chloroquine and deferoxamine

chloroquine has been researched along with deferoxamine in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19904 (14.29)18.7374
1990's9 (32.14)18.2507
2000's5 (17.86)29.6817
2010's8 (28.57)24.3611
2020's2 (7.14)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Glen, RC; Lowe, R; Mitchell, JB1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Gehrke, SS; Hider, RC; Pinto, EG; Pleban, K; Steverding, D; Tempone, AG; Wagner, GK1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Bai, R; Jiang, X; Xie, Y; Zhou, T1
Bienzle, U; Chaves, MF; Kremsner, PG; Neifer, S; Rudolph, R1
Avramovici-Grisaru, S; Iheanacho, EN; Samuni, A; Sarel, S; Spira, DT1
Carnevale, P; Desfontaine, M; Elion, J; Kaptue-Noche, L; Labie, D; M'Bede, J; Nagel, RL; Traore, O1
Beug, H; Birnstiel, ML; Cotten, M; Kirlappos, H; Längle-Rouault, F; Mechtler, K; Wagner, E; Zenke, M1
Larricart, P1
Gekker, G; Keane, WF; Peterson, PK; Schlievert, PM1
Farber, JL; Gilbertson, JD; Starke, PE1
Deppe, WM; Joubert, SM; Shanley, BC; Stewart-Wynne, EG; Taljaard, JJ1
Thompson, DF1
Brunner, G; Deepe, GS; Gootee, L; Newman, SL1
Basco, LK; Le Bras, J1
Dailly, E; Tillement, JP; Urien, S1
Bubendorf, A; Dorn, A; Ridley, RG; Vennerstrom, JL; Vippagunta, SR1
Crichton, RR; Josse, C; Legssyer, R; Piette, J; Ward, RJ1
Garner, P; Omari, A1
Köstler, E; Wollina, U1
Kidane, TZ; Linder, MC; Sauble, E1
Aurizi, C; Barbieri, L; Biolcati, G; Lupia Palmieri, G; Macrì, A1
Mullié, C; Sonnet, P1
Fujita, H; Fukuhara, H; Furihata, M; Inoue, K; Kurabayashi, A; Sasaki, J; Shuin, T; Utsumi, K1
Fan, G; Feng, L; Fu, Y; Hao, H; He, Y; He, Z; Hu, X; Liu, Z; Shen, P; Wang, Y; Wu, J; Zhang, N; Zhu, K1

Reviews

5 review(s) available for chloroquine and deferoxamine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities.
    Journal of medicinal chemistry, 2020, 12-10, Volume: 63, Issue:23

    Topics: Animals; Humans; Iron Chelating Agents; Iron Overload; Pyridones

2020
Deferoxamine treatment of malaria.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:5

    Topics: Animals; Chloroquine; Clinical Trials as Topic; Deferoxamine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum

1994
Malaria in endemic areas.
    Clinical evidence, 2003, Issue:9

    Topics: Antimalarials; Artemether; Artemisinins; Blood Transfusion; Chloroquine; Deferoxamine; Drug Combinations; Humans; Malaria; Malaria, Falciparum; Pyrimethamine; Quinine; Sesquiterpenes; Sulfadoxine

2003
Therapy of porphyria cutanea tarda.
    Expert opinion on pharmacotherapy, 2005, Volume: 6, Issue:3

    Topics: Chloroquine; Deferoxamine; Erythropoietin; Humans; Iron; Phlebotomy; Porphyria Cutanea Tarda; Renal Dialysis; Sunscreening Agents

2005

Trials

1 trial(s) available for chloroquine and deferoxamine

ArticleYear
Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria.
    American journal of hematology, 1991, Volume: 37, Issue:3

    Topics: Animals; Chloroquine; Deferoxamine; Drug Therapy, Combination; Humans; Malaria; Parasite Egg Count; Plasmodium falciparum

1991

Other Studies

22 other study(ies) available for chloroquine and deferoxamine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators.
    Bioorganic & medicinal chemistry, 2013, Feb-01, Volume: 21, Issue:3

    Topics: Aminoquinolines; Antiprotozoal Agents; Deferiprone; Dose-Response Relationship, Drug; Iron Chelating Agents; Leishmania infantum; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyridones; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi

2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.
    European journal of immunology, 1992, Volume: 22, Issue:11

    Topics: Animals; Arginine; Chloroquine; Deferoxamine; Female; Immunization; Interferon-gamma; Liver; Malaria; Mice; Mice, Inbred BALB C; omega-N-Methylarginine; Pentoxifylline; Tumor Necrosis Factor-alpha

1992
Growth inhibition of Plasmodium falciparum involving carbon centered iron-chelate radical (L., X-)-Fe(III) based on pyridoxal-betaine. A novel type of antimalarials active against chloroquine-resistant parasites.
    Free radical research communications, 1991, Volume: 15, Issue:1

    Topics: Animals; Antimalarials; Chloroquine; Deferoxamine; Drug Resistance; Electron Spin Resonance Spectroscopy; Hydrazines; Iron; Iron Chelating Agents; Molecular Structure; Oxidants; Oxidation-Reduction; Plasmodium falciparum; Spectrophotometry

1991
Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:11

    Topics: Chloroquine; Cobalt; Deferoxamine; Heptanoates; Humans; In Vitro Techniques; Luciferases; Monensin; Phagocytosis; Polylysine; Porphobilinogen Synthase; Receptors, Transferrin; Transferrin; Transformation, Genetic; Tumor Cells, Cultured

1990
[Retinal diseases].
    Bulletin des societes d'ophtalmologie de France, 1985, Volume: Spec No

    Topics: Anti-Bacterial Agents; Antimalarials; Antineoplastic Agents; Antipsychotic Agents; Canthaxanthin; Carotenoids; Chloroquine; Contraceptives, Oral; Deferoxamine; Digitalis Glycosides; Epinephrine; Humans; Indomethacin; Macula Lutea; Miotics; Phenothiazines; Quinine; Retinal Diseases

1985
Enhancement of endotoxin-induced isolated renal tubular cell injury by toxic shock syndrome toxin 1.
    The American journal of pathology, 1986, Volume: 122, Issue:1

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Cell Separation; Cell Survival; Chloroquine; Deferoxamine; Endocytosis; Endotoxins; Enterotoxins; Hydroxides; In Vitro Techniques; Kidney Tubules; Lipid A; Lipopolysaccharides; Male; Methylamines; Necrosis; Rats; Rats, Inbred Strains; Superantigens; Thiourea

1986
Lysosomal origin of the ferric iron required for cell killing by hydrogen peroxide.
    Biochemical and biophysical research communications, 1985, Dec-17, Volume: 133, Issue:2

    Topics: Animals; Cell Survival; Chloroquine; Deferoxamine; Ferric Compounds; Hydrogen Peroxide; Hydrogen-Ion Concentration; In Vitro Techniques; Iron; Liver; Lysosomes; Male; Methylamines; Oxidation-Reduction; Rats; Rats, Inbred Strains

1985
Studies on low dose chloroquine therapy and the action of chloroquine in symptomatic porphyria.
    The British journal of dermatology, 1972, Volume: 87, Issue:3

    Topics: Adult; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chloroquine; Deferoxamine; Humans; Iron; Liver; Male; Middle Aged; Porphyrias; Porphyrins; Rats; Recurrence

1972
Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis.
    The Journal of clinical investigation, 1994, Volume: 93, Issue:4

    Topics: Animals; Cells, Cultured; Chloroquine; Deferoxamine; Ferric Compounds; Histoplasma; Histoplasmosis; Humans; Iron; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitrilotriacetic Acid; Transferrin

1994
In vitro activity of chloroquine and quinine in combination with desferrioxamine against Plasmodium falciparum.
    American journal of hematology, 1993, Volume: 42, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Chloroquine; Deferoxamine; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Plasmodium falciparum; Quinine

1993
Chain-breaking antioxidants and ferriheme-bound drugs are synergistic inhibitors of erythrocyte membrane peroxidation.
    Free radical research, 1998, Volume: 28, Issue:2

    Topics: Adult; Amidines; Antioxidants; Ascorbic Acid; Chloroquine; Deferoxamine; Drug Synergism; Erythrocyte Membrane; Fatty Acids; Female; Hemin; Humans; Linoleic Acid; Lipid Peroxidation; Male; Membrane Lipids; Oxidation-Reduction; Oxygen Consumption; Oxyhemoglobins; Probucol; Pyridines; Reperfusion Injury; Vitamin E

1998
Deferoxamine: stimulation of hematin polymerization and antagonism of its inhibition by chloroquine.
    Biochemical pharmacology, 1999, Sep-01, Volume: 58, Issue:5

    Topics: Animals; Antimalarials; Biopolymers; Chelating Agents; Chloroquine; Deferoxamine; Drug Interactions; Hemin; Hydrogen-Ion Concentration; Plasmodium falciparum; Solubility

1999
Changes in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine.
    Journal of inorganic biochemistry, 2003, Feb-01, Volume: 94, Issue:1-2

    Topics: Animals; Chloroquine; Deferoxamine; Iron; Liver; Macrophages, Alveolar; Male; Nitric Oxide; Rats; Rats, Wistar; Spleen

2003
Release of iron from ferritin requires lysosomal activity.
    American journal of physiology. Cell physiology, 2006, Volume: 291, Issue:3

    Topics: Animals; Caco-2 Cells; Chloroquine; Deferoxamine; Enterocytes; Erythroid Cells; Ferritins; Hepatocytes; Humans; Immunoelectrophoresis; Iron; K562 Cells; Leupeptins; Lysosomes; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Rats

2006
Association between porphyria cutanea tarda and beta-thalassemia major.
    Cellular and molecular biology (Noisy-le-Grand, France), 2009, Jul-01, Volume: 55, Issue:2

    Topics: Adult; Anemia; beta-Thalassemia; Chloroquine; Deferoxamine; Female; Hepatitis C; Humans; Iron Overload; Middle Aged; Porphyria Cutanea Tarda; Porphyrins; Siderophores

2009
In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin.
    Experimental parasitology, 2011, Volume: 128, Issue:1

    Topics: Antimalarials; Benzoates; Chloroquine; Deferasirox; Deferiprone; Deferoxamine; Glutathione; Hemeproteins; Hemin; Hydrogen Peroxide; Inhibitory Concentration 50; Iron Chelating Agents; Plasmodium falciparum; Pyridones; Structure-Activity Relationship; Triazoles; Triterpenes; Ursolic Acid

2011
The inhibition of ferrochelatase enhances 5-aminolevulinic acid-based photodynamic action for prostate cancer.
    Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:4

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Chloroquine; Deferoxamine; Drug Synergism; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins

2013
Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis.
    Ecotoxicology and environmental safety, 2022, Oct-15, Volume: 245

    Topics: Autophagy; Cadmium; Chloroquine; Deferoxamine; Endoplasmic Reticulum Stress; Ferritins; Ferroptosis; Humans; Iron; Iron Chelating Agents; Liver Diseases

2022