chloroquine has been researched along with olaparib in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Bakas, NA; Brun, SN; Celeridad, M; Chaikuad, A; Cosford, NDP; Knapp, S; Lambert, LJ; Limpert, AS; Ren, H; Shaw, RJ; Sheffler, DJ; Tautz, L; Vamos, M; Wimer, CD | 1 |
| Cai, B; Chen, Y; Geng, A; Gorbunova, V; Huang, J; Jiang, C; Jiang, Y; Mao, Z; Seluanov, A; Shi, J; Su, T; Tang, H; Tian, X; Wan, X; Xu, Z; Zhang, H | 1 |
| Amaravadi, RK; Bast, RC; Becker, SE; Heinzen, EP; Hou, X; Llombart-Cussac, A; Lu, Z; Matias-Guiu, X; Maurer, MJ; Oberg, AL; Pang, L; Poveda, A; Rask, P; Romero, I; Rubio, MJ; Santacana, M; Santiago-O'Farrill, JM; Weroha, SJ | 1 |
3 other study(ies) available for chloroquine and olaparib
| Article | Year |
|---|---|
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Drug Synergism; Female; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Mice, Inbred C57BL; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Triple Negative Breast Neoplasms | 2020 |
A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites.
Topics: Binding Sites; Cell Line; Cell Line, Tumor; Chloroquine; DNA; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Helicases; Fibroblasts; Gene Expression Regulation; Genes, Reporter; HEK293 Cells; Hepatocytes; Humans; Nuclear Proteins; Nucleosomes; Phenanthrenes; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Protein Binding; Protein Interaction Domains and Motifs; Recombinational DNA Repair; Sirtuin 1; Transcription Factors | 2019 |
Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Indazoles; Mice, Nude; Mice, SCID; Ovarian Neoplasms; Phthalazines; Piperazines; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Xenograft Model Antitumor Assays | 2020 |