chloroquine and clotrimazole

chloroquine has been researched along with clotrimazole in 23 studies

Research

Studies (23)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	12 (52.17)	29.6817
2010's	11 (47.83)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Basilico, N; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fattorusso, E; Gemma, S; Joshi, BP; Kukreja, G; Morace, G; Nacci, V; Novellino, E; Persico, M; Savini, L; Taramelli, D; Yardley, V	1
Basilico, N; Butini, S; Campiani, G; Coccone, SS; Coletta, M; Croft, S; Fattorusso, C; Fattorusso, E; Fiorini, I; Gemma, S; Joshi, BP; Kukreja, G; Marini, S; Morace, G; Nacci, V; Novellino, E; Parapini, S; Persico, M; Savini, L; Taglialatela-Scafati, O; Taramelli, D; Yardley, V	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Adrián, F; Anderson, P; Brinker, A; Caldwell, JS; Chatterjee, A; Gray, NS; Henson, K; Janes, J; Kato, N; Kuhen, K; Matzen, JT; McNamara, C; Nagle, A; Nam, TG; Plouffe, D; Schultz, PG; Trager, R; Winzeler, EA; Yan, SF; Zhou, Y	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Basilico, N; Bernetti, M; Brun, R; Butini, S; Caccia, S; Campiani, G; Coccone, SS; Coletta, M; Croft, S; Fattorusso, C; Fiorini, I; Gemma, S; Guiso, G; Joshi, BP; Keller-Maerki, S; Kukreja, G; Marini, S; Nacci, V; Novellino, E; Parapini, S; Persico, M; Rottmann, M; Taramelli, D; Yardley, V	1
Pratim Roy, P; Roy, K	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Sen, S; Sinha, N	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Basilico, N; Bernetti, M; Bonache de Marcos, MC; Brogi, S; Brun, R; Butini, S; Caccia, S; Camodeca, C; Campiani, G; Gemma, S; Gorelli, B; Guiso, G; Joshi, BP; Lamponi, S; Martin, RE; Moretti, V; Novellino, E; Parapini, S; Rottmann, M; Sanna Coccone, S; Saponara, S; Savini, L; Summers, RL; Taramelli, D	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Avery, VM; Sykes, ML	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Akhter, M; Alam, MM; Kumar, G; Kumar, J; Pillai, CR; Sharma, S; Tanwar, O; Zama, MS	1
Elford, BC; Ginsburg, H; Krugliak, M; Lew, VL; Tiffert, T	1
Ginsburg, H; Lew, VL; Tiffert, T	1
Basilico, N; Bernetti, M; Bertamino, A; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Gemma, S; Joshi, BP; Kukreja, G; Novellino, E; Persico, M; Savini, L; Taramelli, D; Yardley, V	1
Bhasin, VK; Bhattacharya, A; Mishra, LC	1

Reviews

2 review(s) available for chloroquine and clotrimazole

Article	Year
Approaches to protozoan drug discovery: phenotypic screening. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Drug Discovery; Humans; Molecular Structure; Neglected Diseases; Phenotype; Plasmodium falciparum; Protozoan Infections; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2013
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

21 other study(ies) available for chloroquine and clotrimazole

Article	Year
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore. Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4 Topics: Animals; Antifungal Agents; Antimalarials; Cell Line; Clotrimazole; Drug Resistance; Heterocyclic Compounds, 4 or More Rings; Humans; In Vitro Techniques; Models, Molecular; Plasmodium falciparum; Structure-Activity Relationship	2007
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies. Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5 Topics: Animals; Antifungal Agents; Antimalarials; Cell Line; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Drug Design; Female; Ferric Compounds; Heme; Humans; In Vitro Techniques; Mice; Models, Molecular; Oxidoreductases; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium chabaudi; Plasmodium falciparum; Protoporphyrins; Stereoisomerism; Sterol 14-Demethylase; Structure-Activity Relationship	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America, 2008, Jul-01, Volume: 105, Issue:26 Topics: Animals; Antimalarials; Cluster Analysis; Computational Biology; Drug Evaluation, Preclinical; Drug Resistance; Folic Acid Antagonists; Malaria; Models, Molecular; Parasites; Plasmodium falciparum; Reproducibility of Results; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. Journal of medicinal chemistry, 2009, Jan-22, Volume: 52, Issue:2 Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; Clotrimazole; Humans; Magnetic Resonance Spectroscopy; Mice; Plasmodium; Rats; Species Specificity; Spectrometry, Mass, Electrospray Ionization	2009
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. European journal of medicinal chemistry, 2009, Volume: 44, Issue:7 Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results	2009
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (New York, N.Y.), 2011, Dec-09, Volume: 334, Issue:6061 Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance; Erythrocytes; Humans; Imidazoles; Liver; Malaria; Mice; Mice, Inbred BALB C; Molecular Structure; Piperazines; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Polymorphism, Single Nucleotide; Protozoan Proteins; Random Allocation; Small Molecule Libraries; Sporozoites	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of medicinal chemistry, 2012, Aug-09, Volume: 55, Issue:15 Topics: Aminoquinolines; Animals; Antimalarials; Biological Transport; Cell Line; Chloroquine; Clotrimazole; Drug Resistance; Female; Half-Life; Hemeproteins; Humans; Malaria; Male; Membrane Transport Proteins; Mice; Models, Molecular; Mutation; Oocytes; Piperazines; Plasmodium berghei; Plasmodium falciparum; Protozoan Proteins; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Ventricular Pressure; Xenopus laevis	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Pyrazole-pyrazoline as promising novel antimalarial agents: A mechanistic study. European journal of medicinal chemistry, 2018, Apr-10, Volume: 149 Topics: Antimalarials; Benzenesulfonamides; Chloroquine; Hemin; Plasmodium falciparum; Pyrazoles; Sulfonamides	2018
Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum. Proceedings of the National Academy of Sciences of the United States of America, 2000, Jan-04, Volume: 97, Issue:1 Topics: Animals; Antifungal Agents; Antimalarials; Cells, Cultured; Chloroquine; Clotrimazole; Growth Inhibitors; Histocytochemistry; Hypoxanthine; Mefloquine; Plasmodium falciparum	2000
Do azoles and chloroquine share similar mechanisms of antimalarial action? Trends in parasitology, 2002, Volume: 18, Issue:4 Topics: Animals; Antimalarials; Azoles; Chloroquine; Clotrimazole; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum	2002
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. Bioorganic & medicinal chemistry letters, 2007, Jul-01, Volume: 17, Issue:13 Topics: Animals; Antimalarials; Chemistry, Pharmaceutical; Chloroquine; Clotrimazole; Dimerization; Drug Design; Drug Resistance; Ions; Metals; Models, Chemical; Models, Molecular; Molecular Conformation; Piperazine; Piperazines; Plasmodium falciparum	2007
In vitro activity of artemisinin in combination with clotrimazole or heat-treated amphotericin B against Plasmodium falciparum. The American journal of tropical medicine and hygiene, 2008, Volume: 78, Issue:5 Topics: Amphotericin B; Animals; Antimalarials; Artemisinins; Chloroquine; Clotrimazole; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Hot Temperature; Plasmodium falciparum	2008