZ; Liu, C; Liu, L; Sheng, JQ; Tian, DA; Wu, XL; Zhu, HD | 1 |
| He, Y; Liu, B; Peng, H; Qi, Z; Qin, Z; Ren, H; Tang, H; Wang, S; Yves, TD; Zhao, P | 1 |
| Gao, X; Li, Z; Liu, L; Liu, X; Ma, J; Zhang, T | 1 |
| Patel, AA; Popat, A; Warnes, G | 1 |
| Fukuoka, N; Ishibashi, Y; Nakamura, O; Nishimura, H; Yamagami, Y; Yamamoto, T | 1 |
| Li, B; Li, J; Liu, M; Shi, C; Sun, C; Wang, W; Wang, Y; Wang, Z; Wu, J; Zhang, C; Zhou, Y; Zuo, R | 1 |
| Kong, XF; Meng, XP; Yang, JY; Zhang, YF | 1 |
| Emoto, S; Hata, K; Kaneko, M; Kawai, K; Murono, K; Nishikawa, T; Nozawa, H; Otani, K; Sasaki, K; Shiratori, H; Sonoda, H; Tanaka, T | 1 |
| Alizadeh, S; Meshkani, R; Sadeghi, A; Shabani, M | 1 |
| Kou, R; Shan, S; Shen, Z; Song, F; Xie, K; Zhang, C | 1 |
| Hou, JM; Li, N; Wu, HJ; Xue, Y; Zhang, Y; Zhang, ZN; Zhao, LJ | 1 |
| Cheng, R; Huang, Y; Liu, X; Zhao, X | 1 |
| Chen, B; Chen, Z; Jiang, T; Lai, X; Li, C; Li, Y; Liu, Y; Nie, J; Su, Z; Sun, C; Yang, H; Zheng, J; Zhuo, J | 1 |
| Caceres, SM; Grimm, XA; Malcolm, KC; Nick, JA; Poch, KR; Pohl, K; Rysavy, N; Saavedra, M | 1 |
| Li, Z; Ni, Y; Zhang, H; Zhang, J | 1 |
| Cui, Z; Li, J; Liao, S; Qi, M; Sun, P; Tan, B; Tang, S; Tang, Y; Wang, Y; Yin, Y; Zha, A | 1 |
| Balmori-Cedeno, J; Liu, JT; Lumsden, JS; Misk, E | 1 |
| Curiel, TJ; Deng, Y; Gupta, HB; Kancharla, A; Kari, S; Kornepati, AVR; Li, R; Osta, E; Padron, AS; Reyes, RM; Sun, X; Svatek, RS; Vadlamudi, R; Wu, B; Zhang, D | 1 |
| Fu, H; Huang, S; Liu, R; Pan, Y; Ren, X; Wang, K; Wu, D; Yu, Q; Zhang, X | 1 |
| Kapuy, O; Makk-Merczel, K; Szarka, A | 1 |
| Chiu, CH; Hsu, HJ; Hsu, MC; Huang, C; Jiang, YF; Jong, DS; Wang, ME; Wu, LS | 1 |
| Chen, Q; Cheng, Y; He, H; Huang, P; Li, Y; Wei, W; Xiong, L; Yi, W; Zeng, L; Zou, Q | 1 |
| Dai, J; Hong, Y; Hu, Y; Jiang, P; Li, R; Liu, D; Lv, H; Song, M; Wang, H; Wang, Z; Yao, S; Zhang, X; Zhao, G; Zhou, Z | 1 |
| Islam, MK; Lian, HK; Lim, JCW; Sagineedu, SR; Selvarajoo, N; Stanslas, J | 1 |
| Guo, Y; Jiang, XL; Li, H; Xu, XQ; Yang, HD; Zhu, QF | 1 |
| Du, X; Feng, X; Gao, C; Jiang, Q; Li, X; Liu, G; Liu, S; Loor, JJ; Song, Y; Sun, Z; Wang, Z; Yang, Y | 1 |
| Bazinet, RP; Belsham, DD; Chen, CT; He, W; Loganathan, N; Tran, A | 1 |
| Agarwal, V; Kushwaha, A; Verma, RS | 1 |
| Wang, J; Yang, G; Zhang, J; Zhang, L; Zou, Y | 1 |
| Han, Y; Huang, Y; Jin, C; Li, W; Li, X; Yang, Q; Zheng, Y; Zhuang, Z | 1 |
| Cao, Y; Chen, J; Guan, X; Hu, Q; Huang, X; Jiang, J; Li, X; Liu, H; Wu, W; Yin, S; Yuan, S; Zhou, J; Zhou, Y | 1 |
| Shen, Y; Tong, J; Wang, L; Wen, Y; Yu, X; Zhang, D; Zhang, L; Zhu, H | 1 |
| Chen, TC; Cho, HY; Fu, J; Hofman, FM; Minea, RO; Ou, M; Schönthal, AH; Stathopoulos, A; Swenson, SD; Tang, L; Thein, TZ; Wang, W | 1 |
5 review(s) available for chloroquine and sirolimus
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Tackling Fungal Resistance by Biofilm Inhibitors.
Topics: Animals; Antifungal Agents; Biofilms; Drug Discovery; Drug Resistance, Fungal; Fungi; Humans; Models, Molecular; Mycoses; Small Molecule Libraries | 2017 |
Targeting autophagic pathways for cancer drug discovery.
Topics: Antibiotics, Antineoplastic; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Chloroquine; Drug Discovery; Humans; Membrane Proteins; Molecular Targeted Therapy; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2013 |
Targeting autophagy to sensitive glioma to temozolomide treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chloroquine; Clinical Trials as Topic; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Glioblastoma; Humans; Sirolimus; Temozolomide | 2016 |
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; ErbB Receptors; Fluorouracil; Humans; Metformin; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
91 other study(ies) available for chloroquine and sirolimus
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Topics: Animals; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Cloning, Molecular; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunity, Innate; Mass Spectrometry; Molecular Targeted Therapy; Pandemics; Pneumonia, Viral; Protein Binding; Protein Biosynthesis; Protein Domains; Protein Interaction Mapping; Protein Interaction Maps; Receptors, sigma; SARS-CoV-2; SKP Cullin F-Box Protein Ligases; Vero Cells; Viral Proteins | 2020 |
Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy.
Topics: Animals; Autophagy; Biological Products; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 4 or More Rings; Humans; Microtubule-Associated Proteins; Molecular Structure; Porifera; Up-Regulation | 2021 |
Evaluation for synergistic suppression of T cell responses to minor histocompatibility antigens by chloroquine in combination with tacrolimus and a rapamycin derivative, SDZ-RAD.
Topics: Animals; Antigen Presentation; Apoptosis; Cells, Cultured; Chloroquine; Cytokines; Drug Evaluation, Preclinical; Drug Synergism; Everolimus; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Minor Histocompatibility Antigens; Recombinant Proteins; Sirolimus; T-Lymphocytes; Tacrolimus | 2002 |
Autophagy: is it cancer's friend or foe?
Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Survival; Chloroquine; Dacarbazine; Genes, Tumor Suppressor; Humans; Membrane Proteins; Mice; Neoplasms; Oncogenes; Proteins; Sirolimus; Temozolomide | 2006 |
A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Beclin-1; Cell Line, Tumor; Chloroquine; Enzyme Activation; Fusion Regulatory Protein 1, Heavy Chain; Humans; Membrane Proteins; Microtubule-Associated Proteins; Multienzyme Complexes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Saponins; Sirolimus; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Ubiquitin-Activating Enzymes | 2007 |
Autophagy plays a protective role during zVAD-induced necrotic cell death.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Beclin-1; Biomarkers; Caspase Inhibitors; Cathepsins; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Fibroblasts; Gene Targeting; Humans; Lysosomes; Mice; Microtubule-Associated Proteins; Necrosis; Phagosomes; Proteins; Sirolimus | 2008 |
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Membrane; Chloroquine; Culture Media; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hypoxia; Lysosomes; Macrolides; Neuropilin-1; Neuropilin-2; Sirolimus | 2008 |
Autophagy-induced tumor dormancy in ovarian cancer.
Topics: Animals; Antibiotics, Antineoplastic; Antirheumatic Agents; Autophagy; Cell Line, Tumor; Cell Survival; Chloroquine; Cysteine Endopeptidases; Female; Genomic Imprinting; Humans; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Neoplasm Transplantation; Ovarian Neoplasms; Phagosomes; Phosphatidylinositol 3-Kinases; Protein Kinases; rho GTP-Binding Proteins; Sirolimus; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Tumor Suppressor Proteins | 2008 |
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells.
Topics: Animals; Antibiotics, Antineoplastic; Antirheumatic Agents; Autophagy; Cell Line, Tumor; Cell Survival; Chloroquine; Cysteine Endopeptidases; Female; Genomic Imprinting; Humans; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Neoplasm Transplantation; Ovarian Neoplasms; Phagosomes; Phosphatidylinositol 3-Kinases; Protein Kinases; rho GTP-Binding Proteins; Sirolimus; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Tumor Suppressor Proteins | 2008 |
Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain.
Topics: Animals; Anti-Bacterial Agents; Autophagy; Blotting, Western; Calpain; Chloroquine; Chymotrypsin; Enzyme Activation; Lysosomes; Male; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Sirolimus; tau Proteins; Trypsin | 2009 |
Effect of autophagy on multiple myeloma cell viability.
Topics: Adenine; Antifungal Agents; Antimalarials; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Boronic Acids; Bortezomib; Cell Proliferation; Chloroquine; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Immunoblotting; Membrane Proteins; Microscopy, Fluorescence; Multiple Myeloma; Pyrazines; RNA, Small Interfering; Sirolimus; Thapsigargin; Tumor Cells, Cultured | 2009 |
A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions.
Topics: Animals; Autophagy; Chlorocebus aethiops; Chloroquine; COS Cells; Endoplasmic Reticulum; HeLa Cells; Humans; rab GTP-Binding Proteins; Recombinant Fusion Proteins; RNA, Small Interfering; Sirolimus; Vacuoles | 2009 |
Roles of autophagy in cetuximab-mediated cancer therapy against EGFR.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cetuximab; Chloroquine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Neoplasms; Phagosomes; Sirolimus | 2010 |
Akt and autophagy cooperate to promote survival of drug-resistant glioma.
Topics: Animals; Autophagy; Cell Line, Tumor; Chloroquine; Drug Synergism; Flow Cytometry; Furans; Glioma; Histological Techniques; Humans; Imidazoles; Immunoblotting; Immunohistochemistry; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Mitochondria; Mutation; Oncogene Protein v-akt; Phosphoinositide-3 Kinase Inhibitors; PTEN Phosphohydrolase; Pyridines; Pyrimidines; Quinolines; Sirolimus; TOR Serine-Threonine Kinases; Transplantation, Heterologous | 2010 |
Dissecting the dynamic turnover of GFP-LC3 in the autolysosome.
Topics: Amino Acids; Animals; Autophagy; Cell Compartmentation; Chloroquine; Culture Media; Fluorescence; Green Fluorescent Proteins; HCT116 Cells; HeLa Cells; Humans; Hydrogen-Ion Concentration; Luminescent Proteins; Lysosomes; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Models, Biological; Recombinant Fusion Proteins; Red Fluorescent Protein; Sirolimus | 2011 |
Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Autophagy; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Line; Cell Line, Tumor; Chloroquine; Death-Associated Protein Kinases; Fibroblasts; Gene Expression; HEK293 Cells; Humans; Leupeptins; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred Strains; Mice, Knockout; Models, Biological; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Mutation, Missense; Neuropeptides; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Interaction Domains and Motifs; Proteins; Ras Homolog Enriched in Brain Protein; Regulatory-Associated Protein of mTOR; Ribosomal Protein S6 Kinases; RNA, Small Interfering; Sequence Deletion; Sirolimus; TOR Serine-Threonine Kinases; Transfection; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2011 |
Akt and p53 are potential mediators of reduced mammary tumor growth by cloroquine and the mTOR inhibitor RAD001.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; Everolimus; Female; G1 Phase Cell Cycle Checkpoints; Humans; Immunosuppressive Agents; Mice; Mice, Nude; Neoplasms, Experimental; Oncogene Protein v-akt; Sirolimus; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2012 |
Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Axotomy; Beclin-1; Brain Injuries; Cerebellum; Chloroquine; Cytochromes c; Cytoprotection; Mice; Mice, Inbred C57BL; Mitochondria; Nerve Degeneration; Neurons; Neuroprotective Agents; Phagosomes; Sirolimus | 2012 |
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy.
Topics: Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 12; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chloroquine; Chromones; Cisplatin; Drug Screening Assays, Antitumor; Female; Gene Knockdown Techniques; Humans; Macrolides; Mice; Morpholines; Proteins; Sirolimus; Starvation | 2012 |
Autophagy-lysosomal pathway is involved in lipid degradation in rat liver.
Topics: Animals; Asparagine; Autophagy; Cells, Cultured; Chloroquine; Diglycerides; Fatty Acids, Nonesterified; Hepatocytes; Lipolysis; Lipoproteins, VLDL; Liver; Lysosomal-Associated Membrane Protein 2; Lysosomes; Male; Microtubule-Associated Proteins; Oxidation-Reduction; Rats; Rats, Wistar; Sirolimus; Sterol Esterase; Triglycerides | 2012 |
Autophagy in proximal tubules protects against acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 7; Biomarkers; Blood Urea Nitrogen; Cells, Cultured; Chloroquine; Cisplatin; Creatinine; Cytoprotection; Disease Models, Animal; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; Kidney Tubules, Proximal; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Reperfusion Injury; Signal Transduction; Sirolimus; Time Factors; Tumor Suppressor Protein p53 | 2012 |
Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts.
Topics: Azacitidine; beta-Cyclodextrins; Cells, Cultured; Child; Child, Preschool; Chloroquine; Chlorpromazine; Cholesterol; Decitabine; Dose-Response Relationship, Drug; Drug Synergism; Female; Fibroblasts; Humans; Hydroxamic Acids; Indoles; Intracellular Space; Male; Microscopy, Fluorescence; Mutation; Niemann-Pick Disease, Type C; Panobinostat; Sirolimus; Vorinostat | 2012 |
Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice.
Topics: Animals; Autophagy; Biomarkers; Carbamazepine; Cells, Cultured; Chloroquine; Dietary Fats; Disease Models, Animal; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; Hepatocytes; In Vitro Techniques; Lipid Metabolism; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Non-alcoholic Fatty Liver Disease; Sirolimus | 2013 |
Poly(ADP-ribose) polymerase-1 regulates the mechanism of irradiation-induced CNE-2 human nasopharyngeal carcinoma cell autophagy and inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Benzamides; Carcinoma; Cell Line, Tumor; Cell Survival; Chloroquine; Humans; Microtubule-Associated Proteins; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Phagosomes; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Radiation Tolerance; Radiation-Sensitizing Agents; Sirolimus | 2013 |
Use of LysoTracker dyes: a flow cytometric study of autophagy.
Topics: Amines; Autophagy; Biomarkers; Caspases; Chloroquine; Culture Media; Flow Cytometry; Fluorescent Dyes; Gene Expression; Humans; Jurkat Cells; K562 Cells; Lysosomes; Microtubule-Associated Proteins; Oligopeptides; Phagosomes; Sirolimus | 2014 |
Autophagy sensitivity of neuroendocrine lung tumor cells.
Topics: Adaptor Proteins, Signal Transducing; Antimalarials; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Humans; Lung Neoplasms; Macrolides; Microtubule-Associated Proteins; Naphthyridines; Neuroendocrine Tumors; Phosphopyruvate Hydratase; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; Sirolimus; Small Cell Lung Carcinoma; TOR Serine-Threonine Kinases | 2013 |
Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Breast Neoplasms; Cell Hypoxia; Chloroquine; Female; Humans; Mammary Neoplasms, Experimental; Mice, Nude; Sirolimus; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2013 |
New autophagy reporter mice reveal dynamics of proximal tubular autophagy.
Topics: Acute Kidney Injury; Animals; Autophagy; Cells, Cultured; Chloroquine; Culture Media; Epithelial Cells; Female; Genes, Reporter; Green Fluorescent Proteins; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Luminescent Proteins; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Multiprotein Complexes; Phagosomes; Recombinant Fusion Proteins; Red Fluorescent Protein; Regeneration; Reperfusion Injury; Sirolimus; TOR Serine-Threonine Kinases; Vacuoles | 2014 |
The synergistic effect of everolimus and chloroquine on endothelial cell number reduction is paralleled by increased apoptosis and reduced autophagy occurrence.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Count; Cell Proliferation; Cell Survival; Chloroquine; Drug Synergism; Endothelial Cells; Everolimus; Humans; Membrane Proteins; Models, Biological; Proto-Oncogene Proteins c-bcl-2; Sirolimus; Stem Cells | 2013 |
Autophagy activation reduces renal tubular injury induced by urinary proteins.
Topics: Animals; Apoptosis; Autophagy; Chloroquine; Epithelial Cells; Humans; Kidney Tubules; Lysosomes; Male; Microtubule-Associated Proteins; Phagosomes; Rats; Rats, Sprague-Dawley; Sirolimus | 2014 |
The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Butadienes; Cell Line, Tumor; Chloroquine; Cyclin D1; Drug Synergism; Everolimus; Flavonoids; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Membrane Proteins; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Nitriles; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Chloroquine; Colorectal Neoplasms; Cyclin D1; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Mice; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2014 |
Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells.
Topics: Animals; Autophagy; Cell Line, Tumor; Chick Embryo; Chloroquine; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Humans; Lung Neoplasms; Mice; Mice, Nude; Microtubule-Associated Proteins; Neoplasm Transplantation; Newcastle disease virus; Oncolytic Virotherapy; Oncolytic Viruses; Sirolimus; Xenograft Model Antitumor Assays | 2014 |
Impairment of autophagosome-lysosome fusion contributes to chronic ethanol-induced liver injury.
Topics: Animals; Anti-Bacterial Agents; Autophagy; Chloroquine; Ethanol; Liver; Liver Diseases, Alcoholic; Lysosomes; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Sirolimus | 2014 |
Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells.
Topics: Animals; Apoptosis; Autophagy; Caspase 3; Chloroquine; Cytomegalovirus Infections; Disease Models, Animal; Green Fluorescent Proteins; Herpesviridae Infections; Humans; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Muromegalovirus; Recombinant Fusion Proteins; Retinal Pigment Epithelium; Sirolimus; Transfection; Vacuoles | 2014 |
Rapamycin improves palmitate-induced ER stress/NF κ B pathways associated with stimulating autophagy in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Autophagy; Blotting, Western; Chemokine CCL2; Chloroquine; Endoplasmic Reticulum Stress; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Interleukin-6; Mice; Microscopy, Electron; Palmitates; Real-Time Polymerase Chain Reaction; Sirolimus | 2015 |
Regulators of autophagosome formation in Drosophila muscles.
Topics: Animals; Autophagy; Cell Communication; Chloroquine; Drosophila melanogaster; Glycogen; GTPase-Activating Proteins; Larva; Muscle Cells; Muscle, Skeletal; Muscular Diseases; Phagosomes; Protein Interaction Maps; rab3 GTP-Binding Proteins; Sirolimus; Ubiquitin | 2015 |
Rapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem proteinopathy.
Topics: Animals; Apoptosis; Autophagy; Cell Cycle Proteins; Cell Line; Chloroquine; Disease Models, Animal; DNA-Binding Proteins; Eye Proteins; Frontotemporal Dementia; Gene Knock-In Techniques; Humans; Intercellular Signaling Peptides and Proteins; Male; Membrane Transport Proteins; Mice; Muscle, Skeletal; Myoblasts; Osteitis Deformans; Peptides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin | 2015 |
Autophagy promotes DNA-protein crosslink clearance.
Topics: Adenine; Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Camptothecin; Cell Line, Tumor; Cell Survival; Chloroquine; DNA Damage; Formaldehyde; Gene Silencing; Humans; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; RNA, Small Interfering; Sirolimus; Ubiquitin-Activating Enzymes; Ultraviolet Rays | 2016 |
Impaired Autophagy in APOE4 Astrocytes.
Topics: Amyloid beta-Peptides; Animals; Apolipoprotein E3; Apolipoprotein E4; Astrocytes; Autophagy; Brain; Cells, Cultured; Central Nervous System Agents; Chloroquine; Disease Models, Animal; Humans; Mice, Transgenic; Plaque, Amyloid; Sirolimus; Time Factors | 2016 |
Autophagy regulates odontoblast differentiation by suppressing NF-κB activation in an inflammatory environment.
Topics: Alkaline Phosphatase; Animals; Autophagy; Autophagy-Related Protein 5; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Beclin-1; Cell Differentiation; Cell Line; Chloroquine; Genes, Reporter; Lipopolysaccharides; Mice; Microscopy, Fluorescence; Microtubule-Associated Proteins; NF-kappa B; Odontoblasts; RNA Interference; RNA, Small Interfering; Sirolimus; TOR Serine-Threonine Kinases | 2016 |
Bone morphogenetic protein-induced cell differentiation involves Atg7 and Wnt16 sequentially in human stem cell-derived osteoblastic cells.
Topics: Antigens, CD; Autophagy; Autophagy-Related Protein 7; Biomarkers; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Cell Differentiation; Chloroquine; Gene Silencing; Humans; Integrin alpha Chains; Models, Biological; Muscle, Skeletal; Osteoblasts; Osteogenesis; RNA, Messenger; RNA, Small Interfering; Sirolimus; Stem Cells; Tretinoin; Wnt Proteins | 2016 |
Simultaneous activation and inhibition of autophagy sensitizes cancer cells to chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Mitochondrial Membranes; Neoplasms; Phospholipase D; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Vinca Alkaloids; Xenograft Model Antitumor Assays | 2016 |
Role of autophagy in cellular response to infection with Orf virus Jilin isolate.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Chloroquine; Ecthyma, Contagious; Host-Pathogen Interactions; Microscopy, Electron, Transmission; Orf virus; Sheep; Sirolimus; Virus Replication | 2016 |
Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility.
Topics: Adenosine Triphosphate; Adult; AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Proteins; Calcium; Caspases; Cell Movement; Cell Survival; Chloroquine; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Intracellular Space; Macrolides; Male; Membrane Transport Proteins; Mitochondrial Precursor Protein Import Complex Proteins; Phosphorylation; Protein Kinases; Receptors, Cell Surface; Semen; Sequestosome-1 Protein; Sirolimus; Spermatozoa | 2016 |
The regulatory effects of autophagy to the CNE2 cells radio-sensitization.
Topics: Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Cell Survival; Chloroquine; Flow Cytometry; G1 Phase Cell Cycle Checkpoints; Gamma Rays; Humans; Radiation Tolerance; RNA Interference; RNA, Small Interfering; Sirolimus | 2016 |
Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway.
Topics: Adenine; Antimutagenic Agents; Apoptosis; Autophagy; Brain Neoplasms; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Cobalt; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubule-Associated Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sirolimus; Tumor Suppressor Protein p53 | 2017 |
Oxidized low-density lipoprotein induced mouse hippocampal HT-22 cell damage via promoting the shift from autophagy to apoptosis.
Topics: Animals; Annexin A5; Antirheumatic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Cell Line, Transformed; Cell Survival; Chloroquine; Dose-Response Relationship, Drug; Flow Cytometry; Hippocampus; Lipoproteins, LDL; Mice; Microscopy, Electron, Transmission; Neurons; Proto-Oncogene Proteins c-bcl-2; Sequestosome-1 Protein; Sincalide; Sirolimus | 2017 |
Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Line; Chloroquine; Gene Knockdown Techniques; Humans; Hydrogen Peroxide; Hydroquinones; Microtubule-Associated Proteins; Poly (ADP-Ribose) Polymerase-1; Sirolimus; Sirtuin 1 | 2017 |
Diet-induced obesity impairs spermatogenesis: a potential role for autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cells, Cultured; Chloroquine; Diet, High-Fat; Humans; Infertility, Male; Male; Mice; Mice, Inbred C57BL; Obesity; Palmitic Acid; Semen Analysis; Sirolimus; Spermatogenesis; Spermatozoa; Testis | 2017 |
Induction of Atypical Autophagy by Porcine Hemagglutinating Encephalomyelitis Virus Contributes to Viral Replication.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Betacoronavirus 1; Cell Line; Cell Survival; Chloroquine; Coronavirus Infections; Lysosomes; Membrane Proteins; Mice; Sirolimus; Vacuoles; Virus Replication | 2017 |
HMGCS2 promotes autophagic degradation of the amyloid-β precursor protein through ketone body-mediated mechanisms.
Topics: Acetoacetates; Amyloid beta-Protein Precursor; Animals; Autophagy; Cell Line; Chloroquine; Gene Expression Regulation; HEK293 Cells; Hippocampus; Humans; Hydroxymethylglutaryl-CoA Synthase; Ketone Bodies; Mice; Microtubule-Associated Proteins; Neurons; Proteolysis; Recombinant Proteins; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transgenes | 2017 |
Low shear stress‑induced autophagy alleviates cell apoptosis in HUVECs.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagosomes; Autophagy; bcl-2-Associated X Protein; Beclin-1; Blotting, Western; Chloroquine; Human Umbilical Vein Endothelial Cells; Humans; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-bcl-2; RNA-Binding Proteins; Sirolimus; Stress, Mechanical | 2017 |
The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis.
Topics: Age Factors; Animals; Autophagy; Chloroquine; Class III Phosphatidylinositol 3-Kinases; Endotoxemia; Fasting; Hepatitis, Animal; Hepatocytes; Lipid Metabolism; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Sirolimus | 2017 |
Autophagy as a potential therapeutic target during epithelial to mesenchymal transition in renal cell carcinoma: An in vitro study.
Topics: Autophagy; Carcinoma, Renal Cell; Cell Culture Techniques; Cell Line, Tumor; Chloroquine; Epithelial-Mesenchymal Transition; Humans; Kidney Neoplasms; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Bevacizumab; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; Female; Gene Knockdown Techniques; Glioma; Humans; Mice; Mice, SCID; Models, Biological; Neoplastic Stem Cells; Neovascularization, Pathologic; Phosphorylation; Reactive Oxygen Species; Sirolimus; Survival Analysis; Tissue Scaffolds; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2017 |
Gambogic acid improves non-small cell lung cancer progression by inhibition of mTOR signaling pathway.
Topics: A549 Cells; Adenine; Antineoplastic Agents, Phytogenic; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Cisplatin; Drug Combinations; Drug Synergism; Garcinia; Gene Expression Regulation, Neoplastic; Humans; Microtubule-Associated Proteins; Plant Extracts; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Xanthones | 2017 |
Inhibition of Autophagy Attenuated Ethylene Glycol Induced Crystals Deposition and Renal Injury in a Rat Model of Nephrolithiasis.
Topics: Animals; Autophagy; Calcium Oxalate; Chloroquine; Crystallization; Ethylene Glycol; Kidney; Kidney Calculi; Nephrolithiasis; Rats; Sirolimus | 2018 |
Celecoxib alleviates nonalcoholic fatty liver disease by restoring autophagic flux.
Topics: Animals; Autophagy; Celecoxib; Cell Line; Chloroquine; Diet, High-Fat; Humans; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; Sirolimus | 2018 |
Zika Virus Induces Autophagy in Human Umbilical Vein Endothelial Cells.
Topics: Androstadienes; Animals; Autophagy; Chlorocebus aethiops; Chloroquine; Gene Knockout Techniques; Human Umbilical Vein Endothelial Cells; Humans; Phagosomes; RNA, Small Interfering; Signal Transduction; Sirolimus; Vero Cells; Virus Replication; Wortmannin; Zika Virus; Zika Virus Infection | 2018 |
hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells.
Topics: Acetylation; Autophagosomes; Autophagy; Chloroquine; CRISPR-Cas Systems; HEK293 Cells; Heterogeneous-Nuclear Ribonucleoprotein K; Histone Deacetylase 6; Humans; Hydroxamic Acids; Indoles; Lysosomes; RNA, Small Interfering; Sirolimus; Tubulin | 2018 |
A Flow Cytometric Study of ER Stress and Autophagy.
Topics: Apoptosis; Autophagy; Cell Survival; Chloroquine; eIF-2 Kinase; Endoplasmic Reticulum Stress; Flow Cytometry; Fluorescent Antibody Technique; G1 Phase Cell Cycle Checkpoints; Humans; Jurkat Cells; Microtubule-Associated Proteins; Necrosis; Oligopeptides; Sirolimus; Thapsigargin; Unfolded Protein Response | 2019 |
Chloroquine Enhances Rapamycin-induced Apoptosis in MG63 Cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; Autophagy; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Microscopy, Fluorescence; Osteosarcoma; Sirolimus; TOR Serine-Threonine Kinases | 2019 |
Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells.
Topics: Animals; Autophagy; Cartilage; Cell Differentiation; Chloroquine; Chondrogenesis; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Intervertebral Disc; Intervertebral Disc Degeneration; Kelch-Like ECH-Associated Protein 1; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Osteogenesis; Reactive Oxygen Species; Signal Transduction; Sirolimus; Stem Cells; Tumor Necrosis Factor-alpha | 2019 |
Delayed effects of autophagy on T-2 toxin-induced apoptosis in mouse primary Leydig cells.
Topics: Animals; Apoptosis; Autophagy; Chloroquine; Leydig Cells; Male; Mice; Sirolimus; T-2 Toxin | 2019 |
The combination of temsirolimus and chloroquine increases radiosensitivity in colorectal cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Colorectal Neoplasms; HT29 Cells; Humans; Microtubule-Associated Proteins; Phosphorylation; Radiation-Sensitizing Agents; Ribosomal Protein S6 Kinases; RNA-Binding Proteins; Sirolimus | 2019 |
Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chloroquine; Cytokines; Free Radical Scavengers; Inflammation; Interleukin-6; Mice; Microtubule-Associated Proteins; Muscle, Skeletal; Oxidative Stress; Palmitates; Reactive Oxygen Species; Sequestosome-1 Protein; Sirolimus; Tumor Necrosis Factor-alpha | 2020 |
Mitophagy protects against acetaminophen-induced acute liver injury in mice through inhibiting NLRP3 inflammasome activation.
Topics: Acetaminophen; Acute Lung Injury; Animals; Chloroquine; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Mitophagy; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Kinases; Sirolimus; Ubiquitin-Protein Ligases | 2019 |
Nbr1-regulated autophagy in Lactoferrin-induced osteoblastic differentiation.
Topics: Adenine; Animals; Autophagy; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Chloroquine; Intracellular Signaling Peptides and Proteins; Lactoferrin; Mice; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Sirolimus | 2020 |
Autophagy attenuates high glucose-induced oxidative injury to lens epithelial cells.
Topics: Animals; Autophagy; Cataract; Cells, Cultured; Chloroquine; Culture Media; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Epithelial Cells; Glucose; Humans; Lens Capsule, Crystalline; Male; Mice; Mitochondria; Oxidative Stress; Primary Cell Culture; Reactive Oxygen Species; Sirolimus; Streptozocin | 2020 |
Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway.
Topics: Animals; Antidepressive Agents; Autophagy; Behavior, Animal; Chloroquine; Depression; Disks Large Homolog 4 Protein; Hippocampus; Intracellular Signaling Peptides and Proteins; Male; Microtubule-Associated Proteins; Phosphorylation; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Sequestosome-1 Protein; Sesquiterpenes; Signal Transduction; Sirolimus; Stress, Psychological; Synapsins; TOR Serine-Threonine Kinases | 2020 |
Mycobacterium abscessus Clearance by Neutrophils Is Independent of Autophagy.
Topics: Adaptor Proteins, Signal Transducing; Anti-Bacterial Agents; Autophagy; Azithromycin; Case-Control Studies; Chemokine CCL4; Chloroquine; Cystic Fibrosis; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immunosuppressive Agents; Interleukin-8; Mycobacterium abscessus; Neutrophils; Phagocytosis; Primary Cell Culture; Reactive Oxygen Species; Signal Transduction; Sirolimus; Wortmannin | 2020 |
Inhibition of JAK2 by AG490 promotes TNF-α-induced apoptosis by inhibiting autophagy in MC3T3-E1 cells.
Topics: 3T3 Cells; Animals; Apoptosis; Autophagy; Chloroquine; Flow Cytometry; Janus Kinase 2; MAP Kinase Signaling System; Mice; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Tyrphostins | 2020 |
Chloroquine Improves Deoxynivalenol-Induced Inflammatory Response and Intestinal Mucosal Damage in Piglets.
Topics: Amine Oxidase (Copper-Containing); Animals; Antioxidants; Autophagy; Cadherins; Chloroquine; Cytokines; Diet; Inflammation; Integrins; Intestinal Mucosa; Lactic Acid; Occludin; Proliferating Cell Nuclear Antigen; RNA, Messenger; Sirolimus; Swine; Trichothecenes; Zonula Occludens-1 Protein | 2020 |
Pharmacological and nutritional modulation of autophagy in a rainbow trout (Oncorhynchus mykiss) gill cell line, RTgill-W1.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Cell Survival; Chloroquine; Fish Proteins; Gene Expression Regulation; Gills; Microtubule-Associated Proteins; Nutrients; Oncorhynchus mykiss; Pharmaceutical Preparations; Serum; Sirolimus; Time Factors; Trichothecenes | 2020 |
Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Autophagy; B7-H1 Antigen; Cell Line, Tumor; Cell Proliferation; Chloroquine; Cisplatin; Deoxycytidine; Drug Resistance, Neoplasm; Female; Gemcitabine; Gene Expression; Humans; Mechanistic Target of Rapamycin Complex 1; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Neoplasm Metastasis; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Sirolimus; Urinary Bladder Neoplasms | 2021 |
JNK-mediated blockage of autophagic flux exacerbates the triethylene glycol dimethacrylate-induced mitochondrial oxidative damage and apoptosis in preodontoblast.
Topics: Animals; Apoptosis; Autophagy; Cell Line; Cell Survival; Chloroquine; MAP Kinase Signaling System; Mice; Microtubule-Associated Proteins; Mitochondria; Oxidation-Reduction; Oxidative Stress; Polyethylene Glycols; Polymethacrylic Acids; RNA-Binding Proteins; Signal Transduction; Sirolimus | 2021 |
Therapeutic Approach of KRAS Mutant Tumours by the Combination of Pharmacologic Ascorbate and Chloroquine.
Topics: Antineoplastic Agents; Autophagy; Chloroquine; Models, Theoretical; Neoplasms; Proto-Oncogene Proteins p21(ras); Pyruvate Kinase; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Warburg Effect, Oncologic | 2021 |
Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy.
Topics: Animals; Autophagy; Chloroquine; Cholesterol Side-Chain Cleavage Enzyme; Endocrine Cells; Fatty Acids; Gene Expression Regulation; Humans; Leydig Cells; Lipids; Macrolides; Male; Mice; Obesity; Sirolimus; Steroids | 2021 |
Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.
Topics: Aminolevulinic Acid; Apoptosis; Autophagy; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Humans; Hyperparathyroidism, Secondary; Organoids; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sirolimus; Time Factors | 2021 |
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.
Topics: Actins; Adenosine; AMP-Activated Protein Kinases; Animals; Autophagy; Cadherins; Cathepsin D; Chloroquine; Endometrium; Epithelial-Mesenchymal Transition; Female; Fibronectins; Fibrosis; Iodide Peroxidase; Lipopolysaccharides; Lysosomal-Associated Membrane Protein 1; Mice; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Phosphates; Proto-Oncogene Proteins c-akt; Sequestosome-1 Protein; Serine; Sirolimus; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Triiodothyronine | 2022 |
Effect of Neiyi Prescription of QIU on autophagy and angiogenic ability of endometriosis via the PPARγ/NF-κB signaling pathway.
Topics: Animals; Autophagy; Chloroquine; Drugs, Chinese Herbal; Endometriosis; Female; Humans; Neovascularization, Pathologic; NF-kappa B; PPAR gamma; Prescriptions; Rats; Signal Transduction; Sirolimus | 2022 |
Palmitic acid hinders extracellular traps of neutrophil from postpartum dairy cow in vitro.
Topics: 3-Hydroxybutyric Acid; Acetates; Animals; Cattle; Chloroquine; DNA; Extracellular Traps; Fatty Acids; Fatty Acids, Nonesterified; Female; Glucose; Histones; Microtubule-Associated Proteins; Neutrophils; Palmitic Acid; Phenolsulfonphthalein; Postpartum Period; Sirolimus | 2022 |
Oleate restores altered autophagic flux to rescue palmitate lipotoxicity in hypothalamic neurons.
Topics: Autophagy; Chloroquine; Diglycerides; Fatty Acids, Nonesterified; Hypothalamus; Interleukin-6; Neurons; Oleic Acid; Palmitates; Palmitic Acid; RNA, Messenger; Sirolimus | 2022 |
Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl) homoserine lactone induces calcium signaling-dependent crosstalk between autophagy and apoptosis in human macrophages.
Topics: 4-Butyrolactone; Apoptosis; Autophagy; Beclin-1; Calcium; Calcium Signaling; Chelating Agents; Chloroquine; Egtazic Acid; Homoserine; Humans; Macrophages; Phosphatidylserines; Protein Kinases; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Reactive Oxygen Species; Sirolimus; Virulence Factors | 2022 |
Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy.
Topics: Animals; Antiviral Agents; Autophagy; Autophagy-Related Proteins; Benzylisoquinolines; Biological Products; Bovine Virus Diarrhea-Mucosal Disease; Cattle; Cell Line; Chloroquine; Diarrhea; Diarrhea Virus 1, Bovine Viral; Diarrhea Viruses, Bovine Viral; Sirolimus; Virus Replication | 2022 |
Knockdown of circHIPK3 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells through activating the autophagy flux.
Topics: Animals; Autophagy; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Chloroquine; Dactinomycin; Humans; Mesenchymal Stem Cells; Mice; Mice, Nude; Osteogenesis; RNA, Circular; RNA, Messenger; Sirolimus | 2022 |
Danshen injection induces autophagy in podocytes to alleviate nephrotic syndrome via the PI3K/AKT/mTOR pathway.
Topics: Animals; Autophagy; Beclin-1; Caspase 3; Chloroquine; Creatinine; Desmin; Doxorubicin; Eosine Yellowish-(YS); Hematoxylin; Lipopolysaccharides; Mammals; Mice; Microtubule-Associated Proteins; Nephrotic Syndrome; Periodic Acid; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Podocytes; Prednisone; Proto-Oncogene Proteins c-akt; Salvia miltiorrhiza; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
Blue light attenuates TGF-β2-induced epithelial-mesenchymal transition in human lens epithelial cells via autophagy impairment.
Topics: Autophagy; Chloroquine; Epithelial Cells; Epithelial-Mesenchymal Transition; Humans; Light; Sirolimus; Transforming Growth Factor beta2 | 2022 |
Inhibition of autophagy and induction of glioblastoma cell death by NEO214, a perillyl alcohol-rolipram conjugate.
Topics: Autophagy; Cell Death; Chloroquine; Glioblastoma; Glioma; Humans; Lysosomes; Monoterpenes; Rolipram; Sirolimus; Temozolomide; TOR Serine-Threonine Kinases | 2023 |