chloroquine and saquinavir

chloroquine has been researched along with saquinavir in 23 studies

Research

Studies (23)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (39.13)	29.6817
2010's	14 (60.87)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Andrews, KT; Gardiner, DL; McCarthy, J; Melville, L; Skinner-Adams, TS	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chen, L; Chen, X; He, Z; Peng, N; Qin, L; You, J	1
Andrews, KT; Anstey, NM; Boonma, P; Gardiner, DL; Lek-Uthai, U; Machunter, B; McCarthy, JS; Nosten, F; Piera, KA; Price, RN; Ruengweerayut, R; Russell, B; Skinner-Adams, TS; Suwanarusk, R	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Cunico, W; Figueiredo, IH; Gomes, CR; Henriques, MG; Krettli, AU; Manhanini, DP; Moreth, M; Penido, C; Varotti, FP	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Andrews, KT; Butterworth, AS; Eickel, N; Gardiner, DL; MacDonald, T; McCarthy, JS; Peatey, CL; Skinner-Adams, TS; Trenholme, KR	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Aguiar, AC; Cunico, W; de Souza, MV; Gomes, CR; Guedes, GP; Krettli, AU; Krettli, LG; Vasconcelos, TR; Vaz, MG; Vellasco Junior, WT	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Basilico, N; Bernetti, M; Bonache de Marcos, MC; Brogi, S; Brun, R; Butini, S; Caccia, S; Camodeca, C; Campiani, G; Gemma, S; Gorelli, B; Guiso, G; Joshi, BP; Lamponi, S; Martin, RE; Moretti, V; Novellino, E; Parapini, S; Rottmann, M; Sanna Coccone, S; Saponara, S; Savini, L; Summers, RL; Taramelli, D	1
Bartolommei, G; Basilico, N; Brindisi, M; Brogi, S; Butini, S; Camodeca, C; Campiani, G; Fiorini, I; Gabellieri, E; Gemma, S; Gualdani, R; Habluetzel, A; Kukreja, G; Kunjir, S; Lamponi, S; Lucantoni, L; Martin, RE; Moncelli, MR; Novellino, E; Savini, L; Summers, RL; Tadini-Buoninsegni, F; Taramelli, D; Valoti, M	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Andrews, KT; Gardiner, DL; Kelly, M; McCarthy, JS; Ray, J; Redmond, AM; Skinner-Adams, T	1
Chen, L; Chen, X; He, Z; Qin, L; You, J	1
Butterworth, AS; Gardiner, DL; Kirk, K; Martin, RE; McCarthy, JS; Skinner-Adams, TS	1

Reviews

1 review(s) available for chloroquine and saquinavir

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

22 other study(ies) available for chloroquine and saquinavir

Article	Year
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Animals; Antimalarials; Chloroquine; Drug Synergism; HIV Protease Inhibitors; Humans; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Plasmodium falciparum; Ritonavir; Saquinavir	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Synergy of human immunodeficiency virus protease inhibitors with chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7 Topics: Animals; Antimalarials; Atazanavir Sulfate; Chloroquine; Drug Resistance; Drug Synergism; Female; HIV Protease Inhibitors; Humans; In Vitro Techniques; Lopinavir; Malaria; Mice; Nelfinavir; Oligopeptides; Plasmodium chabaudi; Plasmodium falciparum; Pyridines; Pyrimidinones; Ritonavir; Saquinavir	2008
Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7 Topics: Animals; Antimalarials; Drug Resistance, Multiple; Gene Dosage; Genes, MDR; Genes, Protozoan; HIV Infections; HIV Protease Inhibitors; Humans; In Vitro Techniques; Malaria, Falciparum; Malaria, Vivax; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Ritonavir; Saquinavir	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Synthesis and antimalarial activity of hydroxyethylpiperazine derivatives. European journal of medicinal chemistry, 2009, Volume: 44, Issue:3 Topics: Animals; Antimalarials; Chromatography, Liquid; Drug Evaluation, Preclinical; Erythrocytes; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Piperazines; Plasmodium falciparum	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3 Topics: Animals; Antimalarials; Darunavir; Erythrocytes; HIV Protease Inhibitors; Humans; Life Cycle Stages; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyridines; Pyrones; Sulfonamides	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Synthesis and antimalarial activity of thioetherhydroxyethylsulfonamides, potential aspartyl protease inhibitors, Part 3. European journal of medicinal chemistry, 2011, Volume: 46, Issue:11 Topics: Antimalarials; Aspartic Acid Proteases; Chemistry Techniques, Synthetic; Hep G2 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Plasmodium falciparum; Protease Inhibitors; Sulfonamides	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of medicinal chemistry, 2012, Aug-09, Volume: 55, Issue:15 Topics: Aminoquinolines; Animals; Antimalarials; Biological Transport; Cell Line; Chloroquine; Clotrimazole; Drug Resistance; Female; Half-Life; Hemeproteins; Humans; Malaria; Male; Membrane Transport Proteins; Mice; Models, Molecular; Mutation; Oocytes; Piperazines; Plasmodium berghei; Plasmodium falciparum; Protozoan Proteins; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Ventricular Pressure; Xenopus laevis	2012
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents. Journal of medicinal chemistry, 2012, Dec-13, Volume: 55, Issue:23 Topics: Animals; Antimalarials; Benzoxazines; Cell Line; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Mimicry; Quinazolines; Spectrometry, Mass, Electrospray Ionization	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Antimalarial activity of sera from subjects taking HIV protease inhibitors. AIDS (London, England), 2007, Mar-30, Volume: 21, Issue:6 Topics: Animals; Antimalarials; Antiretroviral Therapy, Highly Active; Chloroquine; Drug Synergism; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Malaria, Falciparum; Plasmodium falciparum; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Treatment Outcome	2007
Antiretroviral protease inhibitors potentiate chloroquine antimalarial activity in malaria parasites by regulating intracellular glutathione metabolism. Experimental parasitology, 2009, Volume: 123, Issue:2 Topics: Animals; Anti-Retroviral Agents; Antimalarials; Chloroquine; Drug Resistance; Drug Synergism; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; HIV Protease Inhibitors; Inhibitory Concentration 50; Malaria; Mice; Nelfinavir; Plasmodium chabaudi; Plasmodium falciparum; Ritonavir; Saquinavir	2009
Saquinavir inhibits the malaria parasite's chloroquine resistance transporter. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:5 Topics: Animals; Antimalarials; Biological Transport; Chloroquine; Drug Combinations; Drug Synergism; Female; HIV Protease Inhibitors; Humans; Lopinavir; Malaria, Falciparum; Membrane Transport Proteins; Mutation; Oocytes; Plasmodium falciparum; Protozoan Proteins; Ritonavir; Saquinavir; Tritium; Xenopus laevis	2012