Compounds > chloroquine

chloroquine and dacarbazine

chloroquine has been researched along with dacarbazine in 18 studies

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (22.22)	29.6817
2010's	13 (72.22)	24.3611
2020's	1 (5.56)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Marx, J	1
Chen, TC; Cho, HY; Golden, EB; Hofman, FM; Jahanian, A; Louie, SG; Schönthal, AH	1
Akiyama, Y; Hori, YS; Horio, Y; Hosoda, R; Kuno, A; Maruyama, M; Mikami, T; Mikuni, N; Sebori, R; Sugino, T; Suzuki, K; Tsukamoto, M; Wanibuchi, M	1
Hong, SH; Hong, YK; Joe, YA; Kim, HK; Kim, HS; Lee, NH; Lee, SW; Yi, HY	1
Dai, S; Gong, Z; Qian, L; Sun, L; Xu, Z; Yan, Y	1
Egorova, AV; Emelyanova, MA; Inshakov, AN; Khochenkov, DA; Nasedkina, TV; Ryabaya, OO; Stepanova, EV; Zasedatelev, AS	1
Hegazy, AM; Hirao, A; Ino, Y; Ito, C; Kasahara, A; Kobayashi, M; Nakada, M; Nomura, N; Peng, H; Tadokoro, Y; Takase, Y; Todo, T; Ueno, M; Vu, HT	1
Ji, Z; Xu, C; Xu, R; Zhu, J	1
Chen, H; Fei, X; Huang, Q; Ji, X; Jiang, D; Meng, X; Qin, R; Sun, F; Wang, A; Wang, Z; Xie, X; Zhao, Y	1

Reviews

3 review(s) available for chloroquine and dacarbazine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Targeting autophagy to sensitive glioma to temozolomide treatment. Journal of experimental & clinical cancer research : CR, 2016, Feb-02, Volume: 35 Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chloroquine; Clinical Trials as Topic; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Glioblastoma; Humans; Sirolimus; Temozolomide	2016
The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers: A systematic review and meta-analysis. Medicine, 2018, Volume: 97, Issue:46 Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Chloroquine; Clinical Trials as Topic; Dacarbazine; Deoxycytidine; Doxorubicin; Gemcitabine; Humans; Hydroxychloroquine; Neoplasms; Risk; Temozolomide; Treatment Outcome	2018

Other Studies

15 other study(ies) available for chloroquine and dacarbazine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Autophagy: is it cancer's friend or foe? Science (New York, N.Y.), 2006, May-26, Volume: 312, Issue:5777 Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Survival; Chloroquine; Dacarbazine; Genes, Tumor Suppressor; Humans; Membrane Proteins; Mice; Neoplasms; Oncogenes; Proteins; Sirolimus; Temozolomide	2006
Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy. Neurosurgical focus, 2014, Volume: 37, Issue:6 Topics: Animals; Antineoplastic Agents, Alkylating; Antirheumatic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Death; Cell Line, Tumor; Chloroquine; Dacarbazine; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Gene Expression Regulation, Neoplastic; Glioblastoma; Heat-Shock Proteins; Humans; Membrane Proteins; Mice; Mice, Nude; Poly(ADP-ribose) Polymerases; Temozolomide; Transcription Factor CHOP; Transfection; Xenograft Model Antitumor Assays	2014
Chloroquine potentiates temozolomide cytotoxicity by inhibiting mitochondrial autophagy in glioma cells. Journal of neuro-oncology, 2015, Volume: 122, Issue:1 Topics: Animals; Antimalarials; Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Chloroquine; Dacarbazine; Drug Synergism; Glioma; Humans; Mitochondria; Rats; Reactive Oxygen Species; Temozolomide; Tumor Cells, Cultured	2015
The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells. Cancer letters, 2015, May-01, Volume: 360, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Growth Processes; Cell Line, Tumor; Chloroquine; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Temozolomide; Tumor Suppressor Protein p53	2015
Autophagy inhibitors chloroquine and LY294002 enhance temozolomide cytotoxicity on cutaneous melanoma cell lines in vitro. Anti-cancer drugs, 2017, Volume: 28, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Chromones; Dacarbazine; Drug Synergism; Humans; Melanoma; Morpholines; Skin Neoplasms; Temozolomide	2017
Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas. Cancer science, 2018, Volume: 109, Issue:8 Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Calcium; Cell Line, Tumor; Chloroquine; Dacarbazine; Female; Glioblastoma; Glioma; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Reactive Oxygen Species; Signal Transduction; Temozolomide	2018
Proteomics analysis: inhibiting the expression of P62 protein by chloroquine combined with dacarbazine can reduce the malignant progression of uveal melanoma. BMC cancer, 2022, Apr-14, Volume: 22, Issue:1 Topics: Animals; Cell Line, Tumor; Chloroquine; Dacarbazine; Humans; Melanoma; Mice; Mice, Nude; Proteomics; Tumor Microenvironment; Uveal Neoplasms	2022