chloroquine has been researched along with pepstatin in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 9 (39.13) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Avery, M; Desai, PV; Gut, J; Patny, A; Rosenthal, P; Sabnis, Y; Srivastava, A; Tekwani, B | 1 |
| Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ | 2 |
| Andrews, KT; Gardiner, DL; McCarthy, J; Melville, L; Skinner-Adams, TS | 1 |
| Charris, J; Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ | 1 |
| Alvarez-Larena, A; Andujar, S; Barazarte, A; Camacho, J; Capparelli, MV; Charris, J; Domínguez, J; Enriz, D; Gamboa, N; Lobo, G; Rodrigues, J | 1 |
| Desai, SA; Fay, MP; Furuya, T; Gluzman, IY; Goldberg, DE; Kambhampati, S; Lisk, G; Pain, M; Su, XZ | 1 |
| Alvarez-Larena, A; Barazarte, A; Capparelli, MV; Charris, JE; Gamboa, N; Lobo, G; López, SE; Rodrigues, JR | 1 |
| Barazarte, A; Camacho, J; Charris, J; Gamboa, N; Gilman, R; Rodrigues, J; Rojas, R; Vaisberg, A | 1 |
| Agard, DA; Ashworth, A; Barrio-Hernandez, I; Batra, J; Beltrao, P; Bennett, MJ; Bohn, M; Bouhaddou, M; Braberg, H; Broadhurst, DJ; Cai, Y; Cakir, M; Calviello, L; Cavero, DA; Chang, JCJ; Chorba, JS; Craik, CS; d'Enfert, C; Dai, SA; Eckhardt, M; Emerman, M; Fabius, JM; Fletcher, SJ; Floor, SN; Foussard, H; Frankel, AD; Fraser, JS; Fujimori, DG; Ganesan, SJ; García-Sastre, A; Gordon, DE; Gross, JD; Guo, JZ; Haas, K; Haas, P; Hernandez-Armenta, C; Hiatt, J; Huang, XP; Hubert, M; Hüttenhain, R; Ideker, T; Jacobson, M; Jang, GM; Jura, N; Kaake, RM; Kim, M; Kirby, IT; Klippsten, S; Koh, C; Kortemme, T; Krogan, NJ; Kuzuoglu-Ozturk, D; Li, Q; Liboy-Lugo, J; Lin, Y; Liu, X; Liu, Y; Lou, K; Lyu, J; Mac Kain, A; Malik, HS; Mathy, CJP; McGregor, MJ; Melnyk, JE; Memon, D; Meyer, B; Miorin, L; Modak, M; Moreno, E; Mukherjee, S; Naing, ZZC; Noack, J; O'Meara, MJ; O'Neal, MC; Obernier, K; Ott, M; Peng, S; Perica, T; Pilla, KB; Polacco, BJ; Rakesh, R; Rathore, U; Rezelj, VV; Richards, AL; Roesch, F; Rosenberg, OS; Rosenthal, SB; Roth, BL; Roth, TL; Ruggero, D; Safari, M; Sali, A; Saltzberg, DJ; Savar, NS; Schwartz, O; Sharp, PP; Shen, W; Shengjuler, D; Shi, Y; Shoichet, BK; Shokat, KM; Soucheray, M; Stroud, RM; Subramanian, A; Swaney, DL; Taunton, J; Tran, QD; Trenker, R; Tummino, TA; Tutuncuoglu, B; Ugur, FS; Vallet, T; Venkataramanan, S; Verba, KA; Verdin, E; Vignuzzi, M; von Zastrow, M; Wang, HY; Wankowicz, SA; Wenzell, NA; White, KM; Xu, J; Young, JM; Zhang, Z; Zhou, Y | 1 |
| Morton, PA; Owensby, DA; Schwartz, AL; Underhill, DM | 1 |
| Berman, J; Nichols, JS; Wiseman, JS; Wypij, DM | 1 |
| Atwood, HL; Boegman, RJ; Scarth, B | 1 |
| Campos, NM; Hunsaker, LA; Vander Jagt, DL | 1 |
| Cartledge, TG; Hill, DJ; Jenkins, RO; Lloyd, D | 1 |
| Dickson, RB; Johnson, MD; Lippman, ME; Torri, JA | 1 |
| Kirk, K; Saliba, KJ | 1 |
| O'Brien, PJ; Pourahmad, J; Ross, S | 1 |
| Bellio, N; Cagnin, M; Fiorentino, I; Follo, C; Isidoro, C; Ozzano, M | 1 |
| Baltazar, GC; Boesze-Battaglia, K; Guha, S; Kompella, UB; Laties, AM; Lim, J; Lu, W; Mitchell, CH; Tyagi, P | 1 |
| Allanki, AD; Navale, R; Sijwali, PS | 1 |
| Cheng, J; Duan, S; Jiang, K; Li, C; Wang, Y; Wu, Y; Xu, J; Yu, L; Zhang, X | 1 |
| Callaghan, K; Cocchiaro, P; Fox, C; Genovese, F; Howarth, R; Leslie, J; Luli, S; Moles, A; Oakley, F; Sheerin, NS; Wood, KM | 1 |
23 other study(ies) available for chloroquine and pepstatin
| Article | Year |
|---|---|
Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.
Topics: Animals; Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Databases, Factual; Leishmania donovani; Models, Molecular; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Trypanocidal Agents | 2004 |
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.
Topics: Animals; Antimalarials; Chalcones; Cysteine Endopeptidases; Globins; Heme; Hemeproteins; Hydrolysis; Malaria; Mice; Phenylurea Compounds; Plasmodium berghei; Plasmodium falciparum; Polymers; Protease Inhibitors; Structure-Activity Relationship | 2005 |
Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Chloroquine; Drug Synergism; HIV Protease Inhibitors; Humans; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Plasmodium falciparum; Ritonavir; Saquinavir | 2007 |
Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Malaria; Male; Mice; Molecular Conformation; Plasmodium berghei; Plasmodium falciparum; Sulfonylurea Compounds | 2007 |
Synthesis, antimalarial activity, structure-activity relationship analysis of thieno-[3,2-b]benzothiazine S,S-dioxide analogs.
Topics: Animals; Antimalarials; Benzene; Crystallography, X-Ray; Globins; Hemeproteins; Mice; Models, Molecular; Molecular Structure; Oxides; Plasmodium berghei; Static Electricity; Structure-Activity Relationship; Thiazines | 2008 |
Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.
Topics: Animals; Antimalarials; Biological Transport, Active; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Drug Resistance; Erythrocytes; Genes, Protozoan; Humans; In Vitro Techniques; Ion Channels; Leupeptins; Malaria, Falciparum; Plasmodium falciparum; Protozoan Proteins | 2008 |
Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives.
Topics: Animals; Antimalarials; Magnetic Resonance Spectroscopy; Models, Molecular; Plasmodium berghei; Spectrophotometry, Infrared; Thiazines | 2009 |
Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities.
Topics: Animals; Antimalarials; Chalcone; Hemeproteins; Hemoglobins; Humans; Hydrolysis; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Sulfones | 2009 |
Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents.
Topics: Animals; Antimalarials; Antitubercular Agents; Benzimidazoles; Cell Line, Tumor; Drug Resistance, Multiple; Hemin; Hemoglobins; Humans; Hydrazines; Hydrolysis; Mice; Plasmodium | 2011 |
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Topics: Animals; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Cloning, Molecular; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunity, Innate; Mass Spectrometry; Molecular Targeted Therapy; Pandemics; Pneumonia, Viral; Protein Binding; Protein Biosynthesis; Protein Domains; Protein Interaction Mapping; Protein Interaction Maps; Receptors, sigma; SARS-CoV-2; SKP Cullin F-Box Protein Ligases; Vero Cells; Viral Proteins | 2020 |
Endocytosis and lysosomal delivery of tissue plasminogen activator-inhibitor 1 complexes in Hep G2 cells.
Topics: Ammonium Chloride; beta-N-Acetylhexosaminidases; Carcinoma, Hepatocellular; Chloroquine; Endocytosis; Humans; Kinetics; Leupeptins; Liver Neoplasms; Lysosomes; Pepstatins; Plasminogen Activator Inhibitor 1; Primaquine; Recombinant Proteins; Subcellular Fractions; Tissue Plasminogen Activator; Tumor Cells, Cultured | 1992 |
Evidence against a role for aspartyl proteases in intracellular processing of big endothelin.
Topics: Ammonium Chloride; Aspartic Acid; Aspartic Acid Endopeptidases; Cells, Cultured; Chloroquine; Chromatography, High Pressure Liquid; Endothelin-1; Endothelins; Endothelium; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Monensin; Pepstatins; Protein Precursors | 1991 |
Effect of protease inhibitors on skeletal muscle lysosomal enzyme activity and resting membrane potential.
Topics: Acetylglucosaminidase; Animals; Aprotinin; Chloroquine; Leupeptins; Lysosomes; Male; Membrane Potentials; Muscle Denervation; Muscles; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Rats; Rats, Inbred Strains | 1986 |
Comparison of proteases from chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.
Topics: Aminopeptidases; Animals; Aspartic Acid Endopeptidases; Chloroquine; Drug Resistance; Endopeptidases; Hemin; Hydrogen-Ion Concentration; Pepstatins; Peptide Hydrolases; Plasmodium falciparum; Protease Inhibitors | 1987 |
Changes in proteinase activities and subcellular distribution during inactivation of alcohol oxidase in Candida boidinii.
Topics: Alcohol Oxidoreductases; Candida; Centrifugation, Density Gradient; Chloroquine; Endopeptidases; Ethanol; Methanol; Pepstatins; Phenylmethylsulfonyl Fluoride; Subcellular Fractions | 1986 |
The role of cathepsin D in the invasiveness of human breast cancer cells.
Topics: Breast Neoplasms; Cathepsin D; Chloroquine; Diffusion Chambers, Culture; Female; Humans; Molecular Weight; Neoplasm Invasiveness; Pepstatins | 1993 |
Uptake of an antiplasmodial protease inhibitor into Plasmodium falciparum-infected human erythrocytes via a parasite-induced pathway.
Topics: Animals; Antimalarials; Biological Transport; Chloroquine; Erythrocytes; Furosemide; Humans; Pepstatins; Plasmodium falciparum; Protease Inhibitors | 1998 |
Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+).
Topics: Acridine Orange; Adenine; Animals; Aurothioglucose; Cadmium; Cell Death; Chloroquine; Copper; Endopeptidases; Enzyme Activation; Gentamicins; Leupeptins; Lipid Peroxidation; Liver; Lysosomes; Male; Methylamines; Monensin; Oxidation-Reduction; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2001 |
Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Apoptosis; bcl-2-Associated X Protein; Carbamates; Cathepsin D; Cell Line, Tumor; Chloroquine; Dipeptides; Dopamine; Dose-Response Relationship, Drug; Endocytosis; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Humans; In Situ Nick-End Labeling; Lysosomes; Mice; Mitochondrial Membranes; Neuroblastoma; Pepstatins; Phorbol Esters; Protease Inhibitors; Protein Biosynthesis; Proteolysis; RNA, Small Interfering; Transfection | 2012 |
Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells.
Topics: Animals; Boron Compounds; Catalytic Domain; Cathepsin D; Cattle; Cell Line; Cells, Cultured; Chloroquine; Flow Cytometry; Humans; Hydrogen-Ion Concentration; Immunoblotting; Lactic Acid; Lipofuscin; Lysosomes; Nanoparticles; Nanotechnology; Opsins; Pepstatins; Phagocytosis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Retina | 2012 |
Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum.
Topics: Adenine; Amino Acid Sequence; Antimalarials; Apicoplasts; Autophagy; Autophagy-Related Protein 8 Family; Chloroquine; Doxycycline; Erythrocytes; Gene Expression Regulation; Genome, Protozoan; Humans; Leucine; Life Cycle Stages; Microfilament Proteins; Molecular Sequence Data; Pepstatins; Plasmodium falciparum; Protease Inhibitors; Protozoan Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2014 |
Autophagy inhibitors reduce avian-reovirus-mediated apoptosis in cultured cells and in chicken embryos.
Topics: Animals; Apoptosis; Autophagy; Chick Embryo; Chickens; Chloroquine; Leucine; Orthoreovirus, Avian; Pepstatins; Poultry Diseases; Reoviridae Infections | 2015 |
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.
Topics: Animals; Cathepsin D; Chloroquine; Collagen; Dipeptides; Disease Models, Animal; Extracellular Matrix; Female; Fibrosis; Humans; Lysosomes; Mice; Myofibroblasts; Pepstatins; Renal Insufficiency, Chronic | 2016 |