chloroquine has been researched along with gemcitabine in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 5 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Easwaran, M; Manickam, M; Pillaiyar, T; Wendt, LL | 1 |
| Jenks, S | 1 |
| Bläuer, M; Hashimoto, D; Hirota, M; Ikonen, NH; Laukkarinen, J; Sand, J | 1 |
| Chen, L; Chen, M; Dai, F; He, M; Shen, P; Song, Y; Wan, X; Xiao, P | 1 |
| Bachmann, H; Knuth, A; Nguyen-Kim, TDL; Pascolo, S; Samaras, P; Seifert, B; Tusup, M; von Moos, R | 1 |
| Chen, L; Cheng, X; Feng, H; Fu, Z; Jin, Z; Kuang, J; Liang, J; Peng, C; Qiu, W; Shen, B; Shen, X; Yuen, S | 1 |
| Ji, Z; Xu, C; Xu, R; Zhu, J | 1 |
| Abdel Karim, N; Aljohani, HM; Bahassi, EM; Eldessouki, I; Gaber, O; Morris, J | 1 |
| Deng, CL; Li, XD; Wang, Z; Wei, HP; Xiao, SQ; Xiong, J; Yang, XL; Ye, HQ; Yuan, ZM; Zhang, B; Zhang, QY; Zhang, YN; Zhang, ZR | 1 |
| Fan, YZ; Li, XP; Pan, MS; Sun, W; Wang, FT; Wang, H; Wang, QW | 1 |
| Curiel, TJ; Deng, Y; Gupta, HB; Kancharla, A; Kari, S; Kornepati, AVR; Li, R; Osta, E; Padron, AS; Reyes, RM; Sun, X; Svatek, RS; Vadlamudi, R; Wu, B; Zhang, D | 1 |
| Dai, C; Gong, T; Guo, Y; Huang, Y; Pan, H; Wu, D; Yan, J; Yang, Y; Zhao, Y; Zhu, S | 1 |
3 review(s) available for chloroquine and gemcitabine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The recent outbreaks of human coronaviruses: A medicinal chemistry perspective.
Topics: Antiviral Agents; Chemistry, Pharmaceutical; COVID-19; Disease Outbreaks; Drug Repositioning; Humans; Virus Internalization | 2021 |
The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers: A systematic review and meta-analysis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Chloroquine; Clinical Trials as Topic; Dacarbazine; Deoxycytidine; Doxorubicin; Gemcitabine; Humans; Hydroxychloroquine; Neoplasms; Risk; Temozolomide; Treatment Outcome | 2018 |
1 trial(s) available for chloroquine and gemcitabine
| Article | Year |
|---|---|
Phase I study of a chloroquine-gemcitabine combination in patients with metastatic or unresectable pancreatic cancer.
Topics: Aged; Antimalarials; Antimetabolites, Antineoplastic; Chloroquine; Deoxycytidine; Female; Gemcitabine; Humans; Male; Pancreatic Neoplasms | 2017 |
11 other study(ies) available for chloroquine and gemcitabine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
AACR highlights: promise for treating pancreatic cancer.
Topics: Albumin-Bound Paclitaxel; Albumins; Anilides; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Chloroquine; Clinical Trials as Topic; Delayed Diagnosis; Deoxycytidine; Disease Progression; Gemcitabine; Genes, ras; Humans; Mice; Molecular Targeted Therapy; Mutation; Off-Label Use; Paclitaxel; Pancreatic Neoplasms; Pyridines; Signal Transduction; Transcription Factors; United States | 2011 |
Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs.
Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Deoxycytidine; Fluorouracil; Gemcitabine; Humans; Microtubule-Associated Proteins; Pancreatic Neoplasms; Protein Kinase Inhibitors; Wortmannin | 2014 |
The cytoprotective role of gemcitabine-induced autophagy associated with apoptosis inhibition in triple-negative MDA-MB-231 breast cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; Deoxycytidine; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mammary Glands, Human; Proto-Oncogene Proteins c-bcl-2; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2014 |
CQ sensitizes human pancreatic cancer cells to gemcitabine through the lysosomal apoptotic pathway via reactive oxygen species.
Topics: Animals; Apoptosis; Cell Line, Tumor; Chloroquine; Deoxycytidine; Gemcitabine; Humans; Lysosomes; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Pancreatic Neoplasms; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2018 |
Exosomes as a Surrogate Marker for Autophagy in Peripheral Blood, Correlative Data from Phase I Study of Chloroquine in Combination with Carboplatin/Gemcitabine in Advanced Solid Tumors.
Topics: Antimalarials; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Biomarkers; Carboplatin; Chloroquine; Deoxycytidine; Drug Therapy, Combination; Exosomes; Gemcitabine; Humans; Neoplasms; Tumor Cells, Cultured | 2019 |
Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture.
Topics: Alkaloids; Amaryllidaceae Alkaloids; Animals; Antiviral Agents; Betacoronavirus; Cell Survival; Chlorocebus aethiops; Chloroquine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Gemcitabine; Phenanthridines; SARS-CoV-2; Vero Cells; Virus Replication | 2020 |
Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer.
Topics: Animals; Antimalarials; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Cell Proliferation; Chloroquine; Deoxycytidine; Drug Synergism; Drug Therapy, Combination; Gallbladder Neoplasms; Gemcitabine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Autophagy; B7-H1 Antigen; Cell Line, Tumor; Cell Proliferation; Chloroquine; Cisplatin; Deoxycytidine; Drug Resistance, Neoplasm; Female; Gemcitabine; Gene Expression; Humans; Mechanistic Target of Rapamycin Complex 1; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Neoplasm Metastasis; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Sirolimus; Urinary Bladder Neoplasms | 2021 |
Matrix stiffness triggers chemoresistance through elevated autophagy in pancreatic ductal adenocarcinoma.
Topics: Autophagy; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Chloroquine; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Humans; Pancreatic Neoplasms | 2023 |