chloroquine and quercetin

chloroquine has been researched along with quercetin in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (26.92)29.6817
2010's13 (50.00)24.3611
2020's6 (23.08)2.80

Authors

AuthorsStudies
Croft, SL; del Rayo Camacho, M; Kirby, GC; Marley, D; Phillipson, JD; Warhurst, DC1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Adelekan, AM; Hussein, AA; Liles, DC; Meyer, JJ; Prozesky, EA; Rodríguez, B; Ureña, LD; van Rooyen, PH1
Carrupt, PA; Cressend, D; Gupta, MP; Hay, AE; Hostettmann, K; Martin, F; Reist, M; Vivas, L1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Haiech, J; Hibert, M; Kellenberger, E; Kuhn, I; Lobstein, A; Muller-Steffner, H; Rognan, D; Said-Hassane, F; Schuber, F; Villa, P1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Akoto, M; Avery, VM; Duffy, S; Hagen, TJ; Helgren, TR; Igbinoba, O; Lee, P; Sciotti, RJ1
Acosta, ME; Charris, JE; De Sanctis, JB; Gamboa, ND; Mijares, MR; Romero, JA1
Agard, DA; Ashworth, A; Barrio-Hernandez, I; Batra, J; Beltrao, P; Bennett, MJ; Bohn, M; Bouhaddou, M; Braberg, H; Broadhurst, DJ; Cai, Y; Cakir, M; Calviello, L; Cavero, DA; Chang, JCJ; Chorba, JS; Craik, CS; d'Enfert, C; Dai, SA; Eckhardt, M; Emerman, M; Fabius, JM; Fletcher, SJ; Floor, SN; Foussard, H; Frankel, AD; Fraser, JS; Fujimori, DG; Ganesan, SJ; García-Sastre, A; Gordon, DE; Gross, JD; Guo, JZ; Haas, K; Haas, P; Hernandez-Armenta, C; Hiatt, J; Huang, XP; Hubert, M; Hüttenhain, R; Ideker, T; Jacobson, M; Jang, GM; Jura, N; Kaake, RM; Kim, M; Kirby, IT; Klippsten, S; Koh, C; Kortemme, T; Krogan, NJ; Kuzuoglu-Ozturk, D; Li, Q; Liboy-Lugo, J; Lin, Y; Liu, X; Liu, Y; Lou, K; Lyu, J; Mac Kain, A; Malik, HS; Mathy, CJP; McGregor, MJ; Melnyk, JE; Memon, D; Meyer, B; Miorin, L; Modak, M; Moreno, E; Mukherjee, S; Naing, ZZC; Noack, J; O'Meara, MJ; O'Neal, MC; Obernier, K; Ott, M; Peng, S; Perica, T; Pilla, KB; Polacco, BJ; Rakesh, R; Rathore, U; Rezelj, VV; Richards, AL; Roesch, F; Rosenberg, OS; Rosenthal, SB; Roth, BL; Roth, TL; Ruggero, D; Safari, M; Sali, A; Saltzberg, DJ; Savar, NS; Schwartz, O; Sharp, PP; Shen, W; Shengjuler, D; Shi, Y; Shoichet, BK; Shokat, KM; Soucheray, M; Stroud, RM; Subramanian, A; Swaney, DL; Taunton, J; Tran, QD; Trenker, R; Tummino, TA; Tutuncuoglu, B; Ugur, FS; Vallet, T; Venkataramanan, S; Verba, KA; Verdin, E; Vignuzzi, M; von Zastrow, M; Wang, HY; Wankowicz, SA; Wenzell, NA; White, KM; Xu, J; Young, JM; Zhang, Z; Zhou, Y1
Beus, M; Fallarero, A; Patel, JZ; Savijoki, K; Yli-Kauhaluoma, J; Zorc, B1
Chen, J; Chen, W; Choudhry, N; Xu, D; Yang, Z; Zanin, M; Zhao, X1
Easwaran, M; Manickam, M; Pillaiyar, T; Wendt, LL1
Amaral, KB; Cabral, A; D'Agosto, M; Silveira, P; Soares, GL; Vashist, U1
Chen, L; Huang, C; Lei, Y; Li, J; Liu, R; Mao, J; Wang, K; Wei, Y; Wu, H; Wu, J; Zeng, J; Zhang, T1
Ahn, KS; Cho, SK; Kim, H; Moon, JY1
Emeje, M; Ezenyi, IC; Kulkarni, R; Salawu, OA1
Eo, SK; Lee, JH; Moon, JH; Park, SY1
Bi, Y; Gao, D; Hou, X; Li, C; Liu, H; Liu, Y; Liu, Z; Peng, F; Shen, C; Shi, C; Wang, K; Wang, X; Wu, J; Zhang, J; Zhao, B; Zhao, S; Zheng, Z; Zhong, C; Zou, H1
Chen, Y; Liu, Z; Zhang, G; Zhang, Y1
Cui, H; Fu, R; Gao, N; Gao, Z; Hu, J; Jiang, X; Li, J; Li, L; Li, Y; Zhang, H; Zhang, Y1
Choi, KS; Jang, E; Kim, E; Kim, H; Kim, IY; Lee, DM; Lee, JA; Seo, DY1
An, S; Hu, M1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1

Reviews

2 review(s) available for chloroquine and quercetin

ArticleYear
Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
    Journal of medicinal chemistry, 2020, 11-25, Volume: 63, Issue:22

    Topics: Antiviral Agents; China; Coronavirus Protease Inhibitors; COVID-19; COVID-19 Drug Treatment; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; SARS-CoV-2; Small Molecule Libraries

2020
The recent outbreaks of human coronaviruses: A medicinal chemistry perspective.
    Medicinal research reviews, 2021, Volume: 41, Issue:1

    Topics: Antiviral Agents; Chemistry, Pharmaceutical; COVID-19; Disease Outbreaks; Drug Repositioning; Humans; Virus Internalization

2021

Other Studies

24 other study(ies) available for chloroquine and quercetin

ArticleYear
Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes.
    Journal of natural products, 2002, Volume: 65, Issue:10

    Topics: Animals; Antiprotozoal Agents; Drug Screening Assays, Antitumor; Galphimia; Leishmania donovani; Plasmodium falciparum; Spectrum Analysis; Triterpenes; Trypanosoma brucei brucei; Tumor Cells, Cultured

2002
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Bioactive diterpenes and other constituents of Croton steenkampianus.
    Journal of natural products, 2008, Volume: 71, Issue:11

    Topics: Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Croton; Diterpenes; Drug Resistance; Indans; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum; South Africa; Vero Cells; X-Ray Diffraction

2008
Antioxidant C-glucosylxanthones from the leaves of Arrabidaea patellifera.
    Journal of natural products, 2008, Volume: 71, Issue:11

    Topics: Antimalarials; Antioxidants; Bignoniaceae; Biphenyl Compounds; Free Radical Scavengers; Nuclear Magnetic Resonance, Biomolecular; Panama; Picrates; Plant Leaves; Plasmodium falciparum; Xanthones

2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.
    Bioorganic & medicinal chemistry, 2010, Nov-15, Volume: 18, Issue:22

    Topics: ADP-ribosyl Cyclase 1; Animals; Binding Sites; Catalytic Domain; Computer Simulation; Enzyme Inhibitors; Flavonoids; High-Throughput Screening Assays; Humans; NAD+ Nucleosidase; Schistosoma mansoni; Schistosomicides; Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs.
    Bioorganic & medicinal chemistry letters, 2015, Jan-15, Volume: 25, Issue:2

    Topics: Antimalarials; Humans; Malaria; Models, Molecular; Molecular Structure; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Quercetin; Stereoisomerism

2015
Optimization of antimalarial, and anticancer activities of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate.
    Bioorganic & medicinal chemistry, 2018, 02-15, Volume: 26, Issue:4

    Topics: Acrylates; Animals; Antimalarials; Antineoplastic Agents; Apoptosis; Cells, Cultured; Chloroquine; Hemin; HL-60 Cells; Humans; Jurkat Cells; Malaria; Mice; Plasmodium berghei; Stereoisomerism; Structure-Activity Relationship

2018
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
    Nature, 2020, Volume: 583, Issue:7816

    Topics: Animals; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Cloning, Molecular; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunity, Innate; Mass Spectrometry; Molecular Targeted Therapy; Pandemics; Pneumonia, Viral; Protein Binding; Protein Biosynthesis; Protein Domains; Protein Interaction Mapping; Protein Interaction Maps; Receptors, sigma; SARS-CoV-2; SKP Cullin F-Box Protein Ligases; Vero Cells; Viral Proteins

2020
Chloroquine fumardiamides as novel quorum sensing inhibitors.
    Bioorganic & medicinal chemistry letters, 2020, 08-15, Volume: 30, Issue:16

    Topics: Amides; Anti-Bacterial Agents; Chloroquine; Chromobacterium; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Quorum Sensing; Structure-Activity Relationship

2020
[Malaricide activity of the quercetin in Gallus gallus L., 1758 immunocompromised infected by Plasmodium (Bennettinia) juxtanucleare Versiani and Gomes, 1941].
    Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, 2008, Volume: 17 Suppl 1

    Topics: Animals; Antimalarials; Chickens; Chloroquine; Immunocompromised Host; Malaria, Avian; Quercetin

2008
Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling.
    Autophagy, 2011, Volume: 7, Issue:9

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Line, Tumor; Chloroquine; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Proteins; Microtubule-Associated Proteins; Models, Biological; Proto-Oncogene Proteins c-akt; Quercetin; RNA, Small Interfering; Signal Transduction; Stomach Neoplasms; TOR Serine-Threonine Kinases; Vacuoles

2011
Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells.
    Oxidative medicine and cellular longevity, 2013, Volume: 2013

    Topics: Apoptosis; Autophagy; Brain Neoplasms; Cell Count; Cell Line, Tumor; Cell Proliferation; Chloroquine; G1 Phase; Glioblastoma; Humans; Immunoblotting; Mitochondria; Neoplasm Proteins; Quercetin

2013
Antiplasmodial activity-aided isolation and identification of quercetin-4'-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum.
    Parasitology research, 2014, Volume: 113, Issue:12

    Topics: Animals; Antimalarials; Artemether; Artemisinins; Cell Line; Chloroquine; Chromolaena; Drug Resistance; Female; Inhibitory Concentration 50; Kaempferols; Lethal Dose 50; Malaria; Malaria, Falciparum; Male; Methyl Ethers; Mice; Plant Extracts; Plant Leaves; Plasmodium berghei; Plasmodium falciparum; Quercetin; Random Allocation

2014
Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death.
    Oncology reports, 2015, Volume: 34, Issue:1

    Topics: Antineoplastic Agents; Autophagy; Cell Line, Tumor; Chloroquine; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Microtubule-Associated Proteins; Quercetin; RNA-Binding Proteins; TNF-Related Apoptosis-Inducing Ligand

2015
Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:3

    Topics: Adenine; Animals; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; Glioma; Humans; Male; Neoplasm Staging; Quercetin; Rats; Rats, Sprague-Dawley

2016
High Serum HDGF Levels Are Predictive of Bone Metastasis and Unfavorable Prognosis in Non-Small Cell Lung Cancer.
    The Tohoku journal of experimental medicine, 2017, Volume: 242, Issue:2

    Topics: A549 Cells; Aged; Bone Neoplasms; Carcinoma, Non-Small-Cell Lung; Chloroquine; Cohort Studies; Female; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Prognosis; Quercetin; ROC Curve

2017
ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine.
    Journal of experimental & clinical cancer research : CR, 2019, May-28, Volume: 38, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Dynamins; Female; GTP Phosphohydrolases; Humans; Mice; Microtubule-Associated Proteins; Mitochondrial Dynamics; Mitochondrial Proteins; Quercetin; Reactive Oxygen Species; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2019
Quercetin and chloroquine synergistically kill glioma cells by inducing organelle stress and disrupting Ca
    Biochemical pharmacology, 2020, Volume: 178

    Topics: Antineoplastic Agents, Phytogenic; Astrocytes; Autophagosomes; Autophagy; Calcium; Calcium Channels; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Combinations; Drug Synergism; Endoplasmic Reticulum Stress; Gene Expression; Homeostasis; Humans; Inositol 1,4,5-Trisphosphate Receptors; Lysosomes; Mitochondria; Neuroglia; Quercetin; Reactive Oxygen Species

2020
Quercetin Promotes TFEB Nuclear Translocation and Activates Lysosomal Degradation of Ferritin to Induce Ferroptosis in Breast Cancer Cells.
    Computational intelligence and neuroscience, 2022, Volume: 2022

    Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Breast Neoplasms; Chloroquine; Female; Ferritins; Ferroptosis; Humans; Iron; Lysosomes; Quercetin; RNA, Small Interfering

2022
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009