chloroquine and camptothecin

Topics: Animals; Antioxidants; Atherosclerosis; Cell Survival; Coumaric Acids; Dimerization; Endothelium, Vascular; Esters; Humans; Leukemia P388; Lipoproteins, LDL; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Thiobarbituric Acid Reactive Substances

Topics: Aminoquinolines; Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Base Sequence; Biological Transport, Active; Chloroquine; DNA, Protozoan; Drug Resistance; Fluorescent Dyes; Genes, Protozoan; Humans; Leishmania infantum; Leishmaniasis, Visceral; Lipid Bilayers; Phosphorylcholine; Protozoan Proteins; Recombinant Proteins; Transformation, Genetic

Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

Topics: Alkaloids; Animals; Antimalarials; Chlorocebus aethiops; Coumarins; Glycosides; Inhibitory Concentration 50; Leishmania donovani; Parasitic Sensitivity Tests; Plant Roots; Plasmodium falciparum; Rutaceae; Uganda; Vero Cells

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

Topics: Antimalarials; Cameroon; Carbazoles; Chloroquine; Indole Alkaloids; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plasmodium falciparum; Strychnine; Strychnos; Toxiferine

Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Neoplasms; Quinolines; Stilbenes; Tubulin; Tubulin Modulators

Topics: Amodiaquine; Animals; Cell Line; Chloroquine; Humans; Ligands; Nuclear Magnetic Resonance, Biomolecular; Nuclear Receptor Subfamily 4, Group A, Member 2; Phenylacetates; Protein Binding; Rats; Small Molecule Libraries; Transcription, Genetic

Topics: Antimalarials; Cell Survival; Dose-Response Relationship, Drug; Drug Design; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimidines; Quinolines; Structure-Activity Relationship; Thermodynamics

Topics: Antineoplastic Agents; Camptothecin; Chloroquine; Colchicine; Humans; Hydroxyurea; Imidazoles; Immunotherapy; Iodine Radioisotopes; Melanoma; Nitrosourea Compounds; Radionuclide Imaging; Triazenes

Topics: Antimalarials; Camptothecin; Cell Death; Cell Survival; Chloroquine; DNA Damage; Drug Interactions; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Topoisomerase I Inhibitors; Tumor Cells, Cultured

Topics: Animals; Camptothecin; Cell Line; Chloroquine; Chromatin; COS Cells; DNA Damage; DNA Topoisomerases, Type I; DNA, Superhelical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fungal Proteins; Humans; Micrococcal Nuclease; Models, Genetic; Nucleic Acid Conformation; Plasmids; Simian virus 40; Time Factors; Topoisomerase I Inhibitors; Transfection; Ultraviolet Rays; Yeasts

Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Autophagy; Camptothecin; Cell Line, Tumor; Cellular Senescence; Chloroquine; Class III Phosphatidylinositol 3-Kinases; Colorectal Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Lysosomes; Neoplasm Proteins; Osmolar Concentration; Signal Transduction; Tumor Suppressor Protein p53

Topics: Angiogenesis Inhibitors; Animals; Autophagy; Autophagy-Related Protein 5; Camptothecin; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Synergism; Endothelial Cells; Endothelium, Vascular; Humans; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; Microtubule-Associated Proteins; Neoplasm Invasiveness; Neovascularization, Pathologic; Receptor, Notch1; Skin Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Adenine; Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Camptothecin; Cell Line, Tumor; Cell Survival; Chloroquine; DNA Damage; Formaldehyde; Gene Silencing; Humans; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; RNA, Small Interfering; Sirolimus; Ubiquitin-Activating Enzymes; Ultraviolet Rays

Topics: Animals; Apoptosis; Autophagy; Camptothecin; Cell Line, Tumor; Cell Survival; Chloroquine; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Lysosomes; Mice; Mitochondria; Reactive Oxygen Species; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: Adenine; Apoptosis; Autophagy; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chloroquine; Humans; Lung Neoplasms; Transforming Growth Factor beta1