chloroquine has been researched along with bafilomycin a1 in 106 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (19.81) | 18.2507 |
| 2000's | 24 (22.64) | 29.6817 |
| 2010's | 48 (45.28) | 24.3611 |
| 2020's | 13 (12.26) | 2.80 |
| Authors | Studies |
|---|---|
| Bavari, S; Besch, R; Duplantier, AJ; Jay, WB; Kota, KP; Kuehl, K; Lazić, M; Mudhasani, R; Panchal, RG; Pavić, A; Retterer, C; Sean, VA; Selaković, Ž; Šolaja, BA; Soloveva, V; Tran, JP; Vasiljević, B; Verbić, T | 1 |
| Agard, DA; Ashworth, A; Barrio-Hernandez, I; Batra, J; Beltrao, P; Bennett, MJ; Bohn, M; Bouhaddou, M; Braberg, H; Broadhurst, DJ; Cai, Y; Cakir, M; Calviello, L; Cavero, DA; Chang, JCJ; Chorba, JS; Craik, CS; d'Enfert, C; Dai, SA; Eckhardt, M; Emerman, M; Fabius, JM; Fletcher, SJ; Floor, SN; Foussard, H; Frankel, AD; Fraser, JS; Fujimori, DG; Ganesan, SJ; García-Sastre, A; Gordon, DE; Gross, JD; Guo, JZ; Haas, K; Haas, P; Hernandez-Armenta, C; Hiatt, J; Huang, XP; Hubert, M; Hüttenhain, R; Ideker, T; Jacobson, M; Jang, GM; Jura, N; Kaake, RM; Kim, M; Kirby, IT; Klippsten, S; Koh, C; Kortemme, T; Krogan, NJ; Kuzuoglu-Ozturk, D; Li, Q; Liboy-Lugo, J; Lin, Y; Liu, X; Liu, Y; Lou, K; Lyu, J; Mac Kain, A; Malik, HS; Mathy, CJP; McGregor, MJ; Melnyk, JE; Memon, D; Meyer, B; Miorin, L; Modak, M; Moreno, E; Mukherjee, S; Naing, ZZC; Noack, J; O'Meara, MJ; O'Neal, MC; Obernier, K; Ott, M; Peng, S; Perica, T; Pilla, KB; Polacco, BJ; Rakesh, R; Rathore, U; Rezelj, VV; Richards, AL; Roesch, F; Rosenberg, OS; Rosenthal, SB; Roth, BL; Roth, TL; Ruggero, D; Safari, M; Sali, A; Saltzberg, DJ; Savar, NS; Schwartz, O; Sharp, PP; Shen, W; Shengjuler, D; Shi, Y; Shoichet, BK; Shokat, KM; Soucheray, M; Stroud, RM; Subramanian, A; Swaney, DL; Taunton, J; Tran, QD; Trenker, R; Tummino, TA; Tutuncuoglu, B; Ugur, FS; Vallet, T; Venkataramanan, S; Verba, KA; Verdin, E; Vignuzzi, M; von Zastrow, M; Wang, HY; Wankowicz, SA; Wenzell, NA; White, KM; Xu, J; Young, JM; Zhang, Z; Zhou, Y | 1 |
| Ding, X; Guo, LL; Hao, XJ; Yuan, YX; Zhang, Y | 1 |
| Chida, N; Kawano, S; Miura, K; Sato, T; Simizu, S; Suto, T | 1 |
| Bray, PG; Howells, RE; Ward, SA | 1 |
| Carlson, SL; Constable, CT; Lencer, WI; Madara, JL; Moe, S; Strohmeier, G | 1 |
| Callahan, J; Hinek, A; Keeley, FW | 1 |
| Carrasco, L; Pérez, L | 2 |
| Banting, G; Reaves, B | 1 |
| Anderson, RG; Mineo, C | 1 |
| Beers, MF | 1 |
| Kichler, A; Schmidt, W; Sinski, A; Wagner, E; Zauner, W | 1 |
| Paganetti, PA; Schrader-Fischer, G | 1 |
| Ackermann, MR; Kreutz, LC | 1 |
| Al-Damluji, S; Kopin, IJ | 1 |
| Pless, DD; Wellner, RB | 1 |
| Bray, PG; Hawley, SR; Park, BK; Ward, SA | 1 |
| Kichler, A; Mechtler, K; Schmidt, W; Wagner, E; Zauner, W | 1 |
| Buchmeier, MJ; Nash, TC | 1 |
| Fominaya, J; Uherek, C; Wels, W | 1 |
| DeLuca, A; Eckhardt, AE; Hill, RL; Perez-Vilar, J | 1 |
| Bortzov, F; Budker, V; Gurevich, V; Hagstrom, JE; Wolff, JA | 1 |
| McCullough, KC; Natale, VA | 1 |
| Brech, A; Dannevig, BH; Eliassen, TM; Falk, K; Frøystad, MK; Gjøen, T; Jankowska, M; Romøren, K | 1 |
| Akisaka, T; Inoue, M; Yoshida, H | 1 |
| Coulaud, D; Danos, O; Delain, E; Druillennec, S; Kichler, A; Le Cam, E; Leborgne, C; Lenoir, C; Pages, JC; Roques, BP | 1 |
| Decary, S; Erusalimsky, JD; Hong, Y; Kurz, DJ | 1 |
| Blum, JS; Pathak, SS | 1 |
| Levitz, SM; Weber, SM | 1 |
| Düzgünes, N; Pedroso de Lima, MC; Simões, S; Slepushkin, V | 1 |
| Bevan, S; Latchman, D; Storey, N | 1 |
| Fredericksen, BL; Garcia, JV; Luo, T; Wei, BL; Yao, J | 1 |
| Friedlander, A; Little, S; Mendelson, I; Weeks, S; Welkos, S | 1 |
| Aktories, K; Bachmeyer, C; Barth, H; Benz, R; Blöcker, D | 1 |
| Bashenko, Y; Flugelman, MY; Gingis-Velitski, S; Ilan, N; Kaplan, V; Levy-Adam, F; Schubert, S; Vlodavsky, I; Zetser, A | 1 |
| Akinc, A; Klibanov, AM; Langer, R; Thomas, M | 1 |
| Datta, G; Klocke, BJ; Roth, KA; Schmidt, RE; Shacka, JJ; Shibata, M; Uchiyama, Y | 1 |
| Allen, LA; Schwartz, JT | 1 |
| Brown, TD; Stuart, AD | 1 |
| Bleker, S; Fischer, R; Kleinschmidt, JA; Leuchs, B; Sonntag, F | 1 |
| Adachi, K; Ichinose, T; Kitazato, K; Kobayashi, N; Takizawa, N; Watanabe, K | 1 |
| Gottlieb, RA; Huang, C; Iwai-Kanai, E; Kim, L; Perry-Garza, CN; Sayen, MR; Yuan, H | 1 |
| Bae, D; Lu, S; Mercurio, AM; Taglienti, CA | 1 |
| Davis, DP; De Mazière, A; Degtyarev, M; Friedman, LS; Gray, DC; Hoeflich, KP; Klumperman, J; Lee, BB; Lin, J; Lin, K; Murray, LJ; Orr, C; Prior, WW; Stern, HM; Tien, JY; van Dijk, S; Wu, H | 1 |
| Canine, BF; Hatefi, A; Mangipudi, SS; Wang, Y | 1 |
| Bellodi, C; Calabretta, B; Dinsdale, D; Donato, N; Dyer, MJ; Galavotti, S; Hamilton, A; Helgason, GV; Holyoake, T; Hunter, A; Lidonnici, MR; Nicotera, P; Ronchetti, M; Salomoni, P; Selmi, T; Soliera, AR; Tirrò, E; Van Etten, RA; Vigneri, P; Yacobi, R; Young, KW | 1 |
| Perry, JW; Taube, S; Wobus, CE | 1 |
| Jiang, C; Wang, H | 1 |
| Ballestas, M; Franklin, AV; Ghosh, AP; Klocke, BJ; Roth, KA; Shacka, JJ; Walls, KC; Zhang, J | 1 |
| Coleman, J; Gatica, D; Pande, P; Patton, WF; Shen, D; Xiang, Y | 1 |
| Brady, NR; Efferth, T; Eils, R; Hamacher-Brady, A; Jennewein, N; Mora, R; Stein, HA; Toegel, I; Turschner, S | 1 |
| Bittner, T; Brouwers, N; Capell, A; Carlson, AM; Cruts, M; Dormann, D; Fellerer, K; Gijselinck, I; Haass, C; Herms, J; Jansen, R; Kunze, B; Lammich, S; Liebscher, S; Sasse, F; Sleegers, K; Steinmetz, H; Van Broeckhoven, C; Willem, M | 1 |
| Goto, K; Hayashi, H; Kamiyama, H; Katunuma, N; Kubo, Y; Matsuyama, T; Oishi, K; Sato, H; Tanaka, Y; Yamamoto, N; Yoshii, H | 1 |
| Larsen, CJ | 1 |
| Bergan, J; Dyve Lingelem, AB; Sandvig, K | 1 |
| Aryal, S; Cummings, CT; Maycotte, P; Morgan, MJ; Thorburn, A; Thorburn, J | 1 |
| Larsen, JD; Reilly, MJ; Sullivan, MO | 1 |
| Ashraf, S; Gil, PR; Nazarenus, M; Parak, WJ | 1 |
| Balbis, A; Chevalier, S; Dumas, V; Parmar, A; Posner, BI; Roux, E; Xu, Y | 1 |
| Chiu, LY; Hsin, IL; Jan, MS; Ko, JL; Lue, KH; Sheu, GT; Sun, HL; Wu, TC | 1 |
| Heukers, R; Houtman, MJ; Man, JC; Takanari, H; Tieland, RG; van Bergen En Henegouwen, PM; van der Heyden, MA; Varkevisser, R; Vos, MA; Waasdorp, M | 1 |
| Anghel, EL; Choi, JL; Chou, B; Johnson, RN; Pun, SH; Schellinger, JG; Shi, J | 1 |
| Lamoureux, F; Zoubeidi, A | 1 |
| Chang, SJ; Huang, AC; Lai, TY; Lien, JC; Lin, MW; Wu, PP; Yang, JS | 1 |
| Chen, X; Li, Y; Xu, L; Xu, Z; Yin, Q; Yu, H; Zhang, Z | 1 |
| Hong, SK; Kim, JH; Park, JI; Starenki, D | 1 |
| Degtyarev, M; Lin, K; Reichelt, M | 1 |
| Chang, HW; Choi, JY; Han, MW; Kim, GC; Kim, SW; Kim, SY; Lee, JC; Nam, HY | 1 |
| Gao, Q; Geng, L; Jiang, L; Liu, H; Shi, B; Yang, F; Yao, Y; Zhang, X | 1 |
| Andres, AM; Gottlieb, RA; Gurney, MA; Huang, C; Linton, PJ; Ramil, JM; Ravindran, N; Sin, J | 1 |
| Long, YC; Yu, X | 1 |
| He, CY; Li, FJ | 1 |
| Davies, DM; Errington, RJ; Herbert, TP; Hunt, DK; Johnson, CE; Sampson, JR; Tee, AR; Wiltshire, M | 1 |
| Cho, CS; Choi, YJ; Jiang, T; Kang, SK; Maharjan, S; Park, TE; Singh, B | 1 |
| Chang, LL; Chen, XP; Chen, Y; Li, T; Lu, JJ; Tang, ZH; Wang, YF; Wang, YT; Wu, GS; Xu, WS; Zhu, H | 1 |
| Chen, P; Chu, Y; Dong, Z; Hoffman, RM; Hu, T; Jeong, LS; Jia, L; Jiang, Y; Li, C; Li, P; Liang, Y; Pan, Y; Qi, H; Wei, D; Yang, M; Zhang, P | 1 |
| Bahlmann, AS; Eichenseher, F; Furrer, A; Leimer, N; Loessner, MJ; Matt, U; Palheiros Marques, M; Rachmühl, C; Schuepbach, RA; Seidl, K; Zinkernagel, AS | 1 |
| Ashraf, R; Bhattacharjee, A; Datta, D; Hasanain, M; Mitra, K; Pandey, P; Sarkar, J; Sharma, S; Singh, N; Vishwakarma, AL | 1 |
| Blatter, LA; Davaadelger, B; Dedkova, EN; Duan, L; Maki, CG; Perez, RE | 1 |
| Barui, AK; Hu, Y; Jin, PP; Lin, J; Patra, CR; Ruan, RQ; Shi, SS; Wei, PF; Wen, LP; Zhang, HR; Zhang, JQ; Zhang, L; Zhang, YJ; Zhou, W | 1 |
| Abuznait, AH; Alam, K; Ding, K; Li, L; Pahwa, S; Wang, X; Yue, W; Zhang, P | 1 |
| Chen, X; Leung, CH; Lu, J; Luo, W; Ma, DL; Ma, G; Wang, Y | 1 |
| Aparicio, IM; Bejarano, I; Campo, ML; Espino, J; Gallardo-Soler, A; Pariente, JA; Peña, FJ; Salido, GM; Tapia, JA | 1 |
| Dixon, IM; Ghavami, S; Gupta, SS; Halayko, AJ; Klonisch, T; Landry, NM; Rattan, SG; Wigle, JT; Zeglinski, MR | 1 |
| Diao, A; Feng, Y; Jing, L; Li, Y; Liu, Z; Ma, L; Sun, Y; Wang, J; Yan, Y; Zhang, Y | 1 |
| Barnes, S; Benavides, GA; Berryhill, TF; Darley-Usmar, VM; Johnson, MS; Ouyang, X; Ravi, S; Redmann, M; Wani, WY; Zhang, J | 1 |
| Bao, J; Gulbins, E; Li, G; Li, PL; Yuan, X | 1 |
| Coppes, RP; Engedal, N; Hijlkema, KJ; Luhr, M; Mari, M; Mauthe, M; Orhon, I; Reggiori, F; Rocchi, C; Zhou, X | 1 |
| Costello, JC; Fitzwalter, BE; Gamez, G; Morgan, MJ; Owens, CR; Powers, RK; Sottnik, JL; Theodorescu, D; Thorburn, A | 1 |
| Ferraresi, A; Isidoro, C; Seca, C; Secomandi, E; Vidoni, C | 1 |
| He, H; Li, H; Liu, X; Sun, Y; Xiong, X; Zhao, Y | 1 |
| Kang, R; Liu, J; Tang, D; Wen, Q; Zhou, B | 1 |
| Gao, M; Kong, B; Li, R; Li, Y; Ma, H; Qi, G; Wang, X; Wu, H; Yan, S; Yang, N; Yuan, C | 1 |
| Adam, P; Adam, V; Babula, P; Buchtelova, H; Heger, Z; Jimenez, AMJ; Rodrigo, MAM | 1 |
| Mei, L; Su, C; Tang, FL; Xiong, L; Xiong, WC; Zhao, L; Zhao, Y; Zhu, XJ | 1 |
| Fedele, AO; Proud, CG | 1 |
| Endo, M; Ohba, K; Sato, S; Takahashi, K; Yokota, Y | 1 |
| An, N; Chen, XC; Guo, XY; Jing, KP; Li, ZH; Liu, HF; Pan, QJ; Su, HY; Wu, HL; Yang, C | 1 |
| Bensalem, J; Bryksin, V; Fourrier, C; Hattersley, K; Hein, LK; Sargeant, TJ | 1 |
| Cong, J; Ge, C; Jin, N; Li, T; Li, X; Li, Y; Lu, J; Shang, C; Tian, M; Zhang, H; Zhu, Y; Zhuang, X | 1 |
| Ahmed, R; Bharate, SB; Chandra, A; Das, S; Godbole, R; Guha, A; Gulzar, SE; Jahnavi, S; Lingamallu, SM; Mahajan, B; Mayor, S; Najar, AH; Nuthakki, VK; Panikulam, P; Prabhakara, C; Puthiyapurayil, TP; Sheth, D; Shivaraj, A; Sil, P; Singh, PP; Subhash, N; Sundaramurthy, V; U, I; van Zanten, TS; Vemula, P; Vishwakarma, R | 1 |
| Bian, ZC; Guan, JL; Holm, TM; Manupati, K | 1 |
| Chan, KH; Chan, WM; Chen, H; Chen, LL; Chu, AW; Ip, JD; Jin, DY; Lu, L; Meng, X; Peng, Z; To, KK; Yuen, KY; Zhang, C; Zhao, H | 1 |
| Frey, L; Hendrich, K; Klemmer, A; Lakics, V; Liebl, MP; Meister, SC; Nuber, J; Pohl, C; Untucht, C; Wohlfart, B | 1 |
| Ioannidis, M; Janssens, MH; Mesman, RJ; Revelo, NH; Stempels, FC; Ter Beest, M; van den Bogaart, G | 1 |
106 other study(ies) available for chloroquine and bafilomycin a1
| Article | Year |
|---|---|
Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action.
Topics: Animals; Antiviral Agents; Chrysenes; Ebolavirus; Hemorrhagic Fever, Ebola; Lysosomes; Mice; Surface-Active Agents; Virus Internalization; Zebrafish | 2019 |
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Topics: Animals; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Cloning, Molecular; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunity, Innate; Mass Spectrometry; Molecular Targeted Therapy; Pandemics; Pneumonia, Viral; Protein Binding; Protein Biosynthesis; Protein Domains; Protein Interaction Mapping; Protein Interaction Maps; Receptors, sigma; SARS-CoV-2; SKP Cullin F-Box Protein Ligases; Vero Cells; Viral Proteins | 2020 |
Cytotoxic Monoterpenoid Indole Alkaloids from
Topics: Acids; Antineoplastic Agents, Phytogenic; Autophagy; Circular Dichroism; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Lysosomes; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Secologanin Tryptamine Alkaloids; Tabernaemontana | 2020 |
Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy.
Topics: Animals; Autophagy; Biological Products; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 4 or More Rings; Humans; Microtubule-Associated Proteins; Molecular Structure; Porifera; Up-Regulation | 2021 |
Vacuolar acidification and chloroquine sensitivity in Plasmodium falciparum.
Topics: Animals; Anti-Bacterial Agents; Chloroquine; Drug Resistance; Humans; Hydrogen-Ion Concentration; Macrolides; Plasmodium falciparum; Vacuoles | 1992 |
Signal transduction by cholera toxin: processing in vesicular compartments does not require acidification.
Topics: Acids; Amines; Anti-Bacterial Agents; Cell Line; Chlorides; Chloroquine; Cholera Toxin; G(M1) Ganglioside; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa; Macrolides; Membranes; Nigericin; Permeability; Signal Transduction | 1995 |
Recycling of the 67-kDa elastin binding protein in arterial myocytes is imperative for secretion of tropoelastin.
Topics: Animals; Anti-Bacterial Agents; Aorta; Cell Membrane; Cells, Cultured; Chickens; Chloroquine; Elastin; Enzyme Inhibitors; Fetus; Immunoblotting; Macrolides; Microscopy, Electron; Muscle, Smooth, Vascular; Organ Culture Techniques; Receptors, Cell Surface; Sheep; Tropoelastin; Valine | 1995 |
Involvement of the vacuolar H(+)-ATPase in animal virus entry.
Topics: Amantadine; Animals; Anti-Bacterial Agents; Cadaverine; Cell Line; Chloroquine; Cricetinae; DNA Viruses; Electrophoresis, Polyacrylamide Gel; Endocytosis; HeLa Cells; Humans; Kidney; Macrolides; Methionine; Monensin; Proton-Translocating ATPases; Receptors, Virus; RNA Viruses; Semliki forest virus; Vacuoles; Viral Proteins | 1994 |
Vacuolar ATPase inactivation blocks recycling to the trans-Golgi network from the plasma membrane.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Biological Transport; Cell Compartmentation; Cell Membrane; Cells, Cultured; Chloroquine; Endocytosis; Fluorescent Antibody Technique; Glycoproteins; Golgi Apparatus; Macrolides; Membrane Glycoproteins; Membrane Proteins; Proton Pumps; Rats; Vacuoles | 1994 |
Entry of poliovirus into cells does not require a low-pH step.
Topics: Amantadine; Animals; Anti-Bacterial Agents; Autoradiography; Cadaverine; Cell Line; Chloroquine; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Hydrogen-Ion Concentration; Macrolides; Methionine; Models, Biological; Monensin; Poliovirus; Proton-Translocating ATPases; Semliki forest virus; Sulfur Radioisotopes; Vesicular stomatitis Indiana virus; Viral Proteins; Virus Replication | 1993 |
A vacuolar-type proton ATPase mediates acidification of plasmalemmal vesicles during potocytosis.
Topics: Acids; Ammonium Chloride; Animals; Anti-Bacterial Agents; Antimalarials; Biological Transport; Cell Compartmentation; Cell Line; Cell Membrane; Chloroquine; Enzyme Inhibitors; Epithelial Cells; Epithelium; Folic Acid; Haplorhini; Intracellular Membranes; Ionophores; Kidney; Macrolides; Monensin; Octoxynol; Oligomycins; Proton-Translocating ATPases; Protons; Tetrahydrofolates; Vacuoles | 1996 |
Inhibition of cellular processing of surfactant protein C by drugs affecting intracellular pH gradients.
Topics: Animals; Anti-Bacterial Agents; Antibodies; Cells, Cultured; Chloroquine; Enzyme Inhibitors; Epitopes; Hydrogen-Ion Concentration; Ionophores; Kinetics; Lung; Macrolides; Methylamines; Models, Biological; Monensin; Protein Precursors; Protein Processing, Post-Translational; Proteolipids; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Sulfur Radioisotopes; Time Factors; Vacuoles | 1996 |
Glycerol enhancement of ligand-polylysine/DNA transfection.
Topics: Animals; Anti-Bacterial Agents; beta-Galactosidase; Cell Adhesion; Cell Line; Chloroquine; Clone Cells; DNA; Enzyme Inhibitors; Ethylene Glycol; Ethylene Glycols; Fibroblasts; Gene Expression Regulation; Genes, Reporter; Glycerol; Humans; Interleukin-2; Ligands; Macrolides; Plasmids; Polylysine; Promoter Regions, Genetic; Transfection | 1996 |
Effect of alkalizing agents on the processing of the beta-amyloid precursor protein.
Topics: Alkalies; Ammonium Chloride; Amyloid beta-Protein Precursor; Animals; Anti-Bacterial Agents; Base Sequence; Cell Line; Chloroquine; Cytosol; DNA, Complementary; Endocytosis; Endosomes; Enzyme Inhibitors; Humans; Hybridomas; Hydrogen-Ion Concentration; Lysosomes; Macrolides; Mice; Molecular Sequence Data; Plasmids; Proton-Translocating ATPases | 1996 |
Porcine reproductive and respiratory syndrome virus enters cells through a low pH-dependent endocytic pathway.
Topics: Actin Cytoskeleton; Ammonium Chloride; Animals; Anti-Bacterial Agents; Cell Line; Chloroquine; Endocytosis; Hydrogen-Ion Concentration; Macrolides; Porcine respiratory and reproductive syndrome virus; RNA; Swine; Virus Replication | 1996 |
Functional properties of the uptake of amines in immortalised peptidergic neurones (transport-P).
Topics: Adrenergic Uptake Inhibitors; Amines; Anti-Bacterial Agents; Cell Line; Chloroquine; Desipramine; Hydrogen-Ion Concentration; Hypothalamus; Ionophores; Macrolides; Neurons; Norepinephrine; Prazosin; Proton-Translocating ATPases; Reserpine; Sodium; Sodium-Potassium-Exchanging ATPase; Steroids; Temperature; Vanadates | 1996 |
In vitro fusion of endocytic vesicles: effects of reagents that alter endosomal pH.
Topics: Anti-Bacterial Agents; Cell Fusion; Chloroquine; Endocytosis; Endosomes; Ethylmaleimide; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrogen-Ion Concentration; Macrolides; Monensin; Ricin; Tumor Cells, Cultured | 1996 |
Amodiaquine accumulation in Plasmodium falciparum as a possible explanation for its superior antimalarial activity over chloroquine.
Topics: Adenosine Triphosphate; Ammonium Chloride; Amodiaquine; Animals; Anti-Bacterial Agents; Antimalarials; Biological Transport, Active; Chloroquine; Enzyme Inhibitors; Glucose; Hydrogen-Ion Concentration; Ionophores; Kinetics; Macrolides; Nigericin; Plasmodium falciparum; Proton-Translocating ATPases; Protons | 1996 |
Glycerol and polylysine synergize in their ability to rupture vesicular membranes: a mechanism for increased transferrin-polylysine-mediated gene transfer.
Topics: Anti-Bacterial Agents; Chloroquine; Cytomegalovirus; DNA; Drug Synergism; Erythrocyte Membrane; Genes, Reporter; Glycerol; Humans; Intracellular Membranes; Macrolides; Microsomes; Polylysine; Promoter Regions, Genetic; Transfection; Transferrin; Tumor Cells, Cultured | 1997 |
Entry of mouse hepatitis virus into cells by endosomal and nonendosomal pathways.
Topics: Animals; Anti-Bacterial Agents; Cell Fusion; Cell Membrane; Chloroquine; Endocytosis; Endosomes; Enzyme Inhibitors; Giant Cells; Hydrogen-Ion Concentration; Ionophores; Macrolides; Mice; Monensin; Murine hepatitis virus; Time Factors; Tumor Cells, Cultured | 1997 |
A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery.
Topics: Ammonium Chloride; Animals; Anti-Bacterial Agents; Breast Neoplasms; Chloroquine; COS Cells; Diphtheria Toxin; Female; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Macrolides; Methylamines; Nigericin; Receptor, ErbB-2; Recombinant Fusion Proteins; Single-Chain Antibodies; Transfection; Tumor Cells, Cultured | 1998 |
Porcine submaxillary mucin forms disulfide-linked multimers through its amino-terminal D-domains.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Chloroquine; COS Cells; Cyclopentanes; Disulfides; Glycosylation; Golgi Apparatus; Hydrogen-Ion Concentration; Macrolides; Molecular Sequence Data; Monensin; Mucins; Protein Conformation; Proton-Translocating ATPases; Recombinant Proteins; Submandibular Gland; Swine; Transfection | 1998 |
pH-sensitive, cationic liposomes: a new synthetic virus-like vector.
Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; Brefeldin A; Cations; Chloroquine; Cyclopentanes; Endosomes; Genetic Vectors; Hydrogen-Ion Concentration; Liposomes; Macrolides; Mice; Transfection | 1996 |
Macrophage cytoplasmic vesicle pH gradients and vacuolar H+-ATPase activities relative to virus infection.
Topics: Acridine Orange; African Swine Fever; African Swine Fever Virus; Amantadine; Animals; Anti-Bacterial Agents; Antiviral Agents; Cells, Cultured; Chloroquine; Cytoplasm; Enzyme Inhibitors; Female; Fluorescein-5-isothiocyanate; Hydrogen-Ion Concentration; Lysosomes; Macrolides; Macrophages; Male; Proton Pump Inhibitors; Proton Pumps; Proton-Translocating ATPases; Swine; Vacuoles; Virus Replication; Zymosan | 1998 |
Initial events in infectious salmon anemia virus infection: evidence for the requirement of a low-pH step.
Topics: Ammonium Chloride; Anti-Bacterial Agents; Cell Line; Chloroquine; Cold Temperature; Cytopathogenic Effect, Viral; Humans; Hydrogen-Ion Concentration; Influenza, Human; Macrolides; Membrane Fusion; Microscopy, Electron; Orthomyxoviridae; Protein Synthesis Inhibitors; Viral Proteins | 2000 |
Visualization of acidic compartments in cultured osteoclasts by use of an acidotrophic amine as a marker for low pH.
Topics: Acetazolamide; Acids; Actins; Adenosine Triphosphatases; Ammonium Chloride; Animals; Anti-Bacterial Agents; Antirheumatic Agents; Biomarkers; Carbonic Anhydrase Inhibitors; Cell Compartmentation; Cells, Cultured; Chloroquine; Dinitrobenzenes; Enzyme Inhibitors; Extracellular Space; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Hydrogen-Ion Concentration; Ionophores; Macrolides; Microscopy, Electron; Monensin; Nigericin; Osteoclasts; Rabbits; Vacuoles | 1999 |
Efficient DNA transfection mediated by the C-terminal domain of human immunodeficiency virus type 1 viral protein R.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Cell Cycle; Cell Line; Cell Nucleus; Chemical Precipitation; Chloroquine; DNA-Binding Proteins; Gene Products, vpr; Genes, Reporter; HIV-1; Humans; Hydrogen-Ion Concentration; Macrolides; Mice; Microscopy, Electron; Molecular Sequence Data; Peptide Fragments; Plasmids; Polylysine; Promoter Regions, Genetic; Protein Binding; Transcriptional Activation; Transfection; vpr Gene Products, Human Immunodeficiency Virus | 2000 |
Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells.
Topics: Acridine Orange; Anti-Bacterial Agents; beta-Galactosidase; Cellular Senescence; Chloroquine; Cytoplasm; Endothelium, Vascular; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Fluorescent Dyes; Histocytochemistry; Humans; Hydrogen-Ion Concentration; Lysosomes; Macrolides; Nigericin | 2000 |
Endocytic recycling is required for the presentation of an exogenous peptide via MHC class II molecules.
Topics: Anti-Bacterial Agents; Antigen Presentation; Antigens, Viral; Biotinylation; Brefeldin A; Cell Line; Chloroquine; Deoxyglucose; Endocytosis; Genes, MHC Class II; Hemagglutinin Glycoproteins, Influenza Virus; HLA-DR Antigens; HLA-DR4 Antigen; HLA-DRB1 Chains; Humans; Macrolides; Macromolecular Substances; Peptide Fragments; Protein Transport; Serum Albumin; Severe Combined Immunodeficiency; Sodium Azide; Transfection | 2000 |
Chloroquine antagonizes the proinflammatory cytokine response to opportunistic fungi by alkalizing the fungal phagolysosome.
Topics: Active Transport, Cell Nucleus; Ammonium Chloride; Anti-Bacterial Agents; Candida albicans; Cell Nucleus; Cell Survival; Cells, Cultured; Chloroquine; Cryptococcus neoformans; Cytokines; Endosomes; Enzyme Inhibitors; HIV Seropositivity; Humans; Hydrogen-Ion Concentration; Leukocytes, Mononuclear; Lysosomes; Macrolides; NF-kappa B; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2001 |
On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes.
Topics: Anti-Bacterial Agents; Antimycin A; Cell Line; Chemistry, Pharmaceutical; Chloroquine; Cytoplasm; Drug Delivery Systems; Endocytosis; Endosomes; Fluoresceins; Fluorescent Dyes; Glycerophospholipids; Humans; Hydrogen-Ion Concentration; Intracellular Membranes; Liposomes; Macrolides; Microscopy, Fluorescence; Phosphatidylethanolamines; Rhodamines; Sodium Azide; Sodium Fluoride; Spectrometry, Fluorescence | 2001 |
Selective internalization of sodium channels in rat dorsal root ganglion neurons infected with herpes simplex virus-1.
Topics: Action Potentials; Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Endocytosis; Enzyme Inhibitors; Female; Ganglia, Spinal; Herpes Simplex; Herpesvirus 1, Human; Humans; Immunoenzyme Techniques; Macrolides; Male; Neurons; Proton-Translocating ATPases; Rats; Rats, Sprague-Dawley; Sodium Channels; Viral Proteins; Virus Activation | 2002 |
Inhibition of endosomal/lysosomal degradation increases the infectivity of human immunodeficiency virus.
Topics: Amantadine; Animals; Anti-Bacterial Agents; Cell Line; Chloroquine; Endocytosis; Endosomes; HeLa Cells; HIV Long Terminal Repeat; HIV-1; Humans; Hydrogen-Ion Concentration; Leukemia Virus, Murine; Lysosomes; Macrolides; Mice; Transduction, Genetic | 2002 |
In-vitro characterisation of the phagocytosis and fate of anthrax spores in macrophages and the effects of anti-PA antibody.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Antigens, Bacterial; Bacillus anthracis; Bacterial Toxins; Cell Line; Chloroquine; Genes, Bacterial; In Vitro Techniques; Macrolides; Macrophages; Mice; Mice, Inbred C3H; Mutation; Phagocytosis; Spores, Bacterial | 2002 |
Channel formation by the binding component of Clostridium botulinum C2 toxin: glutamate 307 of C2II affects channel properties in vitro and pH-dependent C2I translocation in vivo.
Topics: ADP Ribose Transferases; Animals; Anti-Bacterial Agents; Binding Sites; Botulinum Toxins; Chlorocebus aethiops; Chloroquine; CHO Cells; Clostridium botulinum; Cricetinae; Electric Conductivity; Escherichia coli; Glutamic Acid; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channel Gating; Ion Channels; Lipid Bilayers; Macrolides; Mutagenesis, Site-Directed; Mutation; Poly(ADP-ribose) Polymerases; Protein Binding; Recombinant Fusion Proteins; Sequence Deletion; Vero Cells | 2003 |
Processing and activation of latent heparanase occurs in lysosomes.
Topics: Animals; Antibodies; Cell Line, Tumor; Chloroquine; CHO Cells; Cricetinae; Enzyme Activation; Glucuronidase; Humans; Hydrolysis; Lysosomes; Macrolides; Protease Inhibitors; Protein Processing, Post-Translational; Protein Transport; Transfection | 2004 |
Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis.
Topics: Animals; Anti-Bacterial Agents; Chlorocebus aethiops; Chloroquine; COS Cells; Cytoplasm; DNA; Endosomes; Gene Transfer Techniques; Genetic Vectors; Hydrogen-Ion Concentration; Luciferases; Macrolides; Polyethyleneimine; Polylysine; Polymers; Proton Pump Inhibitors | 2005 |
Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons.
Topics: Animals; Cerebellum; Chloroquine; Cytoplasmic Granules; Macrolides; Mice; Mice, Inbred C57BL; Neurons | 2006 |
Role of urease in megasome formation and Helicobacter pylori survival in macrophages.
Topics: Adsorption; Ammonia; Ammonium Chloride; Animals; Autoantigens; Cell Line; Chloroquine; Enzyme Induction; Female; Gene Deletion; Genes, Reporter; Helicobacter pylori; Hydrogen-Ion Concentration; Lysosomal Membrane Proteins; Macrolides; Macrophages; Macrophages, Peritoneal; Membrane Fusion; Membrane Proteins; Mice; Microscopy, Fluorescence; Nitric Oxide Synthase Type II; Phagocytosis; Phagosomes; Phenotype; Species Specificity; Urease; Vesicular Transport Proteins | 2006 |
Entry of feline calicivirus is dependent on clathrin-mediated endocytosis and acidification in endosomes.
Topics: Acids; Animals; Antimalarials; Calicivirus, Feline; Cats; Cell Membrane; Chloroquine; Clathrin; Cytoplasm; Endocytosis; Endoribonucleases; Endosomes; Enzyme Inhibitors; Fungal Proteins; Genes, Dominant; Genome, Viral; Macrolides; Permeability; Protein Synthesis Inhibitors; Proton-Translocating ATPases; rab5 GTP-Binding Proteins; Receptors, Virus; RNA, Viral; Virus Replication | 2006 |
Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus.
Topics: Capsid Proteins; Cell Line; Cell Nucleus; Chloroquine; Cytoplasm; Dependovirus; Endosomes; Humans; Macrolides; Nuclear Localization Signals; Protein Conformation; Protein Structure, Tertiary; Virus Internalization | 2006 |
Inhibition of betanodavirus infection by inhibitors of endosomal acidification.
Topics: Ammonium Chloride; Animals; Antiviral Agents; Cells, Cultured; Chloroquine; Cytopathogenic Effect, Viral; Endocytosis; Endosomes; Hydrogen-Ion Concentration; Macrolides; Monensin; Nodaviridae | 2007 |
A method to measure cardiac autophagic flux in vivo.
Topics: Adenine; Animals; Antirheumatic Agents; Autophagy; Cadaverine; Cell Line; Chloroquine; Green Fluorescent Proteins; Macrolides; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Myocytes, Cardiac; Phagosomes; Proton-Translocating ATPases; Recombinant Fusion Proteins | 2008 |
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Membrane; Chloroquine; Culture Media; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hypoxia; Lysosomes; Macrolides; Neuropilin-1; Neuropilin-2; Sirolimus | 2008 |
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Protein 7; Benzylamines; Cell Cycle; Cell Line, Tumor; Chloroquine; Drug Interactions; Female; Furans; Humans; Lysosomes; Macrolides; Mice; Mice, Nude; Mitochondria; Mutation; Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proton-Translocating ATPases; PTEN Phosphohydrolase; Pyridines; Pyrimidines; Quinoxalines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Ubiquitin-Activating Enzymes; Xenograft Model Antitumor Assays | 2008 |
A designer biomimetic vector with a chimeric architecture for targeted gene transfer.
Topics: Animals; Biomimetics; Cell Survival; Chloroquine; DNA; Endosomes; Gene Transfer Techniques; Genetic Engineering; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; HeLa Cells; Histones; Humans; Hydrogen-Ion Concentration; Macrolides; Membrane Fusion; Mice; Nanoparticles; NIH 3T3 Cells; Particle Size; Peptides; Protein Structure, Tertiary; Receptor, ErbB-2; Sensitivity and Specificity; Tandem Repeat Sequences | 2009 |
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.
Topics: Animals; Antineoplastic Agents; Autophagy; Benzamides; Calcium; Cell Death; Cell Line, Tumor; Chloroquine; Dasatinib; Endoplasmic Reticulum; Fusion Proteins, bcr-abl; Gene Expression; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macrolides; Mice; Mice, Inbred C3H; Microtubule-Associated Proteins; Neoplastic Stem Cells; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; RNA Interference; Thiazoles; Transcription Factor CHOP; Xenograft Model Antitumor Assays | 2009 |
Murine norovirus-1 entry into permissive macrophages and dendritic cells is pH-independent.
Topics: Animals; Antirheumatic Agents; Caliciviridae Infections; Cell Culture Techniques; Chloroquine; Dendritic Cells; Endosomes; Enzyme Inhibitors; Hydrogen-Ion Concentration; Macrolides; Macrophages; Male; Mice; Norovirus; Viral Nonstructural Proteins; Virus Internalization | 2009 |
Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis.
Topics: Blotting, Western; Caveolae; Cell Line, Tumor; Cell Survival; Chloroquine; Clathrin; Clathrin Heavy Chains; Endocytosis; Humans; Influenza A Virus, H5N1 Subtype; Macrolides; RNA, Small Interfering; Transfection; Virus Internalization | 2009 |
Lysosome dysfunction triggers Atg7-dependent neural apoptosis.
Topics: Animals; Antifungal Agents; Antimalarials; Apoptosis; Autophagy; Autophagy-Related Protein 7; bcl-2-Associated X Protein; Blotting, Western; Caspases; Cerebellum; Chloroquine; Fibroblast Growth Factor 2; Fluorescent Antibody Technique; Lysosomes; Macrolides; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neurons; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Stem Cells; Tumor Suppressor Protein p53 | 2010 |
A live-cell fluorescence microplate assay suitable for monitoring vacuolation arising from drug or toxic agent treatment.
Topics: Cell Line, Tumor; Cell Survival; Chloroquine; Drug Evaluation, Preclinical; Humans; Luminescent Measurements; Macrolides; Microscopy, Fluorescence; Pharmaceutical Preparations; Phospholipids; Small Molecule Libraries; Vacuoles | 2010 |
Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production.
Topics: Antimalarials; Apoptosis; Artemisinins; Artesunate; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Enzyme Inhibitors; Female; Humans; Iron; Lysosomes; Macrolides; Mitochondria; Mitochondrial Membranes; Permeability; Reactive Oxygen Species | 2011 |
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
Topics: Alkalies; Amiodarone; Animals; Animals, Newborn; Autophagy-Related Protein 5; Bepridil; Blotting, Northern; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Chloroquine; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Frontotemporal Lobar Degeneration; Granulins; HEK293 Cells; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins; Macrolides; Male; Mice; Microtubule-Associated Proteins; Mutation; Neurons; Progranulins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Vacuolar Proton-Translocating ATPases | 2011 |
CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B.
Topics: Acids; Cathepsin B; CD4 Antigens; Chloroquine; Cystatin C; Endocytosis; Endosomes; Genes, Dominant; Genetic Vectors; HEK293 Cells; HeLa Cells; HIV Infections; HIV-1; Humans; Hydrazones; Immunity, Innate; Macrolides; Protease Inhibitors; Signal Transduction; Toll-Like Receptor 4 | 2011 |
[Autophagy: a necessary allied in the growth of pancreatic adenocarcinoma].
Topics: Adenocarcinoma; Animals; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Humans; Immunoglobulin G; Macrolides; Melphalan; Mice; Oxidative Phosphorylation; Pancreatic Neoplasms; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2011 |
Inhibitors of intravesicular acidification protect against Shiga toxin in a pH-independent manner.
Topics: Animals; Biological Transport; Cell Line; Chloroquine; Endoplasmic Reticulum; Endosomes; Enzyme Inhibitors; Hydrogen-Ion Concentration; Macrolides; Nigericin; Shiga Toxin | 2012 |
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy.
Topics: Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 12; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chloroquine; Chromones; Cisplatin; Drug Screening Assays, Antitumor; Female; Gene Knockdown Techniques; Humans; Macrolides; Mice; Morpholines; Proteins; Sirolimus; Starvation | 2012 |
Histone H3 tail peptides and poly(ethylenimine) have synergistic effects for gene delivery.
Topics: Animals; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Genetic Vectors; Histones; Lysosomes; Macrolides; Peptides; Plasmids; Polyethyleneimine; Transfection | 2012 |
pH-sensitive capsules as intracellular optical reporters for monitoring lysosomal pH changes upon stimulation.
Topics: Amiloride; Chloroquine; Fluorescence; Hydrogen-Ion Concentration; Lysosomes; Macrolides; Monensin | 2012 |
Epidermal growth factor-induced vacuolar (H+)-atpase assembly: a role in signaling via mTORC1 activation.
Topics: Amino Acids; Animals; Cells, Cultured; Chloroquine; Endosomes; Epidermal Growth Factor; ErbB Receptors; Female; Hepatocytes; Macrolides; Male; Mechanistic Target of Rapamycin Complex 1; Mitosis; Multiprotein Complexes; Phosphoproteins; Phosphorylation; Protein Multimerization; Protein Subunits; Proteins; Proteome; Rats; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases; Vacuolar Proton-Translocating ATPases | 2012 |
Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.
Topics: Autophagy; Cell Line, Tumor; Chloroquine; Fungal Proteins; Ganoderma; Gene Silencing; Humans; Immunologic Factors; Lysosomes; Macrolides; Phagosomes; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Vacuolar Proton-Translocating ATPases | 2012 |
Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.
Topics: Action Potentials; Antiprotozoal Agents; Cell Membrane; Chloroquine; Chlorpromazine; Clathrin-Coated Vesicles; Down-Regulation; Endocytosis; HEK293 Cells; Humans; Hydrazones; Macrolides; Pentamidine; Potassium Channels, Inwardly Rectifying; Protein Transport; Proteolysis | 2013 |
Influence of histidine incorporation on buffer capacity and gene transfection efficiency of HPMA-co-oligolysine brush polymers.
Topics: Buffers; Chloroquine; Histidine; Lysine; Macrolides; Methacrylates; Microscopy, Electron, Transmission; Plasmids; Polymers; Transfection | 2013 |
Dual inhibition of autophagy and the AKT pathway in prostate cancer.
Topics: Adenine; Autophagy; Cell Line, Tumor; Chloroquine; Clinical Trials, Phase I as Topic; Humans; Macrolides; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Signal Transduction | 2013 |
Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy.
Topics: Antineoplastic Agents, Phytogenic; Antirheumatic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Benzylisoquinolines; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Survival; Chloroquine; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Macrolides; Membrane Proteins; Microtubule-Associated Proteins; Mouth Neoplasms; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; RNA Interference; RNA, Small Interfering | 2013 |
Reversal of lung cancer multidrug resistance by pH-responsive micelleplexes mediating co-delivery of siRNA and paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Chloroquine; Drug Carriers; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Humans; Hydrogen-Ion Concentration; Luciferases; Lung Neoplasms; Macrolides; Micelles; Nanoparticles; Paclitaxel; Polymethacrylic Acids; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Transfection | 2014 |
Autophagy sensitivity of neuroendocrine lung tumor cells.
Topics: Adaptor Proteins, Signal Transducing; Antimalarials; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Humans; Lung Neoplasms; Macrolides; Microtubule-Associated Proteins; Naphthyridines; Neuroendocrine Tumors; Phosphopyruvate Hydratase; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; Sirolimus; Small Cell Lung Carcinoma; TOR Serine-Threonine Kinases | 2013 |
Novel quantitative autophagy analysis by organelle flow cytometry after cell sonication.
Topics: Adenine; Autophagy; Cell Fractionation; Cell Line, Tumor; Chloroquine; Flow Cytometry; Green Fluorescent Proteins; Humans; Macrolides; Microtubule-Associated Proteins; Recombinant Fusion Proteins; Sonication; Staining and Labeling; Vacuoles | 2014 |
Autophagy inhibition can overcome radioresistance in breast cancer cells through suppression of TAK1 activation.
Topics: Antifungal Agents; Antimalarials; Autophagy; Blotting, Western; Breast Neoplasms; Cell Proliferation; Chloroquine; Female; Gamma Rays; Gene Expression Regulation, Neoplastic; Humans; Macrolides; MAP Kinase Kinase Kinases; Phosphorylation; Radiation Tolerance; Signal Transduction; Tumor Cells, Cultured | 2014 |
Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells.
Topics: Abietanes; Adenine; Apoptosis; Autophagy; Cell Proliferation; Chloroquine; Gene Silencing; Hep G2 Cells; Humans; Liver Neoplasms; Macrolides; Phosphatidylinositol 3-Kinases; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; TOR Serine-Threonine Kinases | 2015 |
Measuring cardiac autophagic flux in vitro and in vivo.
Topics: Animals; Autophagy; Blotting, Western; Chloroquine; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; In Vitro Techniques; Macrolides; Mice; Microtubule-Associated Proteins; Myocardium | 2015 |
Autophagy modulates amino acid signaling network in myotubes: differential effects on mTORC1 pathway and the integrated stress response.
Topics: Amino Acids; Animals; Autophagy; Cell Line; Chloroquine; Eukaryotic Initiation Factor-2; Green Fluorescent Proteins; Homeostasis; Lysosomes; Macrolides; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Muscle, Skeletal; Phosphorylation; Proteasome Endopeptidase Complex; Signal Transduction; TOR Serine-Threonine Kinases; Ubiquitin | 2015 |
Acidocalcisome is required for autophagy in Trypanosoma brucei.
Topics: Autophagy; Calcium; Chloroquine; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Lysosomes; Macrolides; Microscopy, Fluorescence; Monensin; Organelles; Phagosomes; Phosphates; Protozoan Proteins; Trypanosoma brucei brucei | 2014 |
Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.
Topics: Adenine; Animals; Autophagy; Cell Death; Cell Line, Tumor; Chloroquine; Embryo, Mammalian; Endoplasmic Reticulum Stress; Fibroblasts; HEK293 Cells; Humans; Macrolides; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Biological; Multiprotein Complexes; Nelfinavir; Signal Transduction; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2015 |
Tuning the buffering capacity of polyethylenimine with glycerol molecules for efficient gene delivery: staying in or out of the endosomes.
Topics: Buffers; Cell Death; Cell Line, Tumor; Chloroquine; DNA; Endocytosis; Endosomes; Flow Cytometry; Gene Expression; Gene Transfer Techniques; Glycerol; Humans; Macrolides; Microscopy, Confocal; Particle Size; Polyethyleneimine; Proton Pump Inhibitors; Static Electricity; Transfection | 2015 |
Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells.
Topics: Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Chloroquine; Extracellular Signal-Regulated MAP Kinases; Humans; Liver Neoplasms; Macrolides; Saponins; Triterpenes | 2015 |
Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer.
Topics: Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Chloroquine; Cyclopentanes; DNA Damage; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Macrolides; Molecular Targeted Therapy; NEDD8 Protein; Neoplasm Proteins; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Random Allocation; RNA, Small Interfering; Transfection; Ubiquitins; Xenograft Model Antitumor Assays | 2015 |
Nonstable Staphylococcus aureus Small-Colony Variants Are Induced by Low pH and Sensitized to Antimicrobial Therapy by Phagolysosomal Alkalinization.
Topics: Ammonium Chloride; Animals; Anti-Bacterial Agents; Cell Line, Tumor; Chloroquine; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Genetic Variation; Humans; Hydrogen-Ion Concentration; Macrolides; Mice; Mice, Inbred C57BL; Phagosomes; Staphylococcal Infections; Staphylococcus aureus | 2016 |
α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway.
Topics: Activating Transcription Factor 4; Activating Transcription Factor 6; Adaptor Proteins, Signal Transducing; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy-Related Protein 8 Family; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Chloroquine; DNA-Binding Proteins; eIF-2 Kinase; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; Macrolides; Membrane Potential, Mitochondrial; Microfilament Proteins; Microtubule-Associated Proteins; Mitochondria; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Regulatory Factor X Transcription Factors; Signal Transduction; Solanine; TOR Serine-Threonine Kinases; Transcription Factors; Unfolded Protein Response | 2015 |
p53-regulated autophagy is controlled by glycolysis and determines cell fate.
Topics: Apoptosis; Autophagy; Caspase 8; Cell Line, Tumor; Cell Lineage; Cell Survival; Cellular Senescence; Chloroquine; Flow Cytometry; Glycolysis; Humans; Imidazoles; Macrolides; MCF-7 Cells; Microscopy, Confocal; Microscopy, Electron; Microscopy, Electron, Transmission; Oxygen; Piperazines; Proto-Oncogene Proteins c-mdm2; RNA, Small Interfering; Superoxides; Tumor Suppressor Protein p53 | 2015 |
Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment.
Topics: Adenine; Androstadienes; Animals; Autophagy; Autophagy-Related Protein 5; Butadienes; Cell Line, Tumor; Cell Survival; Chloroquine; Europium; Extracellular Signal-Regulated MAP Kinases; Green Fluorescent Proteins; HeLa Cells; Humans; Huntingtin Protein; Hydroxides; Lysosomes; Macrolides; Mice; Microscopy, Fluorescence; Microtubule-Associated Proteins; Nanotubes; Nerve Tissue Proteins; Neurodegenerative Diseases; Nitriles; Phagosomes; Phosphorylation; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Trehalose; Wortmannin | 2015 |
Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Antimalarials; Biological Transport, Active; Cells, Cultured; Chloroquine; Down-Regulation; Drug Interactions; Female; Flow Cytometry; Gene Expression Regulation; HEK293 Cells; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Kinetics; Liver; Liver-Specific Organic Anion Transporter 1; Macrolides; Male; Middle Aged; Monensin; Young Adult | 2016 |
Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells.
Topics: Acetylcysteine; Apoptosis; Autophagy; Blotting, Western; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Synergism; Humans; Lung Neoplasms; Macrolides; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Microtubule-Associated Proteins; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Triterpenes | 2016 |
Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility.
Topics: Adenosine Triphosphate; Adult; AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Proteins; Calcium; Caspases; Cell Movement; Cell Survival; Chloroquine; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Intracellular Space; Macrolides; Male; Membrane Transport Proteins; Mitochondrial Precursor Protein Import Complex Proteins; Phosphorylation; Protein Kinases; Receptors, Cell Surface; Semen; Sequestosome-1 Protein; Sirolimus; Spermatozoa | 2016 |
Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts.
Topics: Actins; Animals; Autophagy; Cardiomyopathies; Cell Movement; Cells, Cultured; Chloroquine; Fibroblasts; Fibronectins; Fibrosis; Macrolides; Male; Microtubule-Associated Proteins; Myocardium; Myofibroblasts; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Primary Cell Culture; Rats, Sprague-Dawley; Time Factors | 2016 |
Lysosome Inhibitors Enhance the Chemotherapeutic Activity of Doxorubicin in HepG2 Cells.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Chloroquine; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Hep G2 Cells; Humans; Lysosomes; Macrolides; Membrane Potential, Mitochondrial | 2017 |
Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons.
Topics: Animals; Autophagy; Chloroquine; DNA Damage; DNA, Mitochondrial; Energy Metabolism; Lysosomes; Macrolides; Metabolomics; Microtubule-Associated Proteins; Mitochondria; Neurons; Rats | 2017 |
Contribution of p62 to Phenotype Transition of Coronary Arterial Myocytes with Defective Autophagy.
Topics: ADP-ribosyl Cyclase 1; Animals; Autophagy; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Chloroquine; Coronary Vessels; Lysosomes; Macrolides; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Phenotype; RNA, Small Interfering; Sequestosome-1 Protein; Ubiquitination; Vimentin | 2017 |
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion.
Topics: Animals; Autophagosomes; Autophagy; Cell Line, Tumor; Chloroquine; Endocytosis; Endosomes; ErbB Receptors; Female; Golgi Apparatus; Humans; Hydroxychloroquine; Lysosomes; Macrolides; Membrane Fusion; Mice, Inbred C57BL; Proteolysis; Sequestosome-1 Protein | 2018 |
Metastatic cells are preferentially vulnerable to lysosomal inhibition.
Topics: Animals; Cell Line, Tumor; Chloroquine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Differentiation Proteins; Lung Neoplasms; Lysosomes; Macrolides; Mice; Neoplasm Metastasis; Neoplasm Proteins; Urinary Bladder Neoplasms | 2018 |
Methods for Monitoring Macroautophagy in Pancreatic Cancer Cells.
Topics: Animals; Autophagosomes; Autophagy; Autophagy-Related Proteins; Carcinogenesis; Cell Culture Techniques; Cell Line, Tumor; Chloroquine; Disease Progression; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Humans; Immunoblotting; Lysosomes; Macrolides; Mice; Microscopy, Fluorescence; Pancreas; Pancreatic Neoplasms | 2019 |
Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis.
Topics: Animals; Apoptosis; Autophagy; beta-Transducin Repeat-Containing Proteins; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chloroquine; Epithelial Cells; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Intracellular Signaling Peptides and Proteins; Macrolides; Mechanistic Target of Rapamycin Complex 1; Mice; Ribosomal Proteins; RNA, Small Interfering; Signal Transduction; SKP Cullin F-Box Protein Ligases; Tumor Suppressor Protein p53 | 2018 |
The release and activity of HMGB1 in ferroptosis.
Topics: Animals; Autophagy; Carbolines; Cell Death; Cell Line, Tumor; Chloroquine; Ferritins; Fibroblasts; HMGB1 Protein; Humans; Immunity, Innate; Inflammation; Iron Overload; Lipid Peroxidation; Macrolides; Mice; Neoplasms; Oximes; Piperazines; Sorafenib; Sulfonamides; Toll-Like Receptor 4 | 2019 |
PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Movement; Chloroquine; Cisplatin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Macrolides; MAP Kinase Signaling System; MDS1 and EVI1 Complex Locus Protein; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Neoplasm Metastasis; Ovarian Neoplasms; Prognosis; Retrospective Studies; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells.
Topics: Cell Line, Tumor; Cell Shape; Chloroquine; Cisplatin; Clone Cells; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Ontology; Gene Regulatory Networks; Humans; Lysosomes; Macrolides; Neuroblastoma; Transcriptome; Up-Regulation | 2019 |
pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Line, Tumor; Chloroquine; Female; Fluorescence; Green Fluorescent Proteins; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Luminescent Proteins; Macrolides; Male; Mice; Receptors, Cell Surface; Red Fluorescent Protein; Transfection; Vacuolar Proton-Translocating ATPases | 2019 |
Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling.
Topics: A549 Cells; AMP-Activated Protein Kinases; Autophagosomes; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Chloroquine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Lysosomal Storage Diseases; Lysosomes; Macrolides; Mechanistic Target of Rapamycin Complex 1; Signal Transduction; Up-Regulation; Vacuolar Proton-Translocating ATPases | 2020 |
Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells.
Topics: Autophagy; Cell Line, Tumor; Chloroquine; Cytoplasmic Vesicles; Enzyme Inhibitors; Furin; Humans; Lysosomal Membrane Proteins; Macrolides; Microtubule-Associated Proteins; Peptide Hydrolases; Protease Inhibitors; Receptors, Cell Surface; Renin; RNA-Binding Proteins; Vacuolar Proton-Translocating ATPases | 2020 |
Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-β).
Topics: Autophagy; Cell Line; Cell Proliferation; Chloroquine; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Epithelial Cells; Fibronectins; Fibrosis; G1 Phase Cell Cycle Checkpoints; Humans; In Vitro Techniques; Kidney Tubules; Macrolides; Renal Insufficiency, Chronic; Retinoblastoma Protein; Transforming Growth Factor beta | 2020 |
Comparison of chloroquine-like molecules for lysosomal inhibition and measurement of autophagic flux in the brain.
Topics: Animals; Autophagy; Brain; Chloroquine; Drug Evaluation, Preclinical; Female; HeLa Cells; Humans; Lysosomes; Macrolides; Male; Mefloquine; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Promazine; Quinacrine; Trifluoperazine | 2021 |
Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice.
Topics: Ammonium Chloride; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; Cell Survival; Chlorocebus aethiops; Chloroquine; COVID-19; COVID-19 Drug Treatment; Endosomes; Female; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Lung; Macrolides; Mice; Mice, Transgenic; Random Allocation; SARS-CoV-2; Vero Cells; Virus Replication | 2021 |
Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors.
Topics: Ammonium Chloride; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Chloroquine; Clathrin; COVID-19; COVID-19 Drug Treatment; Drug Synergism; Endocytosis; Endosomes; Humans; Hydrogen-Ion Concentration; Hydroxychloroquine; Macrolides; Niclosamide; Protein Binding; Protein Domains; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Vero Cells; Virus Internalization | 2021 |
Inhibition of autophagy mitigates cell migration and invasion in thyroid cancer.
Topics: Autophagy; Cell Line, Tumor; Cell Movement; Chloroquine; Humans; Macrolides; Neoplasm Invasiveness; Thyroid Neoplasms | 2022 |
SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chlorocebus aethiops; Chloroquine; COVID-19; Endocytosis; Esters; Guanidines; Humans; Immune Evasion; Lung Neoplasms; Macrolides; Recombinant Proteins; SARS-CoV-2; Serine Endopeptidases; Vero Cells; Virus Cultivation; Virus Internalization; Virus Replication; Whole Genome Sequencing | 2022 |
Robust LC3B lipidation analysis by precisely adjusting autophagic flux.
Topics: Autophagosomes; Autophagy; Biological Assay; Biomarkers; Chloroquine; Dose-Response Relationship, Drug; E1A-Associated p300 Protein; HeLa Cells; Humans; Lipid Metabolism; Macrolides; Mechanistic Target of Rapamycin Complex 1; Microtubule-Associated Proteins | 2022 |
Novel and conventional inhibitors of canonical autophagy differently affect LC3-associated phagocytosis.
Topics: Autophagosomes; Autophagy; Cell Differentiation; Chloroquine; Class III Phosphatidylinositol 3-Kinases; Dendritic Cells; Endosomes; Gene Expression Regulation; Humans; Lysosomes; Macrolides; Microtubule-Associated Proteins; Monocytes; Phagocytosis; Phagosomes; Primary Cell Culture; Proteasome Endopeptidase Complex; Pyridines; Pyrimidinones; Thiophenes; Zymosan | 2022 |