chloroquine has been researched along with leucine in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (56.14) | 18.7374 |
| 1990's | 14 (24.56) | 18.2507 |
| 2000's | 5 (8.77) | 29.6817 |
| 2010's | 5 (8.77) | 24.3611 |
| 2020's | 1 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Richards, WH; Williams, SG | 3 |
| Avitabile, M; Cambria, A; Giuffrida, AM; Jarlstedt, J; Karlsson, JO; Serra, I; Sjöstrand, J; Vanella, A | 1 |
| Knops, J; Lieberburg, I; Sinha, S | 1 |
| Ghosh, PC; Madan, S | 1 |
| Mizutani, Y; Nio, Y; Yoshida, O | 1 |
| Knutson, VP | 1 |
| Lockwood, TD; Thorne, DP | 1 |
| Bogitsh, BJ; Davenport, GR | 1 |
| Decker, RS; Ferguson, AG; Lesch, M; Samarel, AM | 1 |
| Araki, S; Fukuhara, N; Ikebe, N; Kumamoto, T; Watanabe, S | 1 |
| Jirsa, M; Kordac, V; Kotal, P; Kotyk, A | 1 |
| Bottger, BA; Sjölund, M; Thyberg, J | 1 |
| Lockwood, TD | 1 |
| Sano, M | 1 |
| Gorski, KM; Spiro, MJ | 1 |
| Antoni, F; Csuka, I; Hrabák, A | 1 |
| Decker, ML; Decker, RS; Fuseler, JW; Thomas, V | 1 |
| Goral, J; Molnar, J; Polet, H | 1 |
| Andersen, KB | 1 |
| Devaskar, SU; Karycki, L | 1 |
| Meier, S; Solursh, M | 1 |
| Wilson, DE | 1 |
| Michael, RO; Williams, GM | 1 |
| Hadwiger, LA | 1 |
| Sinoara, H | 1 |
| Delpino, A; Ferrini, U | 1 |
| Sinohara, H | 1 |
| Gonasun, LM; Potts, AM | 1 |
| Bridgers, WF; Cunningham, RD; Gressett, G | 1 |
| Trist, DG; Weatherall, M | 1 |
| Bailey, A; Goldfine, ID; Iwamoto, Y; Roach, E; Williams, JA | 1 |
| Casey, ML; Johnston, JM; MacDonald, PC | 1 |
| Decker, RS; Fuseler, JF | 1 |
| Ransom, JT; Reeves, JP | 1 |
| Mayer, RJ; Razooki Hasan, H; White, DA | 1 |
| Vladutiu, GD | 1 |
| Bradley, C; Henriquez, DA; Pance, A; Perez, N | 1 |
| Bolli, GB; Brunetti, P; Cruciani, G; De Feo, P; Lucidi, P; Santeusanio, F; Volpi, E | 1 |
| Codogno, P; Houri, JJ; Ogier-Denis, E; Trugnan, G | 1 |
| Moriyasu, Y | 1 |
| Fernandez, C; Sainz, RD | 1 |
| Beyer, EC; Green, K; Laing, JG; Saffitz, JE; Tadros, PN | 1 |
| Hasselgren, PO; Luo, GJ; Wang, JJ; Wang, L | 1 |
| Bray, PG; Mungthin, M; Ridley, RG; Ward, SA | 1 |
| Bradbury, NA; Devor, DC; Hamilton, KL; Jones, HM; Papworth, GD; Syme, CA; Watkins, SC | 1 |
| Che, FY; Fricker, LD; Kalinina, E; Yuan, Q | 1 |
| Hyman, BT; Koh, YH; Tanzi, RE; Tesco, G; von Arnim, CA | 1 |
| Bates, EE; Benguigui, B; Caux, C; de Bouteiller, O; Hasan, UA; Hubac, S; Merck, E; Trinchieri, G | 1 |
| Kim, D; Sabatini, DM; Sheen, JH; Zoncu, R | 1 |
| Allanki, AD; Navale, R; Sijwali, PS | 1 |
| Cheng, J; Duan, S; Jiang, K; Li, C; Wang, Y; Wu, Y; Xu, J; Yu, L; Zhang, X | 1 |
| Chen, F; Jia, J; Li, J; Song, Y; Yin, P; Zhang, Y | 1 |
| de Barros, ALB; de Jesus, MB; de Oliveira Silva, J; Dos Reis, SB; Garcia-Fossa, F; Leite, EA; Malachias, A; Mosqueira, VCF; Oliveira, MC; Pound-Lana, G | 1 |
1 trial(s) available for chloroquine and leucine
| Article | Year |
|---|---|
Chloroquine reduces whole body proteolysis in humans.
Topics: Adult; Blood Glucose; C-Peptide; Chloroquine; Female; Humans; Insulin; Kinetics; Leucine; Male; Oxidation-Reduction; Peptide Hydrolases | 1994 |
56 other study(ies) available for chloroquine and leucine
| Article | Year |
|---|---|
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Malaria in studies in vitro. III: the protein synthesising activity of Plasmodium falciparum in vitro after drug treatment in vivo.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Female; Haplorhini; Leucine; Malaria; Male; Phenylurea Compounds; Plasmodium falciparum; Protein Biosynthesis; Radioisotopes; Tritium | 1975 |
In vitro action of chloroquine on nucleic acid and protein biosynthesis in the rabbit retina.
Topics: Animals; Chloroquine; DNA; Eye Proteins; In Vitro Techniques; Leucine; Rabbits; Retina; RNA; Thymidine; Time Factors; Uridine | 1976 |
Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate.
Topics: Amyloid beta-Protein Precursor; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leucine; Leupeptins; Molecular Weight; Peptide Fragments; Transfection | 1992 |
Interaction of gelonin with macrophages: effect of lysosomotropic amines.
Topics: Ammonium Chloride; Animals; Cell Line; Chloroquine; Cytotoxins; Kinetics; Leucine; Macrophages; Mannans; Mice; Phagocytosis; Pinocytosis; Plant Proteins; Ribosome Inactivating Proteins, Type 1 | 1992 |
Modulation by cis-diamminedichloroplatinum (II) of the susceptibilities of human T24 lined and freshly separated autologous urinary bladder transitional carcinoma cells to peripheral blood lymphocytes and lymphokine activated killer cells.
Topics: Aged; Aged, 80 and over; Carcinoma, Transitional Cell; Cell Line; Chloroquine; Cisplatin; Cytotoxicity, Immunologic; Female; Humans; Killer Cells, Lymphokine-Activated; Leucine; Lymphocytes; Male; Middle Aged; Mitomycin; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1992 |
Proteolytic processing of the insulin receptor beta subunit is associated with insulin-induced receptor down-regulation.
Topics: Animals; Blotting, Western; Cells, Cultured; Chloroquine; Cycloheximide; Cysteine Endopeptidases; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Insulin; Insulin Antagonists; Leucine; Leupeptins; Mice; Peptide Fragments; Receptor, Insulin | 1991 |
Effect of Zn2+ on the proteolytic inhibitory action of insulin and biguanide antihyperglycemic drugs.
Topics: Animals; Chloroquine; Chromium; Cobalt; Edetic Acid; Heart; In Vitro Techniques; Insulin; Iron; Kinetics; Leucine; Manganese; Myocardium; Phenformin; Protease Inhibitors; Protein Biosynthesis; Proteins; Rats; Zinc | 1991 |
The in vitro effects of various lysosomotropic agents on the gut of Schistosoma mansoni schistosomula.
Topics: Acridine Orange; Alanine; Amino Acids; Ammonium Chloride; Animals; Chloroquine; Dipeptides; Esters; Hydrogen-Ion Concentration; Leucine; Microscopy, Electron; Microscopy, Fluorescence; Schistosoma mansoni; Tryptophan | 1991 |
Effects of cysteine protease inhibitors on rabbit cathepsin D maturation.
Topics: Animals; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Proteinase Inhibitors; Fibroblasts; Kinetics; Leucine; Leupeptins; Methionine; Myocardium; Protein Processing, Post-Translational; Rabbits; Sulfur Radioisotopes | 1989 |
Experimental chloroquine myopathy: morphological and biochemical studies.
Topics: Animals; Chloroquine; Leucine; Male; Microscopy, Electron; Muscular Diseases; Rats; Rats, Inbred Strains | 1989 |
Effect of chloroquine on membrane permeability in yeast--release of cellular coproporphyrin.
Topics: Aminoisobutyric Acids; Cell Membrane Permeability; Chloroquine; Coproporphyrins; Kinetics; Leucine; Porphyrins; Saccharomyces cerevisiae; Sorbitol | 1988 |
Chloroquine and monensin inhibit induction of DNA synthesis in rat arterial smooth muscle cells stimulated with platelet-derived growth factor.
Topics: Animals; Cells, Cultured; Chloroquine; DNA; Hydrogen-Ion Concentration; Leucine; Male; Monensin; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Rats; Rats, Inbred Strains; Time Factors; Tritium; Uridine | 1988 |
Distinction between major chloroquine-inhibitable and adrenergic-responsive pathways of protein degradation and their relation to tissue ATP content in the Langendorff isolated perfused rat heart.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Azides; Chloroquine; Dinitrophenols; Heart; Isoproterenol; Leucine; Lysosomes; Myocardium; Perfusion; Proteins; Rats; Sodium Azide | 1988 |
[Biochemical studies in experimental chloroquine myopathy--preventive effect of E-64-d and physicochemical properties of liver autolysosomes].
Topics: Animals; Cathepsins; Chloroquine; Leucine; Liver; Lysosomes; Male; Muscular Diseases; Rats; Rats, Inbred Strains | 1986 |
Studies on the posttranslational migration and processing of thyroglobulin: use of inhibitors and evaluation of the role of phosphorylation.
Topics: Animals; Cattle; Centrifugation, Density Gradient; Chloroquine; Chromatography, Gel; Leucine; Macromolecular Substances; Molecular Weight; Phosphates; Phosphorylation; Protein Processing, Post-Translational; Thyroglobulin; Thyroid Gland | 1986 |
Effect of emetine and chloroquine on phagocytic processes of rat macrophages.
Topics: Animals; Carbon Radioisotopes; Cell Adhesion; Chloroquine; Cytoskeleton; Emetine; Glycolysis; Leucine; Macrophages; Phagocytosis; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1986 |
Responses of cultured cardiac myocytes to lysosomotropic compounds and methylated amino acids.
Topics: Ammonium Chloride; Animals; Cell Membrane Permeability; Cells, Cultured; Chloroquine; Leucine; Lysosomes; Methionine; Methylamines; Microscopy, Electron; Myocardium; Rats; Rats, Inbred Strains | 1985 |
The effects of amino acids on protein degradation and translocation of non-histone proteins to the nucleus in lymphocytes.
Topics: Amino Acids; Biological Transport; Cell Nucleus; Cells, Cultured; Chloroquine; Chromosomal Proteins, Non-Histone; Dactinomycin; Humans; Kinetics; Leucine; Lymphocytes; Phenylalanine; Protein Biosynthesis; Proteins; Tritium; Tryptophan | 1986 |
The fate of the surface protein gp70 during entry of retrovirus into mouse fibroblasts.
Topics: Ammonium Chloride; Animals; Cell Line; Chloroquine; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Glucosamine; Kinetics; Leucine; Leupeptins; Mice; Retroviridae; Retroviridae Proteins; Tritium; Viral Envelope Proteins | 1985 |
Internalization of the neonatal brain insulin receptor.
Topics: Amino Acids; Animals; Animals, Newborn; Arsenicals; Brain Chemistry; Chloroquine; Deoxyglucose; In Vitro Techniques; Leucine; Rabbits; Receptor, Insulin | 1985 |
Malaria studies in vitro. II. The measurement of drug activities using leucocyte-free blood-dilution cultures of Plasmodium berghei and 3H-leucine.
Topics: Adenosine Triphosphate; Animals; Antimalarials; Blood; Cells, Cultured; Chloroquine; Cricetinae; Erythrocytes; Haplorhini; Leucine; Leukocyte Count; Leukocytes; Metabolism; Mice; Plasmodium; Plasmodium berghei; Pyrimethamine; Rats; Reticulocytes | 1973 |
The selective inhibition of mucopolysaccharide synthesis by vitamin A treatment of cultured chick embryo chondrocytes.
Topics: Aminocaproates; Animals; Cartilage; Chick Embryo; Chloroquine; Collagen; Culture Techniques; Fibroblasts; Glycosaminoglycans; Leucine; Lysosomes; Time Factors; Vitamin A | 1973 |
Chloroquine: protection against virus-induced cell damage without inhibition of virus growth.
Topics: Acid Phosphatase; Animals; Carbon Isotopes; Chick Embryo; Chloroquine; Culture Media; Fibroblasts; Leucine; Lysosomes; Newcastle disease virus; Orthomyxoviridae Infections; Protein Biosynthesis; Proteins; RNA; Time Factors; Tritium; Uridine; Virus Replication | 1972 |
Chloroquine inhibition of repair of DNA damage induced in mammalian cells by methyl methanesulfonate.
Topics: Animals; Carbon Radioisotopes; Cell Survival; Cells, Cultured; Centrifugation, Zonal; Chloroquine; DNA Repair; DNA, Single-Stranded; Dose-Response Relationship, Drug; Drug Interactions; Leucine; Liver; Male; Mesylates; Protein Biosynthesis; Rats; Time Factors | 1974 |
Increased levels of pisatin and phenylalanine ammonia lyase activity in Pisum sativum treated with antihistaminic, antiviral, antimalarial, tranquilizing, or other drugs.
Topics: Antidepressive Agents; Antitussive Agents; Antiviral Agents; Chloroquine; Deamination; Ethylamines; Fluorenes; Histamine H1 Antagonists; Imipramine; Ketones; Lectins; Leucine; Lyases; Parasympatholytics; Phenothiazines; Phenylalanine; Piperidines; Plant Lectins; Plant Proteins; Plants, Edible; Propantheline; Quinacrine; Stimulation, Chemical; Tranquilizing Agents; Trimeprazine | 1972 |
Amino acid transport in spores of Aspergillus oryzae.
Topics: Acridines; Amino Acids; Arginine; Aspergillus; Biological Transport; Carbon Radioisotopes; Cell Membrane; Chloroquine; Chlorpromazine; Cycloheximide; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Leucine; Mannitol; Naphthalenesulfonates; Osmolar Concentration; Phosphates; Potassium Chloride; Pronase; Salicylates; Sodium Dodecyl Sulfate; Spores, Fungal; Time Factors | 1974 |
Protein synthesis stimulation in rat liver by chloroquine.
Topics: Adrenalectomy; Animals; Carbon Isotopes; Cell Fractionation; Chloroquine; Cytoplasm; Leucine; Liver; Male; Orotic Acid; Phenylalanine; Polyribosomes; Protein Biosynthesis; Rats; RNA, Messenger; Transcription, Genetic; Tritium | 1972 |
Induction of enzymes in dormant spores of Aspergillus oryzae. IV. Effects of ethidium, aminoacridines, and related compounds.
Topics: Acridines; Alcohol Oxidoreductases; Amines; Aspergillus; Carbon Isotopes; Chloroquine; Enzyme Induction; Ethidium; Fungal Proteins; Glucose; Hydroquinones; Kinetics; Leucine; Oxygen Consumption; Phenanthridines; Phenothiazines; Quinacrine; Spores; Spores, Fungal; Sucrase | 1973 |
In vitro inhibition of protein synthesis in the retinal pigment epithelium by chloroquine.
Topics: Animals; Carbon Radioisotopes; Cattle; Chloroquine; Cycloheximide; Epithelium; Eye Proteins; Hydroxychloroquine; In Vitro Techniques; Leucine; Lysine; Phenylalanine; Puromycin; Quinine; Retina; Tissue Extracts | 1974 |
Action of some antimalaria compounds against Plasmodium berghei in vitro.
Topics: Animals; Antimalarials; Chloroquine; Haplorhini; Leucine; Plasmodium; Primaquine; Proguanil; Pyrimethamine; Quinine; Triazines; Tritium | 1971 |
Properties distinguishing mitochondrial and synaptosomal protein synthesis.
Topics: Animals; Brain; Carbon Isotopes; Centrifugation, Density Gradient; Chloramphenicol; Chloroquine; Cycloheximide; Depression, Chemical; Drug Antagonism; Emetine; Leucine; Mice; Mitochondria; Nerve Endings; Nerve Tissue Proteins; Synaptic Vesicles; Synaptosomes | 1971 |
Inhibition of lymphocyte transformation by mepacrine and chloroquine.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Chloroquine; Humans; In Vitro Techniques; Leucine; Lymphocyte Activation; Phytohemagglutinins; Quinacrine; Thymidine; Uridine | 1981 |
The effect of chloroquine on the binding, intracellular distribution, and action of insulin on isolated mouse pancreatic acini.
Topics: Animals; Chloroquine; Deoxyglucose; Insulin; Leucine; Male; Mice; Microscopy, Electron; Pancreas; Subcellular Fractions | 1983 |
15-Hydroxyprostaglandin dehydrogenase activity in human fetal kidney tissue.
Topics: Ammonium Chloride; Chemical Fractionation; Chloroquine; Cytosol; Fetus; Humans; Hydroxyprostaglandin Dehydrogenases; Kidney; Kidney Medulla; Leucine; Organ Culture Techniques; Time Factors | 1984 |
Methylated amino acids and lysosomal function in cultured heart cells.
Topics: Ammonium Chloride; Animals; Cathepsin B; Cathepsins; Cells, Cultured; Chloroquine; Heart; Leucine; Lysosomes; Methionine; Myocardium; Proteins; Rats | 1984 |
Accumulation of amino acids within intracellular lysosomes of rat polymorphonuclear leukocytes incubated with amino acid methyl esters. Evidence for the internal acidification of azurophilic granules.
Topics: Amino Acids; Animals; Chloroquine; Cytoplasmic Granules; Leucine; Lysosomes; Methionine; Neutrophils; Rats; Temperature | 1983 |
Extensive destruction of newly synthesized casein in mammary explants in organ culture.
Topics: Animals; Caseins; Chloroquine; Cycloheximide; Fatty Acid Synthases; Female; Hexosamines; Leucine; Mammary Glands, Animal; Organ Culture Techniques; Pregnancy; Proline; Rabbits | 1982 |
The effect of chloroquine on the distribution of newly synthesized and old beta-hexosaminidase in fibroblasts.
Topics: Acetylglucosaminidase; Cells, Cultured; Chloroquine; Cycloheximide; Endocytosis; Fibroblasts; Hexosaminidases; Humans; Leucine; Mannosephosphates | 1982 |
Mechanisms of protein degradation in Trypanosoma cruzi.
Topics: Animals; Chloroquine; Cysteine Endopeptidases; Hydrogen-Ion Concentration; Intracellular Membranes; Leucine; Molecular Weight; Peptide Hydrolases; Protease Inhibitors; Protozoan Proteins; Puromycin; Time Factors; Trypanosoma cruzi; Ubiquitins | 1993 |
Autophagic degradation of N-linked glycoproteins is downregulated in differentiated human colon adenocarcinoma cells.
Topics: Adenine; Adenocarcinoma; Asparagine; Autophagy; Carbon Radioisotopes; Carcinogens; Cell Differentiation; Cell Line; Chloroquine; Colonic Neoplasms; Ethers, Cyclic; Glycoproteins; Humans; Kinetics; Leucine; Lysosomes; Mannose; Okadaic Acid; Polysaccharides; Tritium; Tumor Cells, Cultured | 1993 |
Examination of the contribution of vacuolar proteases to intracellular protein degradation in Chara corallina.
Topics: Animals; Cattle; Chlorophyta; Chloroquine; Endopeptidases; Hydrogen-Ion Concentration; Kinetics; Leucine; Mathematics; Models, Theoretical; Plant Proteins; Protease Inhibitors; Serum Albumin, Bovine; Vacuoles | 1995 |
Pathways of protein degradation in L6 myotubes.
Topics: Animals; Cathepsins; Cell Line; Chloroquine; Clenbuterol; Dexamethasone; Endopeptidases; Glucocorticoids; Insulin; Insulin-Like Growth Factor I; Leucine; Lysosomes; Muscle Fibers, Skeletal; Muscle Proteins; Muscles; Myofibrils; Protease Inhibitors; Rats | 1997 |
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Connexin 43; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Hot Temperature; HSP70 Heat-Shock Proteins; Immunoblotting; Leucine; Leupeptins; Lysosomes; Microscopy, Electron; Myocardium; Oligopeptides; Precipitin Tests; Protease Inhibitors; Rats | 1998 |
Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes.
Topics: Adenosine Triphosphate; Animals; Calcium; Calpain; Cathepsin B; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Deoxyglucose; Dexamethasone; Leucine; Leupeptins; Methylamines; Mifepristone; Multienzyme Complexes; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteins; Rats; Tyrosine; Ubiquitins | 1998 |
Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols.
Topics: Amodiaquine; Antimalarials; Chloroquine; Hemoglobins; Humans; Leucine; Mefloquine; Phenanthrenes; Primaquine; Protease Inhibitors | 1998 |
Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1.
Topics: Acetylcysteine; Amino Acid Motifs; Amino Acid Sequence; Cell Line; Cell Membrane; Chloroquine; Dimerization; DNA, Complementary; Electrophysiology; Endocytosis; Epitopes; Humans; Immunoblotting; Intermediate-Conductance Calcium-Activated Potassium Channels; Leucine; Leucine Zippers; Lysosomes; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Calcium-Activated; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Transport; Temperature; Time Factors | 2004 |
Examination of the rate of peptide biosynthesis in neuroendocrine cell lines using a stable isotopic label and mass spectrometry.
Topics: Amino Acid Sequence; Animals; beta-Lipotropin; Cell Line; Chloroquine; Colforsin; Culture Media, Conditioned; Deuterium; Hydrogen-Ion Concentration; Insulin; Islets of Langerhans; Leucine; Mass Spectrometry; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Neuropeptides; Neurosecretory Systems; Pituitary Gland; Potassium Chloride; Rats; Stimulation, Chemical | 2004 |
BACE is degraded via the lysosomal pathway.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amyloid Precursor Protein Secretases; Animals; Antigens, CD; Aspartic Acid Endopeptidases; Blotting, Western; Cell Line, Tumor; Chloroquine; CHO Cells; Cricetinae; DNA, Complementary; Endopeptidases; Endosomes; Humans; Immunohistochemistry; Leucine; Lysosomal Membrane Proteins; Lysosomal-Associated Membrane Protein 2; Lysosomes; Molecular Sequence Data; Mutation; Neurons; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Transfection | 2005 |
Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.
Topics: Amino Acid Sequence; Antigens, CD; Antirheumatic Agents; Base Sequence; Binding Sites; Blotting, Western; Calcium; Cell Line; Cell Membrane; Cell Separation; Chloroquine; Cross-Linking Reagents; Cysteine; Cytokines; Dendritic Cells; Dimerization; DNA; Dose-Response Relationship, Drug; Endosomes; Enzyme Inhibitors; Flow Cytometry; Genes, Dominant; Genes, Reporter; Glycosylation; Humans; Hydrogen-Ion Concentration; Leucine; Leukocytes, Mononuclear; Ligands; Luciferases; Lysosomes; Macrolides; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; NF-kappa B; Phagosomes; Protein Binding; Protein Structure, Tertiary; Receptors, IgG; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Time Factors; Toll-Like Receptor 3; Transfection; Tyrosine; U937 Cells | 2005 |
Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Autophagy; Caspase 3; Cell Line, Tumor; Chloroquine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Melanocytes; Melanoma; Mice; Mice, Nude; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Multiprotein Complexes; Proteins; ras Proteins; RNA Interference; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum.
Topics: Adenine; Amino Acid Sequence; Antimalarials; Apicoplasts; Autophagy; Autophagy-Related Protein 8 Family; Chloroquine; Doxycycline; Erythrocytes; Gene Expression Regulation; Genome, Protozoan; Humans; Leucine; Life Cycle Stages; Microfilament Proteins; Molecular Sequence Data; Pepstatins; Plasmodium falciparum; Protease Inhibitors; Protozoan Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2014 |
Autophagy inhibitors reduce avian-reovirus-mediated apoptosis in cultured cells and in chicken embryos.
Topics: Animals; Apoptosis; Autophagy; Chick Embryo; Chickens; Chloroquine; Leucine; Orthoreovirus, Avian; Pepstatins; Poultry Diseases; Reoviridae Infections | 2015 |
ABT-737, a Bcl-2 Selective Inhibitor, and Chloroquine Synergistically Kill Renal Cancer Cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Biphenyl Compounds; Carcinoma, Renal Cell; Cell Death; Cell Line, Tumor; Chloroquine; Drug Synergism; Humans; Kidney Neoplasms; Leucine; Nitrophenols; Oligopeptides; Piperazines; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thiadiazoles | 2016 |
Mechanistic insights into the intracellular release of doxorubicin from pH-sensitive liposomes.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Caspase 3; Cell Survival; Chloroquine; Doxorubicin; Drug Compounding; Drug Delivery Systems; HeLa Cells; Humans; Hydrogen-Ion Concentration; Intracellular Space; Leucine; Liposomes; Mice | 2021 |