chloroquine and mefloquine hydrochloride

chloroquine has been researched along with mefloquine hydrochloride in 101 studies

Research

Studies (101)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.99)	18.7374
1990's	12 (11.88)	18.2507
2000's	55 (54.46)	29.6817
2010's	30 (29.70)	24.3611
2020's	3 (2.97)	2.80

Authors

Authors	Studies
Angerhofer, CK; König, GM; Pezzuto, JM; Sticher, O; Wright, AD	1
Brossi, A; Buchs, P; Dominguez Gerpe, L; Flippen-Anderson, JL; Luo, XD; Milhous, W; Peters, W; Venugopalan, B; Yeh, HJ	1
Angerhofer, CK; Chai, H; Cordell, GA; Hu, SF; Lin, J; Lin, LZ; Pezzuto, JM; Zaw, K; Zheng, DM	1
Denny, WA; Figgitt, DP; Gamage, SA; Ralph, RK; Tepsiri, N; Wilairat, P; Wojcik, SJ	1
Angerhofer, CK; Chai, H; Cordell, GA; Likhitwitayawuid, K; Pezzuto, JM; Ruangrungsi, N	2
Cabral, JA; McChesney, JD; Milhous, WK	1
Angerhofer, CK; Cordell, GA; Likhitwitayawuid, K; Pezzuto, JM; Ruangrungsi, N	1
Angerhofer, CK; Desqueyroux-Faúndez, R; Greenidge, P; König, GM; Linden, A; Wright, AD	1
Angerhofer, CK; Böhlke, M; Farnsworth, NR; Guinaudeau, H; Mora, GA; Poveda, LJ; Soejarto, DD; Wongpanich, V	1
Angerhofer, C; Arnason, JT; Durst, T; Gbeassor, M; MacKinnon, S; Pezzuto, J; Poveda, LJ; Sanchez-Vindas, PE	1
Cimanga, K; De Bruyne, T; Pieters, L; Turger, CA; Vlietinck, AJ	1
Angerhofer, CK; Cordell, GA; Guinaudeau, H; Pezzuto, JM; Wongpanich, V	1
Berecibar, A; Davioud-Charvet, E; Debreu, MA; Girault, S; Grellier, P; Lemière, P; Maes, L; Mouray, E; Sergheraert, C	1
Angenot, L; Brandt, V; De Pauw, M; DeMol, P; Frédérich, M; Hayette, M; Penelle, J; Prosperi, C; Tits, M	1
Jomaa, H; Mitsch, A; Schlitzer, M; Wiesner, J; Wissner, P	1
Bosisio, E; Cabalion, P; Dell'Agli, M; Giolito, A; Guerrini, M; Verotta, L	1
Ayad, F; Deady, LW; Tilley, L	1
Angerhofer, CK; Cordell, GA; Han, J; Kim, SU; Lee, JG; Min, SS; Park, SH	1
Kyle, DE; Milhous, WK; Riel, MA	1
Gerena, L; Milhous, WK; Opsenica, D; Pocsfalvi, G; Solaja, BA; Terzić, N; Tinant, B	1
Ager, A; Alvim-Gaston, M; Avery, MA; Charman, W; Peters, W; Robinson, BL; Vroman, JA; Wu, B	1
Avery, MA; Bandyopadhyaya, AK; Desai, PV; Furtado, MM; Muraleedharan, KM; Tekwani, BL	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Bhattacharjee, AK; Geyer, JA; Kathcart, AK; Li, Z; Mott, BT; Nichols, DA; Prigge, ST; Waters, NC; Woodard, CL	1
Brun, R; El-Idreesy, TT; Griesbeck, AG; Höinck, LO; Lex, J	1
Bauer, KD; Bendale, P; Buckner, FS; Chakrabarti, D; Floyd, D; Gelb, MH; Hamilton, A; Hornéy, CP; Lombardo, LJ; Nallan, L; Pendyala, PR; Rivas, K; Sebti, S; Van Voorhis, WC; Weber, PC; Williams, DK; Windsor, WT; Yokoyama, K	1
Ager, A; Ellis, W; Guan, J; Kyle, D; Lin, AJ; Milhous, W; Sacci, J; Zhang, Q	1
Bohle, DS; Fotie, J; Georges, E; Leimanis, ML; Nkengfack, AE; Rukunga, G	1
Malik, H; Puri, SK; Singh, C	1
Angelovski, G; Diaz, DS; Doković, D; Eilbracht, P; Juranić, Z; Lehnig, M; Milhous, WK; Opsenica, D; Opsenica, I; Smith, KS; Smith, PL; Solaja, BA; Terzić, N; Tinant, B; Yang, YS	1
Berger, H; Brun, R; Kaiser, M; Saf, R; Seebacher, W; Weis, R	2
Angerhofer, CK; de Nys, R; Gurrath, M; Pezzuto, JM; Wright, AD	1
Andrews, KT; Gardiner, DL; McCarthy, J; Melville, L; Skinner-Adams, TS	1
Harada, S; Huy, NT; Kamei, K; Maeda, A; Oida, T; Trang, DT; Uyen, DT	1
Fukuda, M; Jongsakul, K; Knirsch, C; Krudsood, S; Leowattana, W; Looareesuwan, S; Miller, RS; Noedl, H; Ohrt, C; Sriwichai, S; Tangpukdee, N; Thanachartwet, W; Yingyuen, K	1
Baniecki, ML; Clardy, J; Wirth, DF	1
Dennull, RA; Gerena, L; Johnson, JD; Lopez-Sanchez, M; Roncal, NE; Waters, NC	1
Adagu, IS; Fivelman, QL; Warhurst, DC	1
Brun, R; Kaiser, M; Saf, R; Schlapper, C; Seebacher, W; Weis, R	1
Brun, R; de Koning, HP; Gould, M; Kaiser, M; Koomen, GJ; Rodenko, B; van der Burg, AM; Wanner, MJ	1
Milhous, WK; Milić, D; Opsenica, D; Smith, KS; Solaja, BA; Terzić, N; Tinant, B	1
Dodean, RA; Gard, GL; Kelly, JX; Peyton, D; Riscoe, MK; Winter, RW	1
Anstey, NM; Brockman, A; Chalfein, F; Cheng, Q; Kenangalem, E; Piera, K; Prasetyorini, B; Prayoga, P; Price, RN; Russell, B; Sugiarto, P; Suwanarusk, R; Tjitra, E	1
Becker, K; Davioud-Charvet, E; Friebolin, W; Furrer, J; Jannack, B; Lanzer, M; Oeser, T; Sanchez, CP; Wenzel, N; Yardley, V	1
Fitos, I; Mády, G; Visy, J; Zsila, F	1
Egan, TJ; Hoppe, HC; Joiner, KA; Roberts, L	1
Milhous, WK; Opsenica, D; Opsenica, I; Smith, KS; Solaja, BA	1
Andrews, KT; Anstey, NM; Boonma, P; Gardiner, DL; Lek-Uthai, U; Machunter, B; McCarthy, JS; Nosten, F; Piera, KA; Price, RN; Ruengweerayut, R; Russell, B; Skinner-Adams, TS; Suwanarusk, R	1
Billadeau, DD; Chen, Y; Dow, GS; Kozikowski, AP; Lopez-Sanchez, M; Savoy, DN	1
Anova, L; Opsenica, DM; Smith, KS; Smith, PL; Solaja, BA; Terzić, N; Yang, Y	1
Adrián, F; Anderson, P; Brinker, A; Caldwell, JS; Chatterjee, A; Gray, NS; Henson, K; Janes, J; Kato, N; Kuhen, K; Matzen, JT; McNamara, C; Nagle, A; Nam, TG; Plouffe, D; Schultz, PG; Trager, R; Winzeler, EA; Yan, SF; Zhou, Y	1
Bavari, S; Burnett, JC; Gussio, R; Milhous, WK; Nuss, J; Opsenica, D; Opsenica, I; Smith, KS; Solaja, BA; Terzić, N	1
Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pérez-Victoria, JM	1
Andrews, KT; Caridha, D; Chen, Y; Dow, GS; Gerena, L; Gettayacamin, M; Johnson, J; Kozikowski, AP; Li, Q; Melendez, V; Obaldia, N; Tran, TN	1
Anova, L; Lanteri, CA; Milhous, WK; Opsenica, D; Opsenica, I; Smith, KS; Solaja, BA	1
Anstey, NM; Chalfien, F; Hasugian, AR; Kenangalem, E; Marfurt, J; Penttinen, PM; Piera, KA; Price, RN; Purba, HL; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, RM	1
Borne, RF; Khan, MO; Khan, SI; Kimura, E; Levi, MS; Tekwani, BL	1
Bambal, RB; Bates, M; Berry, N; Biagini, GA; Bonar-Law, R; Bray, PG; Brigandi, RA; Davis, CB; Gargallo, DV; Gibbons, P; Gomez-delas-Heras, FM; Gresham, SL; Hart, TK; Hindley, S; Lawrence, RM; Maggs, JL; Mukhtar, A; O'Neill, PM; Park, BK; Roberts, P; Shone, AE; Stocks, PA; Ward, SA; Winstanley, PA	1
Bacon, DJ; Escalante, AA; Griffing, SM; Haley, R; Lucas, C; McCollum, AM; Salas, C; Santolalla, M; Soberon, V; Tsukayama, P; Udhayakumar, V	1
Asadollahy, E; Bambal, RB; Bates, M; Berry, N; Biagini, G; Bray, PG; Brigandi, RA; Davies, J; Davis, CB; Gargallo, DV; Gomez-de-Las-Heras, FM; Gresham, SL; Hall, C; Hindley, S; Lander, H; Maggs, JL; Nixon, G; O'Neill, PM; Parapini, S; Park, BK; Rimmer, K; Roberts, P; Shone, AE; Stanford, D; Stocks, PA; Taramelli, D; Vivas, L; Ward, SA; Winstanley, PA	1
Baniecki, ML; Clardy, J; Cortese, JF; Mazitschek, R; Rush, MA; Wiegand, R; Wirth, DF	1
Almeras, L; Amalvict, R; Baret, E; Briolant, S; Fusaï, T; Henry, M; Parquet, V; Pradines, B; Rogier, C; Torrentino-Madamet, M	1
Masseno, V; Muriithi, S; Nzila, A	1
Fuehrer, HP; Haque, R; Hofecker, V; Khan, WA; Ley, B; Noedl, H; Siedl, A; Starzengruber, P; Thriemer, K; Wernsdorfer, WH	1
Grimberg, BT; Hough, LB; Jaworska, MM; Phillips, JG; Zimmerman, PA	1
Andrianaranjaka, V; Andriantsoanirina, V; Bouchier, C; Durand, R; Jahevitra, M; Ménard, D; Mercereau-Puijalon, O; Rabarijaona, LP; Rabearimanana, S; Radrianjafy, R; Randriantsoa, T; Rason, MA; Ratsimbasoa, A; Tichit, M	1
Brun, R; Charman, SA; Charman, WN; Chollet, J; Creek, DJ; Dong, Y; Dorn, A; Koltun, M; Matile, H; Morizzi, J; Padmanilayam, M; Santo Tomas, J; Scheurer, C; Snyder, C; Sriraghavan, K; Tang, Y; Urwyler, H; Vennerstrom, JL; Wang, X; Wittlin, S	1
Charman, SA; Charman, WN; Chiu, FC; Chollet, J; Dong, Y; Dorn, A; Johnson, LM; Matile, H; Morizzi, J; Scheurer, C; Snyder, C; Tang, Y; Tomas, JS; Urwyler, H; Vennerstrom, JL; Wittlin, S; Zhou, L	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Connelly, MC; Guiguemde, WA; Guy, RK; Nwaka, S; Sigal, M; Zhang, Y; Zhu, F	1
Datti, A; Liang, M; Pillai, DR; Shahinas, D	1
Brun, R; Chitnumsub, P; Dartois, V; Diagana, TT; Goh, A; Kamchonwongpaisan, S; Keller, TH; Kiara, SM; Lakshminarayana, SB; Ma, NL; Maneeruttanarungroj, C; Nzila, A; Rottmann, M; Taweechai, S; Weaver, M; Wittlin, S; Wong, J; Yeung, BK; Yuthavong, Y; Zou, B	1
Biagini, GA; Chandramohanadas, R; Darling, C; DeGrado, WF; Diamond, SL; Fisher, N; Greenbaum, DC; Jing, H; Jo, H; Lucumi, E; Napper, AD; Shone, AE; Ward, SA	1
Beck, HP; Brun, R; Cohen, SB; Dartois, V; Dharia, NV; Diagana, TT; Fidock, DA; Goh, A; González-Páez, GE; Jegla, T; Keller, TH; Lakshminarayana, SB; Lee, MC; McNamara, C; Nosten, F; Plouffe, DM; Renia, L; Rottmann, M; Russell, B; Schmitt, EK; Seitz, P; Spencer, KR; Suwanarusk, R; Tan, J; Winzeler, EA; Yeung, BK; Zou, B	1
Anstey, NM; Chalfein, F; Kenangalem, E; Marfurt, J; Piera, KA; Price, RN; Russell, B; Tjitra, E	1
Anstey, NM; Chalfein, F; Ebsworth, EP; Kenangalem, E; Marfurt, J; Piera, KA; Prasetyorini, B; Price, RN; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, M	1
Haiech, J; Hibert, M; Kellenberger, E; Kuhn, I; Lobstein, A; Muller-Steffner, H; Rognan, D; Said-Hassane, F; Schuber, F; Villa, P	1
Andrews, KT; Anstey, NM; Chalfein, F; Fairlie, DP; Kenangalem, E; Marfurt, J; Piera, KA; Prayoga, P; Price, RN; Tjitra, E; Wabiser, F	1
Bhattacharjee, AK; Gerena, L; Gutteridge, CE; Hoffman, MM; Milhous, WK	1
Sen, S; Sinha, N	1
Carvalho, L; Castanys, S; Gamarro, F; Manzano, JI; Pérez-Victoria, JM	1
Basilico, N; Bavari, S; Burnett, JC; Gettayacamin, M; Gussio, R; Lanteri, CA; Nuss, JE; Opsenica, D; Opsenica, I; Panchal, RG; Sciotti, RJ; Solaja, BA; Taramelli, D; Todorović, N; Wanner, L	1
Bathurst, I; Buckner, FS; Burrows, J; Charman, SA; Charman, WN; Creason, S; Deng, X; El Mazouni, F; Floyd, DM; Gujjar, R; Matthews, D; Phillips, MA; Rathod, PK; Shackleford, DM; White, J; White, KL	1
Charman, SA; Chibale, K; Fakorede, F; Gessner, RK; Gitari, PW; Hudson, A; Kaiser, M; Ndakala, AJ; October, N; Shackleford, DM; White, KL; Yeates, C	1
Ang, HQ; Borboa, R; Brun, R; Caldwell, C; Chang, J; Chatterjee, AK; Chen, Z; Dartois, V; Diagana, T; Ek, J; Fischli, C; Francek, C; Gagaring, K; Glynne, R; Goh, A; Hollenbeck, T; Isbell, J; Kang, ML; Keller, T; Kuhen, K; Lakshminarayana, SB; Li, C; Lin, X; Liu, F; Nagle, A; Plouffe, D; Rottmann, M; Skolnik, S; Tan, M; Tan, W; Tully, DC; Tuntland, T; Wang, J; Winzeler, E; Wu, J; Wu, T; Ye, N; Zeng, P	1
Auschwitz, J; Bathurst, I; Caridha, D; Dow, G; Gardner, S; Gerena, L; Gettayacamin, M; Grauer, K; Johnson, J; Kozar, M; Lee, P; Leed, S; Li, Q; McCalmont, W; Melendez, V; Milner, E; Moon, J; Roncal, N; Sciotti, R; Smith, B; Sousa, J; Tungtaeng, A; Wipf, P	1
de Azevedo, WF; de Menezes, MN; Krettli, AU; Ribeiro dos Santos, R; Ribeiro, IM; Sá, MS; Soares, MB; Tomassini, TC	1
Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y	1
Chandrashekar, G; Chatterji, D; Meng, L; Robinson, K; Zhu, S	1
Akala, HM; Alao, JP; Ekberg, A; Endale, M; Erdélyi, M; Sunnerhagen, P; Yenesew, A	1
Campbell, M; Charman, SA; Gilbert, IH; Hudson, A; Kaiser, M; Katneni, K; Mital, A; Morizzi, J; Murugesan, D; Shackleford, DM; Yeates, C	1
Akala, H; Manguro, LA; Ochieng, CO; Owuor, PO	1
de Dios, A; Gorka, AP; Roepe, PD	1
Caridha, D; Gerena, L; Korotchenko, V; Kreishman-Deitrick, M; Li, Q; Lin, AJ; Sathunuru, R; Smith, PL	1
Aroonkit, P; Krajangsri, S; Mungthin, M; Ruchirawat, S; Thongsornkleeb, C; Tummatorn, J	1
Djurković-Djaković, O; Opsenica, IM; Pybus, BS; Sciotti, RJ; Slavić, K; Šolaja, BA; Tot, M; Verbić, TŽ	1
Byun, SY; Choi, I; Jeon, S; Kim, S; Ko, M; Lee, J; Park, S; Shum, D	1
Easwaran, M; Manickam, M; Pillaiyar, T; Wendt, LL	1
Agnamey, P; Azas, N; Cohen, A; Damiani, C; Dassonville-Klimpt, A; Dormoi, J; Guillon, J; Marchivie, M; Mullié, C; Pradines, B; Schneider, J; Sonnet, P; Taudon, N; Tisnerat, C; Totet, A	1

Reviews

3 review(s) available for chloroquine and mefloquine hydrochloride

Article	Year
Antimalarial activity: the search for marine-derived natural products with selective antimalarial activity. Journal of natural products, 1996, Volume: 59, Issue:7 Topics: Animals; Antimalarials; Magnetic Resonance Spectroscopy; Marine Toxins; Plants; Plasmodium; Porifera; Rhodophyta; Structure-Activity Relationship	1996
Quinoline drug-heme interactions and implications for antimalarial cytostatic versus cytocidal activities. Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13 Topics: Antimalarials; Crystallization; Drug Resistance; Heme; Hemeproteins; Humans; Malaria, Falciparum; Molecular Structure; Plasmodium falciparum; Quinolines	2013
The recent outbreaks of human coronaviruses: A medicinal chemistry perspective. Medicinal research reviews, 2021, Volume: 41, Issue:1 Topics: Antiviral Agents; Chemistry, Pharmaceutical; COVID-19; Disease Outbreaks; Drug Repositioning; Humans; Virus Internalization	2021

Other Studies

98 other study(ies) available for chloroquine and mefloquine hydrochloride

Article	Year
Antimalarial activity of sesquiterpenes from the marine sponge Acanthella klethra. Journal of natural products, 1992, Volume: 55, Issue:12 Topics: Animals; Antimalarials; Cell Survival; Humans; KB Cells; Plasmodium falciparum; Porifera; Sesquiterpenes	1992
Arteether, a new antimalarial drug: synthesis and antimalarial properties. Journal of medicinal chemistry, 1988, Volume: 31, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Magnetic Resonance Spectroscopy; Malaria; Mice; Models, Molecular; Plasmodium berghei; Plasmodium falciparum; Sesquiterpenes	1988
Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi. Journal of natural products, 1994, Volume: 57, Issue:10 Topics: Alkaloids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Aporphines; Drugs, Chinese Herbal; HIV; Humans; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Mice; Reverse Transcriptase Inhibitors; Tumor Cells, Cultured	1994
Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum. Journal of medicinal chemistry, 1994, May-13, Volume: 37, Issue:10 Topics: Aminoacridines; Animals; Antimalarials; Cell Division; Cells, Cultured; Drug Resistance; Erythrocytes; Humans; Plasmodium falciparum; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured	1994
Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile. Journal of natural products, 1993, Volume: 56, Issue:8 Topics: Alkaloids; Amaryllidaceae Alkaloids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Magnetic Resonance Spectroscopy; Phenanthridines; Plants, Medicinal; Plasmodium falciparum; Spectrophotometry, Ultraviolet	1993
Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei. Journal of natural products, 1993, Volume: 56, Issue:9 Topics: Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Aporphines; Drug Screening Assays, Antitumor; Glucosides; Isoquinolines; Magnetic Resonance Spectroscopy; Molecular Weight; Plants, Medicinal; Plasmodium falciparum; Species Specificity	1993
A new antimalarial quassinoid from Simaba guianensis. Journal of natural products, 1993, Volume: 56, Issue:11 Topics: Animals; Antimalarials; Brazil; Bridged Bicyclo Compounds; Chromatography, Thin Layer; Glaucarubin; Magnetic Resonance Spectroscopy; Plant Extracts; Plants, Medicinal; Plasmodium falciparum; Quassins; Spectrophotometry, Ultraviolet	1993
Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Stephania erecta. Journal of natural products, 1993, Volume: 56, Issue:1 Topics: Alkaloids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Benzylisoquinolines; Cell Survival; Drug Screening Assays, Antitumor; Erythrocytes; Female; Humans; In Vitro Techniques; Male; Mice; Plants, Medicinal; Plasmodium falciparum; Thailand; Tumor Cells, Cultured	1993
Costaricine, a new antiplasmodial bisbenzylisoquinoline alkaloid from Nectandra salicifolia trunk bark. Journal of natural products, 1996, Volume: 59, Issue:6 Topics: Alkaloids; Animals; Antimalarials; Chromatography, Thin Layer; Costa Rica; Mass Spectrometry; Plants, Medicinal; Plasmodium falciparum	1996
Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives. Journal of natural products, 1997, Volume: 60, Issue:4 Topics: Animals; Antimalarials; Cell Survival; Chloroquine; Drug Resistance; Humans; KB Cells; Limonins; Malaria, Falciparum; Mice; Plant Extracts; Plants, Medicinal; Plasmodium falciparum; Rats; Secosteroids; Structure-Activity Relationship	1997
In vitro and in vivo antiplasmodial activity of cryptolepine and related alkaloids from Cryptolepis sanguinolenta. Journal of natural products, 1997, Volume: 60, Issue:7 Topics: Alkaloids; Animals; Antimalarials; Humans; In Vitro Techniques; Indole Alkaloids; Indoles; Mice; Microbial Sensitivity Tests; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Quinolines; Spectrum Analysis	1997
Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids. Journal of natural products, 1999, Volume: 62, Issue:1 Topics: Alkaloids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Tumor Cells, Cultured	1999
Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker. Journal of medicinal chemistry, 2000, Jul-13, Volume: 43, Issue:14 Topics: Acridines; Animals; Antimalarials; Cell Line; Leishmania infantum; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2000
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja. Journal of natural products, 2001, Volume: 64, Issue:1 Topics: Alkaloids; Animals; Antimalarials; HeLa Cells; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plasmodium falciparum; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Strychnine	2001
Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives. Bioorganic & medicinal chemistry letters, 2001, Feb-12, Volume: 11, Issue:3 Topics: Animals; Antimalarials; Cinnamates; Combinatorial Chemistry Techniques; Inhibitory Concentration 50; Microbial Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship	2001
In vitro antiplasmodial activity of extracts of Tristaniopsis species and identification of the active constituents: ellagic acid and 3,4,5-trimethoxyphenyl-(6'-O-galloyl)-O-beta-D-glucopyranoside. Journal of natural products, 2001, Volume: 64, Issue:5 Topics: Animals; Antimalarials; Ellagic Acid; Glucosides; Humans; Magnetic Resonance Spectroscopy; New Caledonia; Plant Epidermis; Plant Extracts; Plants, Medicinal; Plasmodium; Tumor Cells, Cultured	2001
Synthesis, antimalarial activity and inhibition of haem detoxification of novel bisquinolines. Bioorganic & medicinal chemistry letters, 2001, Aug-20, Volume: 11, Issue:16 Topics: Animals; Antimalarials; Chloroquine; Inactivation, Metabolic; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines	2001
Synthesis of new artemisinin analogues from artemisinic acid modified at C-3 and C-13 and their antimalarial activity. Journal of natural products, 2001, Volume: 64, Issue:9 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Chromatography, Thin Layer; Drug Resistance, Microbial; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; KB Cells; Magnetic Resonance Spectroscopy; Molecular Structure; Plasmodium falciparum; Sesquiterpenes; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Structure-Activity Relationship	2001
Efficacy of scopadulcic acid A against Plasmodium falciparum in vitro. Journal of natural products, 2002, Volume: 65, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Diterpenes; Drug Resistance; Humans; In Vitro Techniques; Inhibitory Concentration 50; Mefloquine; Plants, Medicinal; Plasmodium falciparum; Scrophulariaceae	2002
Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity. Journal of medicinal chemistry, 2002, Aug-01, Volume: 45, Issue:16 Topics: Animals; Anti-Bacterial Agents; Antimalarials; Chlorocebus aethiops; Crystallography, X-Ray; Inhibitory Concentration 50; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Plasmodium falciparum; Spectrometry, Mass, Electrospray Ionization; Spiro Compounds; Steroids; Structure-Activity Relationship; Vero Cells	2002
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates. Journal of medicinal chemistry, 2002, Sep-12, Volume: 45, Issue:19 Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Drug Evaluation, Preclinical; Drug Resistance; Injections, Intravenous; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship	2002
Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria. Journal of medicinal chemistry, 2003, Sep-25, Volume: 46, Issue:20 Topics: Animals; Antimalarials; Antiprotozoal Agents; Artemisinins; Clone Cells; Drug Design; Inhibitory Concentration 50; L-Lactate Dehydrogenase; Leishmania donovani; Malaria, Falciparum; Models, Molecular; Molecular Conformation; Plasmodium falciparum; Sesquiterpenes; Static Electricity; Stereoisomerism; Structure-Activity Relationship	2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. Journal of medicinal chemistry, 2004, Oct-21, Volume: 47, Issue:22 Topics: Adenosine Triphosphate; Animals; Antimalarials; Binding Sites; Cyclin-Dependent Kinases; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Plasmodium falciparum; Protein Kinases; Protozoan Proteins; Quantitative Structure-Activity Relationship	2004
Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities. Bioorganic & medicinal chemistry letters, 2005, Feb-01, Volume: 15, Issue:3 Topics: Adamantane; Animals; Antimalarials; Cell Death; Cell Line; Heterocyclic Compounds; Humans; Inhibitory Concentration 50; Molecular Structure; Plasmodium falciparum; Spiro Compounds; Structure-Activity Relationship	2005
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. Journal of medicinal chemistry, 2005, Jun-02, Volume: 48, Issue:11 Topics: Alkyl and Aryl Transferases; Animals; Antimalarials; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Farnesyltranstransferase; Female; Humans; Malaria; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Plasmodium berghei; Plasmodium falciparum; Protein Prenylation; Quinolones; Rats; Structure-Activity Relationship	2005
Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives. Journal of medicinal chemistry, 2005, Oct-06, Volume: 48, Issue:20 Topics: Administration, Oral; Animals; Antimalarials; Carbamates; Guanidines; Imidazoles; Imidazolidines; Malaria; Male; Mice; Plasmodium falciparum; Plasmodium yoelii; Structure-Activity Relationship	2005
Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda. Journal of natural products, 2006, Volume: 69, Issue:1 Topics: Animals; Antimalarials; Cameroon; Erythrocytes; Fatty Acids; Holarrhena; Molecular Structure; Pentacyclic Triterpenes; Plant Bark; Plants, Medicinal; Plasmodium falciparum; Structure-Activity Relationship; Triterpenes	2006
Orally active 1,2,4-trioxanes: synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant plasmodium yoelii nigeriensis in mice. Journal of medicinal chemistry, 2006, May-04, Volume: 49, Issue:9 Topics: Administration, Oral; Amination; Animals; Antimalarials; Artemisinins; Drug Resistance, Multiple; Heterocyclic Compounds; Malaria; Mice; Molecular Structure; Plasmodium yoelii; Structure-Activity Relationship; Survival Rate	2006
Tetraoxane antimalarials and their reaction with Fe(II). Journal of medicinal chemistry, 2006, Jun-29, Volume: 49, Issue:13 Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Free Radicals; Humans; In Vitro Techniques; Mice; Microsomes, Liver; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Tetraoxanes	2006
Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes. Bioorganic & medicinal chemistry letters, 2006, Oct-15, Volume: 16, Issue:20 Topics: Animals; Antiprotozoal Agents; Bridged Bicyclo Compounds, Heterocyclic; In Vitro Techniques; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense	2006
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products. Journal of natural products, 2006, Volume: 69, Issue:8 Topics: Anti-Infective Agents; Antimalarials; Antineoplastic Agents; Antitubercular Agents; Furans; HIV Reverse Transcriptase; Hydrocarbons, Halogenated; Interleukin-1; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Kinase C; Protein-Tyrosine Kinases; Quantitative Structure-Activity Relationship; Rhodophyta	2006
Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Animals; Antimalarials; Chloroquine; Drug Synergism; HIV Protease Inhibitors; Humans; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Plasmodium falciparum; Ritonavir; Saquinavir	2007
Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1 Topics: Animals; Antimalarials; Colorimetry; Crystallization; Drug Evaluation, Preclinical; Heme; Hemeproteins; Plasmodium falciparum; Polysorbates; Reproducibility of Results	2007
In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Azithromycin; Clinical Trials, Phase II as Topic; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinine; Sesquiterpenes	2007
High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Animals; Biological Assay; Child, Preschool; DNA, Protozoan; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Female; Humans; Indoles; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Pregnancy	2007
Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Animals; Antimalarials; Benzothiazoles; Diamines; Drug Evaluation, Preclinical; Erythrocytes; Fluorescent Dyes; Humans; Hypoxanthine; Organic Chemicals; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Reproducibility of Results; Sensitivity and Specificity	2007
Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Antagonism; Drug Combinations; Drug Interactions; Drug Resistance; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Sesquiterpenes; Tritium	2007
Bicyclo[2.2.2]octyl esters of dialkylamino acids as antiprotozoals. Bioorganic & medicinal chemistry, 2007, Aug-15, Volume: 15, Issue:16 Topics: Alkylation; Amino Acids; Animals; Antiprotozoal Agents; Bridged Bicyclo Compounds; Esters; Inhibitory Concentration 50; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Trypanosoma brucei rhodesiense	2007
2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Adenosine; Animals; Antimalarials; Dose-Response Relationship, Drug; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2007
Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives(1). Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21 Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Cyclohexanes; Deoxycholic Acid; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Malaria; Mice; Microsomes; Plasmodium berghei; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship; Tetraoxanes	2007
Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(omega-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone. Bioorganic & medicinal chemistry, 2008, Feb-01, Volume: 16, Issue:3 Topics: Animals; Antimalarials; Fluorine; Heme; Magnetic Resonance Spectroscopy; Molecular Structure; Plasmodium falciparum; Spectrophotometry; Structure-Activity Relationship; Xanthones	2008
Determinants of in vitro drug susceptibility testing of Plasmodium vivax. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Humans; Inhibitory Concentration 50; Life Cycle Stages; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Schizonts; Time Factors	2008
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5 Topics: Animals; Antimalarials; Biological Transport; Cell Line, Tumor; Chloroquine; Drug Resistance; Drug Therapy, Combination; Glutathione Reductase; Humans; In Vitro Techniques; Malaria; Mice; Mice, Inbred BALB C; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship	2008
Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein. Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7 Topics: Antimalarials; Binding Sites; Chromatography, Affinity; Circular Dichroism; Humans; Molecular Structure; Orosomucoid; Protein Binding; Serum Albumin; Spectrophotometry; Stereoisomerism; Structure-Activity Relationship	2008
Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Amodiaquine; Animals; Antimalarials; Blotting, Western; Chloroquine; Endocytosis; Erythrocytes; Hemoglobins; Humans; Mefloquine; Peroxidase; Phenanthrenes; Plasmodium falciparum; Protein Binding; Protozoan Proteins; Quinolines	2008
Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Parasitic Sensitivity Tests; Peroxides; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship; Tetraoxanes	2008
Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7 Topics: Animals; Antimalarials; Drug Resistance, Multiple; Gene Dosage; Genes, MDR; Genes, Protozoan; HIV Infections; HIV Protease Inhibitors; Humans; In Vitro Techniques; Malaria, Falciparum; Malaria, Vivax; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Ritonavir; Saquinavir	2008
A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. Journal of medicinal chemistry, 2008, Jun-26, Volume: 51, Issue:12 Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Isoenzymes; Pancreatic Neoplasms; Parasitic Sensitivity Tests; Plasmodium falciparum; Triazoles	2008
Novel azabicyclo[3.2.2]nonane derivatives and their activities against Plasmodium falciparum K1 and Trypanosoma brucei rhodesiense. Bioorganic & medicinal chemistry, 2008, Jun-15, Volume: 16, Issue:12 Topics: Animals; Antimalarials; Azabicyclo Compounds; Plasmodium falciparum; Trypanocidal Agents; Trypanosoma brucei brucei	2008
Mixed tetraoxanes containing the acetone subunit as antimalarials. Bioorganic & medicinal chemistry, 2008, Jul-15, Volume: 16, Issue:14 Topics: Acetone; Animals; Antimalarials; Artemisinins; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Mefloquine; Mice; Plasmodium falciparum; Tetraoxanes	2008
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America, 2008, Jul-01, Volume: 105, Issue:26 Topics: Animals; Antimalarials; Cluster Analysis; Computational Biology; Drug Evaluation, Preclinical; Drug Resistance; Folic Acid Antagonists; Malaria; Models, Molecular; Parasites; Plasmodium falciparum; Reproducibility of Results; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase	2008
Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A. Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15 Topics: Aminoquinolines; Animals; Botulinum Toxins, Type A; Chloroquine; Drug Resistance; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship	2008
Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10 Topics: Aminoquinolines; Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Base Sequence; Biological Transport, Active; Chloroquine; DNA, Protozoan; Drug Resistance; Fluorescent Dyes; Genes, Protozoan; Humans; Leishmania infantum; Leishmaniasis, Visceral; Lipid Bilayers; Phosphorylcholine; Protozoan Proteins; Recombinant Proteins; Transformation, Genetic	2008
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10 Topics: Animals; Antimalarials; Aotidae; Drug Resistance; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Hydroxamic Acids; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Mice, Inbred ICR; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship; Thiazoles	2008
New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Aminoquinolines; Animals; Antimalarials; Binding Sites; Disease Models, Animal; Dose-Response Relationship, Drug; Malaria; Maximum Tolerated Dose; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship; Tetraoxanes	2008
In vivo and in vitro efficacy of amodiaquine monotherapy for treatment of infection by chloroquine-resistant Plasmodium vivax. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3 Topics: Adolescent; Age Distribution; Amodiaquine; Animals; Antimalarials; Chloroquine; Confidence Intervals; Drug Resistance; Drug Tolerance; Female; Follow-Up Studies; Humans; Inhibitory Concentration 50; Male; Outpatients; Parasitemia; Plasmodium vivax; Prospective Studies; Recurrence; Rural Health; Time Factors; Treatment Failure; Treatment Outcome	2009
Synthesis and antimalarial activities of cyclen 4-aminoquinoline analogs. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:4 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Cyclams; Hemeproteins; Heterocyclic Compounds; Malaria; Male; Mice; Plasmodium berghei	2009
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Benzylamines; Cytochrome P-450 Enzyme Inhibitors; Dogs; Drug Evaluation, Preclinical; Drug Resistance; Female; Haplorhini; Heme; Humans; Malaria; Mice; Models, Molecular; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Rats; Structure-Activity Relationship	2009
Dynamics of malaria drug resistance patterns in the Amazon basin region following changes in Peruvian national treatment policy for uncomplicated malaria. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5 Topics: Animals; Antimalarials; Drug Resistance; Genotype; Haplotypes; Health Policy; Humans; Malaria, Falciparum; Microsatellite Repeats; Mutation; Parasitic Sensitivity Tests; Peru; Plasmodium falciparum; Protozoan Proteins	2009
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine. Journal of medicinal chemistry, 2009, Apr-09, Volume: 52, Issue:7 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Cell Survival; Chloroquine; Dogs; Drug Resistance; Female; Haplorhini; Hepatocytes; Humans; In Vitro Techniques; Malaria; Male; Mice; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Rats; Rats, Wistar; Structure-Activity Relationship	2009
Colorimetric high-throughput screen for detection of heme crystallization inhibitors. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6 Topics: Animals; Antimalarials; Colorimetry; Crystallization; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Heme; Hemeproteins; Plasmodium falciparum	2009
Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6 Topics: Animals; Antimalarials; Atorvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Plasmodium falciparum; Pyrroles	2009
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil	2009
Antimalarial activity of tigecycline, a novel glycylcycline antibiotic. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9 Topics: Animals; Anti-Bacterial Agents; Antimalarials; Doxycycline; Inhibitory Concentration 50; Minocycline; Parasitic Sensitivity Tests; Plasmodium falciparum; Tetracycline; Tetracyclines; Tigecycline	2009
Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials. Bioorganic & medicinal chemistry letters, 2009, Sep-15, Volume: 19, Issue:18 Topics: Animals; Antimalarials; DNA, Protozoan; Drug Discovery; Drug Resistance; Erythrocytes; Flow Cytometry; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; RNA, Protozoan; Structure-Activity Relationship	2009
Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:11 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Dihydropteroate Synthase; Drug Combinations; Drug Resistance; Haplotypes; Madagascar; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase	2009
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1 Topics: Animals; Antimalarials; Heterocyclic Compounds, 1-Ring; Malaria, Falciparum; Mice; Molecular Conformation; Parasitic Sensitivity Tests; Peroxides; Plasmodium falciparum; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship	2010
The comparative antimalarial properties of weak base and neutral synthetic ozonides. Bioorganic & medicinal chemistry letters, 2010, Jan-15, Volume: 20, Issue:2 Topics: Animals; Antimalarials; Heterocyclic Compounds; Mice; Plasmodium falciparum; Rats	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones. Bioorganic & medicinal chemistry, 2010, Apr-01, Volume: 18, Issue:7 Topics: Animals; Antimalarials; Cell Line; Cell Survival; Drug Resistance; Erythrocytes; Escherichia coli; Humans; Indicators and Reagents; Mefloquine; Membranes, Artificial; Permeability; Plasmodium falciparum; Quinolones; Solubility; Structure-Activity Relationship	2010
A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90. Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Adenosine Triphosphate; Antimalarials; Binding Sites; Binding, Competitive; Drug Evaluation, Preclinical; Drug Synergism; HSP90 Heat-Shock Proteins; Humans; Parasitic Sensitivity Tests; Plasmodium falciparum; Small Molecule Libraries; Substrate Specificity	2010
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6 Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Drug Resistance; Female; Folic Acid Antagonists; Humans; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Models, Molecular; Mutation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Quinazolines; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase	2010
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9 Topics: Animals; Antimalarials; Drug Resistance, Multiple; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum	2010
Spiroindolones, a potent compound class for the treatment of malaria. Science (New York, N.Y.), 2010, Sep-03, Volume: 329, Issue:5996 Topics: Adenosine Triphosphatases; Animals; Antimalarials; Cell Line; Drug Discovery; Drug Resistance; Erythrocytes; Female; Genes, Protozoan; Humans; Indoles; Malaria; Male; Mice; Models, Molecular; Mutant Proteins; Mutation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Plasmodium vivax; Protein Synthesis Inhibitors; Protozoan Proteins; Rats; Rats, Wistar; Spiro Compounds	2010
In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Inhibitory Concentration 50; Naphthyridines; Plasmodium falciparum; Plasmodium vivax	2010
In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1 Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Indonesia; Malaria; Male; Middle Aged; Plasmodium malariae; Plasmodium ovale; Treatment Outcome; Young Adult	2011
Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme. Bioorganic & medicinal chemistry, 2010, Nov-15, Volume: 18, Issue:22 Topics: ADP-ribosyl Cyclase 1; Animals; Binding Sites; Catalytic Domain; Computer Simulation; Enzyme Inhibitors; Flavonoids; High-Throughput Screening Assays; Humans; NAD+ Nucleosidase; Schistosoma mansoni; Schistosomicides; Structure-Activity Relationship	2010
Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:3 Topics: Drug Resistance, Multiple, Bacterial; Histone Deacetylase Inhibitors; Hydroxamic Acids; Microbial Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Vorinostat	2011
In vitro efficacy of 7-benzylamino-1-isoquinolinamines against Plasmodium falciparum related to the efficacy of chalcones. Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2 Topics: Aminoquinolines; Antimalarials; Chalcones; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Models, Molecular; Plasmodium falciparum; Structure-Activity Relationship	2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:3 Topics: Adenosine Triphosphate; Aminoquinolines; Antiprotozoal Agents; Drug Resistance; Glycolysis; Leishmania major; Pyruvate Kinase	2011
A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus. Journal of medicinal chemistry, 2011, Mar-10, Volume: 54, Issue:5 Topics: Animals; Anopheles; Anti-Bacterial Agents; Antimalarials; Antiviral Agents; Botulinum Toxins, Type A; Cell Line; Chlorocebus aethiops; Chrysenes; Ebolavirus; Hemeproteins; Malaria; Mice; Models, Molecular; Plasmodium berghei; Plasmodium falciparum; Quinolines; Rats; Stereoisomerism; Structure-Activity Relationship	2011
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. Journal of medicinal chemistry, 2011, Jun-09, Volume: 54, Issue:11 Topics: Animals; Antimalarials; Dihydroorotate Dehydrogenase; Disease Models, Animal; Drug Design; Drug Discovery; Enzyme Inhibitors; Humans; Malaria; Mice; Microsomes, Liver; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium berghei; Plasmodium falciparum; Protein Binding; Pyrimidines; Solubility; Structure-Activity Relationship; Triazoles	2011
Antimalarial pyrido[1,2-a]benzimidazoles. Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13 Topics: Administration, Oral; Animals; Antimalarials; Benzimidazoles; Drug Resistance, Multiple; Humans; In Vitro Techniques; Injections, Intraperitoneal; L Cells; Malaria; Male; Mice; Microsomes, Liver; Plasmodium berghei; Plasmodium falciparum; Pyridines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2011
Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of medicinal chemistry, 2011, Jul-28, Volume: 54, Issue:14 Topics: Amino Acids; Aniline Compounds; Animals; Antimalarials; Benzene Derivatives; Cell Line; Drug Resistance; Female; Humans; Imidazoles; Inhibitory Concentration 50; Malaria; Mice; Mice, Inbred BALB C; Piperazines; Plasmodium berghei; Plasmodium falciparum; Rats; Structure-Activity Relationship	2011
Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum. Journal of medicinal chemistry, 2011, Sep-22, Volume: 54, Issue:18 Topics: Animals; Antimalarials; Cell Line; Cell Membrane Permeability; Dimerization; Dogs; Drug Resistance; Ethanolamines; Ethylenediamines; Malaria; Mefloquine; Methanol; Mice; Plasmodium berghei; Plasmodium falciparum; Quinolines; Stereoisomerism; Structure-Activity Relationship	2011
Antimalarial activity of physalins B, D, F, and G. Journal of natural products, 2011, Oct-28, Volume: 74, Issue:10 Topics: Animals; Antimalarials; Immunosuppressive Agents; Malaria; Mice; Mice, Inbred BALB C; Parasitemia; Physalis; Plasmodium berghei; Plasmodium falciparum; Secosteroids	2011
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (New York, N.Y.), 2011, Dec-09, Volume: 334, Issue:6061 Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance; Erythrocytes; Humans; Imidazoles; Liver; Malaria; Mice; Mice, Inbred BALB C; Molecular Structure; Piperazines; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Polymorphism, Single Nucleotide; Protozoan Proteins; Random Allocation; Small Molecule Libraries; Sporozoites	2011
Febrifugine analogue compounds: synthesis and antimalarial evaluation. Bioorganic & medicinal chemistry, 2012, Jan-15, Volume: 20, Issue:2 Topics: Animals; Antimalarials; Aotus trivirgatus; Drug Evaluation, Preclinical; Malaria; Piperidines; Plasmodium falciparum; Quinazolines	2012
Busseihydroquinones A-D from the roots of Pentas bussei. Journal of natural products, 2012, Jul-27, Volume: 75, Issue:7 Topics: Antimalarials; Chloroquine; Crystallography, X-Ray; Hydroquinones; Kenya; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plasmodium falciparum; Rubiaceae	2012
Discovery and structure-activity relationships of pyrrolone antimalarials. Journal of medicinal chemistry, 2013, Apr-11, Volume: 56, Issue:7 Topics: Animals; Antimalarials; Cell Line; Drug Discovery; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plasmodium falciparum; Pyrroles; Rats; Structure-Activity Relationship	2013
Voulkensin C-E, new 11-oxocassane-type diterpenoids and a steroid glycoside from Caesalpinia volkensii stem bark and their antiplasmodial activities. Bioorganic & medicinal chemistry letters, 2013, May-15, Volume: 23, Issue:10 Topics: Antimalarials; Caesalpinia; Diterpenes; Dose-Response Relationship, Drug; Glycosides; Models, Molecular; Molecular Conformation; Parasitic Sensitivity Tests; Plant Bark; Plant Stems; Plasmodium falciparum; Steroids; Structure-Activity Relationship	2013
Antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives. Journal of medicinal chemistry, 2015, Apr-23, Volume: 58, Issue:8 Topics: Animals; Antimalarials; Hep G2 Cells; Humans; Malaria; Malaria, Falciparum; Male; Mice; Naphthyridines; Plasmodium berghei; Plasmodium falciparum; Quinolines	2015
Synthesis of isocryptolepine analogues and their structure-activity relationship studies as antiplasmodial and antiproliferative agents. European journal of medicinal chemistry, 2015, Apr-13, Volume: 94 Topics: Antimalarials; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Chemistry Techniques, Synthetic; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Humans; Indole Alkaloids; Plasmodium falciparum; Quinolines; Structure-Activity Relationship	2015
Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice. Bioorganic & medicinal chemistry, 2015, May-01, Volume: 23, Issue:9 Topics: Aminoquinolines; Animals; Antimalarials; Cell Proliferation; Dose-Response Relationship, Drug; Furans; Hep G2 Cells; Humans; Macrophages; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium berghei; Structure-Activity Relationship; Thiophenes	2015
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrobial agents and chemotherapy, 2020, 06-23, Volume: 64, Issue:7 Topics: Animals; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Cell Line; Chlorocebus aethiops; Coronavirus Infections; COVID-19; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Niclosamide; Pandemics; Pneumonia, Viral; Pregnenediones; SARS-CoV-2; Vero Cells	2020
Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity. European journal of medicinal chemistry, 2022, Jan-15, Volume: 228 Topics: Amino Alcohols; Animals; Antimalarials; Cell Line; Cricetulus; Dose-Response Relationship, Drug; Drug Design; Ether-A-Go-Go Potassium Channels; Female; Humans; Malaria; Mice; Mice, Inbred BALB C; Microsomes, Liver; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Structure-Activity Relationship	2022