chloroquine has been researched along with e 64 in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 11 (44.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avery, M; Desai, PV; Gut, J; Patny, A; Rosenthal, P; Sabnis, Y; Srivastava, A; Tekwani, B | 1 |
| Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ | 1 |
| Andrews, KT; Gardiner, DL; McCarthy, J; Melville, L; Skinner-Adams, TS | 1 |
| Desai, SA; Fay, MP; Furuya, T; Gluzman, IY; Goldberg, DE; Kambhampati, S; Lisk, G; Pain, M; Su, XZ | 1 |
| Capela, R; Domingos, A; Gonçalves, LM; Gut, J; Lopes, F; Moreira, R; Oliveira, R; Rosenthal, PJ | 1 |
| Büchold, C; Gelhaus, C; Gut, J; Kisker, C; Leippe, M; Leyh, M; Machon, U; Rosenthal, PJ; Schirmeister, T; Schmuck, C; Stempka, M | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Chibale, K; Franzblau, SG; Guantai, EM; Gut, J; Hans, RH; Lategan, C; Rosenthal, PJ; Smith, PJ; Wan, B | 1 |
| Breuning, A; Büchold, C; Degel, B; Gelhaus, C; Gut, J; Heppner, S; Kisker, C; Leippe, M; Leyh, M; Machon, U; Rath, J; Rosenthal, PJ; Schirmeister, T; Schmuck, C; Schulz, F; Stempka, M; Stich, A | 1 |
| Guedes, RC; Gut, J; Moreira, R; Praveen Kumar, S; Rosenthal, PJ; Santos, MM | 1 |
| Chibale, K; Franzblau, SG; Gut, J; Hans, RH; Rosenthal, PJ; van Helden, PD; Wan, B; Wiid, IJ | 1 |
| Bhampidipati, R; Chibale, K; Egan, TJ; Guantai, EM; Gut, J; Kopinathan, A; Ncokazi, K; Rosenthal, PJ; Smith, PJ | 1 |
| Figueiras, M; Gomes, JR; Gomes, P; Gut, J; Pérez, BC; Rosenthal, PJ; Teixeira, C | 1 |
| Gonçalves, LM; Gut, J; Kumar, SP; Moreira, R; Ribeiro, CJ; Rosenthal, PJ; Santos, MM | 1 |
| Ayong, L; Bae, MA; Cechetto, J; Freitas-Junior, LH; Lee, E; Lee, HG; Lee, N; Lee, S; Lim, D; Liuzzi, M; Oh, S; Park, SB; Song, JS | 1 |
| Amendola, G; Chouchene, K; Cosconati, S; Ettari, R; Grasso, S; Gut, J; Hellmich, UA; Krauth-Siegel, RL; Previti, S; Rosenthal, PJ; Schirmeister, T; Schmid, I; Ulrich, K; Wagner, A; Wich, PR; Zappalà, M | 1 |
| Knops, J; Lieberburg, I; Sinha, S | 1 |
| Knutson, VP | 1 |
| Decker, RS; Ferguson, AG; Lesch, M; Samarel, AM | 1 |
| Bradley, C; Henriquez, DA; Pance, A; Perez, N | 1 |
| Beyer, EC; Green, K; Laing, JG; Saffitz, JE; Tadros, PN | 1 |
| Hasselgren, PO; Luo, GJ; Wang, JJ; Wang, L | 1 |
| Bray, PG; Mungthin, M; Ridley, RG; Ward, SA | 1 |
| Allanki, AD; Navale, R; Sijwali, PS | 1 |
| Chen, F; Jia, J; Li, J; Song, Y; Yin, P; Zhang, Y | 1 |
25 other study(ies) available for chloroquine and e 64
| Article | Year |
|---|---|
Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.
Topics: Animals; Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Databases, Factual; Leishmania donovani; Models, Molecular; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Trypanocidal Agents | 2004 |
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.
Topics: Animals; Antimalarials; Chalcones; Cysteine Endopeptidases; Globins; Heme; Hemeproteins; Hydrolysis; Malaria; Mice; Phenylurea Compounds; Plasmodium berghei; Plasmodium falciparum; Polymers; Protease Inhibitors; Structure-Activity Relationship | 2005 |
Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Chloroquine; Drug Synergism; HIV Protease Inhibitors; Humans; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Plasmodium falciparum; Ritonavir; Saquinavir | 2007 |
Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.
Topics: Animals; Antimalarials; Biological Transport, Active; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Drug Resistance; Erythrocytes; Genes, Protozoan; Humans; In Vitro Techniques; Ion Channels; Leupeptins; Malaria, Falciparum; Plasmodium falciparum; Protozoan Proteins | 2008 |
Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Artemisinins; Cysteine Endopeptidases; Dipeptides; Drug Design; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship; Sulfones | 2009 |
On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Cathepsin L; Cathepsins; Cattle; Combinatorial Chemistry Techniques; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diamide; Drug Evaluation, Preclinical; Fumarates; Humans; Peptide Library; Plasmodium falciparum | 2009 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.
Topics: Alkynes; Antimalarials; Antitubercular Agents; Chalcones; Mycobacterium tuberculosis; Plasmodium falciparum | 2010 |
Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.
Topics: Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Plasmodium falciparum; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2010 |
Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.
Topics: Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Indoles; Malaria, Falciparum; Plasmodium falciparum | 2011 |
Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents.
Topics: Animals; Antimalarials; Antitubercular Agents; Isatin; Lactones; Mycobacterium tuberculosis; Plasmodium falciparum; Structure-Activity Relationship | 2011 |
Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.
Topics: Animals; Antimalarials; Antiparasitic Agents; Caco-2 Cells; Chalcone; Chemistry, Pharmaceutical; Computational Biology; Drug Design; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Liver; Permeability; Quinolines | 2011 |
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials.
Topics: Amino Acids; Aminoquinolines; Antimalarials; Cinnamates; Cysteine Endopeptidases; Drug Design; Heme; Inhibitory Concentration 50; Molecular Docking Simulation; Molecular Dynamics Simulation; Plasmodium falciparum; Polymerization; Protease Inhibitors; Protein Conformation | 2012 |
Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents.
Topics: Aminoquinolines; Animals; Antimalarials; Cyclobutanes; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Molecular Structure; NIH 3T3 Cells; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship | 2013 |
Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay.
Topics: Animals; Antimalarials; Area Under Curve; Cell Line, Tumor; Cell Survival; Drug Discovery; Drug Evaluation, Preclinical; Hep G2 Cells; Host-Parasite Interactions; Humans; Life Cycle Stages; Malaria; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Models, Chemical; Molecular Structure; Plasmodium chabaudi; Plasmodium falciparum; Pyrimidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2014 |
Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).
Topics: Antimalarials; Carbamates; Cathepsin L; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; HeLa Cells; Humans; Hydrogen Bonding; Malaria; Molecular Docking Simulation; Molecular Dynamics Simulation; Neglected Diseases; Phenylalanine; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2017 |
Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate.
Topics: Amyloid beta-Protein Precursor; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leucine; Leupeptins; Molecular Weight; Peptide Fragments; Transfection | 1992 |
Proteolytic processing of the insulin receptor beta subunit is associated with insulin-induced receptor down-regulation.
Topics: Animals; Blotting, Western; Cells, Cultured; Chloroquine; Cycloheximide; Cysteine Endopeptidases; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Insulin; Insulin Antagonists; Leucine; Leupeptins; Mice; Peptide Fragments; Receptor, Insulin | 1991 |
Effects of cysteine protease inhibitors on rabbit cathepsin D maturation.
Topics: Animals; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Proteinase Inhibitors; Fibroblasts; Kinetics; Leucine; Leupeptins; Methionine; Myocardium; Protein Processing, Post-Translational; Rabbits; Sulfur Radioisotopes | 1989 |
Mechanisms of protein degradation in Trypanosoma cruzi.
Topics: Animals; Chloroquine; Cysteine Endopeptidases; Hydrogen-Ion Concentration; Intracellular Membranes; Leucine; Molecular Weight; Peptide Hydrolases; Protease Inhibitors; Protozoan Proteins; Puromycin; Time Factors; Trypanosoma cruzi; Ubiquitins | 1993 |
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Connexin 43; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Hot Temperature; HSP70 Heat-Shock Proteins; Immunoblotting; Leucine; Leupeptins; Lysosomes; Microscopy, Electron; Myocardium; Oligopeptides; Precipitin Tests; Protease Inhibitors; Rats | 1998 |
Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes.
Topics: Adenosine Triphosphate; Animals; Calcium; Calpain; Cathepsin B; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Deoxyglucose; Dexamethasone; Leucine; Leupeptins; Methylamines; Mifepristone; Multienzyme Complexes; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteins; Rats; Tyrosine; Ubiquitins | 1998 |
Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols.
Topics: Amodiaquine; Antimalarials; Chloroquine; Hemoglobins; Humans; Leucine; Mefloquine; Phenanthrenes; Primaquine; Protease Inhibitors | 1998 |
Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum.
Topics: Adenine; Amino Acid Sequence; Antimalarials; Apicoplasts; Autophagy; Autophagy-Related Protein 8 Family; Chloroquine; Doxycycline; Erythrocytes; Gene Expression Regulation; Genome, Protozoan; Humans; Leucine; Life Cycle Stages; Microfilament Proteins; Molecular Sequence Data; Pepstatins; Plasmodium falciparum; Protease Inhibitors; Protozoan Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2014 |
ABT-737, a Bcl-2 Selective Inhibitor, and Chloroquine Synergistically Kill Renal Cancer Cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Biphenyl Compounds; Carcinoma, Renal Cell; Cell Death; Cell Line, Tumor; Chloroquine; Drug Synergism; Humans; Kidney Neoplasms; Leucine; Nitrophenols; Oligopeptides; Piperazines; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thiadiazoles | 2016 |