chloroquine and desethylchloroquine

chloroquine has been researched along with desethylchloroquine in 114 studies

Research

Studies (114)

Timeframe	Studies, this research(%)	All Research%
pre-1990	48 (42.11)	18.7374
1990's	30 (26.32)	18.2507
2000's	18 (15.79)	29.6817
2010's	14 (12.28)	24.3611
2020's	4 (3.51)	2.80

Authors

Authors	Studies
Bray, PG; Hawley, SR; O'Neill, PM; Park, BK; Storr, RC; Ward, SA; Willock, DJ	1
Bhattacharjee, AK; Dorn, A; Ellis, WY; Karle, JM; Matile, H; Ridley, RG; Vennerstrom, JL; Vippagunta, SR	1
Cooper, RA; Dodean, RA; Hinrichs, DJ; Janowsky, A; Johnson, RA; Kelly, JX; Lane, KD; Riscoe, M; Smilkstein, MJ; Winter, R	1
Batty, KT; Davis, TM; Ilett, KF; Karunajeewa, HA; Lammey, J; Law, I; Lin, E; Mueller, I; Page-Sharp, M; Siba, P	1
Bergqvist, Y; Kofoed, PE; Rodrigues, A; Rombo, L; Ursing, J	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Augustijns, P; Geusens, P; Verbeke, N	1
Augustijns, P; Verbeke, N	2
Iredale, J; Wainer, IW	1
Khalil, SK; Miller, DR; Nygard, GA	1
Augustijns, P; Jongsma, HW; Verbeke, N	1
Bourdon, R; Chevalier, P; Escande, C; Verdier, F	1
Clavier, F; Le Bras, J; Malhotra, K; Pocidalo, JJ; Pussard, E; Salmon, D; Verdier, F; Vilde, JL	1
Ajayi, FO; Kuye, JO; Salako, LA	2
Davis, DR; Hutton, DC; Rieckmann, KH	1
Björkman, A; Eriksson, O; Hellgren, U; Kihamia, CM; Mahikwano, LF; Rombo, L	1
Ericsson, O; Ofori-Adjei, D	1
Betschart, B; Steiger, S	1
Ajayi, FO; Salako, LA	1
Berry, C; Brown, J; Churchill, FC; Greenwood, BM; Miller, KD; White, NJ; Williams, SB	1
Druilhe, P; Gentilini, M; Stahel, E	1
Brandling-Bennett, AD; Churchill, FC; Kaseje, DC; Mount, DL; Patchen, LC; Roberts, JM; Steketee, RW; Williams, SB	1
Björkman, A; Ericsson, O; Rombo, L; Sego, E	1
Divo, AA; Geary, TG; Jensen, JB	1
Atouk, A; Gasquet, M; Samat, A; Timon-David, P; Viala, A	1
Churchill, FC; Mount, DL; Nahlen, BL; Patchen, LC	1
Aderounmu, AF; Salako, LA; Walker, O	1
Orjih, AU	1
Churchill, FC; Mount, DL; Patchen, LC; Williams, SB	1
Bergqvist, Y; Hellgren, U; Rombo, L	1
Campbell, CC; Heymann, DL; Khoromana, CO; Wirima, JJ	1
Björkman, A; Ericsson, O; Fu, S; Ofori-Adjei, D; Sjöqvist, F; Wåhlin, B	2
Ericsson, O; Kihamia, CM; Mahikwano, LF; Rombo, L; Sjöqvist, F	1
Bolaji, OO; Ogunbona, FA; Onyeji, CO; Torimiro, SE	1
Alván, G; Grahnén, A; Gustafsson, LL; Lindström, B	1
Benziger, DP; Brown, RR; Stroshane, RM	1
Adjepon-Yamoah, KK; Lindström, B; Ofori-Adjei, D; Woolhouse, NM	1
Bergqvist, Y; Ericsson, O; Rais, M	1
Bolaji, OO; Chukwuani, CM; Lawal, AA; Ogunbona, FA; Onyeji, CO	1
Ericsson, O; Lindström, B; Ofori-Adjei, D; Sjöqvist, F	1
Aderounmu, AF; Ekman, L; Lindström, B; Salako, LA; Walker, O	1
Adjepon-Yamoah, K; Ericsson, O; Hermansson, J; Lindström, B; Ofori-Adjei, D; Sjöqvist, F	1
Alván, G; Ekman, L; Ericsson, O; Lindström, B; Rais, M; Rombo, L; Sjöqvist, F	1
Alván, G; Ericsson, O; Gustafsson, LL; Lindström, B; Rombo, L; Sjöqvist, F	1
Bergqvist, Y; Frisk-Holmberg, M; Termond, E	1
Clavier, F; Hatin, I; Le Bras, J; Verdier, F	1
Aderounmu, AF	1
Bergqvist, Y; Domeij-Nyberg, B; Frisk-Holmberg, M; Termond, E	1
Aubert, C; Cano, JP; Delmont, J; Deturmeny, E; Durand, A; Estadieu, M; Viala, A	1
Adeyokunnu, AA; Alvan, G; Dawodu, AH; Salako, LA; Walker, O	1
Churchill, FC; Mount, DL; Patchen, LC; Schwartz, IK	1
Bergqvist, Y; Eckerbom, S	1
Blayo, MC; Clavier, F; Deloron, P; Verdier, F	1
Bergqvist, Y; Domeij-Nyberg, B	1
Alván, G; Beermann, B; Estevez, F; Gleisner, L; Gustafsson, LL; Lindström, B; Sjöqvist, F; Walker, O	1
Churchill, FC; Mount, DL; Schwartz, IK	1
Alván, G; Björkman, A; Gustafsson, LL; Lind, M; Rombo, L; Walker, O	1
Aderounmu, AF; Fleckenstein, L	1
Oosterhuis, B; Van Boxtel, CJ; Van den Berg, M; Wetsteyn, J	1
Costa, A; Eggelte, TA; Rosário, VE; Seixas, E; Vigário, AM	1
Karbwang, J; Limpaibul, L; Na-Bangchang, K; Tan-Ariya, P; Thanavibul, A	1
Bustos, MD; Diquet, B; Gay, F; Thomare, P; Warot, D	1
Ansari, AM; Craig, JC	1
Croes, K; Flanagan, RJ; McCarthy, PT	1
Fieger, H; Iredale, J; Wainer, IW	2
Alván, G; Hellgren, U; Jerling, M	1
Cutler, DJ; McLachlan, AJ; Tett, SE	1
Frisk, M; Gunnert, G	1
Brazier, JL; Chaulet, JF; Prevosto, JM; Robet, Y; Soares, O	1
Ademowo, OG; Walker, O	1
Berne, B; Johansson, M; Olsson, MJ; Rollman, O; Sjölin-Forsberg, G	1
Baird, JK; Candradikusuma, D; Fryauff, DJ; Leksana, B; Marwoto, H; Masbar, S; Richie, T; Romzan, A; Sutamihardja, MA; Tuti, S	1
Baird, JK; Fryauff, DJ; Leksana, B; Masbar, S; Subianto, B; Sutanihardja, MA	1
Baird, JK; Fryauff, DJ; Hoffman, SL; Leksana, B; Masbar, S; Sutanihardja, MA; Wignall, FS	1
Gay, F; Lazaro, E; Traore, B	1
Dua, VK; Gupta, NC; Kar, PK; Sharma, VP	1
Ademowo, OG; Sodeinde, O; Walker, O	1
Dua, VK; Gupta, NC; Sharma, VP	1
Blaschke, G; Müller, D	1
Crawley, J; Kokwaro, G; Marsh, K; Ouma, D; Watkins, W	1
Wu, H	1
Baethge, BA; Botstein, GR; Caldwell, J; Dietz, F; Ettlinger, R; Furst, DE; Gibbs, JP; Golden, HE; Lindsley, H; McLaughlin, GE; Moreland, LW; Munster, T; Roberts, WN; Rooney, TW; Rothschild, B; Sack, M; Sebba, AI; Shen, D; Weisman, M; Welch, KE; Yocum, D	1
Baune, B; Beaune, P; Ducharme, J; Farinotti, R; Flinois, JP; Projean, D; Taburet, AM	1
Baird, JK; Fryauff, DJ; Leksana, B; Subianto, B; Sumawinata, IW; Sutamihardja, A	1
Bagenda, D; Kalyesubula, I; Myers, C; Neely, M; Olness, K	1
Bolaji, OO; Chukwuani, MC; Makinde, ON; Ogunbona, FA; Onyeji, CO	1
Gerstner, U; Prajakwong, S; Sirichaisinthop, J; Wernsdorfer, G; Wernsdorfer, WH; Wiedermann, G	1
Burhenne, J; Fröhlich, M; Haefeli, WE; Hoppe-Tichy, T; Mikus, G; Müller, O; Rengelshausen, J; Riedel, KD; Singh, SK; Tayrouz, Y; Walter-Sack, I	1
Gourmel, B; Houzé, P; Houzé, S; Le bras, J; Le bricon, T; Lejeune, D; Souletie, I	1
Moraes de Oliveira, AR; Sueli Bonato, P	1
Amoura, Z; Aymard, G; Costedoat-Chalumeau, N; Francès, C; Hulot, JS; Lechat, P; Leroux, G; Piette, JC	1
Baiwog, F; Davis, TM; Gomorrai, S; Hackett, LP; Ilett, KF; Karunajeewa, HA; Law, I; Mueller, I; Page-Sharp, M	1
Fernandez, C; Greenwood, BM; Lee, SJ; McGready, R; Nosten, F; Paw, MK; Singhasivanon, P; Stepniewska, K; Thwai, KL; Viladpai-nguen, SJ; Villegas, L; White, NJ	1
Baiwog, F; Davis, TM; Gomorrai, S; Ilett, KF; Karunajeewa, HA; Law, I; Mueller, I; Page-Sharp, M; Rogerson, S; Salman, S; Siba, P	1
Cheomung, A; Na-Bangchang, K	1
Arromdee, E; Boonprasert, R; Chandranipapongse, W; Chatsiricharoenkul, S; Chiowchanwisawakit, P; Danwiriyakul, W; Katchamart, W; Koolvisoot, A; Nilganuwong, S; Pongnarin, P; Ruangvaravate, N; Srinonprasert, V	1
Alecrim, MG; Brasil, LW; Costa, MR; Lacerda, MV; Marques, MM; Monteiro, WM; Nascimento, MT; Nogueira, F; Reyes-Lecca, RC; Santana Filho, FS; Silveira, H; Vieira, JL	1
Blair-Trujillo, S; López-Córdoba, C; Yepes-Jiménez, N; Zuluaga-Idárraga, L	1
Adams, M; Billingsley, PF; Chakravarty, S; Dube, TJ; Edelman, R; Green, M; Hoffman, SL; James, E; Laurens, MB; Li, ML; Lyke, KE; Manoj, A; Plowe, CV; Ruben, A; Sim, BKL; Strauss, K	1
Farrar, J; Nguyen Duc Khanh, T; Nguyen Thanh Thuy, N; Nguyen Thuy Nha, C; Pham Nguyen, P; Pouplin, T; Thwaites, GE; Tran Tinh, H; Van Pham, T	1
Amalvict, R; Benoit, N; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA	1
Charlier, B; Dal Piaz, F; Fasano, S; Filippelli, A; Iudici, M; Izzo, V; Pantano, I; Pierro, L; Pingeon, M	1
Baiwog, F; Davis, TME; Ilett, KF; Karunajeewa, HA; Kose, K; Mueller, I; Page-Sharp, M; Rogerson, SJ; Salman, S; Siba, PM	1
Flexner, C; Ippolito, MM; Jacobson, JM; Lederman, MM; Shapiro, TA; Tarning, J; Winterberg, M	1
Amoura, Z; Combarel, D; Funck-Brentano, C; Lori, L; Noé, G; Seycha, A; Tissot, N; Zahr, N	1
de Ataide, MA; de Sena, LWP; Dias, RM; Ferreira, MVD; Mello, AGNC; Vieira, JLF	1
Abd-Rahman, AN; Chalon, S; Gobeau, N; Kümmel, A; Marquart, L; McCarthy, JS; Möhrle, JJ; Simpson, JA	1
Ge, W; Luo, X; Peng, Y	1
Baud, FJ; Clemessy, JL; Hoglund, RM; Megarbane, B; Tarning, J; Watson, JA; White, NJ	1
Brüggemann, RJ; Burger, DM; de Mast, Q; Frenzel, T; Koch, BCP; Moes, DJAR; Pickkers, P; Polderman, FN; Rahamat-Langedoen, JC; Reijers, MHE; Rettig, TCD; Schouten, J; Ter Heine, R; van 't Veer, NE; van de Veerdonk, FL; van der Linden, PD; van Kimmenade, RRJ; van Paassen, J; van Raalte, R; van Rhee, KP; van Rossum, M; Windsant-van den Tweel, AV	1

Reviews

1 review(s) available for chloroquine and desethylchloroquine

Article	Year
Diagnosis of resistance to chloroquine by Plasmodium vivax: timing of recurrence and whole blood chloroquine levels. The American journal of tropical medicine and hygiene, 1997, Volume: 56, Issue:6 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Malaria, Vivax; Male; Plasmodium vivax; Recurrence	1997

Trials

13 trial(s) available for chloroquine and desethylchloroquine

Article	Year
Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:1 Topics: Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Papua New Guinea; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Quinolines; Sesquiterpenes; Sulfadoxine; Treatment Outcome	2008
Disposition of chloroquine in man after single intravenous and oral doses. British journal of clinical pharmacology, 1983, Volume: 15, Issue:4 Topics: Administration, Oral; Adult; Audiometry; Chloroquine; Chromatography, High Pressure Liquid; Deglutition Disorders; Drug Evaluation; Erythrocytes; Humans; Infusions, Parenteral; Male; Metabolic Clearance Rate; Tablets; Time Factors; Tissue Distribution	1983
On the question of dose-dependent chloroquine elimination of a single oral dose. Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:3 Topics: Adolescent; Adult; Chloroquine; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Middle Aged; Time Factors	1983
The pharmacokinetics of chloroquine in healthy Thai subjects and patients with Plasmodium vivax malaria. British journal of clinical pharmacology, 1994, Volume: 38, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Animals; Chloroquine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Malaria, Vivax; Male; Thailand	1994
The pharmacokinetics and electrocardiographic effects of chloroquine in healthy subjects. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1994, Volume: 45, Issue:2 Topics: Adult; Chloroquine; Electrocardiography; Follow-Up Studies; Heart; Humans; Male	1994
Stereoselective pharmacokinetic properties of chloroquine and de-ethyl-chloroquine in humans. Clinical pharmacokinetics, 1993, Volume: 24, Issue:3 Topics: Administration, Oral; Albumins; Analysis of Variance; Chloroquine; Humans; Orosomucoid; Protein Binding; Stereoisomerism	1993
Chloroquine is not a risk factor for seizures in childhood cerebral malaria. Tropical medicine & international health : TM & IH, 2000, Volume: 5, Issue:12 Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Double-Blind Method; Female; Humans; Infant; Logistic Models; Malaria, Cerebral; Male; Risk Factors; Seizures	2000
Comparison of the in-vitro activity of amodiaquine and its main metabolite, monodesethyl-amodiaquine, in Plasmodium falciparum. Wiener klinische Wochenschrift, 2003, Volume: 115 Suppl 3 Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Cell Proliferation; Chloroquine; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Plasmodium falciparum; Species Specificity; Thailand	2003
Pharmacokinetic interaction of chloroquine and methylene blue combination against malaria. European journal of clinical pharmacology, 2004, Volume: 60, Issue:10 Topics: Administration, Oral; Adult; Anti-Infective Agents, Urinary; Antimalarials; Area Under Curve; Chloroquine; Drug Interactions; Female; Half-Life; Humans; Malaria, Falciparum; Male; Methylene Blue	2004
Pharmacokinetics of chloroquine and monodesethylchloroquine in pregnancy. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3 Topics: Adolescent; Adult; Antimalarials; Area Under Curve; Bayes Theorem; Chloroquine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Malaria, Falciparum; Models, Biological; Papua New Guinea; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Treatment Outcome; Young Adult	2010
Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection. The American journal of tropical medicine and hygiene, 2015, Volume: 93, Issue:6 Topics: Adult; Antibodies, Protozoan; Antimalarials; Chloroquine; Cryopreservation; Female; Humans; Injections, Intradermal; Malaria, Falciparum; Male; Patient Safety; Plasmodium falciparum; Sporozoites; Young Adult	2015
Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 10-30, Volume: 67, Issue:10 Topics: Adult; Alkynes; Anti-Retroviral Agents; Antimalarials; Antiretroviral Therapy, Highly Active; Benzoxazines; Chloroquine; Cyclopropanes; Drug Interactions; Female; HIV Infections; Humans; Malaria; Male; Middle Aged; Protease Inhibitors	2018
Population Pharmacokinetics and Pharmacodynamics of Chloroquine in a Plasmodium vivax Volunteer Infection Study. Clinical pharmacology and therapeutics, 2020, Volume: 108, Issue:5 Topics: Administration, Oral; Adult; Antimalarials; Biotransformation; Chloroquine; Drug Dosage Calculations; Drug Resistance; Female; Humans; Malaria, Vivax; Male; Models, Biological; Parasite Load; Plasmodium vivax; Treatment Outcome; Young Adult	2020

Other Studies

100 other study(ies) available for chloroquine and desethylchloroquine

Article	Year
Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues. Journal of medicinal chemistry, 1997, Feb-14, Volume: 40, Issue:4 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Heme; Humans; Models, Molecular; Plasmodium falciparum	1997
Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth. Journal of medicinal chemistry, 1999, Nov-04, Volume: 42, Issue:22 Topics: Animals; Antimalarials; Biopolymers; Chloroquine; Colorimetry; Depression, Chemical; Hemin; Inhibitory Concentration 50; Models, Molecular; Plasmodium falciparum; Structure-Activity Relationship	1999
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Acridones; Animals; Antimalarials; Cell Survival; Cells, Cultured; Drug Design; Drug Interactions; Drug Resistance, Multiple; Lymphocytes; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Molecular Structure; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Structure-Activity Relationship	2007
Chloroquine is grossly overdosed and overused but well tolerated in Guinea-bissau. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1 Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Female; Guinea-Bissau; Humans; Infant; Male; Surveys and Questionnaires	2009
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Chloroquine levels in blood during chronic treatment of patients with rheumatoid arthritis. European journal of clinical pharmacology, 1992, Volume: 42, Issue:4 Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Proteins; Chloroquine; Female; Humans; Isomerism; Male; Middle Aged; Protein Binding; Retrospective Studies; Time Factors	1992
Stereoselectivity in the disposition of chloroquine and desethylchloroquine in rabbits. Arzneimittel-Forschung, 1992, Volume: 42, Issue:6 Topics: Animals; Chloroquine; Female; Half-Life; Injections, Intramuscular; Male; Rabbits; Stereoisomerism; Tissue Distribution	1992
Determination of hydroxychloroquine and its major metabolites in plasma using sequential achiral-chiral high-performance liquid chromatography. Journal of chromatography, 1992, Jan-17, Volume: 573, Issue:2 Topics: Animals; Biological Availability; Chloroquine; Chromatography, High Pressure Liquid; Hydroxychloroquine; Male; Rabbits; Spectrophotometry, Ultraviolet; Stereoisomerism	1992
Steady-state pharmacokinetics of hydroxychloroquine in rheumatoid arthritis patients. DICP : the annals of pharmacotherapy, 1991, Volume: 25, Issue:12 Topics: Administration, Oral; Arthritis, Rheumatoid; Chloroquine; Female; Half-Life; Humans; Hydroxychloroquine; Male	1991
Transplacental distribution of chloroquine in sheep. Developmental pharmacology and therapeutics, 1991, Volume: 17, Issue:3-4 Topics: Animals; Chloroquine; Female; Fetus; Half-Life; Injections, Intramuscular; Maternal-Fetal Exchange; Placenta; Pregnancy; Sheep	1991
Sensitive radioimmunoassay and enzyme-linked immunosorbent assay for the simultaneous determination of chloroquine and its metabolites in biological fluids. Journal of pharmaceutical sciences, 1990, Volume: 79, Issue:1 Topics: Animals; Chloroquine; Enzyme-Linked Immunosorbent Assay; Haptens; Humans; Indicators and Reagents; Iodine Radioisotopes; Polylysine; Rabbits; Radioimmunoassay; Swine	1990
Absence of effect of chloroquine in vivo on neutrophil oxidative metabolism in human subjects. The Journal of antimicrobial chemotherapy, 1990, Volume: 25, Issue:3 Topics: Administration, Oral; Adult; Chloroquine; Female; Humans; Luminescent Measurements; Male; Middle Aged; Neutrophils; Oxidation-Reduction	1990
Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. African journal of medicine and medical sciences, 1989, Volume: 18, Issue:2 Topics: Adolescent; Adult; Animals; Child; Chloroquine; Erythrocytes; Female; Humans; Kinetics; Malaria; Male; Plasma; Plasmodium falciparum; Time Factors	1989
Plasmodium vivax resistance to chloroquine? Lancet (London, England), 1989, Nov-18, Volume: 2, Issue:8673 Topics: Acute Disease; Animals; Antimalarials; Blood Specimen Collection; Chloroquine; Dapsone; Drug Administration Schedule; Drug Combinations; Drug Evaluation; Drug Resistance; Humans; Malaria; Male; Papua New Guinea; Plasmodium vivax; Pyrimethamine	1989
Response of Plasmodium falciparum to chloroquine treatment: relation to whole blood concentrations of chloroquine and desethylchloroquine. Bulletin of the World Health Organization, 1989, Volume: 67, Issue:2 Topics: Adolescent; Animals; Child; Chloroquine; Humans; Malaria; Plasmodium falciparum	1989
Chloroquine in nail clippings. Lancet (London, England), 1985, Aug-10, Volume: 2, Issue:8450 Topics: Chloroquine; Humans; Nails; Time Factors	1985
Quantitative determination of chloroquine and desethylchloroquine in biological fluids by high performance thin layer chromatography. Acta tropica, 1986, Volume: 43, Issue:2 Topics: Chloroquine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Spectrometry, Fluorescence	1986
Distribution and urinary excretion of the desethylmetabolites of chloroquine in the rat. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:10 Topics: Animals; Chloroquine; Dealkylation; Female; Male; Rats; Tissue Distribution	1987
Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations. The New England journal of medicine, 1988, Dec-08, Volume: 319, Issue:23 Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Administration Schedule; Humans; Hypotension; Infant; Infusions, Intravenous; Injections, Intramuscular; Injections, Subcutaneous; Intubation, Gastrointestinal; Malaria; Plasmodium falciparum; Prospective Studies	1988
Antagonism of chloroquine with other antimalarials. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:2 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Interactions; Drug Resistance; Mefloquine; Plasmodium falciparum; Pyrimethamine; Quinine; Quinolines; Sesquiterpenes; Sulfadoxine	1988
Field application of a colorimetric method of assaying chloroquine and desethylchloroquine in urine. Bulletin of the World Health Organization, 1988, Volume: 66, Issue:4 Topics: Adolescent; Chloroquine; Chromatography, High Pressure Liquid; Colorimetry; Female; Humans	1988
Whole blood concentrations of chloroquine and desethylchloroquine during and after treatment of adult patients infected with Plasmodium vivax, P. ovale or P. malariae. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1986, Volume: 80, Issue:5 Topics: Adult; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Plasmodium malariae; Plasmodium vivax; Time Factors	1986
Activity of quinoline-containing antimalarials against chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Microbial Sensitivity Tests; Plasmodium falciparum; Primaquine; Quinolines	1987
In vitro chemosensitivity of Plasmodium falciparum to four chloroquine derivatives. Annals of tropical medicine and parasitology, 1987, Volume: 81, Issue:4 Topics: Animals; Chloroquine; Microbial Sensitivity Tests; Plasmodium falciparum	1987
Antimalarial activity of bisdesethylchloroquine against P. falciparum and P. berghei berghei. Annals of tropical medicine and parasitology, 1987, Volume: 81, Issue:4 Topics: Animals; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum	1987
Field-adapted method for high-performance thin-layer chromatographic detection and estimation of chloroquine and desethylchloroquine in urine. Journal of chromatography, 1987, Dec-25, Volume: 423 Topics: Child, Preschool; Chloroquine; Chromatography, Thin Layer; Female; Humans; Indicators and Reagents; Male; Spectrophotometry, Ultraviolet	1987
Influence of route of administration on the pharmaco-kinetics of chloroquine and desethylchloroquine. Bulletin of the World Health Organization, 1987, Volume: 65, Issue:1 Topics: Administration, Oral; Adult; Chloroquine; Humans; Injections, Intramuscular; Kinetics; Male	1987
Increased accumulation of chloroquine and desethylchloroquine in homozygous sickle cells. Bulletin of the World Health Organization, 1987, Volume: 65, Issue:1 Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Chloroquine; Erythrocytes, Abnormal; Female; Genotype; Hemoglobin, Sickle; Humans; Male	1987
Colorimetric and thin-layer chromatographic methods for field assay of chloroquine and its metabolites in urine. Bulletin of the World Health Organization, 1987, Volume: 65, Issue:5 Topics: Chloroquine; Chromatography, Thin Layer; Colorimetry; Humans	1987
Chloroquine and desethylchloroquine concentrations during regular long-term malaria prophylaxis. Bulletin of the World Health Organization, 1987, Volume: 65, Issue:6 Topics: Adult; Chloroquine; Chromatography, High Pressure Liquid; Female; Humans; Malaria; Male	1987
In vivo efficacy of chloroquine treatment for Plasmodium falciparum in Malawian children under five years of age. The American journal of tropical medicine and hygiene, 1986, Volume: 35, Issue:3 Topics: Administration, Oral; Child, Preschool; Chloroquine; Drug Evaluation; Humans; Malaria; Malawi; Plasmodium falciparum	1986
In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum. British journal of clinical pharmacology, 1986, Volume: 22, Issue:1 Topics: Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Naphthyridines; Plasmodium falciparum; Stereoisomerism	1986
Concentrations of chloroquine and desethylchloroquine in capillary blood dried on filter paper during and after treatment of Tanzanian children infected with Plasmodium falciparum. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1986, Volume: 37, Issue:3 Topics: Adolescent; Child; Chloroquine; Chromatography, Liquid; Humans; Kinetics; Malaria; Plasmodium falciparum; Tanzania	1986
[In vitro activity of chloroquine, two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum]. Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1986, Volume: 4, Issue:4 Topics: Animals; Chloroquine; Drug Resistance; Isomerism; Naphthyridines; Plasmodium falciparum	1986
Excretion of chloroquine and desethylchloroquine in human milk. British journal of clinical pharmacology, 1987, Volume: 23, Issue:4 Topics: Chloroquine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Hydrogen-Ion Concentration; Milk, Human; Saliva; Spectrophotometry, Ultraviolet	1987
Chloroquine excretion following malaria prophylaxis. British journal of clinical pharmacology, 1987, Volume: 24, Issue:2 Topics: Adult; Chloroquine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Malaria; Male	1987
High-performance liquid chromatographic assay for hydroxychloroquine and three of its major metabolites, desethylhydroxychloroquine, desethylchloroquine and bidesethylchloroquine, in human plasma. Journal of chromatography, 1986, Apr-25, Volume: 377 Topics: Chloroquine; Chromatography, High Pressure Liquid; Freezing; Humans; Hydroxychloroquine	1986
Whole-blood single-dose kinetics of chloroquine and desethylchloroquine in Africans. Therapeutic drug monitoring, 1986, Volume: 8, Issue:2 Topics: Administration, Oral; Adult; Black People; Chloroquine; Ghana; Half-Life; Humans; Kinetics; Male; Middle Aged	1986
Determination of chloroquine in dried blood spots on filter paper: importance of sample handling. Therapeutic drug monitoring, 1986, Volume: 8, Issue:2 Topics: Chloroquine; Chromatography, High Pressure Liquid; Filtration; Humans; Mass Spectrometry; Specimen Handling	1986
Liquid chromatographic analysis of chloroquine and desethylchloroquine in human plasma, saliva and urine. Journal of chromatography, 1986, Aug-02, Volume: 380, Issue:2 Topics: Chloroquine; Chromatography, High Pressure Liquid; Humans; Kinetics; Saliva; Spectrophotometry, Ultraviolet	1986
Protein binding of chloroquine enantiomers and desethylchloroquine. British journal of clinical pharmacology, 1986, Volume: 22, Issue:3 Topics: Chloroquine; Humans; Protein Binding; Stereoisomerism	1986
Comparison of the pharmacokinetics of chloroquine after single intravenous and intramuscular administration in healthy Africans. British journal of clinical pharmacology, 1986, Volume: 22, Issue:5 Topics: Adult; Chloroquine; Humans; Infusions, Intravenous; Injections, Intramuscular; Kinetics; Male; Nigeria	1986
Enantioselective analysis of chloroquine and desethylchloroquine after oral administration of racemic chloroquine. Therapeutic drug monitoring, 1986, Volume: 8, Issue:4 Topics: Adult; Chloroquine; Chromatography, High Pressure Liquid; Humans; Kinetics; Male; Middle Aged; Protein Binding; Stereoisomerism	1986
Determination of chloroquine and its desethyl metabolite in whole blood: an application for samples collected in capillary tubes and dried on filter paper. Therapeutic drug monitoring, 1985, Volume: 7, Issue:2 Topics: Blood Specimen Collection; Chloroquine; Chromatography, High Pressure Liquid; Humans; Paper	1985
Chloroquine and desethylchloroquine in plasma, serum, and whole blood: problems in assay and handling of samples. Therapeutic drug monitoring, 1985, Volume: 7, Issue:2 Topics: Blood Specimen Collection; Centrifugation; Chloroquine; Chromatography, Liquid; Humans; Plasma; Spectrometry, Fluorescence	1985
Further support for changes in chloroquine disposition and metabolism between a low and a high dose. European journal of clinical pharmacology, 1985, Volume: 28, Issue:6 Topics: Aged; Arthritis, Rheumatoid; Chloroquine; Creatinine; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Kinetics; Metabolic Clearance Rate; Middle Aged	1985
Blood levels and in vitro activity of desethylchloroquine against Plasmodium falciparum. Lancet (London, England), 1984, May-26, Volume: 1, Issue:8387 Topics: Africa, Western; Chloroquine; Humans; Plasmodium falciparum	1984
In vitro assessment of the antimalarial activity of chloroquine and its major metabolites. Annals of tropical medicine and parasitology, 1984, Volume: 78, Issue:6 Topics: Chloroquine; Drug Resistance, Microbial; Microbial Sensitivity Tests; Plasmodium falciparum	1984
The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects. European journal of clinical pharmacology, 1984, Volume: 26, Issue:4 Topics: Administration, Oral; Adult; Chloroquine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Kinetics; Malaria; Male; Rheumatic Diseases	1984
Determination of chloroquine and monodesethylchloroquine in hair. Journal of forensic sciences, 1983, Volume: 28, Issue:4 Topics: Chloroquine; Chromatography, Gas; Chromatography, Thin Layer; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; Time Factors	1983
Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria. British journal of clinical pharmacology, 1983, Volume: 16, Issue:6 Topics: Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria	1983
Analysis of filter-paper-absorbed, finger-stick blood samples for chloroquine and its major metabolite using high-performance liquid chromatography with fluorescence detection. Journal of chromatography, 1983, Nov-11, Volume: 278, Issue:1 Topics: Blood Specimen Collection; Chloroquine; Chromatography, High Pressure Liquid; Filtration; Humans; Male; Spectrometry, Fluorescence; Time Factors	1983
An improved gas chromatographic method for the simultaneous determination of chloroquine and two metabolites using capillary columns. Journal of chromatography, 1984, Mar-09, Volume: 306 Topics: Biotransformation; Chloroquine; Chromatography, Gas; Humans	1984
[Distribution of chloroquine and desethylchloroquine in blood, plasma and erythrocytes of healthy subjects and malaria patients. Assay using HPLC]. Pathologie-biologie, 1984, Volume: 32, Issue:5 Topics: Chloroquine; Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Malaria; Male; Plasma	1984
Distribution of chloroquine and its metabolite desethyl-chloroquine in human blood cells and its implication for the quantitative determination of these compounds in serum and plasma. Journal of chromatography, 1983, Jan-14, Volume: 272, Issue:1 Topics: Arthritis, Rheumatoid; Blood Platelets; Cell Separation; Chloroquine; Chromatography, High Pressure Liquid; Erythrocytes; Granulocytes; Humans	1983
Determination of chloroquine and its major metabolite in blood using perfluoroacylation followed by fused-silica capillary gas chromatography with nitrogen-sensitive detection. Journal of chromatography, 1983, May-13, Volume: 274 Topics: Chloroquine; Chromatography, Gas; Drug Resistance, Microbial; Gas Chromatography-Mass Spectrometry; Humans; Malaria; Methods; Time Factors	1983
Pharmacokinetics of chloroquine diphosphate in the dog. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3 Topics: Absorption; Administration, Oral; Animals; Antimalarials; Chloroquine; Chromatography, Thin Layer; Dogs; Injections, Intravenous; Kinetics; Male	1983
HPLC-analysis and preliminary pharmacokinetic parameter estimations of chloroquine. Pharmaceutisch weekblad. Scientific edition, 1981, Dec-18, Volume: 3, Issue:6 Topics: Chloroquine; Chromatography, High Pressure Liquid; Half-Life; Humans; Kinetics; Labetalol	1981
Investigation of chloroquine intake in Biombo region, Guinea Bissau. Applied parasitology, 1994, Volume: 35, Issue:4 Topics: Animals; Chloroquine; Chromatography, High Pressure Liquid; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Guinea-Bissau; Humans; Malaria; Plasmodium falciparum	1994
Metabolites of chloroquine: some observations on desethylchloroquine and N-acetyldesethylchloroquine. Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:7 Topics: Acetylation; Chloroquine; Chromatography, Thin Layer; Circular Dichroism; Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stereoisomerism	1994
Simple and rapid HPLC of quinine, hydroxychloroquine, chloroquine, and desethylchloroquine in serum, whole blood, and filter paper-adsorbed dry blood. Journal of analytical toxicology, 1994, Volume: 18, Issue:5 Topics: Adsorption; Chloroquine; Chromatography, High Pressure Liquid; Humans; Hydroxychloroquine; Quinine; Sensitivity and Specificity; Specimen Handling	1994
Determination of the stereoisomers of hydroxychloroquine and its major metabolites in plasma and urine following a single oral administration of racemic hydroxychloroquine. Seminars in arthritis and rheumatism, 1993, Volume: 23, Issue:2 Suppl 1 Topics: Chloroquine; Humans; Hydroxychloroquine; Male; Stereoisomerism; Time Factors	1993
On the question of interindividual variations in chloroquine concentrations. European journal of clinical pharmacology, 1993, Volume: 45, Issue:4 Topics: Adult; Child; Chloroquine; Drug Monitoring; Humans; Malaria; Rheumatic Diseases	1993
Enantioselective determination of hydroxychloroquine and its major metabolites in urine and the observation of a reversal in the (+)/(-)-hydroxychloroquine ratio. Chirality, 1993, Volume: 5, Issue:2 Topics: Chloroquine; Chromatography, High Pressure Liquid; Humans; Hydroxychloroquine; Stereoisomerism	1993
Plasma protein binding of the enantiomers of hydroxychloroquine and metabolites. European journal of clinical pharmacology, 1993, Volume: 44, Issue:5 Topics: Blood Proteins; Chloroquine; Humans; Hydroxychloroquine; Protein Binding; Stereoisomerism	1993
Chloroquine in malaria. Isn't it time for revision of prophylaxis schedules? European journal of clinical pharmacology, 1993, Volume: 44, Issue:3 Topics: Chloroquine; Clinical Protocols; Drug Administration Schedule; Female; Humans; Malaria; Male; Sweden	1993
Simultaneous determination of chloroquine and quinine in human biological fluids by high-performance liquid chromatography. Journal of chromatography, 1993, Apr-02, Volume: 613, Issue:2 Topics: Chloroquine; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Indicators and Reagents; Plasma; Quinine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet	1993
A rapid, cost-effective liquid chromatographic method for the determination of chloroquine and desethylchloroquine in biological fluids. Therapeutic drug monitoring, 1996, Volume: 18, Issue:1 Topics: Antimalarials; Calibration; Chloroquine; Chromatography, High Pressure Liquid; Cost-Benefit Analysis; Humans; Spectrophotometry, Ultraviolet	1996
Differential uptake of chloroquine by human keratinocytes and melanocytes in culture. Archives of dermatological research, 1996, Volume: 288, Issue:4 Topics: Adult; Cells, Cultured; Chloroquine; Chromatography, High Pressure Liquid; Female; Humans; Infant, Newborn; Keratinocytes; Male; Melanocytes	1996
Survey of in vivo sensitivity to chloroquine by Plasmodium falciparum and P. vivax in Lombok, Indonesia. The American journal of tropical medicine and hygiene, 1997, Volume: 56, Issue:2 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Indonesia; Malaria, Falciparum; Malaria, Vivax; Middle Aged; Parasitemia; Plasmodium falciparum; Plasmodium vivax; Prevalence; Recurrence; Treatment Outcome	1997
Whole blood chloroquine concentrations with Plasmodium vivax infection in Irian Jaya, Indonesia. The American journal of tropical medicine and hygiene, 1997, Volume: 56, Issue:6 Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Chromatography, High Pressure Liquid; Female; Humans; Indonesia; Malaria, Vivax; Male; Middle Aged	1997
A bioassay for evaluating antimalarial activity and for measuring concentration in plasma. Tropical medicine & international health : TM & IH, 1997, Volume: 2, Issue:10 Topics: Adolescent; Adult; Biological Assay; Child; Chloroquine; Chromatography, High Pressure Liquid; Humans; Malaria, Falciparum; Middle Aged	1997
Determination of chloroquine and desethylchloroquine in plasma and blood cells of Plasmodium vivax malaria cases using liquid chromatography. Journal of pharmaceutical and biomedical analysis, 1999, Volume: 21, Issue:1 Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Drug Stability; Humans; Malaria, Vivax; Middle Aged; Reproducibility of Results	1999
The disposition of chloroquine and its main metabolite desethylchloroquine in volunteers with and without chloroquine-induced pruritus: evidence for decreased chloroquine metabolism in volunteers with pruritus. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:3 Topics: Adult; Antimalarials; Area Under Curve; Chloroquine; Chromatography, High Pressure Liquid; Humans; Male; Pruritus	2000
Chloroquine concentration profile in the community of Mewat region, district Gurgaon (Haryana), India. The Southeast Asian journal of tropical medicine and public health, 1999, Volume: 30, Issue:2 Topics: Adult; Antimalarials; Body Weight; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Humans; India; Malaria, Falciparum; Malaria, Vivax	1999
Enantioselective assay of chloroquine and its main metabolite deethyl chloroquine in human plasma by capillary electrophoresis. Journal of chromatographic science, 2000, Volume: 38, Issue:10 Topics: Antimalarials; Calibration; Chloroquine; Electrophoresis, Capillary; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism	2000
[Determination of chloroquine in human urine]. Fa yi xue za zhi, 1998, Volume: 14, Issue:4 Topics: Chloroquine; Chromatography, Gas; Humans	1998
Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis. Arthritis and rheumatism, 2002, Volume: 46, Issue:6 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Eye Diseases; Gastrointestinal Diseases; Humans; Hydroxychloroquine; Logistic Models; Multicenter Studies as Topic; Oxidation-Reduction; Randomized Controlled Trials as Topic; Retrospective Studies; Severity of Illness Index	2002
In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:6 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cells, Cultured; Chloroquine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Insecta; Isoenzymes; Kinetics; Microsomes, Liver; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Transfection	2003
Very high risk of therapeutic failure with chloroquine for uncomplicated Plasmodium falciparum and P. vivax malaria in Indonesian Papua. The American journal of tropical medicine and hygiene, 2003, Volume: 68, Issue:4 Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Indonesia; Life Tables; Malaria, Falciparum; Malaria, Vivax; Parasitemia; Recurrence; Risk Factors; Treatment Failure	2003
Effect of chloroquine on human immunodeficiency virus (HIV) vertical transmission. African health sciences, 2003, Volume: 3, Issue:2 Topics: Animals; Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Cohort Studies; Female; Fetal Blood; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Malaria, Falciparum; Pregnancy; Pregnancy Complications, Infectious; Uganda	2003
Evidence for increased metabolism of chloroquine during the early third trimester of human pregnancy. Tropical medicine & international health : TM & IH, 2004, Volume: 9, Issue:5 Topics: Adult; Antimalarials; Chloroquine; Female; Humans; Pregnancy; Pregnancy Trimester, Third	2004
Simultaneous determination of monodesethylchloroquine, chloroquine, cycloguanil and proguanil on dried blood spots by reverse-phase liquid chromatography. Journal of pharmaceutical and biomedical analysis, 2007, Feb-19, Volume: 43, Issue:3 Topics: Antimalarials; Calibration; Chloroquine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Proguanil; Quality Control; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Triazines	2007
Stereoselective determination of hydroxychloro-quine and its major metabolites in human urine by solid-phase microextraction and HPLC. Journal of separation science, 2007, Volume: 30, Issue:15 Topics: Calibration; Chemistry Techniques, Analytical; Chloroquine; Chromatography; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Hydroxychloroquine; Methanol; Models, Chemical; Reproducibility of Results; Solid Phase Extraction; Stereoisomerism; Temperature; Time Factors	2007
Relationship between blood hydroxychloroquine and desethylchloroquine concentrations and cigarette smoking in treated patients with connective tissue diseases. Annals of the rheumatic diseases, 2007, Volume: 66, Issue:11 Topics: Adult; Antirheumatic Agents; Chloroquine; Connective Tissue Diseases; Female; Humans; Hydroxychloroquine; Male; Middle Aged; Smoking	2007
Transfer of chloroquine and desethylchloroquine across the placenta and into milk in Melanesian mothers. British journal of clinical pharmacology, 2008, Volume: 65, Issue:5 Topics: Adult; Antimalarials; Area Under Curve; Breast Feeding; Chloroquine; Chromatography, High Pressure Liquid; Female; Humans; Malaria, Falciparum; Maternal-Fetal Exchange; Melanesia; Milk, Human; Placenta; Pregnancy; Pregnancy Complications, Parasitic	2008
Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria. European journal of clinical pharmacology, 2008, Volume: 64, Issue:10 Topics: Acute Disease; Adolescent; Adult; Animals; Antimalarials; Area Under Curve; Chloroquine; Female; Humans; Malaria, Vivax; Plasmodium vivax; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Outcome; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Retrospective Studies; Thailand; Young Adult	2008
HPLC with ultraviolet detection for the determination of chloroquine and desethylchloroquine in whole blood and finger-prick capillary blood dried on filter paper. Journal of pharmaceutical and biomedical analysis, 2011, Jul-15, Volume: 55, Issue:5 Topics: Animals; Blood; Calibration; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chloroquine; Chromatography; Chromatography, High Pressure Liquid; Clinical Chemistry Tests; Humans; Models, Chemical; Plasmodium vivax; Quality Control; Quinine; Reproducibility of Results; Spectrophotometry, Ultraviolet; Ultraviolet Rays	2011
Prevalence and risk factors for chloroquine maculopathy and role of plasma chloroquine and desethylchloroquine concentrations in predicting chloroquine maculopathy. International journal of rheumatic diseases, 2013, Volume: 16, Issue:1 Topics: Antirheumatic Agents; Chloroquine; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Prevalence; Retinal Diseases; Risk Factors; Tandem Mass Spectrometry; Thailand	2013
Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:1 Topics: Anemia; Antimalarials; Brazil; Chloroquine; Drug Resistance; Female; Humans; Malaria, Vivax; Male; Plasmodium vivax	2014
Validation of a method for the simultaneous quantification of chloroquine, desethylchloroquine and primaquine in plasma by HPLC-DAD. Journal of pharmaceutical and biomedical analysis, 2014, Volume: 95 Topics: Calibration; Chloroquine; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Malaria, Vivax; Primaquine	2014
An HPLC method with diode array detector for the simultaneous quantification of chloroquine and desethylchloroquine in plasma and whole blood samples from Plasmodium vivax patients in Vietnam, using quinine as an internal standard. Biomedical chromatography : BMC, 2016, Volume: 30, Issue:7 Topics: Chloroquine; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Malaria, Vivax; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Vietnam	2016
Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:8 Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Lumefantrine; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Quinine; Quinolines; Senegal; Ubiquitin-Protein Ligases	2016
Health status and concomitant prescription of immunosuppressants are risk factors for hydroxychloroquine non-adherence in systemic lupus patients with prolonged inactive disease. Lupus, 2018, Volume: 27, Issue:2 Topics: Adult; Antirheumatic Agents; Chloroquine; Female; Health Status; Humans; Hydroxychloroquine; Immunosuppressive Agents; Italy; Lupus Erythematosus, Systemic; Male; Middle Aged; Patient Reported Outcome Measures; Quality of Life; Risk Factors; Self-Assessment; Severity of Illness Index; Treatment Adherence and Compliance	2018
Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling. International journal of antimicrobial agents, 2017, Volume: 50, Issue:4 Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Female; Humans; Malaria, Falciparum; Metabolic Clearance Rate; Models, Biological; Papua New Guinea; Plasmodium falciparum; Pregnancy; Pyrimethamine; Sulfadoxine	2017
Development and Validation of a Fast Ultra-High Performance Liquid Chromatography-Fluorescent Method for the Quantification of Hydroxychloroquine and Its Metabolites in Patients With Lupus. Therapeutic drug monitoring, 2019, Volume: 41, Issue:4 Topics: Antirheumatic Agents; Calibration; Chloroquine; Chromatography, High Pressure Liquid; Drug Monitoring; Fluorescence; Humans; Hydroxychloroquine; Indicators and Reagents; Lupus Erythematosus, Systemic; Reproducibility of Results	2019
Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin. Malaria journal, 2019, Dec-21, Volume: 18, Issue:1 Topics: Adolescent; Antimalarials; Brazil; Child; Child, Preschool; Chloroquine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Malaria, Vivax; Male; Plasmodium vivax	2019
A Sensitive and Optimized HPLC-FLD Method for the Simultaneous Quantification of Hydroxychloroquine and Its Two Metabolites in Blood of Systemic Lupus Erythematosus Patients. Journal of chromatographic science, 2020, Jul-24, Volume: 58, Issue:7 Topics: Adult; Chloroquine; Chromatography, High Pressure Liquid; Female; Humans; Hydroxychloroquine; Linear Models; Lupus Erythematosus, Systemic; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Young Adult	2020
Concentration-dependent mortality of chloroquine in overdose. eLife, 2020, 07-08, Volume: 9 Topics: Adult; Antimalarials; Biotransformation; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Dose-Response Relationship, Drug; Drug Overdose; Drug Repositioning; Electrocardiography; Female; Heart Diseases; Humans; Hydroxychloroquine; Long QT Syndrome; Malaria; Male; Pandemics; Pneumonia, Viral; Randomized Controlled Trials as Topic; Risk Assessment; Suicide; Suicide, Attempted	2020
Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals. International journal of antimicrobial agents, 2021, Volume: 57, Issue:3 Topics: Aged; Chloroquine; COVID-19 Drug Treatment; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; SARS-CoV-2	2021