chloroquine and desipramine

chloroquine has been researched along with desipramine in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (10.00)	18.7374
1990's	12 (30.00)	18.2507
2000's	12 (30.00)	29.6817
2010's	12 (30.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Cooper, RA; Dodean, RA; Hinrichs, DJ; Janowsky, A; Johnson, RA; Kelly, JX; Lane, KD; Riscoe, M; Smilkstein, MJ; Winter, R	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Sen, S; Sinha, N	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Kiryon, C; Miki, A; Nakayama, T; Ohsawa, K; Tanabe, K	1
Facer, CA; Salama, A	1
Basco, LK; Le Bras, J	1
Anderson, SN; Kacew, S; Ruben, Z	1
Bitonti, AJ; McCann, PP	1
Bitonti, AJ; Davidson, DE; Kyle, DE; McCann, PP; Milhous, WK; Oduola, AM; Rossan, RN; Sjoerdsma, A	1
Burghardt, C; Sheppard, H; Tsien, WH	1
Andersson, A; Olsson, S; Tjälve, H	1
Basco, LK; Camus, D; Cremer, G; Le Bras, J; Slomianny, C	1
Arnot, DE; Babiker, HA; Bayoumi, RA	1
Coutaux, AF; Mooney, JJ; Wirth, DF	1
Andersen, SL; Basco, LK; Le Bras, J; Milhous, WK; Vennerstrom, JL	1
Boulter, MK; Bray, PG; Howells, RE; Ritchie, GY; Ward, SA	1
Bray, PG; Howells, RE; Ndifor, AM; Ngu, JL; Ward, SA	1
Al-Damluji, S; Kopin, IJ	1
Bickel, MH; Daniel, WA; Honegger, UE	1
Al-Damluji, S; Shen, WB	1
Bhattacharjee, AK; Kyle, DE; Vennerstrom, JL	1
Gbotosho, GO; Gerena, L; Happi, CT; Kyle, DE; Milhous, WK; Oduola, AM; Ogundahunsi, OA; Salako, LA; Sowunmi, A	1
Brouwer, KL; Ferslew, BC	1

Reviews

1 review(s) available for chloroquine and desipramine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

39 other study(ies) available for chloroquine and desipramine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Acridones; Animals; Antimalarials; Cell Survival; Cells, Cultured; Drug Design; Drug Interactions; Drug Resistance, Multiple; Lymphocytes; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Molecular Structure; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Structure-Activity Relationship	2007
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells). Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4 Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Plasmodium chabaudi: association of reversal of chloroquine resistance with increased accumulation of chloroquine in resistant parasites. Experimental parasitology, 1992, Volume: 74, Issue:2 Topics: Animals; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Chromatography, High Pressure Liquid; Desipramine; Drug Resistance; Erythrocytes; Female; Imipramine; Malaria; Mice; Mice, Inbred ICR; Plasmodium chabaudi; Trifluoperazine	1992
Desipramine reversal of chloroquine resistance in wild isolates of Plasmodium falciparum. Lancet (London, England), 1990, Jan-20, Volume: 335, Issue:8682 Topics: Animals; Chloroquine; Desipramine; Drug Resistance; Drug Synergism; Humans; Plasmodium falciparum	1990
Desipramine or cyproheptadine for reversing chloroquine resistance? Lancet (London, England), 1990, Feb-17, Volume: 335, Issue:8686 Topics: Animals; Chloroquine; Cyproheptadine; Desipramine; Drug Resistance; Humans; Plasmodium falciparum	1990
Changes in saccharide and phospholipid content associated with drug storage in cultured rabbit aorta muscle cells. Laboratory investigation; a journal of technical methods and pathology, 1991, Volume: 64, Issue:4 Topics: Amines; Amiodarone; Animals; Anti-Arrhythmia Agents; Aorta; Cells, Cultured; Chloroquine; Desipramine; Ethylenediamines; Kinetics; Microscopy, Electron; Monosaccharides; Muscle, Smooth, Vascular; Phospholipids; Piperidines; Rabbits; Tilorone	1991
Desipramine and cyproheptadine for reversal of chloroquine resistance in Plasmodium falciparum. Lancet (London, England), 1989, Nov-25, Volume: 2, Issue:8674 Topics: Animals; Chloroquine; Cyproheptadine; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Plasmodium falciparum	1989
Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine. Science (New York, N.Y.), 1988, Dec-02, Volume: 242, Issue:4883 Topics: Animals; Antidepressive Agents, Tricyclic; Aotus trivirgatus; Chloroquine; Desipramine; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Malaria; Plasmodium falciparum	1988
Effect of drugs on the hemolysis of rat erythrocytes. Biochemical pharmacology, 1969, Volume: 18, Issue:9 Topics: Animals; Aspirin; Bile Acids and Salts; Chlordiazepoxide; Chloroquine; Chlorpromazine; Chlorprothixene; Cocaine; Desipramine; Desoxycorticosterone; Digitalis Glycosides; Diuretics; Erythrocytes; Glucose; Guanethidine; Hemolysis; Hydrocortisone; Hypotonic Solutions; Indomethacin; Levorphanol; Male; Neostigmine; Rats; Tripelennamine	1969
The uptake of 14C-chloroquine by mouse pancreatic islets in vitro. Acta pharmacologica et toxicologica, 1980, Volume: 47, Issue:1 Topics: Absorption; Animals; Chloroquine; Chlorpromazine; Desipramine; Glucose; Hydrogen-Ion Concentration; Imipramine; Islets of Langerhans; Lidocaine; Mice; Nicotine; Nitrogen; Ouabain; Quinacrine; Temperature	1980
Plasmodium falciparum: detection of P-glycoprotein in chloroquine-susceptible and chloroquine-resistant clones and isolates. Experimental parasitology, 1995, Volume: 81, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Chloroquine; Desipramine; Drug Resistance, Multiple; Erythrocytes; Fluorescent Antibody Technique; Humans; Malaria, Falciparum; Plasmodium falciparum	1995
Uptake and efflux of chloroquine by chloroquine-resistant Plasmodium falciparum clones recently isolated in Africa. Acta tropica, 1994, Volume: 58, Issue:2 Topics: Africa; Animals; Chloroquine; Desipramine; Drug Resistance; Erythrocytes; Plasmodium falciparum; Verapamil	1994
Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:6 Topics: 1-Naphthylamine; Animals; Chloroquine; Desipramine; Drug Resistance; Drug Synergism; Fluoxetine; Neurotransmitter Uptake Inhibitors; Plasmodium falciparum; Sertraline	1994
In vitro activity of bisquinoline WR268,668 against African clones and isolates of Plasmodium falciparum. The American journal of tropical medicine and hygiene, 1994, Volume: 50, Issue:2 Topics: Africa; Animals; Antimalarials; Chloroquine; Cyclohexylamines; Desipramine; Drug Interactions; Drug Resistance; Humans; Malaria, Falciparum; Molecular Structure; Plasmodium falciparum; Quinolines	1994
Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum. Molecular and biochemical parasitology, 1994, Volume: 63, Issue:1 Topics: Animals; Biological Transport, Active; Chloroquine; Desipramine; Drug Resistance; Humans; Hydrogen-Ion Concentration; Kinetics; Malaria, Falciparum; Plasmodium falciparum; Verapamil	1994
Enhancement of drug susceptibility in Plasmodium falciparum in vitro and Plasmodium berghei in vivo by mixed-function oxidase inhibitors. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:6 Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Desipramine; Drug Interactions; Drug Resistance, Microbial; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Mixed Function Oxygenases; Plasmodium berghei; Plasmodium falciparum	1993
Functional properties of the uptake of amines in immortalised peptidergic neurones (transport-P). British journal of pharmacology, 1996, Volume: 117, Issue:1 Topics: Adrenergic Uptake Inhibitors; Amines; Anti-Bacterial Agents; Cell Line; Chloroquine; Desipramine; Hydrogen-Ion Concentration; Hypothalamus; Ionophores; Macrolides; Neurons; Norepinephrine; Prazosin; Proton-Translocating ATPases; Reserpine; Sodium; Sodium-Potassium-Exchanging ATPase; Steroids; Temperature; Vanadates	1996
The contribution of lysosomal trapping in the uptake of desipramine and chloroquine by different tissues. Pharmacology & toxicology, 1995, Volume: 77, Issue:6 Topics: Adipose Tissue; Animals; Brain; Chloroquine; Desipramine; Diaphragm; Diazepam; In Vitro Techniques; Kidney; Liver; Lung; Lysosomes; Male; Microtomy; Muscle, Skeletal; Myocardium; Rats; Rats, Sprague-Dawley; Thiopental; Tissue Distribution	1995
Release of amines from acidified stores following accumulation by Transport-P. British journal of pharmacology, 2001, Volume: 132, Issue:4 Topics: Antidepressive Agents; Biological Transport; Boron Compounds; Cells, Cultured; Chloroquine; Desipramine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Hypothalamus; Monensin; Prazosin; Temperature	2001
Structural analysis of chloroquine resistance reversal by imipramine analogs. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:9 Topics: Animals; Antimalarials; Chloroquine; Desipramine; Drug Interactions; Drug Resistance; Humans; Imipramine; Models, Molecular; Parasitic Sensitivity Tests; Plasmodium falciparum	2001
The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum. Annals of tropical medicine and parasitology, 2006, Volume: 100, Issue:7 Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Chlorpheniramine; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Enzyme Inhibitors; Histamine H1 Antagonists; Orosomucoid; Plasmodium falciparum; Promethazine; Verapamil	2006
Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates. Toxicological sciences : an official journal of the Society of Toxicology, 2014, Volume: 139, Issue:1 Topics: Amiodarone; Animals; Anions; Azithromycin; Biliary Tract; Cells, Cultured; Chloroquine; Desipramine; Fluorobenzenes; Gentamicins; Hepatocytes; Male; Models, Biological; Phospholipids; Pyrimidines; Rats; Rats, Wistar; Rosuvastatin Calcium; Sulfonamides; Taurocholic Acid	2014