chloroquine and simalikalactone-D

chloroquine has been researched along with simalikalactone-D* in 3 studies

Other Studies

3 other study(ies) available for chloroquine and simalikalactone-D

ArticleYear
A new antimalarial quassinoid from Simaba orinocensis.
    Journal of natural products, 2004, Volume: 67, Issue:5

    A new antimalarial quassinoid, namely, orinocinolide (1), was isolated from the root bark of Simaba orinocensis, together with the previously reported simalikalactone D (2). The structure of 1 was determined primarily from 1D and 2D NMR analysis, as well as by chemical derivatization. Compound 1 was found to be as equally potent as 2 against Plasmodium falciparum clones D6 and W2 (IC(50) 3.27 and 8.53 ng/mL vs 3.0 and 3.67 ng/mL, respectively), but was 4- and 28-fold less toxic than 2 against VERO cells (IC(50) 10 vs 2.3 microg/mL) and HL-60 (IC(50) 0.7 vs 0.025 microg/mL), respectively. In addition, 2 was >46- and >31-fold more potent than pentamidine and amphotericin B (IC(50) 0.035 vs 1.6 and 1.1 microg/mL) against Leishmania donovani, while 1 was inactive. Orinocinolide (1) inhibited growth of human cancer cells SK-MEL, KB, BT-549, and SK-OV-3, but was less potent than 2 (IC(50) 0.8-1.9 vs 0.3-1.0 microg/mL) against these cells.

    Topics: Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Peru; Plants, Medicinal; Plasmodium falciparum; Quassins; Simaroubaceae; Tumor Cells, Cultured

2004
A new antimalarial quassinoid from Simaba guianensis.
    Journal of natural products, 1993, Volume: 56, Issue:11

    Two antimalarial quassinoids, gutolactone [1] and simalikalactone D [2], have been characterized by bioactivity-directed fractionation from the bark of Simaba guianensis collected near Manaus, Brazil. Compound 2 was previously isolated from Simaba multiflora and Quassia africana and shown to be an active antimalarial in vitro. This is the first occurrence of 1. The structure of the novel quassinoid was established by spectral methods including 2D nmr spectroscopy.

    Topics: Animals; Antimalarials; Brazil; Bridged Bicyclo Compounds; Chromatography, Thin Layer; Glaucarubin; Magnetic Resonance Spectroscopy; Plant Extracts; Plants, Medicinal; Plasmodium falciparum; Quassins; Spectrophotometry, Ultraviolet

1993
Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro.
    The American journal of tropical medicine and hygiene, 1981, Volume: 30, Issue:3

    The growth of Plasmodium falciparum in vitro was markedly inhibited by certain quassinoids (the bitter principles from plants of the family Simaroubaceae). The most active compound, simalikalactone D, gave complete inhibition at 0.005 microgram/ml. Glaucarubinone an soularubinone were equally effective at 0.006 microgram/ml, whereas chaparrinone and simarolide had little effect even at 0.01 microgram/ml. These relative activities are parallel to the antineoplastic activities of these materials.

    Topics: Chloroquine; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Glaucarubin; Phenanthrenes; Plasmodium falciparum; Quassins

1981