chloroquine has been researched along with acetylcysteine in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (9.62) | 18.2507 |
| 2000's | 22 (42.31) | 29.6817 |
| 2010's | 22 (42.31) | 24.3611 |
| 2020's | 3 (5.77) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Mori, S; Omura, S; Saito, Y; Tanaka, K | 1 |
| Breitschopf, K; Ciechanover, A; Gautschi, I; Ishikawa, T; Rotin, D; Schild, L; Staub, O | 1 |
| Alderson, MR; Briden, AL; Grabstein, KH; Lewinsohn, DM; Reed, SG; Riddell, SR | 1 |
| Beyer, EC; Green, K; Laing, JG; Saffitz, JE; Tadros, PN | 1 |
| Amara, SG; Daniels, GM | 1 |
| Fayadat, L; Franc, JL; Lanet, J; Siffroi-Fernandez, S | 1 |
| Ostrand-Rosenberg, S; Qi, L | 1 |
| Dautry-Varsat, A; Lamaze, C; Rocca, A; Subtil, A | 1 |
| Fujii, Y; Fujimoto, K; Fujita, J; Fujita, T; Masunaga, Y; Mayumi, T; Mori, K; Nakagawa, S; Nakanishi, T; Okada, N; Saito, T; Tanaka, K; Yamamoto, A | 1 |
| Carthy, CM; Granville, DJ; Hunt, DW; Jolois, O; Matroule, JY; Piette, J | 1 |
| Fouchier, RA; Nieuwkoop, NJ; Osterhaus, AD; Rimmelzwaan, GF; Voeten, JT | 1 |
| Gafni, M; Keren, O; Sarne, Y; Shapira, M | 1 |
| Engström, A; Larsson, M; Rask, L; Sakwe, AM | 1 |
| Barkan, D; Deharo, E; Ginsburg, H; Golenser, J; Krugliak, M | 1 |
| Bradbury, NA; Devor, DC; Hamilton, KL; Jones, HM; Papworth, GD; Syme, CA; Watkins, SC | 1 |
| Ginsburg, H; Golenser, J | 1 |
| Benveniste, EN; Choi, C; Choi, K; Jeong, E; Kwon, D; Park, J | 1 |
| Jarosz-Wilkołazka, A; Staszczak, M | 1 |
| Couillaud-Battaglia, S; Fortun, Y; Heymann, D; Padrines, M; Redini, F; Tat, SK; Theoleyre, S | 1 |
| Deng, L; Frank, SJ; Fuchs, SY; He, K; Jiang, J; Thangavel, C; Wang, X; Yang, N | 1 |
| Gerelchuluun, T; Han, K; Im, SA; Kim, K; Lee, CK; Lee, YH; Lee, YR; Park, JS; Song, S | 1 |
| Donachie, AM; Mowat, AM; Robson, NC | 1 |
| Lim, G; Mao, J; Sung, B; Wang, S; Yang, L | 1 |
| Qiao, L; Zhang, J | 1 |
| Hou, JC; Pessin, JE; Vicogne, J; Williams, D | 1 |
| Kubo, M; Obata, F; Ohta, E | 1 |
| Alouane, Z; Bahadi, A; El Kabbaj, D; Laalou, A; Oualim, Z | 1 |
| Han, HJ; Kim, MO; Suh, HN | 1 |
| Ann, EJ; Kim, MY; Kim, SM; Mo, JS; Park, HS; Yoon, JH | 1 |
| Radhika, A; Sudhakaran, PR | 1 |
| Bray, PG; Krishna, S; Maughan, SC; Müller, S; Murray, JA; Patzewitz, EM; Salcedo-Sora, JE; Sethia, S; Stocks, PA; Ward, SA; Wong, EH | 1 |
| Bian, ZC; Guan, JL; Liang, CC; Wang, C; Zhu, Y | 1 |
| Aschner, M; Cai, J; Chenjia, G; Guangwei, X; Haifeng, S; Jian, L; Panpan, Z; Rongzhu, L; Suhua, W; Wanxin, P; Wenjun, Z; Yun, F; Yuntao, F | 1 |
| Bian, J; Gu, J; Liu, X; Liu, Z; Song, R; Wang, Q; Wang, T; Yuan, Y; Zhang, K; Zhang, Y | 1 |
| de Andrade-Lima, LC; Garcia, CC; Martins, DJ; Menck, CF; Quinet, A; Rocha, CR; Vessoni, AT; Vieira, DB | 1 |
| Brilot, F; Fonteneau, JF; Gannagé, M; Münz, C | 1 |
| Chen, X; Leung, CH; Lu, J; Luo, W; Ma, DL; Ma, G; Wang, Y | 1 |
| Gao, W; Liu, J; Liu, Z; Man, S; Wang, Y; Yu, P; Zhang, L | 1 |
| Ji, Y; Ju, D; Li, L; Liu, H; Luan, J; Tao, Q; Zhang, X; Zhao, S | 1 |
| Fu, X; Klaunig, JE; Lu, Y; Shi, J; Wang, X; Wu, Q; Zhou, Q; Zhou, S | 1 |
| Ganaes, JOF; Lopes-Pires, ME; Naime, ACA | 1 |
| Nazim, UM; Park, SY | 1 |
| Cai, X; Chen, K; Chen, X; Hu, J; Hu, Y; Huang, A; Li, X; Liang, L; Tang, N; Wang, K; Zhang, W | 1 |
| Nazim, UM; Park, SY; Yin, H | 1 |
| Alizadeh, S; Meshkani, R; Sadeghi, A; Shabani, M | 1 |
| Li, X; Liu, F; Luo, J; Yang, H; Yang, Y; Zhao, Q | 1 |
| Kommalapati, VK; Kumar, D; Tangutur, AD | 1 |
| Chen, J; Du, J; Li, T; Liu, Y; Peng, X; Wang, X; Wang, Y; Yao, Y | 1 |
3 review(s) available for chloroquine and acetylcysteine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Glutathione is involved in the antimalarial action of chloroquine and its modulation affects drug sensitivity of human and murine species of Plasmodium.
Topics: Acetylcysteine; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Glutathione; Hemin; Humans; Malaria; Mice; Plasmodium | 2003 |
Sepsis: The Involvement of Platelets and the Current Treatments.
Topics: Acetylcysteine; Animals; Blood Platelets; Capsaicin; Chloroquine; Disseminated Intravascular Coagulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-7; Platelet Aggregation Inhibitors; Sepsis; Software; Thrombocytopenia; Toll-Like Receptor 4 | 2018 |
49 other study(ies) available for chloroquine and acetylcysteine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway.
Topics: Acetylcysteine; Animals; Chloroquine; Cysteine Endopeptidases; Dipeptides; Humans; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rabbits; Receptors, Platelet-Derived Growth Factor; Swine; Ubiquitins | 1995 |
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Brefeldin A; Calcium-Binding Proteins; Cell Line; Chloroquine; Cyclopentanes; Cysteine Endopeptidases; Dogs; Endosomal Sorting Complexes Required for Transport; Endosomes; Epithelial Sodium Channels; Epithelium; Half-Life; Ion Channel Gating; Ion Transport; Ligases; Lysosomes; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutation; Nedd4 Ubiquitin Protein Ligases; Nuclear Magnetic Resonance, Biomolecular; Oocytes; Point Mutation; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Conformation; Protein Processing, Post-Translational; Rats; Recombinant Fusion Proteins; Sodium; Sodium Channels; Transfection; Ubiquitin-Protein Ligases; Ubiquitins; Up-Regulation; Xenopus laevis; Xenopus Proteins | 1997 |
Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antigen Presentation; CD8-Positive T-Lymphocytes; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Lymphocyte Cooperation; Mice; Molecular Sequence Data; Mycobacterium tuberculosis; Tuberculosis | 1998 |
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Connexin 43; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Hot Temperature; HSP70 Heat-Shock Proteins; Immunoblotting; Leucine; Leupeptins; Lysosomes; Microscopy, Electron; Myocardium; Oligopeptides; Precipitin Tests; Protease Inhibitors; Rats | 1998 |
Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Chloroquine; Clathrin; Colforsin; Cycloheximide; Dogs; Dopamine; Dopamine Plasma Membrane Transport Proteins; Endocytosis; Enzyme Activation; Humans; Kinetics; Lysosomes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phorbols; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Degradation of human thyroperoxidase in the endoplasmic reticulum involves two different pathways depending on the folding state of the protein.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Antibodies, Monoclonal; Chloroquine; CHO Cells; Cricetinae; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Emetine; Endoplasmic Reticulum; Humans; Multienzyme Complexes; Peroxidase; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Folding; Thyroid Gland | 2000 |
MHC class II presentation of endogenous tumor antigen by cellular vaccines depends on the endocytic pathway but not H2-M.
Topics: Acetylcysteine; Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Neoplasm; Antimalarials; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Coculture Techniques; Cysteine Proteinase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Endocytosis; Endoplasmic Reticulum; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Genes, MHC Class II; Humans; Hybridomas; Leupeptins; Major Histocompatibility Complex; Mice; Muramidase; Plasmids; Primaquine; Protein Synthesis Inhibitors; Protein Transport; Ribonucleases; Transfection; Tumor Cells, Cultured | 2000 |
Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments.
Topics: Acetylcysteine; Antimalarials; Cell Line; Chloroquine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endocytosis; Humans; Immunoblotting; Leupeptins; Microscopy, Fluorescence; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Sorting Signals; Protein Subunits; Receptors, Interleukin-2; Recombinant Fusion Proteins; Transfection; Ubiquitins | 2001 |
Effects of lipofectin-antigen complexes on major histocompatibility complex class I-restricted antigen presentation pathway in murine dendritic cells and on dendritic cell maturation.
Topics: Acetylcysteine; Animals; Antigen Presentation; Antigens; Brefeldin A; Cell Line; Cell Survival; Chloroquine; Cytochalasin B; Dendritic Cells; Histocompatibility Antigens Class I; Major Histocompatibility Complex; Mice; Ovalbumin; Phosphatidylethanolamines; Time Factors | 2001 |
Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization.
Topics: Acetylcysteine; Adenocarcinoma; Antioxidants; Apoptosis; Caspase 3; Caspases; Ceramides; Chloroquine; Colonic Neoplasms; Cytochrome c Group; Deuterium Oxide; Endoplasmic Reticulum; Gene Expression Regulation, Neoplastic; Golgi Apparatus; Humans; Lysosomes; Mannans; Mannosephosphates; Microscopy, Fluorescence; Mitochondria; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Oxygen; Phosphorylation; Photochemistry; Photosensitizing Agents; Proline; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Radiation-Protective Agents; Reactive Oxygen Species; Second Messenger Systems; Singlet Oxygen; Thiocarbamates; Tumor Cells, Cultured | 2001 |
Antigen processing for MHC class I restricted presentation of exogenous influenza A virus nucleoprotein by B-lymphoblastoid cells.
Topics: Acetylcysteine; Antigen Presentation; B-Lymphocytes; Brefeldin A; Chloroquine; Endosomes; Enzyme Inhibitors; Hematopoietic Stem Cells; Histocompatibility Antigens Class I; Humans; Influenza A virus; Major Histocompatibility Complex; Nucleocapsid Proteins; Nucleoproteins; Peptide Fragments; RNA-Binding Proteins; Viral Core Proteins | 2001 |
Divers pathways mediate delta-opioid receptor down regulation within the same cell.
Topics: Acetylcysteine; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Cysteine Proteinase Inhibitors; Diprenorphine; Down-Regulation; Etorphine; Flavonoids; Genistein; GTP-Binding Proteins; Humans; Kidney; MAP Kinase Signaling System; Narcotic Antagonists; Neuroblastoma; Phosphorylation; Radioligand Assay; Receptors, Opioid, delta; Staurosporine; Teprotide; Transfection; Tritium; Tumor Cells, Cultured | 2001 |
Biosynthesis and secretion of parathyroid hormone are sensitive to proteasome inhibitors in dispersed bovine parathyroid cells.
Topics: Acetylcysteine; Animals; Brefeldin A; Calpain; Cattle; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Multienzyme Complexes; Parathyroid Glands; Parathyroid Hormone; Proteasome Endopeptidase Complex; Protein Precursors | 2002 |
Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.
Topics: Acetaminophen; Acetylcysteine; Aminoquinolines; Animals; Antimalarials; Chloroquine; Disulfiram; Drug Synergism; Glutathione; Indomethacin; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum | 2003 |
Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1.
Topics: Acetylcysteine; Amino Acid Motifs; Amino Acid Sequence; Cell Line; Cell Membrane; Chloroquine; Dimerization; DNA, Complementary; Electrophysiology; Endocytosis; Epitopes; Humans; Immunoblotting; Intermediate-Conductance Calcium-Activated Potassium Channels; Leucine; Leucine Zippers; Lysosomes; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Calcium-Activated; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Transport; Temperature; Time Factors | 2004 |
Reactive oxygen species mediate chloroquine-induced expression of chemokines by human astroglial cells.
Topics: Acetylcysteine; Astrocytes; Biphenyl Compounds; Cells, Cultured; Chemokines; Chloroquine; Dose-Response Relationship, Drug; Encephalitis; Humans; Inflammation Mediators; Leupeptins; NF-kappa B; Onium Compounds; Reaction Time; Reactive Oxygen Species; RNA, Messenger; Tosylphenylalanyl Chloromethyl Ketone | 2004 |
Inhibition of the proteasome strongly affects cadmium stimulated laccase activity in Trametes versicolor.
Topics: Acetylcysteine; Cadmium; Chloroquine; Dose-Response Relationship, Drug; Fungal Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Laccase; Leupeptins; Mycelium; Proteasome Endopeptidase Complex; Proteasome Inhibitors | 2005 |
OPG/membranous--RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation.
Topics: Acetylcysteine; Animals; Antibodies; Blotting, Western; Cell Line; Cells, Cultured; Chloroquine; Clathrin; Cysteine Proteinase Inhibitors; Enzyme-Linked Immunosorbent Assay; Heparin; Humans; Lysosomes; Mice; Microscopy, Confocal; Osteoclasts; Osteoprotegerin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Syndecans | 2006 |
Determinants of growth hormone receptor down-regulation.
Topics: Acetylcysteine; Animals; Cell Line; Chloroquine; Cycloheximide; Down-Regulation; Human Growth Hormone; Humans; Janus Kinase 2; Lysosomes; Mice; Mutation; Phosphorylation; Proteasome Inhibitors; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Rabbits; Receptors, Somatotropin; Recombinant Proteins; Transfection; Tyrosine | 2007 |
Dendritic cells process antigens encapsulated in a biodegradable polymer, poly(D,L-lactide-co-glycolide), via an alternate class I MHC processing pathway.
Topics: Acetylcysteine; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Brefeldin A; Cell Line; Chloroquine; Dendritic Cells; Histocompatibility Antigens Class I; Humans; Lactic Acid; Nanospheres; Ovalbumin; Phagocytosis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers | 2007 |
Simultaneous presentation and cross-presentation of immune-stimulating complex-associated cognate antigen by antigen-specific B cells.
Topics: Acetylcysteine; Adoptive Transfer; Animals; Antigen Presentation; Antigens; B-Lymphocytes; Brefeldin A; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Chloroquine; Cysteine Proteinase Inhibitors; Epitopes, B-Lymphocyte; ISCOMs; Kinetics; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Mice, Transgenic; Muramidase; Ovalbumin; Peptide Fragments; Receptors, Antigen, T-Cell; Vaccination | 2008 |
Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation.
Topics: Acetylcysteine; Amino Acid Transport System X-AG; Analgesics, Opioid; Animals; Chloroquine; Excitatory Amino Acid Transporter 3; Humans; Leupeptins; Male; Morphine; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitin | 2008 |
Inhibition of lysosomal functions reduces proteasomal activity.
Topics: Acetylcysteine; alpha-Synuclein; Ammonium Chloride; Autophagy; Blotting, Western; Cell Line, Tumor; Chloroquine; Enzyme Inhibitors; HSC70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Hydrogen-Ion Concentration; Lysosomes; Neurons; Proteasome Endopeptidase Complex | 2009 |
The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner.
Topics: 3T3-L1 Cells; Acetylcysteine; Animals; Benzoquinones; Cell Membrane; Chloroquine; Endocytosis; Exocytosis; Glucose Transporter Type 1; Glucose Transporter Type 2; Glucose Transporter Type 4; Lactams, Macrocyclic; Lysosomes; Mice | 2009 |
Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.
Topics: Acetylcysteine; Apoptosis; Chloroquine; Gene Knockdown Techniques; Humans; Hydrogen Peroxide; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Leupeptins; Lysosomes; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Serine-Threonine Kinases | 2010 |
Hemodialysis-associated pseudoporphyria resistant to N-acetylcysteine.
Topics: Acetylcysteine; Administration, Oral; Adult; Chloroquine; Drug Resistance; Female; Humans; Kidney Failure, Chronic; Porphyrias; Renal Dialysis; Skin; Treatment Failure | 2011 |
Laminin-111 stimulates proliferation of mouse embryonic stem cells through a reduction of gap junctional intercellular communication via RhoA-mediated Cx43 phosphorylation and dissociation of Cx43/ZO-1/drebrin complex.
Topics: Acetylcysteine; Actins; Animals; Cell Proliferation; Chloroquine; Connexin 43; Embryonic Stem Cells; Extracellular Matrix; Fibronectins; Focal Adhesion Kinase 1; Gap Junctions; Glycyrrhetinic Acid; Isoquinolines; Laminin; Mice; Multiprotein Complexes; Neuropeptides; Phosphorylation; Protease Inhibitors; Protein Kinase C; Protein Stability; Proteolysis; Receptors, Laminin; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA, Small Interfering; Zonula Occludens-1 Protein | 2012 |
Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.
Topics: Acetylcysteine; Ammonium Chloride; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Gene Knockout Techniques; HEK293 Cells; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Leupeptins; Lysosomes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Presenilin-1; Presenilin-2; Proteasome Inhibitors; Proteolysis; Receptor, Notch1; Transcription, Genetic; Transcriptional Activation; Ubiquitination | 2012 |
Upregulation of macrophage-specific functions by oxidized LDL: lysosomal degradation-dependent and -independent pathways.
Topics: Acetylcysteine; Cell Differentiation; Cells, Cultured; Chloroquine; Chromones; Copper Sulfate; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Gene Expression; Humans; Imidazoles; Leukocytes, Mononuclear; Lipoproteins, LDL; Lysosomes; Macrophages; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Morpholines; Naphthalenes; NF-kappa B; Oxidation-Reduction; PPAR gamma; Proteolysis; Pyridines; Signal Transduction; Transcription Factor AP-1; Transcriptional Activation; Up-Regulation | 2013 |
Glutathione transport: a new role for PfCRT in chloroquine resistance.
Topics: Acetylcysteine; Animals; Antimalarials; Biological Transport; Cells, Cultured; Chloroquine; Drug Resistance; Erythrocytes; Free Radical Scavengers; Gene Expression; Glutathione; Glutathione Synthase; Hemeproteins; Humans; Membrane Transport Proteins; Plasmodium falciparum; Protein Transport; Protozoan Proteins; Xenopus laevis | 2013 |
FIP200 is required for maintenance and differentiation of postnatal neural stem cells.
Topics: Acetylcysteine; Age Factors; Animals; Animals, Newborn; Apoptosis; Autophagy; Autophagy-Related Proteins; Bromodeoxyuridine; Cell Differentiation; Cerebral Ventricles; Chloroquine; Dentate Gyrus; Dicarbethoxydihydrocollidine; Embryo, Mammalian; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; In Situ Nick-End Labeling; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Mutation; Nerve Degeneration; Neural Cell Adhesion Molecule L1; Neural Stem Cells; Reactive Oxygen Species; Sialic Acids; SOXB1 Transcription Factors; Transcription Factor TFIIH; Transcription Factors; Tumor Suppressor Protein p53 | 2013 |
Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes.
Topics: Acetylcysteine; Animals; Apoptosis; Astrocytes; Autophagy; Autophagy-Related Protein 5; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Methylmercury Compounds; Neurotoxicity Syndromes; Rats | 2016 |
Autophagy Plays a Cytoprotective Role During Cadmium-Induced Oxidative Damage in Primary Neuronal Cultures.
Topics: Acetylcysteine; Animals; Antioxidants; Autophagy; Cadmium; Cells, Cultured; Cerebral Cortex; Chloroquine; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Microtubule-Associated Proteins; Neurons; Oxidative Stress; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2015 |
Chloroquine-induced glioma cells death is associated with mitochondrial membrane potential loss, but not oxidative stress.
Topics: Acetylcysteine; Cell Death; Cell Line, Tumor; Chloroquine; Glioma; Humans; Membrane Potential, Mitochondrial; Oxidative Stress; Reactive Oxygen Species | 2016 |
The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.
Topics: Acetylcysteine; Antigen Presentation; Antigens, Neoplasm; Autophagy; Autophagy-Related Protein 12; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Chloroquine; Dendritic Cells; Endocytosis; Epitopes, T-Lymphocyte; Histocompatibility Antigens Class II; Humans; Immunotherapy, Adoptive; Leupeptins; Lymphocyte Activation; Lysosomal-Associated Membrane Protein 2; Melanoma; Membrane Proteins; RNA Interference; RNA, Small Interfering; Small Ubiquitin-Related Modifier Proteins | 2016 |
Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells.
Topics: Acetylcysteine; Apoptosis; Autophagy; Blotting, Western; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Synergism; Humans; Lung Neoplasms; Macrolides; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Microtubule-Associated Proteins; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Triterpenes | 2016 |
Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells.
Topics: A549 Cells; Acetylcysteine; Apoptosis; Autophagy; Blotting, Western; Cell Line; Chloroquine; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Rhizome; Saponins; Signal Transduction | 2016 |
Deprivation of asparagine triggers cytoprotective autophagy in laryngeal squamous cell carcinoma.
Topics: Acetylcysteine; Apoptosis; Asparaginase; Asparagine; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Chloroquine; Humans; Laryngeal Neoplasms; Mitochondria; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2017 |
Autophagy plays a protective role in Mn-induced toxicity in PC12 cells.
Topics: Acetylcysteine; Animals; Autophagy; Cell Respiration; Chlorides; Chloroquine; Dopamine; Manganese Compounds; Mitochondria; Neurosecretory Systems; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Resveratrol; Stilbenes | 2018 |
Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS.
Topics: Acetylcysteine; Apoptosis; Autophagy; Caspases, Initiator; Catechols; Cell Line, Tumor; Chloroquine; Drug Synergism; Drug Therapy, Combination; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mutagens; Plant Extracts; Reactive Oxygen Species; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53; Zingiber officinale | 2019 |
Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway.
Topics: Acetylcysteine; Adenine; Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Chloroquine; Cisplatin; Gene Expression Regulation; Genes, Reporter; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; Red Fluorescent Protein; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; TOR Serine-Threonine Kinases; Virus Activation; Virus Replication | 2019 |
Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species.
Topics: A549 Cells; Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Caspase 8; Cell Line, Tumor; Chloroquine; Drug Combinations; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Mitochondria; Pentacyclic Triterpenes; Reactive Oxygen Species; Sequestosome-1 Protein; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Triterpenes | 2019 |
Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chloroquine; Cytokines; Free Radical Scavengers; Inflammation; Interleukin-6; Mice; Microtubule-Associated Proteins; Muscle, Skeletal; Oxidative Stress; Palmitates; Reactive Oxygen Species; Sequestosome-1 Protein; Sirolimus; Tumor Necrosis Factor-alpha | 2020 |
Naringenin Exerts Cardiovascular Protective Effect in a Palmitate-Induced Human Umbilical Vein Endothelial Cell Injury Model via Autophagy Flux Improvement.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Autophagy; Cardiotonic Agents; Chloroquine; Endothelium, Vascular; Flavanones; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; MAP Kinase Signaling System; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Palmitates; Pyridines; Reactive Oxygen Species | 2019 |
Inhibition of JNJ-26481585-mediated autophagy induces apoptosis via ROS activation and mitochondrial membrane potential disruption in neuroblastoma cells.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Drug Synergism; Free Radical Scavengers; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Peripheral Nervous System Neoplasms; Reactive Oxygen Species | 2020 |
Autophagy triggered by the ROS/ERK signaling pathway protects mouse embryonic palatal cells from apoptosis induced by nicotine.
Topics: Acetylcysteine; Animals; Apoptosis; Autophagy; Chloroquine; Cleft Lip; Cleft Palate; Electronic Nicotine Delivery Systems; MAP Kinase Signaling System; Mice; Microtubule-Associated Proteins; Nicotine; Osteogenesis; Reactive Oxygen Species; Signal Transduction; Teratogens | 2022 |