chloroquine has been researched along with leupeptin in 87 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (39.08) | 18.7374 |
| 1990's | 37 (42.53) | 18.2507 |
| 2000's | 14 (16.09) | 29.6817 |
| 2010's | 2 (2.30) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ | 2 |
| Charris, J; Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ | 1 |
| Alvarez-Larena, A; Andujar, S; Barazarte, A; Camacho, J; Capparelli, MV; Charris, J; Domínguez, J; Enriz, D; Gamboa, N; Lobo, G; Rodrigues, J | 1 |
| Desai, SA; Fay, MP; Furuya, T; Gluzman, IY; Goldberg, DE; Kambhampati, S; Lisk, G; Pain, M; Su, XZ | 1 |
| Alvarez-Larena, A; Barazarte, A; Capparelli, MV; Charris, JE; Gamboa, N; Lobo, G; López, SE; Rodrigues, JR | 1 |
| Barazarte, A; Camacho, J; Charris, J; Gamboa, N; Gilman, R; Rodrigues, J; Rojas, R; Vaisberg, A | 1 |
| Ramanujam, KS; Seetharam, B; Seetharam, S | 1 |
| Clementi, F; Passafaro, M; Sher, E | 1 |
| Morton, PA; Owensby, DA; Schwartz, AL; Underhill, DM | 1 |
| Berg, T; Roseng, L; Tolleshaug, H | 1 |
| Marinelli, RA; Peñalva, GL | 1 |
| Banerjee, D; Grieninger, G; Mukhopadhyay, G; Oddoux, C; Overton, O; Redman, C; Roy, S; Yu, S | 1 |
| Haspel, HC; Honkanen, RA; Klingman, DE; Ortiz, PA | 1 |
| Knops, J; Lieberburg, I; Sinha, S | 1 |
| Homma, S; Oppenheim, RW; Prevette, D; Tytell, M | 1 |
| Bettens, F; Brander, C; Mijic, D; Pichler, WJ; Wyss-Coray, T | 1 |
| Baron, PL; Meola, G; Moggio, M; Santilli, I; Scarlato, G; Scarpini, E | 1 |
| Knutson, VP | 1 |
| Augustine, EC; Kensinger, RS | 1 |
| Goldberg, IJ; Klein, MG; Saxena, U | 1 |
| Grisolía, S; Knecht, E; Vargas, JL | 1 |
| Clem, LW; Jørgensen, T; Miller, NW; Vallejo, AN | 1 |
| Atwood, HL; Boegman, RJ; Scarth, B | 1 |
| Amara, JF; Lederkremer, G; Lodish, HF | 1 |
| Rizzolo, LJ | 1 |
| Clarke, BL; Weigel, PH | 1 |
| Alpers, DH; Ramasamy, M; Seetharam, B; Tiruppathi, C | 1 |
| Moss, AL; Ward, WF | 1 |
| Kovács, J; Réz, G | 1 |
| Maeda, M; Neda, H; Niitsu, Y; Sone, H; Urushizaki, I; Watanabe, N; Yamauchi, N | 1 |
| McClain, DA; Olefsky, JM | 1 |
| Charlwood, PA; Chindemi, PA; Regoeczi, E | 1 |
| Presky, DH; Schonbrunn, A | 1 |
| Carpentier, JL; Hachiya, HL; King, GL | 1 |
| Hozumi, N; Watanabe, M; Yoshikawa, M | 1 |
| Harford, JB; Klausner, RD; Rao, K; Weissman, AM | 1 |
| Schaudies, RP; Wray, HL | 1 |
| Bauer, A; Kirchner, H; Rutenfranz, I | 1 |
| Blum, JS; Cresswell, P | 1 |
| Coffey, RJ; Kost, LJ; LaRusso, NF; Lyons, RM; Moses, HL | 1 |
| Ahlberg, J; Glaumann, H | 1 |
| Decker, RS; Ridout, RM; Wildenthal, K | 1 |
| Ahlberg, J; Berkenstam, A; Glaumann, H; Henell, F | 2 |
| Wakeland, JR; Wildenthal, K | 1 |
| Etlinger, JD; Silver, G | 1 |
| Aronson, NN; Dennis, PA | 2 |
| Kempen, HJ; Kruijt, JK; van Berkel, TJ | 1 |
| Andersen, KB | 1 |
| Chang, TM; Kullberg, DW | 1 |
| Berkower, IJ; Berzofsky, JA; Busch, M; Gurd, FR; Streicher, HZ | 1 |
| Bystryn, JC; Johnston, D | 1 |
| Scornik, OA | 1 |
| Baudry, M; Ivy, GO; Lynch, G; Schottler, F; Wenzel, J | 1 |
| Bates, PJ; Coetzee, GA; Van der Westhuyzen, DR | 1 |
| Bunnett, NW; Garland, AM; Grady, EF; Payan, DG; Vigna, SR | 1 |
| Hitzel, C; Koch, N; van Endert, P | 1 |
| Corradin, G; Escobar, P; Healy, F; Mach, JP; Valmori, D; Yu, Z | 1 |
| Esko, JD; Hager, KM; Hajduk, SL; Moore, DR; Pierce, MA; Tytler, EM | 1 |
| DelValle, J; Kokudo, N; Kothary, PC; Raper, SE | 1 |
| Hunt, D; Mookerjea, S; Nagpurkar, A; Yang, CY | 1 |
| Adams, PC; Chau, LA | 1 |
| Loss, GE; Sant, AJ | 1 |
| Lodish, HF; Neumann, D; Watowich, SS; Wikström, L | 1 |
| Rathod, PK; Young, RD | 1 |
| Ashton-Rickardt, PG; Bachmann, MF; Hengartner, H; Oxenius, A; Tonegawa, S; Zinkernagel, RM | 1 |
| Inagaki, H; Lin, KH; Maeda, S; Saito, T | 1 |
| Lindner, R; Unanue, ER | 1 |
| Fibach, E; Konijn, AM; Vaisman, B | 1 |
| Bakke, O; Stang, E | 1 |
| Hasselgren, PO; Luo, GJ; Wang, JJ; Wang, L | 1 |
| Beech, W; Chu, T; Cole, GM; Frautschy, SA; Tran, T; Yang, F | 1 |
| DeMoss, J; Gordon, SR | 1 |
| Bray, PG; Ginsburg, H; Janneh, O; Mungthin, M; Raynes, KJ; Ward, SA | 1 |
| Aminoff, M; Christensen, EI; Cui, S; de la Chapelle, A; Fyfe, J; Gerdes, C; Jacobsen, C; Kozyraki, R; Krahe, R; Kristiansen, M; Moestrup, SK; Verroust, PJ | 1 |
| Hu, Gf; Kim, Hj; Riordan, JF; Xu, Cj | 1 |
| Chou, GY; Li, NL; Shen, BH; Zheng, ZX | 1 |
| O'Brien, PJ; Pourahmad, J; Ross, S | 1 |
| Fujimura, S; Furuya, N; Kadowaki, M; Kanazawa, T; Kominami, E; Ueno, T | 1 |
| Ostrand-Rosenberg, S; Qi, L | 1 |
| Dautry-Varsat, A; Lamaze, C; Rocca, A; Subtil, A | 1 |
| Kidane, TZ; Linder, MC; Sauble, E | 1 |
| Hällbrink, M; Jayamanne, M; Kjellander, M; Palm, C | 1 |
| de Boer, TP; Jansen, JA; van der Heyden, MA; van Rijen, HV; van Veen, TA; Vos, MA; Wolswinkel, R | 1 |
| Garner, B; Li, H; Ruberu, K; Zhao, H | 1 |
1 review(s) available for chloroquine and leupeptin
| Article | Year |
|---|---|
Quantitative aspects of cellular autophagocytosis. Morphometric and cell fractionation studies.
Topics: Animals; Autophagy; Cell Compartmentation; Cell Fractionation; Chloroquine; Leupeptins; Liver; Lysosomes; Male; Methylamines; Pancreas; Phagocytosis; Rats; Seminal Vesicles; Vacuoles; Vinblastine | 1989 |
86 other study(ies) available for chloroquine and leupeptin
| Article | Year |
|---|---|
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.
Topics: Animals; Antimalarials; Chalcones; Cysteine Endopeptidases; Globins; Heme; Hemeproteins; Hydrolysis; Malaria; Mice; Phenylurea Compounds; Plasmodium berghei; Plasmodium falciparum; Polymers; Protease Inhibitors; Structure-Activity Relationship | 2005 |
Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Malaria; Male; Mice; Molecular Conformation; Plasmodium berghei; Plasmodium falciparum; Sulfonylurea Compounds | 2007 |
Synthesis, antimalarial activity, structure-activity relationship analysis of thieno-[3,2-b]benzothiazine S,S-dioxide analogs.
Topics: Animals; Antimalarials; Benzene; Crystallography, X-Ray; Globins; Hemeproteins; Mice; Models, Molecular; Molecular Structure; Oxides; Plasmodium berghei; Static Electricity; Structure-Activity Relationship; Thiazines | 2008 |
Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.
Topics: Animals; Antimalarials; Biological Transport, Active; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Drug Resistance; Erythrocytes; Genes, Protozoan; Humans; In Vitro Techniques; Ion Channels; Leupeptins; Malaria, Falciparum; Plasmodium falciparum; Protozoan Proteins | 2008 |
Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives.
Topics: Animals; Antimalarials; Magnetic Resonance Spectroscopy; Models, Molecular; Plasmodium berghei; Spectrophotometry, Infrared; Thiazines | 2009 |
Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities.
Topics: Animals; Antimalarials; Chalcone; Hemeproteins; Hemoglobins; Humans; Hydrolysis; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Sulfones | 2009 |
Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents.
Topics: Animals; Antimalarials; Antitubercular Agents; Benzimidazoles; Cell Line, Tumor; Drug Resistance, Multiple; Hemin; Hemoglobins; Humans; Hydrazines; Hydrolysis; Mice; Plasmodium | 2011 |
Synthesis and brush border expression of intrinsic factor-cobalamin receptor from rat renal cortex.
Topics: Animals; Chloroquine; Chromatography, Liquid; Culture Techniques; Electrophoresis, Polyacrylamide Gel; Intrinsic Factor; Kidney Cortex; Leupeptins; Male; Microvilli; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Vitamin B 12 | 1992 |
Metabolism of omega-conotoxin-sensitive voltage-operated calcium channels in human neuroblastoma cells: modulation by cell differentiation and anti-channel antibodies.
Topics: Antibodies; Calcium Channels; Cell Differentiation; Chloroquine; Electrophysiology; Humans; Leupeptins; Neuroblastoma; omega-Conotoxins; Peptides, Cyclic; Temperature | 1992 |
Endocytosis and lysosomal delivery of tissue plasminogen activator-inhibitor 1 complexes in Hep G2 cells.
Topics: Ammonium Chloride; beta-N-Acetylhexosaminidases; Carcinoma, Hepatocellular; Chloroquine; Endocytosis; Humans; Kinetics; Leupeptins; Liver Neoplasms; Lysosomes; Pepstatins; Plasminogen Activator Inhibitor 1; Primaquine; Recombinant Proteins; Subcellular Fractions; Tissue Plasminogen Activator; Tumor Cells, Cultured | 1992 |
Uptake, intracellular transport, and degradation of polyethylene glycol-modified asialofetuin in hepatocytes.
Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Biological Transport; Cells, Cultured; Chloroquine; Fetuins; Kinetics; Kupffer Cells; Leupeptins; Liver; Polyethylene Glycols; Rats; Time Factors | 1992 |
Effect of lysosomotropic agents on the taurocholate-stimulated biliary excretion of horseradish peroxidase.
Topics: Acid Phosphatase; Animals; Bile Acids and Salts; Biliary Tract; Chloroquine; Horseradish Peroxidase; Leupeptins; Lysosomes; Male; Rats; Rats, Wistar; Taurocholic Acid | 1992 |
Assembly and secretion of fibrinogen. Degradation of individual chains.
Topics: Ammonium Chloride; Animals; Cell Line; Chickens; Chloroquine; Fibrinogen; Humans; Kinetics; Leupeptins; Liver; Lysosomes; Macromolecular Substances; Methionine; Sulfur Radioisotopes; Transfection; Tumor Cells, Cultured | 1992 |
Regulation of the functional expression of hexose transporter GLUT-1 by glucose in murine fibroblasts: role of lysosomal degradation.
Topics: 3T3 Cells; Animals; Biological Transport; Cell Compartmentation; Chloroquine; Glucose; Hexoses; In Vitro Techniques; Leupeptins; Lysosomes; Membrane Proteins; Mice; Monosaccharide Transport Proteins | 1992 |
Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate.
Topics: Amyloid beta-Protein Precursor; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leucine; Leupeptins; Molecular Weight; Peptide Fragments; Transfection | 1992 |
Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes.
Topics: Animals; Cell Survival; Chick Embryo; Chloroquine; Curare; Cycloheximide; Dactinomycin; Ganglia, Spinal; Gene Expression; Genotype; Leupeptins; Microscopy, Electron; Motor Neurons; Protein Biosynthesis; Puromycin; RNA; Spinal Cord | 1990 |
Use of antibody/peptide constructs of direct antigenic peptides to T cells: evidence for T cell processing and presentation.
Topics: Antigen-Antibody Complex; Antigen-Presenting Cells; Antigens, Bacterial; Chloroquine; Clone Cells; Dose-Response Relationship, Immunologic; Humans; In Vitro Techniques; Leupeptins; Lymphocyte Activation; Peptides; T-Lymphocytes; Tetanus Toxoid | 1992 |
Lysosomotropic agents induce morphological and functional changes in human muscle cells in vitro.
Topics: Cells, Cultured; Chloroquine; Histocytochemistry; Humans; Leupeptins; Lysosomes; Microscopy, Electron; Muscles; Propranolol | 1991 |
Proteolytic processing of the insulin receptor beta subunit is associated with insulin-induced receptor down-regulation.
Topics: Animals; Blotting, Western; Cells, Cultured; Chloroquine; Cycloheximide; Cysteine Endopeptidases; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Insulin; Insulin Antagonists; Leucine; Leupeptins; Mice; Peptide Fragments; Receptor, Insulin | 1991 |
Endocytosis and degradation of ovine prolactin by Nb2 lymphoma cells: characterization and effects of agents known to alter prolactin-induced mitogenesis.
Topics: Amiloride; Animals; Calcimycin; Cell Division; Cell Membrane; Chloroquine; Endocytosis; Kinetics; Leupeptins; Lymphoma; Methylamines; Mitosis; Monensin; Prolactin; Rats; Receptors, Prolactin; Sheep; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling.
Topics: Animals; Aorta; Biological Transport; Cattle; Cells, Cultured; Chloroquine; Chondroitin Sulfate Proteoglycans; Cytochalasin B; Endothelium, Vascular; Female; Glycosaminoglycans; Heparan Sulfate Proteoglycans; Heparin; Heparin Lyase; Heparitin Sulfate; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Lipoprotein Lipase; Milk; Monensin; Polysaccharide-Lyases; Protein Binding; Proteoglycans; Swine | 1990 |
Endocytosis of liposomes containing lysosomal proteins increases intracellular protein degradation in growing L-132 cells.
Topics: Cathepsins; Cells, Cultured; Chloroquine; Drug Carriers; Endocytosis; Ferritins; Humans; L Cells; Leupeptins; Liposomes; Lysosomes; Membrane Proteins; Microinjections; Microscopy, Electron; Peptide Hydrolases; Protein Biosynthesis; Proteins; Time Factors | 1990 |
Phylogeny of immune recognition: antigen processing/presentation in channel catfish immune responses to hemocyanins.
Topics: Ammonium Chloride; Animals; Antibody Formation; Antigen-Presenting Cells; Antigens; B-Lymphocytes; Chloroquine; Fixatives; Hemocyanins; Ictaluridae; In Vitro Techniques; Leupeptins; Lymphocyte Activation; Monensin; Monocytes; Phenylmethylsulfonyl Fluoride | 1990 |
Effect of protease inhibitors on skeletal muscle lysosomal enzyme activity and resting membrane potential.
Topics: Acetylglucosaminidase; Animals; Aprotinin; Chloroquine; Leupeptins; Lysosomes; Male; Membrane Potentials; Muscle Denervation; Muscles; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Rats; Rats, Inbred Strains | 1986 |
Intracellular degradation of unassembled asialoglycoprotein receptor subunits: a pre-Golgi, nonlysosomal endoproteolytic cleavage.
Topics: Acetylglucosaminidase; Animals; Asialoglycoprotein Receptor; Cell Line; Chloroquine; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fluorescent Antibody Technique; Golgi Apparatus; Half-Life; Leupeptins; Lysosomes; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Microscopy, Fluorescence; Molecular Weight; Monensin; Receptors, Immunologic; Temperature | 1989 |
A growth hormone-vesicular stomatitis virus G hybrid protein is rapidly degraded in lysosomes following transport to the cell surface.
Topics: Animals; Cells, Cultured; Chloroquine; Cricetinae; Endocytosis; Growth Hormone; Kidney; Leupeptins; Lysosomes; Membrane Proteins; Monensin; Vesicular stomatitis Indiana virus; Viral Proteins | 1989 |
Differential effects of leupeptin, monensin and colchicine on ligand degradation mediated by the two asialoglycoprotein receptor pathways in isolated rat hepatocytes.
Topics: Animals; Asialoglycoproteins; Cells, Cultured; Chloroquine; Colchicine; Dose-Response Relationship, Drug; Galactose; Leupeptins; Liver; Male; Monensin; Oligopeptides; Orosomucoid; Rats; Rats, Inbred Strains; Receptors, Cell Surface | 1989 |
Cobalamin release from intrinsic factor and transfer to transcobalamin II within the rat enterocyte.
Topics: Administration, Oral; Animals; Animals, Suckling; Chloroquine; Gastric Mucosa; Immune Sera; Intestinal Mucosa; Intestines; Intrinsic Factor; Leupeptins; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Transcobalamins; Vitamin B 12 | 1989 |
Effects of lysosomal inhibitors on 125I-insulin and 125I-asialofetuin degradation by the isolated, perfused rat liver and isolated rat hepatocytes.
Topics: alpha-Fetoproteins; Ammonium Chloride; Animals; Asialoglycoproteins; Chloroquine; Fetuins; In Vitro Techniques; Insulin; Iodine Radioisotopes; Leupeptins; Liver; Lysosomes; Male; Perfusion; Rats; Rats, Inbred Strains | 1985 |
Cytocidal mechanism of TNF: effects of lysosomal enzyme and hydroxyl radical inhibitors on cytotoxicity.
Topics: Ammonium Chloride; Animals; Chloroquine; Cytotoxicity, Immunologic; Dimethyl Sulfoxide; Free Radicals; Hydroxides; Hydroxyl Radical; Leupeptins; Masoprocol; Methylamines; Mice; Muramidase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1988 |
Evidence for two independent pathways of insulin-receptor internalization in hepatocytes and hepatoma cells.
Topics: 2,4-Dinitrophenol; Animals; Biological Transport; Biotransformation; Carcinoma, Hepatocellular; Cells, Cultured; Chloroquine; Coated Pits, Cell-Membrane; Dinitrophenols; Humans; Insulin; Leupeptins; Liver; Liver Neoplasms; Monensin; Osmolar Concentration; Potassium; Rats; Receptor, Insulin; Tumor Cells, Cultured | 1988 |
The effects of cytotropic compounds on the resialylation of human asialotransferrin type 3 in the rat.
Topics: Alkaloids; Animals; Asialoglycoproteins; Chloroquine; Colchicine; Female; Humans; Leupeptins; Liver; Lysine; Male; Microtubules; Paclitaxel; Protein Biosynthesis; Rats; Starvation; Transferrin; Vinblastine | 1985 |
Receptor-bound somatostatin and epidermal growth factor are processed differently in GH4C1 rat pituitary cells.
Topics: Ammonium Chloride; Animals; Cell Compartmentation; Cell Line; Cell Membrane; Chloroquine; Cytosol; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Leupeptins; Lysosomes; Pituitary Neoplasms; Protein Binding; Rats; Receptors, Cell Surface; Receptors, Somatostatin; Somatostatin | 1986 |
Comparative studies on insulin-like growth factor II and insulin processing by vascular endothelial cells.
Topics: Animals; Aorta; Biological Transport; Cattle; Cells, Cultured; Chloroquine; Endothelium; Insulin; Insulin-Like Growth Factor II; Kinetics; Leupeptins; Models, Biological; Monensin; Receptor, Insulin; Receptors, Somatomedin; Somatomedins | 1986 |
Analysis of proteolytic processing during specific antigen presentation.
Topics: Animals; Antigen-Presenting Cells; Antigens; B-Lymphocytes; Cells, Cultured; Chloroquine; Haptens; Leupeptins; Lymphocyte Cooperation; Mice; Peptide Hydrolases; Receptors, Antigen, T-Cell; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Tosylphenylalanyl Chloromethyl Ketone; Trinitrobenzenes | 1987 |
Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor.
Topics: Antibodies, Monoclonal; Binding Sites, Antibody; Cell Line; Chloroquine; Endocytosis; Half-Life; Humans; Iron; Leukemia, Erythroblastic, Acute; Leupeptins; Receptors, Cell Surface; Receptors, Transferrin | 1986 |
Inhibition of EGF processing in responsive and nonresponsive human fibroblasts.
Topics: Animals; Cells, Cultured; Chloroquine; Epidermal Growth Factor; Humans; Iodine Radioisotopes; Kinetics; Leupeptins; Lung; Male; Mice; Protein Processing, Post-Translational; Skin | 1988 |
Processing requirements for T cell activation by Mycoplasma arthritidis-derived mitogen.
Topics: Ammonium Chloride; Antigen-Presenting Cells; Chloroquine; Formaldehyde; Leupeptins; Lymphocyte Activation; Lysosomes; Macrophages; Mitogens; Monensin; Mycoplasma; Polymers; T-Lymphocytes | 1988 |
Role for intracellular proteases in the processing and transport of class II HLA antigens.
Topics: Biological Transport; Chloroquine; HLA-D Antigens; Humans; Leupeptins; Molecular Weight; Monensin; Peptide Hydrolases; Protein Processing, Post-Translational | 1988 |
Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion.
Topics: Animals; Bile; Chloroquine; Leupeptins; Liver; Male; Organoids; Peptides; Rats; Transforming Growth Factors | 1987 |
Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity--formation of crinosomes.
Topics: Animals; Autophagy; Chloroquine; Leupeptins; Lipid Metabolism; Liver; Lysosomes; Microscopy, Electron; Phagocytosis; Proteins; Rats; Vacuoles; Vinblastine | 1987 |
Influence of agents that alter lysosomal function on fetal mouse hearts recovering from anoxia and substrate depletion.
Topics: Animals; Chloroquine; Female; Fetus; Hydrocortisone; Hypoxia; Kinetics; Leupeptins; Lysosomes; Mice; Microscopy, Electron; Myocardium; Oligopeptides; Organ Culture Techniques; Pregnancy; Vacuoles | 1986 |
Degradation of short- and long-lived proteins in perfused liver and in isolated autophagic vacuoles--lysosomes.
Topics: Animals; Autophagy; Chloroquine; Half-Life; Leupeptins; Liver; Lysosomes; Male; Phagocytosis; Proteins; Rats; Rats, Inbred Strains; Vacuoles | 1987 |
Comparison of proteolysis in perfused rat liver and in isolated autophagic vacuoles.
Topics: Animals; Autophagy; Chloroquine; Leupeptins; Liver; Lysosomes; Microscopy, Electron; Organoids; Peptide Hydrolases; Phagocytosis; Rats; Vacuoles | 1985 |
The role of lysosomes in the degradation of myofibrillar and non-myofibrillar proteins in heart.
Topics: Adenine; Animals; Chloroquine; Fetus; Insulin; Kinetics; Leupeptins; Lysosomes; Mice; Myocardium; Myofibrils; Proteins | 1985 |
Regulation of myofibrillar accumulation in chick muscle cultures: evidence for the involvement of calcium and lysosomes in non-uniform turnover of contractile proteins.
Topics: Animals; Calcimycin; Calcium; Cells, Cultured; Chickens; Chloroquine; Contractile Proteins; Leupeptins; Lysosomes; Methylamines; Muscle Proteins; Muscles; Myosins; Tropomyosin; Troponin | 1985 |
Metabolism of [3H]leupeptin by rat liver.
Topics: Animals; Binding, Competitive; Biological Transport, Active; Chloroquine; Leupeptins; Liver; Lysosomes; Male; Oligopeptides; Perfusion; Rats; Rats, Inbred Strains; Temperature | 1985 |
Specific targeting of high density lipoproteins to liver hepatocytes by incorporation of a tris-galactoside-terminated cholesterol derivative.
Topics: Animals; Chloroquine; Cholesterol Esters; Endothelium; Humans; In Vitro Techniques; Kinetics; Kupffer Cells; Leupeptins; Lipoproteins, HDL; Lipoproteins, LDL; Liver; Male; Rats; Rats, Inbred Strains; Receptors, LDL | 1985 |
The fate of the surface protein gp70 during entry of retrovirus into mouse fibroblasts.
Topics: Ammonium Chloride; Animals; Cell Line; Chloroquine; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Glucosamine; Kinetics; Leucine; Leupeptins; Mice; Retroviridae; Retroviridae Proteins; Tritium; Viral Envelope Proteins | 1985 |
Diacytosis of 125I-asialoorosomucoid by rat hepatocytes. A non-lysosomal pathway insensitive to inhibition by inhibitors of ligand degradation.
Topics: Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Cells, Cultured; Chloroquine; Colchicine; Cold Temperature; Endocytosis; Endosomes; Exocytosis; Kinetics; Leupeptins; Liver; Lysosomes; Monensin; Rats; Receptors, Immunologic | 1984 |
Antigen conformation determines processing requirements for T-cell activation.
Topics: Ammonium Chloride; Animals; Antigens; Chloroquine; Clone Cells; Leupeptins; Lymphocyte Activation; Lysosomes; Mice; Monensin; Myoglobin; Peptide Fragments; Protein Conformation; Protein Denaturation; Structure-Activity Relationship; T-Lymphocytes | 1984 |
Mechanism of autodegradation of cell-surface macromolecules shed by human melanoma cells.
Topics: Ammonium Chloride; Biological Transport; Cadaverine; Cell Line; Chloroquine; Coated Pits, Cell-Membrane; Colchicine; Cytochalasin B; Endocytosis; Humans; Leupeptins; Lysosomes; Melanoma; Membrane Proteins; Monensin; Neoplasm Proteins; Time Factors; Tunicamycin | 1984 |
Effects of inhibitors of protein degradation on the rate of protein synthesis in Chinese hamster ovary cells.
Topics: Amino Acids; Animals; Cell Line; Chloroquine; Cricetinae; Cricetulus; Female; Kinetics; Leupeptins; Oligopeptides; Ovary; Protein Biosynthesis; Proteins | 1984 |
Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain.
Topics: Animals; Brain; Chloroquine; Leupeptins; Lysosomes; Microscopy, Electron; Oligopeptides; Rats; Rats, Inbred Strains | 1984 |
The effects of low temperature and chloroquine on 125I-insulin degradation by the perfused rat liver.
Topics: Animals; Biological Transport; Chloroquine; Cold Temperature; Insulin; Kinetics; Leupeptins; Liver; Perfusion; Rats; Subcellular Fractions | 1981 |
The degradation of endogenous and exogenous proteins in cultured smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Cattle; Cell Line; Chloroquine; Chymotrypsin; Embryo, Mammalian; Humans; Kinetics; Leupeptins; Lipoproteins, LDL; Lysosomes; Muscle, Smooth, Vascular; Oligopeptides; Proteins | 1982 |
Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells.
Topics: Amino Acid Sequence; Ammonium Chloride; Animals; Arsenicals; Cell Line, Transformed; Chloroquine; Colchicine; Endocytosis; Epithelium; Hypertonic Solutions; Immune Sera; Immunohistochemistry; Kinetics; Leupeptins; Microscopy, Fluorescence; Molecular Sequence Data; Monensin; Peptides; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Time Factors; Transfection | 1994 |
Acquisition of peptides by MHC class II polypeptides in the absence of the invariant chain.
Topics: Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Differentiation, B-Lymphocyte; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Leupeptins; Molecular Sequence Data; Peptides; Precipitin Tests; Protein Binding; Rats; Sodium Dodecyl Sulfate; Transfection; Tumor Cells, Cultured | 1995 |
Peptide-antibody conjugates for tumour therapy: a MHC-class-II-restricted tetanus toxin peptide coupled to an anti-Ig light chain antibody can induce cytotoxic lysis of a human B-cell lymphoma by specific CD4 T cells.
Topics: Amino Acid Sequence; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; CD4-Positive T-Lymphocytes; Chloroquine; Histocompatibility Antigens Class II; Humans; Immunoglobulin Light Chains; Immunotoxins; Leupeptins; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Peptides; Tetanus Toxin | 1994 |
Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes.
Topics: Acids; Ammonium Chloride; Animals; Chloroquine; Dose-Response Relationship, Drug; Endocytosis; Flagella; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Intracellular Membranes; Leupeptins; Lipoproteins, HDL; Microscopy, Immunoelectron; Models, Biological; Monensin; Organelles; Protein Binding; Trypanosoma brucei brucei | 1994 |
Hepatectomy impairs hepatic processing of somatostatin-14.
Topics: Animals; Biological Transport; Chloroquine; Colchicine; Hepatectomy; Iodine Radioisotopes; Leupeptins; Liver; Liver Regeneration; Male; Rats; Rats, Sprague-Dawley; Somatostatin; Vinblastine | 1993 |
Degradation of rat C-reactive protein by macrophages.
Topics: Animals; Biological Transport; C-Reactive Protein; Cations, Divalent; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Edetic Acid; Immunoglobulin G; Leupeptins; Macrophages, Peritoneal; Peptides; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Uptake of ferritin by isolated rat hepatocytes. Effect of metabolic inhibitors and iron.
Topics: Animals; Antimetabolites; Cell Survival; Chloroquine; Endocytosis; Ferritins; Iodine Radioisotopes; Iron; Leupeptins; Liver; Monensin; Rats; Rats, Wistar; Trypan Blue | 1993 |
Invariant chain retains MHC class II molecules in the endocytic pathway.
Topics: Ammonium Chloride; Animals; Antigens, Differentiation, B-Lymphocyte; Cell Line; Chloroquine; Endocytosis; Histocompatibility Antigens Class II; Leupeptins; Lysosomes; Primaquine | 1993 |
Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes.
Topics: 3T3 Cells; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Cycloheximide; Endoplasmic Reticulum; Golgi Apparatus; Hexosaminidases; Leupeptins; Lysosomes; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Peptide Fragments; Receptors, Erythropoietin | 1993 |
Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate.
Topics: Animals; Antimalarials; Cell Division; Chloroquine; Drug Resistance; Humans; Leupeptins; Orotic Acid; Plasmodium falciparum | 1993 |
Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system.
Topics: Animals; Antigen Presentation; Antigens, Differentiation, B-Lymphocyte; ATP-Binding Cassette Transporters; Cell Compartmentation; Chloroquine; Drug Resistance; Epitopes; Glycoproteins; Histocompatibility Antigens Class II; Hybridomas; Leupeptins; Lymphocyte Activation; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nucleoproteins; T-Lymphocytes; Viral Structural Proteins | 1995 |
Induction of apoptosis in primary culture of rat hepatocytes by protease inhibitors.
Topics: Animals; Apoptosis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cathepsins; Cell Nucleus; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Electrophoresis, Agar Gel; Female; Glycoproteins; Leupeptins; Liver; Lysosomes; Microscopy, Fluorescence; Protease Inhibitors; Rats; Rats, Wistar; Transforming Growth Factor beta | 1996 |
Distinct antigen MHC class II complexes generated by separate processing pathways.
Topics: Cell Line; Chloroquine; Histocompatibility Antigens Class II; Kinetics; Leupeptins; Protein Binding; Protein Folding; Protein Processing, Post-Translational; Sodium Dodecyl Sulfate | 1996 |
Utilization of intracellular ferritin iron for hemoglobin synthesis in developing human erythroid precursors.
Topics: Autoradiography; Cells, Cultured; Chloroquine; Enzyme-Linked Immunosorbent Assay; Erythroblasts; Erythroid Precursor Cells; Ferritins; Flow Cytometry; Heme; Hemoglobins; Humans; Iron; Iron Radioisotopes; Kinetics; Leupeptins; Oligopeptides; Protease Inhibitors | 1997 |
MHC class II-associated invariant chain-induced enlarged endosomal structures: a morphological study.
Topics: Adenine; Antigens, CD; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Endocytosis; Endosomes; Fibroblasts; HLA-DR alpha-Chains; HLA-DR Antigens; Humans; Immunohistochemistry; Leupeptins; Lysosomal Membrane Proteins; Lysosomes; Macromolecular Substances; Membrane Glycoproteins; Receptor, IGF Type 2; Recombinant Proteins; Transfection | 1997 |
Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes.
Topics: Adenosine Triphosphate; Animals; Calcium; Calpain; Cathepsin B; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Deoxyglucose; Dexamethasone; Leucine; Leupeptins; Methylamines; Mifepristone; Multienzyme Complexes; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteins; Rats; Tyrosine; Ubiquitins | 1998 |
Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (A beta) 1-42 peptide in a murine N9 microglial cell line.
Topics: Amyloid beta-Peptides; Animals; Biological Transport; Cell Line; Cells, Cultured; Chloroquine; Kinetics; Leupeptins; Membrane Proteins; Mice; Microglia; Peptide Fragments; Polysaccharides; Rats; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class B | 1998 |
Exposure to lysosomotropic amines and protease inhibitors retard corneal endothelial cell migration along the natural basement membrane during wound repair.
Topics: Amines; Animals; Antipain; Basement Membrane; Cell Movement; Chloroquine; Culture Techniques; Descemet Membrane; Endopeptidases; Endothelium, Corneal; Freezing; Leupeptins; Lysosomes; Metalloendopeptidases; Methylamines; Propylamines; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Trypsin Inhibitor, Kunitz Soybean; Wound Healing | 1999 |
Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum.
Topics: Amiloride; Animals; Antimalarials; Bicarbonates; Biological Transport; Chloroquine; Erythrocyte Membrane; Erythrocytes; Hemin; Hemoglobins; Humans; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Plasmodium falciparum; Sodium-Hydrogen Exchangers; Verapamil | 1999 |
The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.
Topics: Anemia, Megaloblastic; Animals; Antibodies; Apolipoprotein A-I; Case-Control Studies; Chloroquine; Chromatography, Affinity; Dog Diseases; Dogs; Endocytosis; Epithelial Cells; Female; Humans; Iodine Radioisotopes; Kidney; Leupeptins; Lipoproteins, HDL; Malabsorption Syndromes; Male; Rats; Rats, Wistar; Receptors, Cell Surface; Reference Values; Syndrome; Vitamin B 12 Deficiency; Yolk Sac | 1999 |
Fibroblast growth factors are translocated to the nucleus of human endothelial cells in a microtubule- and lysosome-independent pathway.
Topics: Biological Transport, Active; Cell Nucleus; Cells, Cultured; Chloroquine; Colchicine; Cytosol; Endothelium, Vascular; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Fibroblast Growth Factors; Humans; Kinetics; Leupeptins; Lysosomes; Microtubules; Subcellular Fractions | 2000 |
[Modulation of T-cell-mediated immune responses by trichosanthin via antigen processing and presentation].
Topics: Antigen Presentation; Antigen-Presenting Cells; Cell Division; Chloroquine; Humans; Leupeptins; T-Lymphocytes; Trichosanthin | 1997 |
Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+).
Topics: Acridine Orange; Adenine; Animals; Aurothioglucose; Cadmium; Cell Death; Chloroquine; Copper; Endopeptidases; Enzyme Activation; Gentamicins; Leupeptins; Lipid Peroxidation; Liver; Lysosomes; Male; Methylamines; Monensin; Oxidation-Reduction; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2001 |
Leupeptin-induced appearance of partial fragment of betaine homocysteine methyltransferase during autophagic maturation in rat hepatocytes.
Topics: Animals; Autophagy; Betaine-Homocysteine S-Methyltransferase; Chloroquine; Cytosol; Hepatocytes; In Vitro Techniques; Leupeptins; Lysosomes; Male; Methyltransferases; Molecular Probes; Peptide Fragments; Proton-Translocating ATPases; Rats; Rats, Wistar; Vacuolar Proton-Translocating ATPases | 2001 |
MHC class II presentation of endogenous tumor antigen by cellular vaccines depends on the endocytic pathway but not H2-M.
Topics: Acetylcysteine; Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Neoplasm; Antimalarials; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Coculture Techniques; Cysteine Proteinase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Endocytosis; Endoplasmic Reticulum; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Genes, MHC Class II; Humans; Hybridomas; Leupeptins; Major Histocompatibility Complex; Mice; Muramidase; Plasmids; Primaquine; Protein Synthesis Inhibitors; Protein Transport; Ribonucleases; Transfection; Tumor Cells, Cultured | 2000 |
Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments.
Topics: Acetylcysteine; Antimalarials; Cell Line; Chloroquine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endocytosis; Humans; Immunoblotting; Leupeptins; Microscopy, Fluorescence; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Sorting Signals; Protein Subunits; Receptors, Interleukin-2; Recombinant Fusion Proteins; Transfection; Ubiquitins | 2001 |
Release of iron from ferritin requires lysosomal activity.
Topics: Animals; Caco-2 Cells; Chloroquine; Deferoxamine; Enterocytes; Erythroid Cells; Ferritins; Hepatocytes; Humans; Immunoelectrophoresis; Iron; K562 Cells; Leupeptins; Lysosomes; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Rats | 2006 |
Peptide degradation is a critical determinant for cell-penetrating peptide uptake.
Topics: Androstadienes; Animals; Carrier Proteins; Cell Membrane; Cell-Penetrating Peptides; Chloroquine; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Cytochalasin B; Deoxyglucose; Endocytosis; Leupeptins; Membrane Glycoproteins; Models, Biological; Nocodazole; Oligopeptides; Peptide Fragments; Peptides; Perforin; Phenanthrolines; Phenylmethylsulfonyl Fluoride; Pore Forming Cytotoxic Proteins; Protease Inhibitors; Protein Transport; Sodium Azide; Wortmannin | 2007 |
Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.
Topics: Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Fluorescent Antibody Technique; Humans; Intracellular Fluid; Leupeptins; Lysosomes; Mice; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Time Factors | 2008 |
Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition.
Topics: Biological Transport, Active; Cell Line, Tumor; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lysosomal-Associated Membrane Protein 2; Lysosomes; Neurons; Vitamin B 12 | 2014 |