chloroquine and heme

chloroquine has been researched along with heme in 110 studies

Research

Studies (110)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (24.55)	18.7374
1990's	28 (25.45)	18.2507
2000's	25 (22.73)	29.6817
2010's	21 (19.09)	24.3611
2020's	9 (8.18)	2.80

Authors

Authors	Studies
Berger, E; Eaton, JW; Eckman, JR; Engel, RR; Modler, S	1
Wellems, TE	2
Cerami, A; Slater, AF	1
Dutta, GP; Pandey, VC; Sahni, SK; Saxena, N; Tekwani, BL	1
Padmanaban, G; Surolia, N	1
Cervinka, J; Jirsa, M; Kaláb, M; Kordac, V; Kotal, P; Martásek, P	1
Fitch, CD	3
Fitch, CD; Kanjananggulpan, P	1
Hempelmann, E; Zhang, Y	1
Fitch, CD; Kanjananggulpan, P; Orjih, AU	1
Sweeney, GD	1
Nakano, M; Sugioka, K; Sugioka, Y; Suzuki, M	1
Chevli, R; Fitch, CD; Orjih, AU	1
Fitch, CD; Janney, SK; Joist, JJ	1
Chachaty, C; Deleuze, C; Moreau, S; Perly, B	1
Cohen, SN; Phifer, KO; Yielding, KL	1
Demel, RA; Ginsburg, H	2
Balasubramanian, D; Mohan Rao, C; Panijpan, B	1
Chevli, R; Dutta, P; Fitch, CD; Kanjananggulpan, P	1
Eaton, JW; Rock, LM; Wood, PA	1
Forsbeck, K; Nilsson, K	1
Dutta, P; Fitch, CD	1
Banyal, HS; Fitch, CD	1
Chevli, R; Chou, AC; Fitch, CD	1
Govitrapong, P; Jearnpipatkul, A; Panijpan, B; Wilairat, P; Yuthavong, Y	1
Banyal, HS; Chevli, R; Fitch, CD; Orjih, AU	1
Banyal, HS; Chevli, R; Fitch, CD; Krogstad, DJ; Pfaller, MA; Phillips, G	1
Chou, AC; Fitch, CD	1
Hodgson, LL; Morgan, EH; Quail, EA	1
Pandey, VC; Puri, SK; Srivastava, P	1
Eaton, JW; Wood, PA	1
Dutta, GP; Pandey, VC; Puri, SK; Srivastava, P	1
Bhaduri, AP; Pandey, VC; Srivastava, R	1
Adams, PA; Berman, PA; Egan, TJ; Marsh, PJ; Silver, J	1
Ridley, RG	1
Pandey, VC; Srivastava, P	1
Gluzman, IY; Goldberg, DE; Russell, DG; Sullivan, DJ	1
Pandey, AV; Tekwani, BL	1
Gluzman, IY; Goldberg, DE; Oksman, A; Piwnica-Worms, D; Sharma, V; Wellems, TE	1
Csato, M; Dorn, A; Girometta, MA; Gocke, E; Guenzi, A; Hofheinz, W; Jaquet, C; Leupin, W; Masciadri, R; Matile, H; Peters, W; Potthast, JM; Richter, WF; Ridley, RG; Theil, FP; Thomas, A; Urwyler, H	1
Bächinger, HP; Hinrichs, DJ; Ignatushchenko, MV; Riscoe, MK; Winter, RW	1
Fibach, E; Konijn, AM; Vaisman, B	1
Berger, BJ; Cerami, A; Dai, WW; Paciorkowski, A	1
Chauhan, VS; Joshi, R; Pandey, AV; Singh, RL; Tekwani, BL	1
Bray, PG; Hawley, SR; O'Neill, PM; Park, BK; Ward, SA	1
Atkinson, JD; Bray, PG; Hawley, SR; Mungthin, M; O'Neill, PM; Ward, SA	1
Aldieri, E; Bosia, A; Costamagna, C; Garbarino, G; Ghigo, D; Pescarmona, G; Todde, R	1
Goldberg, DE; Matile, H; Ridley, RG; Sullivan, DJ	1
Famin, O; Ginsburg, H; Krugliak, M; Zhang, J	1
Foley, M; Loria, P; Miller, S; Tilley, L	1
Kamboj, KK; Pandey, VC; Puri, SK; Srivastava, P	1
Padmanaban, G; Rangarajan, PN	1
Surolia, I	1
Dorn, A; Ridley, RG; Vennerstrom, JL; Vippagunta, SR	1
Braga, CM; Dansa-Petretski, M; de Souza, W; Masuda, H; Oliveira, MF; Oliveira, PL; Silva, JR	1
Batra, S; Bhaduri, AP; Pandey, VC; Roy, K; Srivastava, P	1
Chen, MM; Shi, L; Sullivan, DJ	1
Babbarwal, VK; Bisht, H; Chauhan, VS; Pandey, AV; Pandey, KC; Srivastava, J	1
Monti, D; Olliaro, P; Omodeo-Salè, F; Taramelli, D	1
Chauhan, VS; Kannan, R; Sahal, D	1
Badminton, MN; Elder, GH	1
Sullivan, DJ	1
Herrero, C; Lecha, M; Ozalla, D	1
Berrien, JF; Cicéron, L; Coquillay, M; Danis, M; Gay, F; Mayrargue, J; Meunier, B; Provot, O; Robert, A	1
CANTRELL, WF; SCHUELER, FW	1
Biot, C; Davioud-Charvet, E; Dessolin, J; Grellier, P	1
d'Avila, JC; Ferreira, ST; Ferreira-Pereira, A; Oliveira, MF; Oliveira, PL; Rumjanek, FD; Soares, JB; Tempone, AJ	1
Basilico, N; Mondani, M; Monti, D; Olliaro, P; Parapini, S; Taramelli, D	1
Deharo, E; Garavito, G; Maurel, S; Monje, MC; Nepveu, F; Valentin, A	1
Benoit-Vical, F; Lelièvre, J; Loup, C; Meunier, B	1
Davenport, L; Kopkalli, Y; Martínez, A; Naoulou, B; Rajapakse, CS; Sánchez-Delgado, RA	1
Andersen, J; Angel, R; Beatty, W; Jani, D; Kumar, S; Nagarkatti, R; Rathore, D; Slebodnick, C	1
Alumasa, JN; An, D; Casabianca, LB; de Dios, AC; Natarajan, JK; Roepe, PD; Wolf, C	1
Becker, K; Fritz-Wolf, K; Hu, Y; Rahlfs, S; Sturm, N; Wittlin, S; Zimmermann, H	1
Dautriche, C; Jalloh, D; Martínez, A; Rajapakse, CS; Sánchez-Delgado, RA	1
McNaughton, D; Webster, GT; Wood, BR	1
Brun, R; Burgess, SJ; Kelly, JX; Liebmann, K; Peyton, DH; Shomloo, S; Wittlin, S	1
Kittikool, D; Sibmooh, N; Srihirun, S; Tangnitipong, S; Thaptimthong, T; Udomsangpetch, R; Unchern, S	1
de Kock, C; Ehnbom, A; Estrada, J; Glans, L; Haukka, M; Martínez, A; Nordlander, E; Sánchez-Delgado, RA; Smith, PJ	1
Cresteil, T; Forterre, P; Gadelle, D; Guetzoyan, L; Mahy, JP; Pethe, S; Pradines, B; Quintino, E; Ramiandrasoa, F; Yu, XM	1
Ambele, MA; Combrinck, JM; Egan, TJ; Hoppe, HC; Mabotha, TE; Ncokazi, KK; Smith, PJ; Taylor, D	1
Alumasa, JN; Brower, JP; de Dios, AC; Gorka, AP; Jacobs, LM; Nickley, KB; Roepe, PD; Sherlach, KS	1
Fabre, PL; Ibrahim, H; Najahi, E; Nepveu, F; Perio, P; Reybier, K; Souard, F; Yen, NT	1
Laczko, E; Schaer, CA; Schaer, DJ; Schoedon, G; Vallelian, F	1
Balzarini, J; Chibale, K; de Kock, C; Kaur, H; Singh, K; Smith, P	1
Bohle, DS; Dodd, EL	1
Combrinck, JM; Egan, TJ; Fong, KY; Gibhard, L; Smith, PJ; Wright, DW	1
Craig, JC; Raheem, KS; Warhurst, DC	1
Jain, V; Sharma, A; Yogavel, M	1
Agarwal, P; Ahmad, H; Dola, VR; Dwivedi, AK; Haq, W; Katti, SB; Puri, SK; Raju, KS; Rashid, M; Soni, A; Srivastava, K; Wahajuddin, M	1
Burgess, SJ; Gunsaru, B; Kelly, JX; Liebman, K; Morrill, W; Peyton, DH; Shomloo, S; Smilkstein, MJ	1
Kumar, P; Manhas, A; Mishra, S; Pal, A; Sashidhara, KV; Shanker, K; Singh, SP; Singh, SV; Srivastava, K; Tiwari, N	1
Nguyen, TQ; Olafson, KN; Rimer, JD; Vekilov, PG	1
Chakrabarti, A; Das, D; Tarafdar, PK	1
Jiang, TL; Li, CH; Tang, T	1
Goggins, E; Heller, LE; Roepe, PD	1
Cumming, BM; Goldring, JPD	1
Arwati, H; Basuki, DR; Ekasari, W; Wahyuni, TS	1
Bozza, MT; Gama, AM; Gomes, CP; Manoury, B; Oliveira, PL; Paiva, CN; Prestes, EB; Rodrigues, DA; Silva, RCMC; Tan, L	1
Held, J; Moita, D; Perković, I; Pessanha de Carvalho, L; Poje, G; Prudêncio, M; Rajić, Z; Tandarić, T; Vianello, R	1
Araujo-Neto, JH; Chibale, K; Dziwornu, GA; Moreira, DRM; Quadros, HC; Sousa, CC	1
Chibale, K; Kaur, N; Korkor, C; Mobin, SM; Singh, K	1
Albert, I; Bath, J; Fidock, DA; Koo, I; Llinás, M; Mok, S; Okombo, J; Orchard, LM; Owens, E; Qahash, T; Yeo, T	1
Chibale, K; Egan, TJ; Kumar, M; Okombo, J; Redhi, D; Wicht, KJ; Wiesner, L	1
Hu, M; Liu, H; Liu, L; Wang, C; Zhang, Z; Zhou, T; Zhu, S	1
Makde, RD; Singh, R; Srihari, V	1

Reviews

9 review(s) available for chloroquine and heme

Article	Year
Ferriprotoporphyrin IX: role in chloroquine susceptibility and resistance in malaria. Progress in clinical and biological research, 1989, Volume: 313 Topics: Animals; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemin; Hemoglobins; Malaria; Plasmodium; Verapamil	1989
Porphyria cutanea tarda, or the uroporphyrinogen decarboxylase deficiency diseases. Clinical biochemistry, 1986, Volume: 19, Issue:1 Topics: Animals; Bloodletting; Carboxy-Lyases; Chloroquine; Chromatography, High Pressure Liquid; Disease Models, Animal; Feces; Female; Heme; Hexachlorobenzene; Humans; Hydroxamic Acids; Iron; Lead Poisoning; Male; Mice; Polychlorinated Dibenzodioxins; Porphyrias; Porphyrins; Rats; Skin Diseases; Uroporphyrinogen Decarboxylase	1986
4-Aminoquinolines--past, present, and future: a chemical perspective. Pharmacology & therapeutics, 1998, Volume: 77, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; DNA; Drug Design; Heme; Humans; Models, Molecular; Structure-Activity Relationship	1998
Involvement of heme in the antimalarial action of chloroquine. Transactions of the American Clinical and Climatological Association, 1998, Volume: 109 Topics: Animals; Antimalarials; Chloroquine; Digestion; Drug Resistance; Erythrocytes; Heme; Hemeproteins; Hemoglobins; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Malaria; Mice; Plasmodium; Vacuoles	1998
Heme metabolism of Plasmodium is a major antimalarial target. Biochemical and biophysical research communications, 2000, Feb-24, Volume: 268, Issue:3 Topics: 5-Aminolevulinate Synthetase; Animals; Antimalarials; Chloroquine; Erythrocytes; Heme; Humans; Malaria; Models, Biological; Plasmodium; Porphobilinogen Synthase	2000
Management of acute and cutaneous porphyrias. International journal of clinical practice, 2002, Volume: 56, Issue:4 Topics: Arginine; beta Carotene; Chloroquine; Estrogens; Ethanol; Heme; Humans; Phlebotomy; Porphyria Cutanea Tarda; Porphyria, Acute Intermittent; Porphyrias; Sunlight	2002
Theories on malarial pigment formation and quinoline action. International journal for parasitology, 2002, Dec-04, Volume: 32, Issue:13 Topics: Animals; Antimalarials; Chloroquine; Heme; Hemeproteins; Humans; Pigments, Biological; Plasmodium	2002
Diagnosis and treatment of the hepatic porphyrias. Dermatologic therapy, 2003, Volume: 16, Issue:1 Topics: Acute Disease; Antimalarials; Chloroquine; Heme; Humans; Photosensitivity Disorders; Porphyrias, Hepatic; Porphyrins	2003
[Research progress on heme metabolism in intraerythrocytic plasmodium]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2018, Volume: 43, Issue:18 Topics: Antimalarials; Artemisinins; Atovaquone; Chloroquine; Erythrocytes; Heme; Hemoglobins; Humans; Plasmodium	2018

Other Studies

101 other study(ies) available for chloroquine and heme

Article	Year
Host heme catabolism in drug-sensitive and drug-resistant malaria. The Journal of laboratory and clinical medicine, 1977, Volume: 90, Issue:4 Topics: Animals; Carbon Monoxide; Chloroquine; Drug Resistance; Heme; Malaria; Male; Mice; Plasmodium berghei	1977
Malaria. How chloroquine works. Nature, 1992, Jan-09, Volume: 355, Issue:6356 Topics: Animals; Chloroquine; Drug Resistance; Heme; Plasmodium; Plasmodium falciparum	1992
Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites. Nature, 1992, Jan-09, Volume: 355, Issue:6356 Topics: Animals; Chloroquine; Erythrocytes; Heme; Hemeproteins; Hemoglobins; Humans; Kinetics; Pigments, Biological; Plasmodium falciparum; Transferases; Vacuoles	1992
Status of hepatic heme and heme oxygenase during Plasmodium yoelii nigeriensis infection in mice. Experimental and molecular pathology, 1991, Volume: 55, Issue:1 Topics: Administration, Oral; Animals; Cell Fractionation; Chloroquine; Cobalt; Heme; Heme Oxygenase (Decyclizing); Injections, Subcutaneous; Liver; Malaria; Mice; Plasmodium yoelii	1991
Chloroquine inhibits heme-dependent protein synthesis in Plasmodium falciparum. Proceedings of the National Academy of Sciences of the United States of America, 1991, Jun-01, Volume: 88, Issue:11 Topics: Animals; Cell-Free System; Chloroquine; Eukaryotic Initiation Factor-2; Heme; Kinetics; Methionine; Phosphorylation; Plasmodium falciparum; Protein Biosynthesis; Protozoan Proteins; Rabbits; Reticulocytes; Ribosomes	1991
[A new model for testing substances affecting the synthesis of heme]. Sbornik lekarsky, 1989, Volume: 91, Issue:4 Topics: Chloroquine; Drug Evaluation, Preclinical; Heme; Porphyrins; Pyrimethamine; Saccharomyces cerevisiae	1989
The state of ferriprotoporphyrin IX in malaria pigment. The Journal of biological chemistry, 1987, Nov-15, Volume: 262, Issue:32 Topics: Animals; Chloroquine; Drug Resistance; Heme; Hemin; Malaria; Mice; Osmotic Fragility; Peptide Hydrolases; Plasmodium berghei; Solubility; Streptomyces griseus	1987
Lysis of malarial parasites and erythrocytes by ferriprotoporphyrin IX-chloroquine and the inhibition of this effect by proteins. Biochemical pharmacology, 1987, Apr-15, Volume: 36, Issue:8 Topics: Chloroquine; Erythrocytes; Heme; Hemin; Hemolysis; Humans; Plasmodium falciparum; Proteins	1987
Ferriprotoporphyrin IX and cell lysis: a protective role for hydrogen peroxide. Life sciences, 1988, Volume: 42, Issue:25 Topics: Chloroquine; Heme; Hemin; Hemolysis; Humans; Hydrogen Peroxide; In Vitro Techniques; Inactivation, Metabolic; Spectrum Analysis	1988
A ferriprotoporphyrin IX-chloroquine complex promotes membrane phospholipid peroxidation. A possible mechanism for antimalarial action. FEBS letters, 1987, Nov-02, Volume: 223, Issue:2 Topics: Chloroquine; Fatty Acids; Ferric Compounds; Ferrous Compounds; Heme; Hemin; Kinetics; Lipid Peroxides; Oxidation-Reduction; Phospholipids; Spectrum Analysis; Structure-Activity Relationship	1987
Toxic heme in sickle cells: an explanation for death of malaria parasites. The American journal of tropical medicine and hygiene, 1985, Volume: 34, Issue:2 Topics: Adolescent; Adult; Anemia, Sickle Cell; Animals; Chloroquine; Erythrocytes; Female; Heme; Hemin; Humans; Male; Plasmodium falciparum; Sickle Cell Trait	1985
Excess release of ferriheme in G6PD-deficient erythrocytes: possible cause of hemolysis and resistance to malaria. Blood, 1986, Volume: 67, Issue:2 Topics: Chloroquine; Erythrocyte Membrane; Ferric Compounds; Glucosephosphate Dehydrogenase Deficiency; Heme; Hemolysis; Humans; Malaria; Male; Vitamin K	1986
A nuclear magnetic resonance study of the interactions of antimalarial drugs with porphyrins. Biochimica et biophysica acta, 1985, May-29, Volume: 840, Issue:1 Topics: Chloroquine; Heme; Hemin; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Porphyrins; Quinine; Uroporphyrins	1985
Investigations of the possible relation of ferrihemic acid to drug resistance in Plasmodium berghei. Experimental parasitology, 1966, Volume: 19, Issue:1 Topics: Chloroquine; Drug Antagonism; Drug Resistance, Microbial; Heme; Oxygen Consumption; Plasmodium; Quinine; Spectrophotometry	1966
Interactions of hemin, antimalarial drugs and hemin-antimalarial complexes with phospholipid monolayers. Chemistry and physics of lipids, 1984, Volume: 35, Issue:4 Topics: Animals; Antimalarials; Cattle; Chloroquine; Heme; Hemin; Mathematics; Mefloquine; Membranes, Artificial; Phospholipids; Quinine; Quinolines; Surface Properties	1984
Mode of action of antimalarial drugs. Ciba Foundation symposium, 1983, Volume: 94 Topics: Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Drug Resistance; Heme; Hemin; Hemoglobins; Humans; Malaria; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Receptors, Drug	1983
Interaction of antimalarial drugs with hemin. Bioscience reports, 1983, Volume: 3, Issue:12 Topics: Animals; Antimalarials; Chemical Phenomena; Chemistry; Chloroquine; Circular Dichroism; Heme; Hemin; Plasmodium berghei; Quinidine; Quinine; Spectrometry, Fluorescence; Spectrum Analysis	1983
Ferriprotoporphyrin IX: a mediator of the antimalarial action of oxidants and 4-aminoquinoline drugs. Progress in clinical and biological research, 1984, Volume: 155 Topics: Aminoquinolines; Animals; Antimalarials; Cell Membrane; Chloroquine; Erythrocytes; Heme; Hemin; Hemolysis; Malaria; Oxidation-Reduction; Plasmodium berghei; Rabbits; Vitamin K	1984
Chloroquine resistance and host cell hemoglobin catabolism in Plasmodium berghei. Progress in clinical and biological research, 1984, Volume: 155 Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Heme; Hemoglobins; Iron; Kinetics; Malaria; Male; Mice; Plasmodium berghei	1984
Iron metabolism of established human hematopoietic cell lines in vitro. Experimental cell research, 1983, Apr-01, Volume: 144, Issue:2 Topics: Ammonium Chloride; Cell Line; Chloroquine; Endocytosis; Erythrocytes; Ferritins; Heme; Humans; Iron; Kinetics; Leukemia, Erythroblastic, Acute; Lymphocytes; Lymphoma; Macrophages; Transferrin	1983
Diverse membrane-active agents modify the hemolytic response to ferriprotoporphyrin IX. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 225, Issue:3 Topics: Adult; Antimalarials; Calcium; Chloroquine; Drug Synergism; Erythrocytes; Female; Heme; Hemin; Hemolysis; Humans; Male; Mefloquine; Osmotic Fragility; Quinine; Quinolines; Sodium Chloride	1983
Ferriprotoporphyrin IX binding substances and the mode of action of chloroquine against malaria. Life sciences, 1982, Sep-13, Volume: 31, Issue:11 Topics: Animals; Chloroquine; Heme; Hemin; Malaria; Plasmodium berghei; Serum Albumin, Bovine	1982
The effect of ferriprotoporphyrin IX and chloroquine on phospholipid monolayers and the possible implications to antimalarial activity. Biochimica et biophysica acta, 1983, Jul-13, Volume: 732, Issue:1 Topics: Chloroquine; Heme; Hemin; Humans; Liposomes; Malaria; Phosphatidylcholines; Structure-Activity Relationship	1983
Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasites. Biochemistry, 1980, Apr-15, Volume: 19, Issue:8 Topics: Animals; Binding, Competitive; Chloroquine; Erythrocyte Membrane; Heme; Hemin; Hemoglobins; Kinetics; Male; Mice; Plasmodium berghei; Protein Binding; Spectrophotometry	1980
Binding of antimalarial drugs to hemozoin from Plasmodium berghei. Experientia, 1980, Sep-15, Volume: 36, Issue:9 Topics: Animals; Antimalarials; Chloroquine; Heme; Hemeproteins; Mefloquine; Methemoglobin; Pigments, Biological; Piperidines; Plasmodium berghei; Protein Binding; Protoporphyrins; Quinacrine; Quinolines; Spectrophotometry	1980
Hemin lyses malaria parasites. Science (New York, N.Y.), 1981, Nov-06, Volume: 214, Issue:4521 Topics: Animals; Chloroquine; Drug Interactions; Drug Resistance; Heme; Hemin; Mice; Plasmodium berghei	1981
Lysis of Plasmodium falciparum by ferriprotoporphyrin IX and a chloroquine-ferriprotoporphyrin IX complex. Antimicrobial agents and chemotherapy, 1982, Volume: 21, Issue:5 Topics: Chloroquine; Erythrocytes; Heme; Hemin; Humans; In Vitro Techniques; Plasmodium falciparum; Time Factors	1982
Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications. The Journal of clinical investigation, 1980, Volume: 66, Issue:4 Topics: Animals; Chloroquine; Drug Interactions; Erythrocytes; Heme; Hemin; Hemolysis; In Vitro Techniques; Malaria; Mice	1980
Receptor-independent uptake of transferrin-bound iron by reticulocytes. Archives of biochemistry and biophysics, 1994, Volume: 308, Issue:1 Topics: Animals; Biological Transport; Cations; Chloroquine; Cytosol; Dicumarol; Edetic Acid; Egtazic Acid; Endocytosis; Erythrocyte Membrane; Heme; In Vitro Techniques; Iodine Radioisotopes; Iron; Iron Radioisotopes; Kinetics; Quinacrine; Rabbits; Receptors, Transferrin; Reticulocytes; Transferrin; Tretinoin	1994
Effect of Plasmodium berghei infection and antimalarial treatment on heme synthesis in mice. International journal for parasitology, 1994, Volume: 24, Issue:5 Topics: 5-Aminolevulinate Synthetase; Animals; Chloroquine; Ferrochelatase; Heme; Liver; Malaria; Mice; Plasmodium berghei; Porphobilinogen Synthase; Tryptophan Oxygenase	1994
Hemoglobin catabolism and host-parasite heme balance in chloroquine-sensitive and chloroquine-resistant Plasmodium berghei infections. The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:4 Topics: Analysis of Variance; Animals; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemoglobins; Host-Parasite Interactions; Malaria; Male; Mice; Plasmodium berghei; Rats; Rats, Sprague-Dawley; Reticulocytes	1993
Effect of chloroquine on hepatic heme-oxygenase during Plasmodium berghei infection in mice. International journal for parasitology, 1993, Volume: 23, Issue:2 Topics: Animals; Chloroquine; Heme; Heme Oxygenase (Decyclizing); Liver; Malaria; Mice; Microsomes, Liver; Plasmodium berghei	1993
Evaluation of resistant-reversal, CDRI compound 87/209 and its possible mode of action in rodent experimental malaria. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1995, Volume: 46, Issue:2 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Malaria; Mice; Muridae; Pigments, Biological; Plasmodium; Plasmodium berghei; Plasmodium yoelii; Pyrrolidines; Species Specificity; Transferases	1995
The iron environment in heme and heme-antimalarial complexes of pharmacological interest. Journal of inorganic biochemistry, 1996, Volume: 63, Issue:1 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Heme; Hemeproteins; Hemin; Humans; Iron; Malaria; Quinine; Sesquiterpenes; Spectroscopy, Mossbauer	1996
Haemozoin formation in malaria parasites: is there a haem polymerase? Trends in microbiology, 1996, Volume: 4, Issue:7 Topics: Animals; Biopolymers; Carrier Proteins; Chloroquine; Heme; Hemeproteins; Humans; Plasmodium	1996
Heme oxygenase and related indices in chloroquine-resistant and -sensitive strains of Plasmodium berghei. International journal for parasitology, 1995, Volume: 25, Issue:9 Topics: Animals; Biomarkers; Chloroquine; Drug Resistance; Heme; Heme Oxygenase (Decyclizing); Muridae; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium berghei; Porphyrins; Species Specificity; Transferases	1995
On the molecular mechanism of chloroquine's antimalarial action. Proceedings of the National Academy of Sciences of the United States of America, 1996, Oct-15, Volume: 93, Issue:21 Topics: Animals; Antimalarials; Chloroquine; Erythrocytes; Heme; Hemeproteins; Humans; In Vitro Techniques; Models, Structural; Plasmodium falciparum; Proteins; Protozoan Proteins; Quinolines; Vacuoles	1996
Depolymerization of malarial hemozoin: a novel reaction initiated by blood schizontocidal antimalarials. FEBS letters, 1997, Feb-03, Volume: 402, Issue:2-3 Topics: Animals; Antimalarials; Chloroquine; Heme; Hemeproteins; Hemoglobins; Kinetics; Malaria; Mice; Models, Biological; Pigments, Biological; Plasmodium yoelii	1997
Probing the chloroquine resistance locus of Plasmodium falciparum with a novel class of multidentate metal(III) coordination complexes. The Journal of biological chemistry, 1997, Mar-07, Volume: 272, Issue:10 Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Cations; Chloroquine; Drug Resistance; Ferric Compounds; Heme; Hemeproteins; Metals; Plasmodium falciparum	1997
Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Cyclohexylamines; Dogs; Drug Resistance; Half-Life; Heme; Malaria, Vivax; Male; Mice; Plasmodium falciparum; Plasmodium vivax; Quinolines; Rats; Rats, Wistar; Stereoisomerism	1997
Xanthones as antimalarial agents; studies of a possible mode of action. FEBS letters, 1997, Jun-02, Volume: 409, Issue:1 Topics: Animals; Antimalarials; Chloroquine; Heme; Humans; Plasmodium falciparum; Polymers; Primaquine; Quinacrine; Structure-Activity Relationship; Xanthenes; Xanthones	1997
Utilization of intracellular ferritin iron for hemoglobin synthesis in developing human erythroid precursors. Blood, 1997, Jul-15, Volume: 90, Issue:2 Topics: Autoradiography; Cells, Cultured; Chloroquine; Enzyme-Linked Immunosorbent Assay; Erythroblasts; Erythroid Precursor Cells; Ferritins; Flow Cytometry; Heme; Hemoglobins; Humans; Iron; Iron Radioisotopes; Kinetics; Leupeptins; Oligopeptides; Protease Inhibitors	1997
Synergism of cimetidine with anti-malarial agents. The Journal of parasitology, 1997, Volume: 83, Issue:5 Topics: Animals; Antimalarials; Chloroquine; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Heme; Histamine H2 Antagonists; Plasmodium falciparum; Polymers; Proadifen; Pyrimethamine	1997
Synthetic peptides corresponding to a repetitive sequence of malarial histidine rich protein bind haem and inhibit haemozoin formation in vitro. Molecular and biochemical parasitology, 1997, Dec-01, Volume: 90, Issue:1 Topics: Amino Acid Sequence; Animals; Antimalarials; Binding Sites; Binding, Competitive; Chloroquine; Heme; Hemeproteins; Male; Mice; Molecular Sequence Data; Peptide Fragments; Plasmodium; Proteins; Protozoan Proteins	1997
Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Drug Design; Drug Resistance; Heme; Plasmodium falciparum; Polymers; Sensitivity and Specificity	1998
Chloroquine stimulates nitric oxide synthesis in murine, porcine, and human endothelial cells. The Journal of clinical investigation, 1998, Aug-01, Volume: 102, Issue:3 Topics: Aconitate Hydratase; Animals; Calcium; Canavanine; Cell Division; Cell Line, Transformed; Chloroquine; Cycloheximide; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Guanidines; Heme; Humans; Hydrogen-Ion Concentration; Iron; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Ornithine Decarboxylase; Protein Synthesis Inhibitors; Stimulation, Chemical; Swine	1998
A common mechanism for blockade of heme polymerization by antimalarial quinolines. The Journal of biological chemistry, 1998, Nov-20, Volume: 273, Issue:47 Topics: Animals; Antimalarials; Chloroquine; Erythrocytes; Heme; Hemeproteins; Mefloquine; Plasmodium falciparum; Polymers; Quinidine; Quinolines	1998
Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action. Biochemical pharmacology, 1998, Nov-15, Volume: 56, Issue:10 Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Glutathione; Heme; Plasmodium falciparum	1998
Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials. The Biochemical journal, 1999, Apr-15, Volume: 339 ( Pt 2) Topics: Animals; Antimalarials; Catalase; Chloroquine; Erythrocyte Membrane; Heme; Peroxides; Plasmodium falciparum; Protein Binding; Quinolines	1999
Glutathione-S-transferase activity in malarial parasites. Tropical medicine & international health : TM & IH, 1999, Volume: 4, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Cricetinae; Drug Resistance; Glutathione Transferase; Heme; Humans; Macaca mulatta; Mesocricetus; Mice; Plasmodium berghei; Plasmodium falciparum; Plasmodium knowlesi; Plasmodium yoelii; Protoporphyrins	1999
Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase--a response. Parasitology today (Personal ed.), 2000, Volume: 16, Issue:3 Topics: Animals; Antimalarials; Binding Sites; Chloroquine; Heme; L-Lactate Dehydrogenase; Plasmodium falciparum	2000
Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry. Biochimica et biophysica acta, 2000, Jul-03, Volume: 1475, Issue:2 Topics: Antimalarials; Calorimetry; Chloroquine; Dimerization; Heme; Hemin; Hydrogen-Ion Concentration; Osmolar Concentration; Salts; Spectrophotometry, Ultraviolet; Temperature	2000
Haemozoin formation in the midgut of the blood-sucking insect Rhodnius prolixus. FEBS letters, 2000, Jul-14, Volume: 477, Issue:1-2 Topics: Animals; Biological Factors; Chloroquine; Crystallization; Female; Heme; Hemeproteins; Hemolymph; Hot Temperature; Intestinal Mucosa; Intestines; Lipid Peroxidation; Microscopy, Electron; Pigments, Biological; Quinine; Rhodnius; Spectroscopy, Fourier Transform Infrared	2000
A new class of potential chloroquine-resistance reversal agents for Plasmodia: syntheses and biological evaluation of 1-(3'-diethylaminopropyl)-3-(substituted phenylmethylene)pyrrolidines. Journal of medicinal chemistry, 2000, Sep-07, Volume: 43, Issue:18 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Mice; Plasmodium; Pyrrolidines; Structure-Activity Relationship	2000
Haemoproteus and Schistosoma synthesize heme polymers similar to Plasmodium hemozoin and beta-hematin. Molecular and biochemical parasitology, 2001, Volume: 113, Issue:1 Topics: Animals; Antimalarials; Apicomplexa; Biopolymers; Chloroquine; Columbidae; Female; Heme; Hemeproteins; Hydrogen Peroxide; Male; Microscopy, Electron, Scanning; Pigments, Biological; Plasmodium falciparum; Quinolines; Schistosoma mansoni; Spectroscopy, Fourier Transform Infrared	2001
Mechanism of malarial haem detoxification inhibition by chloroquine. The Biochemical journal, 2001, Apr-15, Volume: 355, Issue:Pt 2 Topics: Amino Acid Sequence; Animals; Antimalarials; Chloroquine; Heme; Molecular Sequence Data; Plasmodium falciparum; Protein Binding; Proteins; Repetitive Sequences, Amino Acid	2001
Prooxidant activity of beta-hematin (synthetic malaria pigment) in arachidonic acid micelles and phospholipid large unilamellar vesicles. Biochemical pharmacology, 2001, Apr-15, Volume: 61, Issue:8 Topics: Arachidonic Acid; Cell Membrane; Chloroquine; Drug Interactions; Erythrocytes; Free Radical Scavengers; Glutathione; Heme; Hemeproteins; Hemin; Humans; Hydrogen-Ion Concentration; Lipid Peroxidation; Micelles; Oxidants; Oxidative Stress; Phospholipids; Spectrum Analysis; Statistics as Topic	2001
Heme-artemisinin adducts are crucial mediators of the ability of artemisinin to inhibit heme polymerization. Chemistry & biology, 2002, Volume: 9, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Heme; Plasmodium yoelii; Polymers; Protein Binding; Proteins; Sesquiterpenes	2002
Plasmodium chloroquine resistance and the search for a replacement antimalarial drug. Science (New York, N.Y.), 2002, Oct-04, Volume: 298, Issue:5591 Topics: Alleles; Animals; Antimalarials; ATP-Binding Cassette Transporters; Biological Evolution; Chloroquine; Databases, Nucleic Acid; Drug Resistance; Genes, Protozoan; Genetic Variation; Genome, Protozoan; Heme; Humans; Malaria; Malaria, Falciparum; Membrane Proteins; Membrane Transport Proteins; Plasmodium; Plasmodium falciparum; Point Mutation; Polymorphism, Single Nucleotide; Protozoan Proteins; Selection, Genetic; Sequence Analysis, DNA	2002
Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane. Organic & biomolecular chemistry, 2003, Aug-21, Volume: 1, Issue:16 Topics: Alkylation; Animals; Antimalarials; Chloroquine; Crystallography, X-Ray; Heme; Heterocyclic Compounds; Inhibitory Concentration 50; Metalloporphyrins; Models, Chemical; Molecular Structure; Plasmodium falciparum	2003
ANTAGONISM OF THE ANTIMALARIAL ACTION OF CHLOROQUINE BY FERRIHEMATE AND AN HYPOTHESIS FOR THE MECHANISM OF CHLOROQUINE RESISTANCE. The Journal of pharmacology and experimental therapeutics, 1964, Volume: 143 Topics: Antimalarials; Chloroquine; Drug Tolerance; Heme; Malaria; Pharmacology; Rats; Research	1964
Double-drug development against antioxidant enzymes from Plasmodium falciparum. Redox report : communications in free radical research, 2003, Volume: 8, Issue:5 Topics: Animals; Antimalarials; Antioxidants; Chloroquine; Drug Resistance; Enzyme Inhibitors; Erythrocytes; Glutathione; Glutathione Reductase; Heme; Humans; Malaria, Falciparum; Mice; Plasmodium falciparum; Prodrugs; Sulfhydryl Compounds; Thioredoxin-Disulfide Reductase	2003
Inhibition of heme aggregation by chloroquine reduces Schistosoma mansoni infection. The Journal of infectious diseases, 2004, Aug-15, Volume: 190, Issue:4 Topics: Animals; Cell Fractionation; Chloroquine; Cohort Studies; Disease Models, Animal; Drug Design; Female; Heme; Hemeproteins; Injections, Intraperitoneal; Liver; Mice; Parasite Egg Count; Parasitemia; Schistosoma mansoni; Schistosomiasis	2004
Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin. FEBS letters, 2004, Sep-24, Volume: 575, Issue:1-3 Topics: Animals; Antimalarials; Artemisinins; Carbon Monoxide; Chloroquine; Erythrocytes; Heme; Hemoglobins; Humans; Iron; Malaria; Oxidation-Reduction; Oxidative Stress; Oxygen; Plasmodium falciparum; Sesquiterpenes	2004
A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds. Experimental parasitology, 2007, Volume: 116, Issue:3 Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artemisinins; Atovaquone; Chloroquine; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Glutathione; Heme; Indicators and Reagents; Mefloquine; Methylene Blue; o-Phthalaldehyde; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinine; Spectrometry, Fluorescence	2007
Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:10 Topics: Alkylation; Animals; Antimalarials; Artemisinins; Chloroquine; Dioxanes; Heme; Hemeproteins; Plasmodium; Sesquiterpenes; Spectrophotometry, Infrared	2007
The mechanism of antimalarial action of the ruthenium(II)-chloroquine complex [RuCl(2)(CQ)] (2). Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2008, Volume: 13, Issue:5 Topics: 1-Octanol; Acids; Animals; Antimalarials; Buffers; Chemical Phenomena; Chemistry, Physical; Chloroquine; DNA; Drug Resistance; Heme; Hemin; Hydrolysis; Nucleic Acid Denaturation; Organometallic Compounds; Plasmodium berghei; Plasmodium falciparum; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet	2008
HDP-a novel heme detoxification protein from the malaria parasite. PLoS pathogens, 2008, Apr-25, Volume: 4, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Cytosol; Endocytosis; Erythrocytes; Heme; Hemeproteins; Inclusion Bodies; Plasmodium falciparum; Plasmodium vivax; Protein Binding; Protein Processing, Post-Translational; Protozoan Proteins; Recombinant Proteins; RNA, Protozoan	2008
Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium. Inorganic chemistry, 2008, Jul-07, Volume: 47, Issue:13 Topics: Chloroquine; Dimerization; Heme; Hemin; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Magnetics; Quinine	2008
Compounds structurally related to ellagic acid show improved antiplasmodial activity. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2 Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; DNA, Complementary; Drug Resistance; Ellagic Acid; Glutathione Peroxidase; Glutathione Transferase; Heme; Humans; Kinetics; Plasmodium falciparum; Reverse Transcriptase Polymerase Chain Reaction	2009
The antimalarial activity of Ru-chloroquine complexes against resistant Plasmodium falciparum is related to lipophilicity, basicity, and heme aggregation inhibition ability near water/n-octanol interfaces. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2009, Volume: 14, Issue:6 Topics: Acetates; Animals; Antimalarials; Buffers; Chloroquine; Drug Resistance; Heme; Hemin; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Octanols; Plasmodium falciparum; Ruthenium; Water	2009
Aggregated enhanced Raman scattering in Fe(III)PPIX solutions: the effects of concentration and chloroquine on excitonic interactions. The journal of physical chemistry. B, 2009, May-14, Volume: 113, Issue:19 Topics: Chloroquine; Dimerization; Electrons; Heme; Models, Molecular; Molecular Conformation; Protoporphyrins; Solutions; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman	2009
Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds. Journal of medicinal chemistry, 2010, Sep-09, Volume: 53, Issue:17 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Heme; Hemeproteins; Lymphocytes; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Protein Binding; Pyridines; Spleen; Structure-Activity Relationship	2010
Extracellular heme enhances the antimalarial activity of artemisinin. Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:1 Topics: Antimalarials; Antioxidants; Artemisia; Artemisinins; Chloroquine; Cholesterol, LDL; Fluorescence; Heme; Hemin; Humans; Lipid Peroxidation; Mefloquine; Oxidants; Oxidation-Reduction; Plasmodium falciparum; Quinine; Tryptophan; Vitamin E	2012
Ruthenium(II) arene complexes with chelating chloroquine analogue ligands: synthesis, characterization and in vitro antimalarial activity. Dalton transactions (Cambridge, England : 2003), 2012, Mar-07, Volume: 41, Issue:9 Topics: 1-Octanol; Animals; Antimalarials; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Electric Conductivity; Heme; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Organometallic Compounds; Plasmodium falciparum; Ruthenium; Water	2012
Synthesis and biological evaluation of acridine derivatives as antimalarial agents. ChemMedChem, 2012, Volume: 7, Issue:4 Topics: Acridines; Aminacrine; Antimalarials; Cell Line; Chloroquine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Heme; Hemeproteins; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; KB Cells; Molecular Structure; Plasmodium falciparum; Sulfolobus; Topoisomerase Inhibitors	2012
Insights into the role of heme in the mechanism of action of antimalarials. ACS chemical biology, 2013, Jan-18, Volume: 8, Issue:1 Topics: Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Heme; Microscopy, Electron, Transmission; Plasmodium falciparum; Trophozoites	2013
Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:1 Topics: Antimalarials; Cells, Cultured; Chloroquine; Crystallization; Cytostatic Agents; Cytotoxins; Erythrocytes; Heme; Hemeproteins; Humans; Inhibitory Concentration 50; Kinetics; Phospholipids; Plasmodium falciparum	2013
Pro-oxidant properties of indolone-N-oxides in relation to their antimalarial properties. Journal of inorganic biochemistry, 2013, Volume: 126 Topics: Antimalarials; Artemisinins; Chloroquine; Cyclic N-Oxides; Cysteine; Electron Spin Resonance Spectroscopy; Enzyme Activation; Erythrocyte Membrane; Heme; Hemin; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Iron; Models, Biological; Models, Chemical; Oxidation-Reduction; Protein-Tyrosine Kinases; Reactive Oxygen Species; Solutions; Syk Kinase	2013
Chloroquine interference with hemoglobin endocytic trafficking suppresses adaptive heme and iron homeostasis in macrophages: the paradox of an antimalarial agent. Oxidative medicine and cellular longevity, 2013, Volume: 2013 Topics: Amino Acid Sequence; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimalarials; Chloroquine; Endocytosis; Haptoglobins; HEK293 Cells; Heme; Heme Oxygenase-1; Hemoglobins; Homeostasis; Humans; Intracellular Space; Iron; Macrophages; Molecular Sequence Data; Peptides; Protein Transport; Receptors, Cell Surface	2013
Quinoline-pyrimidine hybrids: synthesis, antiplasmodial activity, SAR, and mode of action studies. Journal of medicinal chemistry, 2014, Jan-23, Volume: 57, Issue:2 Topics: Aminoquinolines; Antimalarials; Antiviral Agents; Cell Line; Chloroquine; Crystallography, X-Ray; DNA; Drug Resistance; Heme; Humans; Plasmodium falciparum; Protein Binding; Pyrimidines; Solubility; Structure-Activity Relationship; Water	2014
Orienting the heterocyclic periphery: a structural model for chloroquine's antimalarial activity. Chemical communications (Cambridge, England), 2014, Nov-18, Volume: 50, Issue:89 Topics: Antimalarials; Chloroquine; Gallium; Heme; Models, Chemical; Molecular Structure; Protoporphyrins	2014
Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials. Malaria journal, 2015, Jun-24, Volume: 14 Topics: Amodiaquine; Antimalarials; Atovaquone; Chloroquine; Colorimetry; Heme; Plasmodium falciparum; Pyrimethamine; Trophozoites	2015
Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance. PloS one, 2016, Volume: 11, Issue:8 Topics: Amodiaquine; Antimalarials; Biological Transport; Chloroquine; Drug Design; Drug Resistance; Heme; Hemin; Hydrophobic and Hydrophilic Interactions; Plasmodium falciparum; Quinolines; Structure-Activity Relationship; Vacuoles	2016
Dimerization of Arginyl-tRNA Synthetase by Free Heme Drives Its Inactivation in Plasmodium falciparum. Structure (London, England : 1993), 2016, 09-06, Volume: 24, Issue:9 Topics: Amino Acid Sequence; Antimalarials; Arginine; Arginine-tRNA Ligase; Binding Sites; Chloroquine; Crystallography, X-Ray; Gene Expression; Heme; Hemin; Humans; Models, Molecular; Plasmodium falciparum; Protein Binding; Protein Biosynthesis; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; RNA, Transfer, Arg; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Substrate Specificity	2016
Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3 Topics: Administration, Oral; Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemin; Inhibitory Concentration 50; Macaca mulatta; Malaria; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium cynomolgi; Plasmodium falciparum; Plasmodium yoelii; Structure-Activity Relationship; Vero Cells	2017
Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:5 Topics: Animals; Antimalarials; Chloroquine; Drug Discovery; Female; Heme; Hemeproteins; Malaria, Falciparum; Mice; Plasmodium falciparum; Plasmodium yoelii; Protein Binding; Structure-Activity Relationship	2017
A phenolic glycoside from Flacourtia indica induces heme mediated oxidative stress in Plasmodium falciparum and attenuates malaria pathogenesis in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2017, Jul-01, Volume: 30 Topics: Animals; Antimalarials; Chloroquine; Glycosides; Heme; Malaria; Male; Mice; Oxidative Stress; Phenols; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Salicaceae	2017
Antimalarials inhibit hematin crystallization by unique drug-surface site interactions. Proceedings of the National Academy of Sciences of the United States of America, 2017, 07-18, Volume: 114, Issue:29 Topics: Adsorption; Antimalarials; Binding Sites; Chloroquine; Crystallization; Crystallography, X-Ray; Drug Evaluation, Preclinical; Heme; Hemeproteins; Hemin; Plasmodium falciparum; Quinolines	2017
Structure-activity relationship of heme and its analogues in membrane damage and inhibition of fusion. FEBS letters, 2018, Volume: 592, Issue:14 Topics: Cell Membrane Permeability; Chloroquine; Fluoresceins; Heme; Hemin; Humans; Membrane Fusion; Membranes; Phospholipids; Protoporphyrins; Structure-Activity Relationship; Unilamellar Liposomes	2018
Dihydroartemisinin-Ferriprotoporphyrin IX Adduct Abundance in Plasmodium falciparum Malarial Parasites and the Relationship to Emerging Artemisinin Resistance. Biochemistry, 2018, 12-26, Volume: 57, Issue:51 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemin; Humans; Malaria, Falciparum; Plasmodium falciparum	2018
Monocyte phagocytosis of malaria β-haematin in the presence of artemisinin, amodiaquine, chloroquine, doxycycline, primaquine, pyrimethamine and quinine. Experimental parasitology, 2019, Volume: 197 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Cell Count; Cell Line; Chloroquine; Doxycycline; Electron Probe Microanalysis; Heme; Hemeproteins; Humans; Leukocytes, Mononuclear; Mice; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Monocytes; Peroxidase; Phagocytosis; Primaquine; Pyrimethamine; Quinine; Spectrophotometry; Temperature; U937 Cells	2019
Antiplasmodial activity of Ethanolic extract of Cassia spectabilis DC leaf and its inhibition effect in Heme detoxification. BMC complementary medicine and therapies, 2021, Feb-19, Volume: 21, Issue:1 Topics: Animals; Antimalarials; Artesunate; Cassia; Chloroquine; Heme; Ketones; Malaria; Male; Mice, Inbred BALB C; Phytotherapy; Piperidines; Plant Extracts; Plant Leaves; Plasmodium berghei; Plasmodium falciparum	2021
Chloroquine inhibits pro-inflammatory effects of heme on macrophages and invivo. Free radical biology & medicine, 2021, Volume: 173 Topics: Animals; Chloroquine; Cytokines; Heme; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice	2021
Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents. European journal of medicinal chemistry, 2022, Aug-05, Volume: 238 Topics: Antimalarials; Chloroquine; Harmine; Heme; Humans; Malaria, Falciparum; Plasmodium falciparum	2022
Antimalarial Pyrido[1,2- ACS infectious diseases, 2022, 08-12, Volume: 8, Issue:8 Topics: Aminoquinolines; Animals; Antimalarials; Antiparasitic Agents; Benzimidazoles; Chloroquine; Folic Acid Antagonists; Heme; Malaria; Mice; Plasmodium falciparum	2022
Fluorene-Chloroquine Hybrids: Synthesis, in vitro Antiplasmodial Activity, and Inhibition of Heme Detoxification Machinery of Plasmodium falciparum. ChemMedChem, 2022, Oct-06, Volume: 17, Issue:19 Topics: Antimalarials; Chloroquine; Fluorenes; Heme; Humans; Plasmodium falciparum	2022
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages. PLoS pathogens, 2022, Volume: 18, Issue:10 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Heme; Hemoglobins; Humans; Malaria, Falciparum; Membrane Transport Proteins; Mutation; Parasites; Plasmodium falciparum; Protozoan Proteins	2022
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in ACS infectious diseases, 2023, 03-10, Volume: 9, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Heme; Mice; Plasmodium falciparum	2023
Identification and characterisation of the haemozoin of Haemonchus contortus. Parasites & vectors, 2023, Mar-06, Volume: 16, Issue:1 Topics: Animals; Chloroquine; Haemonchus; Heme; Hemeproteins	2023
ACS infectious diseases, 2023, 08-11, Volume: 9, Issue:8 Topics: Antimalarials; Chloroquine; Heme; Humans; Malaria	2023