chloroquine has been researched along with amiodarone in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.16) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 9 (23.68) | 29.6817 |
| 2010's | 19 (50.00) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Blank, BR; Gut, J; Renslo, AR; Rosenthal, PJ | 1 |
| Kivistö, KT; Laine, K; Neuvonen, PJ | 1 |
| Jaanus, SD | 1 |
| Anderson, SN; Kacew, S; Ruben, Z | 1 |
| Butany, J; Downar, E; Shaikh, NA | 1 |
| George, JL | 1 |
| Coudert, B; Dwyer, TM; Joshi, UM; Kodavanti, PR; Mehendale, HM | 1 |
| D'Amico, DJ; Kenyon, KR | 1 |
| Lüllmann-Rauch, R | 1 |
| Kumamoto, T | 1 |
| Bradley, KA; Damoiseaux, R; Gillespie, EJ; Huang, J; Manchester, M; Rogers, J; Sanchez, AM; Saxe, JP; Thomas, D | 1 |
| Ikebe, T; Ikewaki, J; Imaizumi, M; Nakatsuka, K | 1 |
| Bittner, T; Brouwers, N; Capell, A; Carlson, AM; Cruts, M; Dormann, D; Fellerer, K; Gijselinck, I; Haass, C; Herms, J; Jansen, R; Kunze, B; Lammich, S; Liebscher, S; Sasse, F; Sleegers, K; Steinmetz, H; Van Broeckhoven, C; Willem, M | 1 |
| Brouwer, KL; Ferslew, BC | 1 |
| Chen, YJ; Chen, YS; Chung, WL; Dai, CY; Huang, JF; Kuo, PL; Lee, PH; Lin, CC; Lin, CW; Lo, GH; Yu, ML | 1 |
| Marceau, F; Parks, A | 1 |
| Koizumi, H; Kurata, M; Nemoto, S; Satoh, H; Takei, Y; Yamagiwa, Y | 1 |
| Eguchi, A; Ichikawa, R; Masuda, S; Mizukami, S; Nakamura, K; Nakamura, M; Okada, R; Shibutani, M; Tanaka, T; Yoshida, T | 1 |
| Bantel, H; Frangež, Ž; John, K; Liebig, S; Pfeffer, TJ; Schulze-Osthoff, K; Shibolet, O; Simon, HU; Veltmann, C; Vondran, F; Wandrer, F; Wedemeyer, H | 1 |
| Absenger-Novak, M; Fröhlich, E; Meindl, C; Ober, J; Öhlinger, K | 1 |
5 review(s) available for chloroquine and amiodarone
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Ocular side effects of selected systemic drugs.
Topics: Amiodarone; Anti-Inflammatory Agents; Antirheumatic Agents; Chloroquine; Chlorpromazine; Drug Interactions; Eye Diseases; Humans; Organogold Compounds; Steroids; Sulfonamides; Vision Disorders | 1992 |
Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review.
Topics: Amiodarone; Animals; Chloroquine; Chlorphentermine; Imipramine; Lipidoses; Microscopy, Electron; Perhexiline; Pigment Epithelium of Eye; Rats | 1981 |
[Amphiphilic cationic drug myopathy, drug-induced lysosomal storage lipidosis].
Topics: Aminoquinolines; Amiodarone; Animals; Anti-Arrhythmia Agents; Antimalarials; Autophagy; Cations; Chloroquine; Diagnosis, Differential; Humans; Hydroxychloroquine; Lysosomes; Muscle, Skeletal; Muscular Diseases; Perhexiline; Prognosis; Vacuoles | 2001 |
[Drug-induced visual disturbance].
Topics: Amiodarone; Anti-Asthmatic Agents; Antimalarials; Antitubercular Agents; Antiviral Agents; Chloroquine; Chlorpromazine; Dopamine Antagonists; Ethambutol; Eye Diseases; Glucocorticoids; Humans; Interferons; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones | 2007 |
1 trial(s) available for chloroquine and amiodarone
| Article | Year |
|---|---|
Failure of oral activated charcoal to accelerate the elimination of amiodarone and chloroquine.
Topics: Administration, Oral; Amiodarone; Animals; Charcoal; Chloroquine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; Half-Life; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley | 1992 |
32 other study(ies) available for chloroquine and amiodarone
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.
Topics: Animals; Antimalarials; Female; Ferrous Compounds; Heterocyclic Compounds, 1-Ring; Malaria; Mice; Peroxides; Plasmodium berghei; Plasmodium falciparum; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship | 2017 |
Changes in saccharide and phospholipid content associated with drug storage in cultured rabbit aorta muscle cells.
Topics: Amines; Amiodarone; Animals; Anti-Arrhythmia Agents; Aorta; Cells, Cultured; Chloroquine; Desipramine; Ethylenediamines; Kinetics; Microscopy, Electron; Monosaccharides; Muscle, Smooth, Vascular; Phospholipids; Piperidines; Rabbits; Tilorone | 1991 |
Amiodarone--an inhibitor of phospholipase activity: a comparative study of the inhibitory effects of amiodarone, chloroquine and chlorpromazine.
Topics: Amiodarone; Chloroquine; Chlorpromazine; Humans; Inclusion Bodies; Leukocytes; Microscopy, Electron; Phospholipases | 1987 |
[Corneal, conjunctival and lacrimal changes (excluding dry eye)].
Topics: Adrenal Cortex Hormones; Amiodarone; Anesthetics, Local; Anti-Bacterial Agents; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; Chloroquine; Conjunctival Diseases; Contact Lenses; Corneal Diseases; Drug Hypersensitivity; Humans; Lacrimal Apparatus Diseases; Ophthalmic Solutions; Phenothiazines; Pigmentation Disorders | 1985 |
Types of interaction of amphiphilic drugs with phospholipid vesicles.
Topics: Amiodarone; Anilino Naphthalenesulfonates; Binding Sites; Chloramphenicol; Chloroquine; Chlorpromazine; Diphenylhexatriene; Imipramine; Lipidoses; Lung Diseases; Membrane Lipids; Phospholipids; Promethazine; Propranolol; Surface-Active Agents; Trimipramine | 1988 |
Drug-induced lipidoses of the cornea and conjunctiva.
Topics: Amiodarone; Amodiaquine; Chloroquine; Conjunctival Diseases; Corneal Diseases; Fabry Disease; Female; Gentamicins; Humans; Hydroquinones; Lipidoses; Male; Tilorone | 1981 |
Amiodarone and bepridil inhibit anthrax toxin entry into host cells.
Topics: Amiodarone; Animals; Anthrax; Antigens, Bacterial; Bacterial Toxins; Bepridil; Cell Line; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Macrophages, Peritoneal; Male; Mice; Molecular Structure; Rats; Rats, Inbred F344; Time Factors | 2007 |
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
Topics: Alkalies; Amiodarone; Animals; Animals, Newborn; Autophagy-Related Protein 5; Bepridil; Blotting, Northern; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Chloroquine; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Frontotemporal Lobar Degeneration; Granulins; HEK293 Cells; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins; Macrolides; Male; Mice; Microtubule-Associated Proteins; Mutation; Neurons; Progranulins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Vacuolar Proton-Translocating ATPases | 2011 |
Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates.
Topics: Amiodarone; Animals; Anions; Azithromycin; Biliary Tract; Cells, Cultured; Chloroquine; Desipramine; Fluorobenzenes; Gentamicins; Hepatocytes; Male; Models, Biological; Phospholipids; Pyrimidines; Rats; Rats, Wistar; Rosuvastatin Calcium; Sulfonamides; Taurocholic Acid | 2014 |
Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.
Topics: Amiodarone; Animals; Autophagy; Autophagy-Related Protein 7; Chloroquine; Disease Models, Animal; Hepatectomy; Interleukin-6; Interleukin-8; Liver Diseases; Liver Regeneration; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Mitochondria; RNA Interference; Signal Transduction; Survival Rate; TOR Serine-Threonine Kinases | 2015 |
Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation.
Topics: Amiodarone; Anticholesteremic Agents; Autophagy; beta-Cyclodextrins; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chloroquine; Cholesterol; Cytostatic Agents; Cytotoxins; Human Umbilical Vein Endothelial Cells; Humans; Hydroxychloroquine; Lidocaine; Lovastatin; Lysosomes; Microtubule-Associated Proteins; Poly (ADP-Ribose) Polymerase-1; Procainamide; Quinacrine | 2016 |
Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone.
Topics: Administration, Ophthalmic; Aging; Amiodarone; Animals; Chloroquine; Cornea; Disease Models, Animal; Female; Inclusion Bodies; Instillation, Drug; Lipidoses; Male; Phospholipids; Rabbits | 2019 |
Immunohistochemical expression of autophagosome markers LC3 and p62 in preneoplastic liver foci in high fat diet-fed rats.
Topics: Amiodarone; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Chloroquine; Diet, High-Fat; Disease Models, Animal; Gene Expression; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Male; Microtubule-Associated Proteins; Non-alcoholic Fatty Liver Disease; Precancerous Conditions; Rats, Inbred F344; RNA-Binding Proteins | 2019 |
Autophagy alleviates amiodarone-induced hepatotoxicity.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Apoptosis; Autophagy; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chloroquine; CRISPR-Cas Systems; Endoplasmic Reticulum Stress; Female; Gene Knockout Techniques; Hep G2 Cells; Hepatocytes; Humans; Keratin-18; Lipid Metabolism; Male | 2020 |
Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs.
Topics: Amiodarone; Animals; Cations; Cell Line; Chloroquine; Humans; Lysosomal Storage Diseases; Macrophages; Mice; Monocytes; Phospholipids; RAW 264.7 Cells; THP-1 Cells | 2020 |