chloroquine and pyronaridine

chloroquine has been researched along with pyronaridine in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (21.21)	18.7374
1990's	22 (33.33)	18.2507
2000's	6 (9.09)	29.6817
2010's	19 (28.79)	24.3611
2020's	5 (7.58)	2.80

Authors

Authors	Studies
Denny, WA; Figgitt, DP; Gamage, SA; Ralph, RK; Tepsiri, N; Wilairat, P; Wojcik, SJ	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Anstey, NM; Chalfein, F; Kenangalem, E; Marfurt, J; Piera, KA; Price, RN; Russell, B; Tjitra, E	1
Anstey, NM; Chalfein, F; Ebsworth, EP; Kenangalem, E; Marfurt, J; Piera, KA; Prasetyorini, B; Price, RN; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, M	1
Avery, VM; Sykes, ML	1
Andrews, KT; Avery, VM; Duffy, S; Hamacher, A; Hansen, FK; Kassack, MU; Kuna, K; Kurz, T; Marek, L; Meister, S; Mordmüller, B; Schmetter, R; Stenzel, K; Sumanadasa, SD; Winzeler, EA	1
Avery, V; Derese, S; Deyou, T; Duffy, S; Erdélyi, M; Fitzpatrick, PA; Gruhonjic, A; Gumula, I; Heydenreich, M; Holleran, J; Landberg, G; Mumo, M; Pang, F; Rissanen, K; Yenesew, A	1
Avery, VM; Baell, JB; Bullen, HE; Cowman, AF; Crabb, BS; Curtis, JM; Di Rago, AE; Duffy, S; Gilson, PR; Hutton, CA; Jarman, KE; Jousset Subroux, H; Lowes, KN; Nguyen, W; Prinz, B; Sleebs, BE; Tan, C	1
Avery, VM; Carroll, AR; Duffy, S; Senadeera, SPD	1
Avery, VM; Carroll, AR; Duffy, S; Robertson, LP; Wang, D; Wang, Y	1
Avery, VM; Carroll, AR; Duffy, S; Lucantoni, L; Senadeera, SPD	1
Andrews, KT; Antonova-Koch, Y; Avery, VM; Diedrich, D; Duffy, S; Fisher, G; Gebru, T; Hansen, FK; Held, J; Hesping, E; Kurz, T; Meister, S; Schöler, A; Stenzel, K; Winzeler, EA	1
Avery, VM; Butler, GS; Drinkwater, N; Duffy, S; Grin, PM; Kassiou, M; Lucantoni, L; Malcolm, TR; McGowan, S; Overall, CM; Scammells, PJ; Vinh, NB	1
Avery, VM; Carroll, AR; Duffy, S; Lucantoni, L; Robertson, LP	1
Avery, VM; Duffy, S; Erdélyi, M; Lindblad, S; Maeda, G; Munissi, JJE; Nyandoro, SS; Pelletier, J	1
Avery, VM; Dans, MG; de Koning-Ward, TF; Duffy, S; Gancheva, MR; Gilson, PR; Lowes, KN; Ngo, A; Nguyen, W; Romeo, O; Sabroux, HJ; Sleebs, BE; Wilson, DW	1
Baum, J; Bridgford, JL; Charman, SA; Churchyard, A; Crespo, B; Deni, I; Fidock, DA; Gahalawat, S; Gamo, FJ; Laleu, B; Lawong, A; Mittal, N; Mok, S; Niederstrasser, H; Okombo, J; Palmer, MJ; Phillips, MA; Posner, B; Ready, JM; Striepen, J; Winzeler, E; Wittlin, S; Yeo, T; Zhou, A	1
Avery, VM; Challis, MP; Creek, DJ; De Paoli, A; Devine, SM; Kigotho, JK; MacRaild, CA; Norton, RS; Scammells, PJ; Siddiqui, G	1
Basco, LK; Le Bras, J	2
Cao, DQ; Dong, Y; He, H; Liu, DQ; Liu, RJ; Yang, HL; Yang, PF; Zhang, CY	1
Chen, C; Zheng, X	1
Chen, KY; Ha, SH; Lin, BY; Shao, BR; Ye, XY; Zhan, CQ; Zhang, JX	1
Rooney, W; Schildbach, S; Suebsaeng, L; Wernsdorfer, WH	1
Ha, SH; Shao, BR; Zhan, CQ	1
Shao, BR; Ye, XY	1
Huang, WJ; Li, J	1
Wu, LJ	2
Shao, BR; Xu, YQ	1
Boudreau, EF; Chen, C; Childs, GE; Häusler, B; Milhous, W; Pooyindee, N; Wimonwattrawatee, T	1
Chen, KY; Ha, SH; Shao, BR; Zhan, CQ	1
Che, LG; Huang, KG; Huang, R; Lin, ZL; Yang, HL; Yu, L	1
Björkman, A; Ericsson, O; Fu, S; Ofori-Adjei, D; Sjöqvist, F; Wåhlin, B	2
Chen, KY; Lin, BY; Shao, BR; Zhang, JX	1
Shao, BR; Ye, XY; Zheng, H	1
Chen, KY; Lin, BY; Ye, XY; Zhang, JX; Zheng, H	1
Dong, Y; Liu, D; Liu, R; Yang, H; Yang, P; Zhang, B; Zhang, C	1
Li, GD; Liu, SQ; Qu, FY; Ye, XY	1
Yang, H; Yang, P; Yang, Y	1
Chen, YD; Lin, BY; Pan, YR; Tang, WZ; Xu, B; Zhang, JX; Zheng, H	1
Fang, Y; Lin, BY; Pan, YR; Zhang, JX; Zheng, H	1
Basco, L; Bickii, J; Ringwald, P	1
Fleck, SL; Peters, W; Robinson, BL	1
Barlin, GB; Edstein, MD; Kotecka, BM; Rieckmann, KH	1
Croft, SL; Elueze, EI; Warhurst, DC	1
Dong, Y; Huang, KG; Liao, MZ; Liu, DQ; Yang, HL; Yang, PF; Yang, YM; Zhang, CY	1
Doury, JC; Fusai, T; Hienne, R; Parzy, D; Pradines, B; Spiegel, A; Tall, A; Trape, JF	1
Doury, JC; Kombila, M; Lebeau, C; Mabika Mamfoumbi, M; Mourou Mbina, JR; Owono Medang, M; Parzy, D; Pradines, B	1
Basco, LK; Meche, FS; Ringwald, P	1
Basco, LK; Ringwald, P	1
Auparakkitanon, S; Chavalitshewinkoon-Petmitr, P; Pongvilairat, G; Wilairat, P	1
Björkman, A; Gupta, S; Mariga, ST; Thapar, MM; Wernsdorfer, WH	1
Fan, B; Huang, Z; Ma, X; Wen, Y; Yang, J; Yang, Z; Zhao, W	1
Agnamey, P; Brasseur, P; Galega, PF; Moyou, SR	1
Feng, XP; Liu, DQ	1
Auparakkitanon, S; Chapoomram, S; Chirachariyavej, T; Kuaha, K; Wilairat, P	1
Bélard, S; Kremsner, PG; Kurth, F; Mordmüller, B; Pongratz, P; Ramharter, M	1
Borghini-Fuhrer, I; Duparc, S; Fleckenstein, L; Poravuth, Y; Purnama, A; Pyae Phyo, A; Rao, BH; Rueangweerayut, R; Shin, CS; Socheat, D; Tjitra, E; Uthaisin, C; Valecha, N	1
Liu, H; Wang, J; Zhang, CL; Zhou, HN	1
Arzika, I; Fandeur, T; Guillebaud, J; Issaka, M; Maazou, A; Salissou, A; Specht, S; Zamanka, H	1
Cui, L; Gupta, B; Miao, J; Sun, L; Wang, Z; Xu, S; Yang, Z	1
Amalvict, R; Benoit, N; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA	1
Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA	1
Chu, WY; Dorlo, TPC	1

Reviews

3 review(s) available for chloroquine and pyronaridine

Article	Year
Approaches to protozoan drug discovery: phenotypic screening. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Drug Discovery; Humans; Molecular Structure; Neglected Diseases; Phenotype; Plasmodium falciparum; Protozoan Infections; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2013
Development of the new antimalarial drug pyronaridine: a review. Biomedical and environmental sciences : BES, 1992, Volume: 5, Issue:2 Topics: Administration, Oral; Animals; Antimalarials; Cardiovascular System; Chloroquine; Dogs; Drug Evaluation; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, Combination; Haplorhini; Humans; Injections, Intramuscular; Lethal Dose 50; Malaria, Falciparum; Mice; Naphthyridines; Pyrimethamine; Rabbits; Sulfadoxine	1992
Pyronaridine: a review of its clinical pharmacology in the treatment of malaria. The Journal of antimicrobial chemotherapy, 2023, 10-03, Volume: 78, Issue:10 Topics: Antimalarials; Child; Chloroquine; Female; Humans; Malaria; Malaria, Falciparum; Naphthyridines; Pregnancy	2023

Trials

6 trial(s) available for chloroquine and pyronaridine

Article	Year
Development of the new antimalarial drug pyronaridine: a review. Biomedical and environmental sciences : BES, 1992, Volume: 5, Issue:2 Topics: Administration, Oral; Animals; Antimalarials; Cardiovascular System; Chloroquine; Dogs; Drug Evaluation; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, Combination; Haplorhini; Humans; Injections, Intramuscular; Lethal Dose 50; Malaria, Falciparum; Mice; Naphthyridines; Pyrimethamine; Rabbits; Sulfadoxine	1992
[Combined use of pyronaridine, sulfadoxine and primaquine in areas with chloroquine-resistant falciparum malaria]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1987, Volume: 5, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Naphthyridines; Plasmodium falciparum; Primaquine; Sulfadoxine; Sulfanilamides	1987
Randomised trial of pyronaridine versus chloroquine for acute uncomplicated falciparum malaria in Africa. Lancet (London, England), 1996, Jan-06, Volume: 347, Issue:8993 Topics: Administration, Oral; Adolescent; Adult; Animals; Antimalarials; Cameroon; Chloroquine; Drug Resistance; Female; Follow-Up Studies; Humans; Malaria, Falciparum; Male; Middle Aged; Naphthyridines; Plasmodium falciparum; Treatment Outcome	1996
Short report: effects of pyronaridine on gametocytes in patients with acute uncomplicated falciparum malaria. The American journal of tropical medicine and hygiene, 1999, Volume: 61, Issue:3 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Naphthyridines; Parasitemia; Plasmodium falciparum	1999
Molecular epidemiology of malaria in Yaounde, Cameroon V. analysis of the omega repetitive region of the plasmodium falciparum CG2 gene and chloroquine resistance. The American journal of tropical medicine and hygiene, 1999, Volume: 61, Issue:5 Topics: Adolescent; Adult; Animals; Antimalarials; Cameroon; Child; Chloroquine; DNA Primers; DNA, Protozoan; Drug Resistance; Electrophoresis, Agar Gel; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Naphthyridines; Parasitemia; Phenanthrenes; Plasmodium falciparum; Polymerase Chain Reaction; Regression Analysis; Repetitive Sequences, Nucleic Acid; Scintillation Counting; Sequence Analysis, DNA	1999
Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial. PloS one, 2011, Jan-18, Volume: 6, Issue:1 Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Fever; Humans; Malaria, Vivax; Male; Middle Aged; Naphthyridines; Time Factors; Treatment Outcome; Young Adult	2011

Other Studies

58 other study(ies) available for chloroquine and pyronaridine

Article	Year
Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum. Journal of medicinal chemistry, 1994, May-13, Volume: 37, Issue:10 Topics: Aminoacridines; Animals; Antimalarials; Cell Division; Cells, Cultured; Drug Resistance; Erythrocytes; Humans; Plasmodium falciparum; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured	1994
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Inhibitory Concentration 50; Naphthyridines; Plasmodium falciparum; Plasmodium vivax	2010
In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1 Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Indonesia; Malaria; Male; Middle Aged; Plasmodium malariae; Plasmodium ovale; Treatment Outcome; Young Adult	2011
Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. European journal of medicinal chemistry, 2014, Jul-23, Volume: 82 Topics: Antimalarials; Dose-Response Relationship, Drug; Drug Discovery; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Repressor Proteins; Structure-Activity Relationship	2014
Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis. Journal of natural products, 2015, Dec-24, Volume: 78, Issue:12 Topics: Antimalarials; Chalcones; Chloroquine; Crystallography, X-Ray; Flavanones; Flavonoids; HEK293 Cells; Humans; Millettia; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Bark; Plant Extracts; Plasmodium falciparum	2015
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity. Journal of medicinal chemistry, 2017, 02-09, Volume: 60, Issue:3 Topics: Administration, Oral; Animals; Antimalarials; Disease Models, Animal; Mice; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship	2017
Antiplasmodial β-triketones from the flowers of the Australian tree Angophora woodsiana. Bioorganic & medicinal chemistry letters, 2017, 06-01, Volume: 27, Issue:11 Topics: Antimalarials; Australia; Cell Survival; Chloroquine; Drug Resistance; Flowers; HEK293 Cells; Humans; Ketones; Magnetic Resonance Spectroscopy; Molecular Conformation; Myrtaceae; Plant Extracts; Plasmodium falciparum; Sesquiterpenes	2017
Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana. Journal of natural products, 2017, 12-22, Volume: 80, Issue:12 Topics: Antimalarials; Australia; Biological Products; Indole Alkaloids; Magnetic Resonance Spectroscopy; Plant Extracts; Plant Leaves; Plasmodium falciparum; Rutaceae; Trees	2017
Antiplasmodial β-Triketone-Flavanone Hybrids from the Flowers of the Australian Tree Corymbia torelliana. Journal of natural products, 2018, 07-27, Volume: 81, Issue:7 Topics: Antimalarials; Flavanones; Flowers; HEK293 Cells; Humans; Ketones; Magnetic Resonance Spectroscopy; Molecular Structure; Myrtaceae; Plant Extracts; Trees	2018
One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites. European journal of medicinal chemistry, 2018, Oct-05, Volume: 158 Topics: Acetylation; Antimalarials; Hep G2 Cells; Histone Deacetylase Inhibitors; Histones; Humans; Malaria, Falciparum; Peptoids; Plasmodium falciparum; Protozoan Proteins	2018
Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. Journal of medicinal chemistry, 2019, 01-24, Volume: 62, Issue:2 Topics: Aminopeptidases; Antimalarials; Binding Sites; Catalytic Domain; Cell Survival; Drug Resistance; HEK293 Cells; Humans; Hydroxamic Acids; Molecular Docking Simulation; Plasmodium; Protease Inhibitors; Protozoan Proteins; Structure-Activity Relationship	2019
Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens. Journal of natural products, 2019, 04-26, Volume: 82, Issue:4 Topics: Oxidation-Reduction; Plant Roots; Rutaceae; Xanthenes	2019
A Meroisoprenoid, Heptenolides, and Journal of natural products, 2020, 02-28, Volume: 83, Issue:2 Topics: Annonaceae; Antimalarials; Flavanones; Flavonoids; HEK293 Cells; Humans; Molecular Structure; Plant Extracts; Plant Leaves; Plasmodium berghei; Plasmodium falciparum	2020
Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion. European journal of medicinal chemistry, 2021, Mar-15, Volume: 214 Topics: Animals; Antimalarials; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Erythrocytes; Hep G2 Cells; Humans; Malaria, Falciparum; Mice; Microsomes, Liver; Molecular Structure; Parasitic Sensitivity Tests; Piperazines; Plasmodium falciparum; Plasmodium knowlesi; Solubility; Structure-Activity Relationship	2021
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Journal of medicinal chemistry, 2021, 03-11, Volume: 64, Issue:5 Topics: Amides; Antimalarials; Drug Resistance, Microbial; Hemeproteins; Hemoglobins; Hep G2 Cells; Humans; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Small Molecule Libraries; Structure-Activity Relationship; Tetrazoles	2021
Discovery and development of 2-aminobenzimidazoles as potent antimalarials. European journal of medicinal chemistry, 2021, Oct-05, Volume: 221 Topics: Antimalarials; Benzimidazoles; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Malaria, Falciparum; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship	2021
In vitro activity of pyronaridine against African strains of Plasmodium falciparum. Annals of tropical medicine and parasitology, 1992, Volume: 86, Issue:5 Topics: Africa; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Naphthyridines; Plasmodium falciparum	1992
[Sensitivity in vitro of Plasmodium falciparum to chloroquine, pyronaridine, artesunate and piperaquine in south Yunnan]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1992, Volume: 10, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Naphthyridines; Plasmodium falciparum; Quinolines; Sesquiterpenes	1992
Experimental studies on combinations of pyronaridine/primaquine versus chloroquine/primaquine. Chinese medical journal, 1990, Volume: 103, Issue:12 Topics: Animals; Antimalarials; Chloroquine; Drug Therapy, Combination; Macaca mulatta; Malaria; Mice; Naphthyridines; Plasmodium; Plasmodium yoelii; Primaquine	1990
In vitro sensitivity of multiresistant Plasmodium falciparum to new candidate antimalarial drugs in western Thailand. The Southeast Asian journal of tropical medicine and public health, 1990, Volume: 21, Issue:1 Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Humans; Naphthyridines; Phenanthrenes; Plasmodium falciparum; Thailand	1990
[Evaluation of the phototoxicity of five antimalarial agents and praziquantel in mice]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Female; Male; Mice; Naphthyridines; Photosensitivity Disorders; Praziquantel; Quinacrine; Quinazolines; Quinolines; Ultraviolet Rays	1986
[Delay in emergence of resistance to pyronaridine phosphate in Plasmodium berghei]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:5 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Synergism; Mice; Naphthyridines; Plasmodium berghei; Pyrimethamine; Sulfadoxine	1986
[Effects of artesunate, pyronaridine and hydroxypiperaquine on chloroquine-sensitive and chloroquine-resistant isolates of Plasmodium falciparum in vitro]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1988, Volume: 9, Issue:1 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Naphthyridines; Plasmodium falciparum; Quinolines; Sesquiterpenes	1988
[Effects of large doses of pyronaridine and chloroquine on the ultrastructure of the erythrocytic stages of pyronaridine-resistant line of Plasmodium berghei]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1988, Volume: 9, Issue:1 Topics: Animals; Chloroquine; Drug Resistance; Erythrocytes; Mice; Microscopy, Electron; Naphthyridines; Plasmodium berghei	1988
[The mouse micronucleus test for mutagenicity of pyronaridine, chloroquine, quinacrine, primaquine, furapyrimidone and phenthiourezine]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1988, Volume: 6, Issue:4 Topics: Animals; Anthelmintics; Antimalarials; Chloroquine; Filaricides; Male; Mice; Micronucleus Tests; Mutagenicity Tests; Naphthyridines; Nitrofurans; Piperazines; Primaquine; Quinacrine	1988
In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum. The American journal of tropical medicine and hygiene, 1988, Volume: 38, Issue:1 Topics: Amodiaquine; Animals; Antimalarials; Chemical Phenomena; Chemistry; Chloroquine; Drug Resistance; Humans; Mefloquine; Naphthyridines; Plasmodium falciparum; Pyrimethamine; Quinine; Quinolines; Thailand	1988
[Sensitivities of different stages of erythrocytic Plasmodium falciparum to pyronaridine]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1987, Volume: 8, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Erythrocytes; Naphthyridines; Plasmodium falciparum	1987
In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum. British journal of clinical pharmacology, 1986, Volume: 22, Issue:1 Topics: Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Naphthyridines; Plasmodium falciparum; Stereoisomerism	1986
[Ultrastructural study on the effect of pyronaridine on the erythrocytic stages of chloroquine-resistant strain of Plasmodium berghei]. Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1986, Volume: 4, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Malaria; Mice; Naphthyridines; Plasmodium berghei	1986
[In vitro activity of chloroquine, two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum]. Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1986, Volume: 4, Issue:4 Topics: Animals; Chloroquine; Drug Resistance; Isomerism; Naphthyridines; Plasmodium falciparum	1986
[Therapeutic effect of pyronaridine given intragastrically on Plasmodium cynomolgi-infected rhesus monkeys]. Yao xue xue bao = Acta pharmaceutica Sinica, 1985, Volume: 20, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Macaca fascicularis; Macaca mulatta; Malaria; Naphthyridines; Recurrence	1985
[Residual blood schizontocidal activity of pyronaridine against rodent malaria]. Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1984, Volume: 2, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Erythrocytes; Mice; Naphthyridines; Plasmodium	1984
[A combined regimen of pyronaridin-artemether-chloroquine (PAC) for the treatment of Plasmodium cynomolgi infection in the rhesus monkey]. Yao xue xue bao = Acta pharmaceutica Sinica, 1984, Volume: 19, Issue:8 Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Drug Therapy, Combination; Macaca mulatta; Malaria; Naphthyridines; Pyrans; Sesquiterpenes	1984
[Sensitivity of Plasmodium falciparum to seven antimalarials in China-Laos border]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1995, Volume: 13, Issue:2 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Humans; Naphthyridines; Plasmodium falciparum; Quinolines; Sesquiterpenes	1995
Detection of 54-kDa protein overexpressed by chloroquine-resistant Plasmodium berghei ANKA strain in pyronaridine-resistant P berghei ANKA strain. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995, Volume: 16, Issue:1 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Immunoblotting; Mice; Microscopy, Immunoelectron; Naphthyridines; Plasmodium berghei; Protozoan Proteins	1995
[In vitro sensitivity of Plasmodium falciparum to mefloquine, quinine, amodiaquine, chloroquine, pyronaridine and sulfadoxine/pyrimethamine in south Yunnan]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1994, Volume: 12, Issue:2 Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Mefloquine; Naphthyridines; Plasmodium falciparum; Pyrimethamine; Quinine; Sulfadoxine	1994
In vitro susceptibility of Cambodian isolates of Plasmodium falciparum to halofantrine, pyronaridine and artemisinin derivatives. Annals of tropical medicine and parasitology, 1994, Volume: 88, Issue:2 Topics: Adult; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; Mefloquine; Naphthyridines; Phenanthrenes; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Triazines	1994
[Studies on the establishment of malarial animal model of short-term relapse. IV. Short-term relapse in rhesus monkeys infected with sporozoites of Plasmodium cynomolgi]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1993, Volume: 11, Issue:4 Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Disease Models, Animal; Drug Therapy, Combination; Erythrocytes; Macaca mulatta; Malaria; Naphthyridines; Plasmodium cynomolgi; Recurrence; Sesquiterpenes	1993
[Studies on the establishment of malarial animal model of short-term relapse. III. Combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1993, Volume: 11, Issue:3 Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Disease Models, Animal; Drug Therapy, Combination; Macaca mulatta; Malaria; Naphthyridines; Plasmodium cynomolgi; Recurrence; Sesquiterpenes	1993
The chemotherapy of rodent malaria. LIV. Combinations of 'Fenozan B07' (Fenozan-50F), a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane, with other drugs against drug-sensitive and drug-resistant parasites. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Antagonism; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Malaria; Mefloquine; Mice; Naphthyridines; Parasitemia; Phenanthrenes; Phenylpropionates; Plasmodium berghei; Plasmodium yoelii	1997
New quinoline di-Mannich base compounds with greater antimalarial activity than chloroquine, amodiaquine, or pyronaridine. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:6 Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Mannich Bases; Microbial Sensitivity Tests; Naphthyridines; Plasmodium falciparum; Quinolines; Saimiri; Structure-Activity Relationship	1997
Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro. The Journal of antimicrobial chemotherapy, 1996, Volume: 37, Issue:3 Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Mefloquine; Naphthyridines; Plasmodium falciparum; Quinacrine; Quinine	1996
In vitro sensitivity of Plasmodium falciparum to eight antimalarials in China-Myanmar and China-Lao PDR border areas. The Southeast Asian journal of tropical medicine and public health, 1997, Volume: 28, Issue:3 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; China; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Humans; Laos; Microbial Sensitivity Tests; Myanmar; Naphthyridines; Plasmodium falciparum; Quinine; Sesquiterpenes	1997
In-vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents. The Journal of antimicrobial chemotherapy, 1998, Volume: 42, Issue:3 Topics: Africa; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Naphthyridines; Plasmodium falciparum; Quinine	1998
In vitro susceptibility of African isolates of Plasmodium falciparum from Gabon to pyronaridine. The American journal of tropical medicine and hygiene, 1999, Volume: 60, Issue:1 Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Gabon; Humans; Infant; Malaria, Falciparum; Naphthyridines; Phenanthrenes; Plasmodium falciparum; Quinine	1999
Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro. Parasitology international, 2000, Volume: 48, Issue:4 Topics: Amsacrine; Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Enzyme Inhibitors; Etoposide; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Mefloquine; Naphthyridines; Norfloxacin; Nucleic Acid Synthesis Inhibitors; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Thailand; Topoisomerase II Inhibitors; Triazines	2000
Plasmodium falciparum: in vitro interactions of artemisinin with amodiaquine, pyronaridine, and chloroquine. Experimental parasitology, 2002, Volume: 100, Issue:1 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Interactions; Drug Resistance; Naphthyridines; Parasitic Sensitivity Tests; Plasmodium falciparum; Sesquiterpenes	2002
[In vitro sensitivity of Plasmodium falciparum to chloroquine, piperaquine, pyronaridine and artesunate in Yuxi prefecture of Yunnan province]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1998, Volume: 16, Issue:6 Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; In Vitro Techniques; Infant; Inhibitory Concentration 50; Malaria, Falciparum; Male; Middle Aged; Naphthyridines; Plasmodium falciparum; Quinolines; Sesquiterpenes	1998
[Center of multidrug-resistant malaria in a forest zone of Cameroon revisited after 14 years]. Medecine tropicale : revue du Corps de sante colonial, 2002, Volume: 62, Issue:2 Topics: Amodiaquine; Animals; Cameroon; Chloroquine; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Naphthyridines; Plasmodium falciparum; Quinine; Trees	2002
[Factors affecting the in vitro microtest for drug sensitivity of Plasmodium falciparum]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 2003, Volume: 21, Issue:4 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Blood; Chloroquine; Humans; Malaria, Falciparum; Naphthyridines; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Sesquiterpenes	2003
Targeting of hematin by the antimalarial pyronaridine. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:6 Topics: Animals; Antimalarials; Chloroquine; Drug Delivery Systems; Erythrocytes; Glutathione; Hemeproteins; Hemin; Hemolysis; In Vitro Techniques; Inhibitory Concentration 50; Molecular Structure; Naphthyridines; Plasmodium falciparum; Protein Binding	2006
In vitro activity of pyronaridine against Plasmodium falciparum and comparative evaluation of anti-malarial drug susceptibility assays. Malaria journal, 2009, Apr-23, Volume: 8 Topics: Administration, Oral; Adolescent; Animals; Antigens, Protozoan; Antimalarials; Artemisinins; Artesunate; Biological Assay; Child; Child, Preschool; Chloroquine; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; Female; Gabon; Humans; Infant; Malaria, Falciparum; Male; Naphthyridines; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinine; Regression Analysis	2009
[In vitro sensitivity of Plasmodium falciparum isolates from China-Myanmar border region to chloroquine, piperaquine and pyronaridine]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 2012, Feb-29, Volume: 30, Issue:1 Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; China; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Myanmar; Naphthyridines; Plasmodium falciparum; Quinolines; Young Adult	2012
Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:7 Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Naphthyridines; Niger; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines	2013
Plasmodium falciparum multidrug resistance protein 1 (pfmrp1) gene and its association with in vitro drug susceptibility of parasite isolates from north-east Myanmar. The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:8 Topics: Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Chloroquine; Drug Resistance; Ethanolamines; Fluorenes; Geography; Humans; Lumefantrine; Malaria, Falciparum; Mefloquine; Multidrug Resistance-Associated Proteins; Mutation; Myanmar; Naphthyridines; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Single Nucleotide; Selection, Genetic; Sequence Analysis, DNA	2014
Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:8 Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Lumefantrine; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Quinine; Quinolines; Senegal; Ubiquitin-Protein Ligases	2016
Association between Polymorphisms in the Pf Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3 Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal	2017