chloroquine has been researched along with 3-methyladenine in 103 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (3.88) | 18.7374 |
| 1990's | 7 (6.80) | 18.2507 |
| 2000's | 4 (3.88) | 29.6817 |
| 2010's | 74 (71.84) | 24.3611 |
| 2020's | 14 (13.59) | 2.80 |
| Authors | Studies |
|---|---|
| Bansal, DD; MacGregor, RR | 3 |
| Caro, LH; Kerkhof, C; Meijer, AJ; Plomp, PJ; Wolvetang, EJ | 1 |
| Gordon, PB; Høyvik, H; Seglen, PO | 1 |
| Wakeland, JR; Wildenthal, K | 1 |
| Dash, PK; Moore, AN | 1 |
| Codogno, P; Houri, JJ; Ogier-Denis, E; Trugnan, G | 1 |
| Bakke, O; Stang, E | 1 |
| Hatch, GM; Ross, TK | 1 |
| Dunn, WA; Hickson, I; Jasionowski, T; Lenk, SE; Susan, PP | 1 |
| O'Brien, PJ; Pourahmad, J; Ross, S | 1 |
| Gottlieb, RA; Huang, C; Iwai-Kanai, E; Kim, L; Perry-Garza, CN; Sayen, MR; Yuan, H | 1 |
| Bae, D; Lu, S; Mercurio, AM; Taglienti, CA | 1 |
| Benavides, A; Frost, P; Hoang, B; Lichtenstein, A; Shi, Y | 1 |
| Dong, Z; Jiang, M; Liu, K; Luo, J | 1 |
| Chaachouay, H; Kehlbach, R; Multhoff, G; Ohneseit, P; Rodemann, HP; Toulany, M | 1 |
| Cao, S; Cao, T; Fan, J; Huang, F; Li, S; Mao, H; Wang, Y; Yu, X; Zhou, Y; Zhuang, S | 1 |
| Kang, J; Li, H; Qin, H; Su, J; Sun, L; Xu, Y; Yu, C; Yu, H; Zhong, J | 1 |
| Du, J; Eis, A; Guan, T; Konduri, GG; Shi, Y; Teng, RJ; Welak, S | 1 |
| Abagnale, A; Barbato, S; Beguinot, F; Botta, G; Formisano, P; Hallden, G; Libertini, S; Maione, AS; Passaro, C; Portella, G | 1 |
| Ding, ZB; Fan, J; Gu, CY; Hui, B; Liu, WR; Peng, YF; Shi, GM; Shi, YH; Yang, H; Zhou, J | 1 |
| Menshikov, M; Pliyev, BK | 1 |
| Chowdhury, RD; Driscoll, JJ | 1 |
| Liu, CX; Ma, CM; Sun, Y; Wei, W; Wu, YL; Yan, H; Zhao, S | 1 |
| Hou, KZ; Liu, J; Liu, YP; Qu, XJ; Wang, KF; Wu, B; Zhan, YH | 1 |
| Jin, X; Kong, X; Li, H; Xing, Y; Zhang, Z | 1 |
| Chou, B; Hiromatsu, K; Imafuku, S; Ishii, K; Itoh, R; Nakayama, J; Sato, E; Soejima, T | 1 |
| Aki, T; Komatsu, M; Kuwahira, I; Maeda, H; Nagai, H; Ogura, S; Shintani-Ishida, K; Shirai, M; Takemura, G; Yoshida, K | 1 |
| Liang, LZ; Liang, YJ; Liao, GQ; Liu, HC; Ma, B; Su, YX; Zheng, GS | 1 |
| Dickman, MB; Kabbage, M; Williams, B | 1 |
| Lamoureux, F; Zoubeidi, A | 1 |
| Cheng, PC; Chiang, WF; Hong, WZ; Lee, SY; Lin, MH; Lin, PY; Liu, SY; Liu, YC; Yen, CY | 1 |
| Chen, SF; Ma, KG; Shao, ZW; Wang, BC; Wang, J; Wu, Q; Xiong, LM; Yang, SH | 1 |
| Chen, H; Dong, Y; Feng, SS; Jiang, Y; Li, X; Liang, X; Mei, L; Tao, W; Zeng, X; Zhang, X | 1 |
| Chang, YF; Hsieh, YC; Kuo, PL; Lee, PH; Lin, CW; Lo, S; Perng, DS; Wu, DB; Yu, ML; Yuan, SS | 1 |
| Chang, J; Cheng, L; Ji, D; Li, J; Liu, R; Liu, X; Sun, Z; Wang, C; Wang, S; Wang, X; Zhang, X; Zhang, Z; Zheng, B; Zheng, R | 1 |
| Degtyarev, M; Lin, K; Reichelt, M | 1 |
| Barbosa, CM; Bincoletto, C; Jurkiewicz, A; Palmeira dos Santos, C; Pereira, GJ; Smaili, SS | 1 |
| Hergert, P; Nho, RS | 1 |
| Chen, W; Li, S; Peng, W; Sun, H; Wu, J; Yang, X; Yu, X; Zeng, Y | 1 |
| Chen, ZR; Huang, M; Min, H; Xu, M; Zheng, K; Zhou, JD; Zou, XP | 1 |
| Li, R; Liu, WT; Song, JR; Sun, K; Wei, LX; Wu, MC; Zhang, JW; Zhang, SS; Zhao, QD; Zong, C | 1 |
| Gao, Q; Geng, L; Jiang, L; Liu, H; Shi, B; Yang, F; Yao, Y; Zhang, X | 1 |
| Allanki, AD; Navale, R; Sijwali, PS | 1 |
| Davies, DM; Errington, RJ; Herbert, TP; Hunt, DK; Johnson, CE; Sampson, JR; Tee, AR; Wiltshire, M | 1 |
| Cheng, J; Feng, S; Li, G; Liang, J; Liu, S; Quan, M; Wang, Q; Zhang, Y | 1 |
| Bi, Y; Chen, X; Cho, K; Hou, X; Li, C; Liu, H; Liu, Y; Peng, F; Shen, C; Wang, K; Wang, X; Yang, Z; Zhang, J; Zhang, W; Zhang, X; Zhao, S; Zheng, Z; Zhong, C; Zou, H | 1 |
| Godschalk, RW; Jutten, B; Keulers, TG; Peeters, HJ; Rouschop, KM; Savelkouls, KG; Schaaf, MB; van den Beucken, T; van Schooten, FJ; Vooijs, M | 1 |
| Chang, YT; Huang, HJ; Hwang, MH; Lin, AM; Tang, MC; Wu, MY; Yang, JC | 1 |
| Britschgi, A; Cahill, MR; Gudas, LJ; McKenna, SL; Mongan, NP; Nyhan, MJ; O'Donovan, TR; Orfali, N; Tschan, MP | 1 |
| Chen, X; Chen, YH; Jiang, PF; Li, LJ; Li, W; Shen, HQ; Zheng, XY | 1 |
| Barui, AK; Hu, Y; Jin, PP; Lin, J; Patra, CR; Ruan, RQ; Shi, SS; Wei, PF; Wen, LP; Zhang, HR; Zhang, JQ; Zhang, L; Zhang, YJ; Zhou, W | 1 |
| Cai, W; Di, W; Ji, Y; Lu, Z; Wu, J; Yang, Q | 1 |
| Bi, Y; Gao, D; Hou, X; Li, C; Liu, H; Liu, Y; Liu, Z; Peng, F; Shen, C; Shi, C; Wang, K; Wang, X; Wu, J; Zhang, J; Zhao, B; Zhao, S; Zheng, Z; Zhong, C; Zou, H | 1 |
| Chen, G; Fan, W; Lai, Y; Long, Y; Wang, X; Zhu, B | 1 |
| Huangfu, CS; Ji, AL; Li, YZ; Liu, B; Zhang, YJ; Zheng, NR | 1 |
| Duan, J; Liu, Q; Mu, H; Niu, H; Tang, J; Wang, D | 1 |
| Gao, R; Guo, J; Li, N; Ma, Z; Shi, S; Tan, P; Wang, J; Yan, B; Zhao, J | 1 |
| Gu, HF; Li, HZ; Liao, DF; Tang, XQ; Tang, YL; Zheng, XL | 1 |
| Bi, H; Gao, J; Lu, X; Zhang, G; Zheng, Y | 1 |
| Cui, L; Yang, S; Zhang, J; Zhang, W | 1 |
| Chen, LX; Ran, DH; Xie, WY; Yang, J; Zhou, XD | 1 |
| Bi, J; Gao, F; He, W; Huang, H; Lan, Y; Song, D; Wang, G; Zhang, D; Zhao, K | 1 |
| Akhtar, S; Facskó, A; Fésüs, L; Kaarniranta, K; Kauppinen, A; Kristóf, E; Petrovski, G; Szatmári-Tóth, M; Veréb, Z | 1 |
| Chen, G; Chen, P; Di, C; Gong, L; Shi, J; Wang, J; Xia, X; Xu, H; Zhang, W | 1 |
| Hahm, KB; Han, YM; Jeong, M; Kim, MY; Lee, HJ; Ock, CY; Park, JM | 1 |
| Fu, J; Hu, J; Liu, Z; Tang, M; Wang, L; Wen, J; Xue, L; Yang, R; Zhang, Y | 1 |
| Chen, JT; Chen, RM; Cheng, BC; Chio, CC; Liu, SH; Yang, ST | 1 |
| Chen, S; Chen, Y; Lai, B; Liang, H; Liu, J; Song, L; Tang, H; Xu, L; Yang, H; Yun, L; Zhou, K | 1 |
| Li, J; Mu, Y; Yan, WJ; Yang, J; Yin, TL; Zhang, Y | 1 |
| Ding, N; Gao, F; He, W; Lan, Y; Li, Z; Lu, H; Lv, X; Su, J; Zhao, K | 1 |
| Jeong, K; Jeong, MS; Kim, SH; Kwon, HY; Sohn, EJ | 1 |
| Lee, DI; Lee, JE; Lee, JS; Lee, SM; Park, SH; Yu, HS | 1 |
| He, F; Huang, G; Li, B; Li, X; Lian, J; Lyu, X; Ni, Z; Wu, Y; Xiong, H; Yan, X; Zeng, Y; Zhang, N; Zhang, Y | 1 |
| Hu, LK; Sun, YL; Wang, HJ; Zhao, T; Zhao, WW | 1 |
| Atsuzawa, Y; Fujisaki, H; Hattori, S; Hayashi, T; Ikejima, T; Liu, W; Liu, WW; Liu, XL; Lu, ZY; Onodera, S; Tashiro, SI; Wu, QJ; Yamato, M; Yao, GD; Zhang, X; Zhao, YL | 1 |
| Cao, L; Cheng, K; Su, Q; Zhang, X; Zhang, Y | 1 |
| Ding, X; Gao, Y; Li, Q; Xie, J | 1 |
| Li, Q; Qin, J; Sheng, X; Zhu, P | 1 |
| Hou, HT; Liu, B; Long, HL; Wang, HL; Yang, WS; Yu, JK; Zhang, FF | 1 |
| Eberli, D; Gross, O; Kranzbühler, B; Mortezavi, A; Salemi, S; Simon, HU; Sulser, T | 1 |
| Ajami, M; Anjam-Najmedini, A; Atashi, A; Houshmand, M; Kazemi, A; Ojaghi, M; Sadri, M; Tavakoli, R; Yazdi, N; Zarif, MN | 1 |
| Hseu, YC; Kao, MC; Karuppaiya, P; Li, ML; Mathew, DC; Shen, YC; Yang, HL | 1 |
| Cai, X; Chen, K; Chen, X; Hu, J; Hu, Y; Huang, A; Li, X; Liang, L; Tang, N; Wang, K; Zhang, W | 1 |
| Li, J; Li, JY; Li, YF; Lu, YT; Nan, FJ; Xiao, YF | 1 |
| Cao, L; Cheng, K; Yuan, S; Zhang, X | 1 |
| He, Q; He, X; Wang, DH | 1 |
| Bagamanshina, AV; Kähne, T; Kit, YY; Koval, OA; Kuligina, EV; Lavrik, IN; Nushtaeva, AA; Richter, M; Richter, VA; Starykovych, MO; Troitskaya, OS; Wohlfromm, F; Yunusova, AY | 1 |
| Alizadeh, S; Meshkani, R; Sadeghi, A; Shabani, M | 1 |
| Chen, B; He, S; Li, L; Luo, B; Yan, F; Zhou, Q | 1 |
| Chen, J; Chen, X; Li, A; Li, X; Li, Z; Wang, Z; Zeng, C | 1 |
| Hou, JM; Li, N; Wu, HJ; Xue, Y; Zhang, Y; Zhang, ZN; Zhao, LJ | 1 |
| Ohta, T; Okubo, S; Shoyama, Y; Uto, T | 1 |
| Wu, X; Zeng, X; Zhou, W | 1 |
| Eberli, D; Kranzbühler, B; Mortezavi, A; Salemi, S; Sulser, T | 1 |
| Ahmadi, Z; Ashrafizadeh, M; Mohammadinejad, R; Sahebkar, A; Tavakol, S | 1 |
| Balmori-Cedeno, J; Liu, JT; Lumsden, JS; Misk, E | 1 |
| Guo, L; Li, S; Qian, G; Wu, X; Zhang, X; Zhao, S | 1 |
| Bi, Y; Fang, F; Huang, Y; Liu, X; Lu, YY; Shu, S; Xi, T; Zhang, L; Zhang, X; Zhang, Z | 1 |
| Feng, L; Li, X; Liu, Q; Qiao, J; Shi, S; Wang, B; Wang, S; Wang, Y; Zhang, D; Zhong, C | 1 |
| Deng, Y; Hao, Y; Liao, W; Liu, H; Mao, L; Sun, S; Yuan, M; Zhang, R | 1 |
| Cao, L; Chen, M; Furlong, F; Guo, X; Li, X; Meng, Z; Ren, Y; Wang, L; Wu, X; Xu, K; Zhang, Q; Zheng, S | 1 |
3 review(s) available for chloroquine and 3-methyladenine
| Article | Year |
|---|---|
Molecular crosstalk between the proteasome, aggresomes and autophagy: translational potential and clinical implications.
Topics: Adenine; Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Chloroquine; Clinical Trials as Topic; Drug Resistance, Neoplasm; Drug Synergism; Forecasting; Humans; Inclusion Bodies; Medical Oncology; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Pyrazines; Translational Research, Biomedical; Ubiquitin | 2012 |
Inhibition of autophagy enhances heat-induced apoptosis in human non-small cell lung cancer cells through ER stress pathways.
Topics: A549 Cells; Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chloroquine; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Flow Cytometry; Hot Temperature; Humans; Hyperthermia, Induced; Immunohistochemistry; In Situ Nick-End Labeling; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Phosphorylation; RNA, Small Interfering | 2016 |
New Insight into Triple-Negative Breast Cancer Therapy: The Potential Roles of Endoplasmic Reticulum Stress and Autophagy Mechanisms.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Design; Endoplasmic Reticulum Stress; Female; Humans; Phytochemicals; Signal Transduction; Triple Negative Breast Neoplasms | 2021 |
100 other study(ies) available for chloroquine and 3-methyladenine
| Article | Year |
|---|---|
Calcium-regulated secretion of tissue plasminogen activator and parathyroid hormone from human parathyroid cells.
Topics: Adenine; Adenoma; Calcium; Chloroquine; Humans; Immune Sera; In Vitro Techniques; Kinetics; Parathyroid Glands; Parathyroid Hormone; Parathyroid Neoplasms; Subcellular Fractions; Tissue Plasminogen Activator | 1992 |
Secretion of plasminogen activator from bovine parathyroid cells.
Topics: Adenine; Amiloride; Animals; Calcitriol; Calcium; Cattle; Cells, Cultured; Chloroquine; Fibrin; Hydrocortisone; Microsomes; Molecular Weight; Oligopeptides; Organelles; Parathyroid Glands; Parathyroid Hormone; Plasminogen Activators; Plasminogen Inactivators; Urokinase-Type Plasminogen Activator | 1990 |
Inhibitors of cellular proteolysis cause increased secretion from parathyroid cells.
Topics: 1-Deoxynojirimycin; Adenine; Animals; Calcium; Calcium-Binding Proteins; Cattle; Cells, Cultured; Chloroquine; Chromogranin A; Chromogranins; Exocytosis; Glucosamine; Parathyroid Glands; Parathyroid Hormone; Protease Inhibitors; Radioimmunoassay | 1989 |
3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism.
Topics: Adenine; Animals; Cells, Cultured; Chloroquine; Glucagon; Glucose; Hydrogen-Ion Concentration; Kinetics; Liver; Liver Glycogen; Lysosomes; Male; Methylamines; Mitochondria, Liver; Rats; Rats, Inbred Strains | 1988 |
Use of a hydrolysable probe, [14C]lactose, to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway.
Topics: Adenine; Animals; Autophagy; Chloroquine; Hydrolysis; Lactose; Liver; Lysosomes; Male; Phagocytosis; Phagosomes; Rats; Rats, Inbred Strains; Sucrose; Vinblastine | 1986 |
The role of lysosomes in the degradation of myofibrillar and non-myofibrillar proteins in heart.
Topics: Adenine; Animals; Chloroquine; Fetus; Insulin; Kinetics; Leupeptins; Lysosomes; Mice; Myocardium; Myofibrils; Proteins | 1985 |
Inhibitors of endocytosis, endosome fusion, and lysosomal processing inhibit the intracellular proteolysis of the amyloid precursor protein.
Topics: Adenine; Amyloid beta-Protein Precursor; Animals; Chloroquine; Colchicine; Cytochalasin B; Endocytosis; Lysosomes; Monensin; Organelles; PC12 Cells; Rats | 1993 |
Autophagic degradation of N-linked glycoproteins is downregulated in differentiated human colon adenocarcinoma cells.
Topics: Adenine; Adenocarcinoma; Asparagine; Autophagy; Carbon Radioisotopes; Carcinogens; Cell Differentiation; Cell Line; Chloroquine; Colonic Neoplasms; Ethers, Cyclic; Glycoproteins; Humans; Kinetics; Leucine; Lysosomes; Mannose; Okadaic Acid; Polysaccharides; Tritium; Tumor Cells, Cultured | 1993 |
MHC class II-associated invariant chain-induced enlarged endosomal structures: a morphological study.
Topics: Adenine; Antigens, CD; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Endocytosis; Endosomes; Fibroblasts; HLA-DR alpha-Chains; HLA-DR Antigens; Humans; Immunohistochemistry; Leupeptins; Lysosomal Membrane Proteins; Lysosomes; Macromolecular Substances; Membrane Glycoproteins; Receptor, IGF Type 2; Recombinant Proteins; Transfection | 1997 |
Role of an antimalarial drug in diphosphatidylglycerol biosynthesis in rat liver hepatocytes.
Topics: Adenine; Animals; Antimalarials; Cardiolipins; Chloroquine; Glucose; In Vitro Techniques; Liver; Male; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1997 |
Ubiquitinated aldolase B accumulates during starvation-induced lysosomal proteolysis.
Topics: Adenine; Amino Acid Sequence; Amino Acids; Animals; Antimalarials; Blood Proteins; Carcinoma, Hepatocellular; Cell Survival; Chloroquine; Cytosol; Fructose-Bisphosphate Aldolase; Kidney; Liver; Lysosomes; Molecular Sequence Data; Rats; Starvation; Tumor Cells, Cultured; Ubiquitins | 1999 |
Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+).
Topics: Acridine Orange; Adenine; Animals; Aurothioglucose; Cadmium; Cell Death; Chloroquine; Copper; Endopeptidases; Enzyme Activation; Gentamicins; Leupeptins; Lipid Peroxidation; Liver; Lysosomes; Male; Methylamines; Monensin; Oxidation-Reduction; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2001 |
A method to measure cardiac autophagic flux in vivo.
Topics: Adenine; Animals; Antirheumatic Agents; Autophagy; Cadaverine; Cell Line; Chloroquine; Green Fluorescent Proteins; Macrolides; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Myocytes, Cardiac; Phagosomes; Proton-Translocating ATPases; Recombinant Fusion Proteins | 2008 |
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Membrane; Chloroquine; Culture Media; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hypoxia; Lysosomes; Macrolides; Neuropilin-1; Neuropilin-2; Sirolimus | 2008 |
Effect of autophagy on multiple myeloma cell viability.
Topics: Adenine; Antifungal Agents; Antimalarials; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Boronic Acids; Bortezomib; Cell Proliferation; Chloroquine; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Immunoblotting; Membrane Proteins; Microscopy, Fluorescence; Multiple Myeloma; Pyrazines; RNA, Small Interfering; Sirolimus; Thapsigargin; Tumor Cells, Cultured | 2009 |
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Line; Chloroquine; Cytoprotection; Gene Knockdown Techniques; Hypoxia; Kidney; Kidney Tubules, Proximal; Mice; Mice, Inbred C57BL; Proteins; Rats; Reperfusion Injury; Vacuoles | 2010 |
Autophagy contributes to resistance of tumor cells to ionizing radiation.
Topics: Adenine; Autophagy; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electrophoresis, Polyacrylamide Gel; Female; Humans; Microtubule-Associated Proteins; Radiation Tolerance; Signal Transduction; Tumor Cells, Cultured | 2011 |
Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Survival; Cells, Cultured; Chloroquine; Diterpenes; Dose-Response Relationship, Drug; Epithelial Cells; Green Fluorescent Proteins; HSP72 Heat-Shock Proteins; Lipopolysaccharides; Luminescent Agents; Male; MAP Kinase Signaling System; Peritoneal Cavity; Peritonitis; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Up-Regulation | 2011 |
Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Proliferation; Chloroquine; Cisplatin; Endoplasmic Reticulum Stress; Endoribonucleases; Female; HeLa Cells; Humans; MAP Kinase Signaling System; Membrane Proteins; Protein Serine-Threonine Kinases; Tunicamycin; Uterine Cervical Neoplasms | 2012 |
Cross talk between NADPH oxidase and autophagy in pulmonary artery endothelial cells with intrauterine persistent pulmonary hypertension.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Cells, Cultured; Chloroquine; Endothelial Cells; Endothelium, Vascular; Green Fluorescent Proteins; Hypertension, Pulmonary; Microtubule-Associated Proteins; NADPH Oxidases; Neovascularization, Physiologic; Nuclear Proteins; Pulmonary Artery; Reactive Oxygen Species; Receptors, Immunologic; Recombinant Fusion Proteins; Sheep | 2012 |
Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo.
Topics: Adenine; Adenoviridae; Adenovirus E1A Proteins; Adjuvants, Immunologic; Animals; Autophagy; Cell Line, Tumor; Chloroquine; Fluorescent Antibody Technique; Genetic Vectors; Glioma; Humans; Mice; Mice, Nude; Oncolytic Viruses; Polymerase Chain Reaction; Signal Transduction | 2012 |
Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Boronic Acids; Bortezomib; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Membrane Proteins; Microtubule-Associated Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines | 2012 |
Differential effects of the autophagy inhibitors 3-methyladenine and chloroquine on spontaneous and TNF-α-induced neutrophil apoptosis.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Apoptosis; Autophagy; Chloroquine; Down-Regulation; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Neutrophils; Proto-Oncogene Proteins c-bcl-2; Quinolines; Tumor Necrosis Factor-alpha | 2012 |
Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cells, Cultured; Chalcones; Chloroquine; Gene Knockdown Techniques; HEK293 Cells; Humans; Macrolides; Membrane Potential, Mitochondrial; Membrane Proteins; Mitochondria; Multiple Myeloma; Protein Kinase C-delta; Proteolysis | 2012 |
β-Elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/ mTOR signalling pathways.
Topics: Adenine; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Chloroquine; Extracellular Signal-Regulated MAP Kinases; Humans; Kidney Neoplasms; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Sesquiterpenes; TOR Serine-Threonine Kinases | 2012 |
Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells.
Topics: Adenine; Apoptosis; Autophagy; Carcinoma, Renal Cell; Cell Line, Tumor; Chloroquine; Drug Synergism; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Kidney Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells.
Topics: Adenine; Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Autophagy; Autophagy-Related Protein 5; Calcitriol; Cathelicidins; Cell Line, Tumor; Chloroquine; Cytokines; Fibroblasts; Humans; Mice, Knockout; Microtubule-Associated Proteins; Monocytes; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Receptors, Calcitriol; RNA Interference; Time Factors; Transfection; Up-Regulation | 2013 |
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.
Topics: Adenine; Animals; Autophagy; Chloroquine; Heart Diseases; Heart Failure; Hypoxia; Lysosomes; Male; Muscle Contraction; Myocardium; Myocytes, Cardiac; Necrosis; Phagosomes; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases; Troponin T | 2013 |
Inhibition of autophagy enhances cisplatin cytotoxicity in human adenoid cystic carcinoma cells of salivary glands.
Topics: Adenine; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Adenoid Cystic; Cell Culture Techniques; Cell Death; Cell Line, Tumor; Cell Survival; Chloroquine; Cisplatin; Coloring Agents; Drug Resistance, Neoplasm; Green Fluorescent Proteins; Humans; Luminescent Agents; Membrane Proteins; Microtubule-Associated Proteins; Salivary Gland Neoplasms; Tetrazolium Salts; Thiazoles | 2013 |
Cell death control: the interplay of apoptosis and autophagy in the pathogenicity of Sclerotinia sclerotiorum.
Topics: Adenine; Androstadienes; Antifungal Agents; Apoptosis; Arabidopsis; Ascomycota; Autophagy; Chloroquine; Chromones; Host-Pathogen Interactions; Morpholines; Mycoses; Oxalic Acid; Plant Diseases; Reactive Oxygen Species; Respiratory Burst; Wortmannin | 2013 |
Dual inhibition of autophagy and the AKT pathway in prostate cancer.
Topics: Adenine; Autophagy; Cell Line, Tumor; Chloroquine; Clinical Trials, Phase I as Topic; Humans; Macrolides; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Signal Transduction | 2013 |
Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity.
Topics: Actins; Adenine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Areca; Autophagy; Autophagy-Related Proteins; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Cisplatin; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Fluorouracil; Glucose; Humans; Indicators and Reagents; Jurkat Cells; Microtubule-Associated Proteins; Mouth Neoplasms; Plant Extracts; Tetrazolium Salts; Time Factors | 2014 |
Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression.
Topics: Adenine; Animals; Apoptosis; Autophagy; Blotting, Western; Cells, Cultured; Chloroquine; Immunohistochemistry; Intervertebral Disc; Intervertebral Disc Degeneration; Microscopy, Electron, Transmission; Rats; Reactive Oxygen Species; Stress, Mechanical | 2013 |
The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment.
Topics: Adenine; Animals; Autophagy; Cell Line, Tumor; Chloroquine; Drug Delivery Systems; Female; Humans; Immunoblotting; Lactic Acid; Mice, SCID; Nanomedicine; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Xenograft Model Antitumor Assays | 2014 |
Complete activation of autophagic process attenuates liver injury and improves survival in septic mice.
Topics: Adenine; Amebicides; Animals; Anticonvulsants; Autophagy; Carbamazepine; Chloroquine; Liver; Lysosomes; Mice; Phagosomes; Sepsis | 2014 |
The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Butadienes; Cell Line, Tumor; Chloroquine; Cyclin D1; Drug Synergism; Everolimus; Flavonoids; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Membrane Proteins; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Nitriles; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
Novel quantitative autophagy analysis by organelle flow cytometry after cell sonication.
Topics: Adenine; Autophagy; Cell Fractionation; Cell Line, Tumor; Chloroquine; Flow Cytometry; Green Fluorescent Proteins; Humans; Macrolides; Microtubule-Associated Proteins; Recombinant Fusion Proteins; Sonication; Staining and Labeling; Vacuoles | 2014 |
Comparative study of autophagy inhibition by 3MA and CQ on Cytarabine‑induced death of leukaemia cells.
Topics: Adenine; Antimalarials; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Blotting, Western; Caspase 3; Cell Proliferation; Chloroquine; Cytarabine; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunophenotyping; Leukemia; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2014 |
IPF fibroblasts are desensitized to type I collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases.
Topics: Adenine; Autophagy; Cell Line; Cell Proliferation; Cell Survival; Chloroquine; Collagen Type I; Enzyme Activation; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Phagosomes; Protein Multimerization; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2014 |
Autophagy inhibitors promoted aristolochic acid I induced renal tubular epithelial cell apoptosis via mitochondrial pathway but alleviated nonapoptotic cell death in mouse acute aritolochic acid nephropathy model.
Topics: Adenine; Animals; Apoptosis; Aristolochia; Aristolochic Acids; Autophagy; Chloroquine; Drugs, Chinese Herbal; Endoplasmic Reticulum Stress; Epithelial Cells; Kidney Diseases; Kidney Tubules; Mice; Mice, Inbred BALB C; Mitochondria | 2014 |
Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells.
Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Cell Survival; Cells, Cultured; Chloroquine; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Humans; Neoplasm Proteins; Pancreatic Neoplasms; Proteasome Inhibitors; Protein Kinase Inhibitors; Pyrazines; RNA Interference; RNA, Small Interfering | 2014 |
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells.
Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Autophagy; Camptothecin; Cell Line, Tumor; Cellular Senescence; Chloroquine; Class III Phosphatidylinositol 3-Kinases; Colorectal Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Lysosomes; Neoplasm Proteins; Osmolar Concentration; Signal Transduction; Tumor Suppressor Protein p53 | 2014 |
Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells.
Topics: Abietanes; Adenine; Apoptosis; Autophagy; Cell Proliferation; Chloroquine; Gene Silencing; Hep G2 Cells; Humans; Liver Neoplasms; Macrolides; Phosphatidylinositol 3-Kinases; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; TOR Serine-Threonine Kinases | 2015 |
Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum.
Topics: Adenine; Amino Acid Sequence; Antimalarials; Apicoplasts; Autophagy; Autophagy-Related Protein 8 Family; Chloroquine; Doxycycline; Erythrocytes; Gene Expression Regulation; Genome, Protozoan; Humans; Leucine; Life Cycle Stages; Microfilament Proteins; Molecular Sequence Data; Pepstatins; Plasmodium falciparum; Protease Inhibitors; Protozoan Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2014 |
Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.
Topics: Adenine; Animals; Autophagy; Cell Death; Cell Line, Tumor; Chloroquine; Embryo, Mammalian; Endoplasmic Reticulum Stress; Fibroblasts; HEK293 Cells; Humans; Macrolides; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Biological; Multiprotein Complexes; Nelfinavir; Signal Transduction; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2015 |
NS5ATP9 Promotes Beclin 1-Dependent Starvation-Induced Autophagy of Hepatoblastoma Cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carrier Proteins; Cell Proliferation; Chloroquine; DNA-Binding Proteins; Hep G2 Cells; Hepatoblastoma; Humans; Liver Neoplasms; Membrane Proteins; Stress, Physiological | 2015 |
Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Autophagy; Beclin-1; Blotting, Western; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Chloroquine; Drug Synergism; Flow Cytometry; Glioblastoma; Humans; Membrane Proteins; Microscopy, Electron, Transmission; Oxides; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; RNA Interference; RNA, Small Interfering | 2015 |
Canonical autophagy does not contribute to cellular radioresistance.
Topics: Adenine; Autophagy; Cell Line, Tumor; Chloroquine; DNA Repair; Humans; Phosphorylation; Radiation Tolerance; Radiation-Sensitizing Agents; Radiation, Ionizing; Signal Transduction | 2015 |
Chloroquine enhances gefitinib cytotoxicity in gefitinib-resistant nonsmall cell lung cancer cells.
Topics: Adenine; Antineoplastic Agents; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chloroquine; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Quinazolines | 2015 |
Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Antineoplastic Agents; Antirheumatic Agents; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Protein 8 Family; Cell Differentiation; Chloroquine; Granulocytes; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Microfilament Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Tretinoin; Ubiquitin-Activating Enzymes | 2015 |
Low concentrations of chloroquine and 3-methyladenine suppress the viability of retinoblastoma cells synergistically with vincristine independent of autophagy inhibition.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Antirheumatic Agents; Apoptosis; Autophagy; Blotting, Western; Cell Cycle Checkpoints; Cell Survival; Chloroquine; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Microtubule-Associated Proteins; Retinal Neoplasms; Retinoblastoma; RNA-Binding Proteins; Sincalide; Tumor Cells, Cultured; Vincristine | 2015 |
Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment.
Topics: Adenine; Androstadienes; Animals; Autophagy; Autophagy-Related Protein 5; Butadienes; Cell Line, Tumor; Cell Survival; Chloroquine; Europium; Extracellular Signal-Regulated MAP Kinases; Green Fluorescent Proteins; HeLa Cells; Humans; Huntingtin Protein; Hydroxides; Lysosomes; Macrolides; Mice; Microscopy, Fluorescence; Microtubule-Associated Proteins; Nanotubes; Nerve Tissue Proteins; Neurodegenerative Diseases; Nitriles; Phagosomes; Phosphorylation; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Trehalose; Wortmannin | 2015 |
Inhibition of Autophagy Increases Proliferation Inhibition and Apoptosis Induced by the PI3K/mTOR Inhibitor NVP-BEZ235 in Breast Cancer Cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Protein 7; Breast Neoplasms; Cell Proliferation; Cell Survival; Chloroquine; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; MCF-7 Cells; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolines; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Transfection; Ubiquitin-Activating Enzymes | 2015 |
Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells.
Topics: Adenine; Animals; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; Glioma; Humans; Male; Neoplasm Staging; Quercetin; Rats; Rats, Sprague-Dawley | 2016 |
NPAS4 Facilitates the Autophagic Clearance of Endogenous Tau in Rat Cortical Neurons.
Topics: Adenine; Animals; Autophagy; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Cerebral Cortex; Chloroquine; Cyclin-Dependent Kinase 5; Glycogen Synthase Kinase 3; Leupeptins; Neurons; Proteolysis; Rats; Rats, Sprague-Dawley; tau Proteins | 2016 |
[Sodium nitrite reduces lipid accumulation in steatotic cells by enhancing autophagy].
Topics: Adenine; Autophagy; Blotting, Western; Cells, Cultured; Chloroquine; Cytoplasm; Fatty Liver; Hepatocytes; Humans; Lipid Metabolism; Microscopy, Fluorescence; Microtubule-Associated Proteins; Oleic Acid; Sodium Nitrite; Triglycerides | 2015 |
Autophagy promotes DNA-protein crosslink clearance.
Topics: Adenine; Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Camptothecin; Cell Line, Tumor; Cell Survival; Chloroquine; DNA Damage; Formaldehyde; Gene Silencing; Humans; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; RNA, Small Interfering; Sirolimus; Ubiquitin-Activating Enzymes; Ultraviolet Rays | 2016 |
ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells.
Topics: A549 Cells; Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Cell Proliferation; Chloroquine; Cisplatin; Endoplasmic Reticulum Stress; Humans; Inhibitory Concentration 50; Lung Neoplasms; Membrane Potential, Mitochondrial | 2016 |
Nicotinate-Curcumin Impedes Foam Cell Formation from THP-1 Cells through Restoring Autophagy Flux.
Topics: Adenine; Atherosclerosis; Autophagy; Cell Line; Chloroquine; Cholesterol; Curcumin; Foam Cells; Humans; Lipid Metabolism; Lipoproteins, LDL; Macrophages; Niacin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Inhibition of autophagy and enhancement of endoplasmic reticulum stress increase sensitivity of osteosarcoma Saos-2 cells to cannabinoid receptor agonist WIN55,212-2.
Topics: Adenine; Apoptosis; Autophagy; Benzoxazines; Cannabinoid Receptor Agonists; Cell Line, Tumor; Cell Proliferation; Chloroquine; Endoplasmic Reticulum Stress; Humans; Mitochondria; Morpholines; Naphthalenes; Osteosarcoma; Signal Transduction; Up-Regulation | 2016 |
Neutrophil gelatinase-associated lipocalin worsens ischemia/reperfusion damage of kidney cells by autophagy.
Topics: Acute Kidney Injury; Adenine; Autophagy; Blotting, Western; Cell Line; Cell Survival; Chloroquine; Fluorescent Antibody Technique; Humans; Kidney Tubules; Lipocalin-2; Microtubule-Associated Proteins; Recombinant Proteins; Reperfusion Injury | 2016 |
Role of autophagy in cellular response to infection with Orf virus Jilin isolate.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Chloroquine; Ecthyma, Contagious; Host-Pathogen Interactions; Microscopy, Electron, Transmission; Orf virus; Sheep; Sirolimus; Virus Replication | 2016 |
Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.
Topics: Adenine; Autophagy; Biomarkers; Cell Line; Chloroquine; Coculture Techniques; Culture Media, Serum-Free; Gene Expression; Genes, Reporter; Green Fluorescent Proteins; Humans; Hydrogen Peroxide; Interleukin-6; Interleukin-8; Macrophages; Macular Degeneration; Microtubule-Associated Proteins; Models, Biological; Oxidative Stress; Phagocytosis; Primary Cell Culture; Retinal Pigment Epithelium; Triamcinolone | 2016 |
AKT/mTOR signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Benzofurans; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drugs, Chinese Herbal; Humans; Liver Neoplasms; Mitochondria; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Salvia miltiorrhiza; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages.
Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Cell Line; Chloroquine; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gastric Mucosa; Humans; Indomethacin; Male; Microtubule-Associated Proteins; Protective Agents; Rats, Inbred WKY; RNA Interference; RNAi Therapeutics; Stomach; Stomach Ulcer | 2017 |
Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis.
Topics: Adenine; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Autophagy; Blotting, Western; Cell Hypoxia; Cell Survival; Cells, Cultured; Chloroquine; Fibroblasts; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Mice, Nude; Microscopy, Fluorescence; Reverse Transcriptase Polymerase Chain Reaction; Synoviocytes | 2017 |
Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway.
Topics: Adenine; Antimutagenic Agents; Apoptosis; Autophagy; Brain Neoplasms; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Cobalt; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubule-Associated Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sirolimus; Tumor Suppressor Protein p53 | 2017 |
Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Line; Chloroquine; Gene Knockdown Techniques; Humans; Hydrogen Peroxide; Hydroquinones; Microtubule-Associated Proteins; Poly (ADP-Ribose) Polymerase-1; Sirolimus; Sirtuin 1 | 2017 |
Diet-induced obesity impairs spermatogenesis: a potential role for autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cells, Cultured; Chloroquine; Diet, High-Fat; Humans; Infertility, Male; Male; Mice; Mice, Inbred C57BL; Obesity; Palmitic Acid; Semen Analysis; Sirolimus; Spermatogenesis; Spermatozoa; Testis | 2017 |
Induction of Atypical Autophagy by Porcine Hemagglutinating Encephalomyelitis Virus Contributes to Viral Replication.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Betacoronavirus 1; Cell Line; Cell Survival; Chloroquine; Coronavirus Infections; Lysosomes; Membrane Proteins; Mice; Sirolimus; Vacuoles; Virus Replication | 2017 |
CNOT2 promotes degradation of p62/SQSTM1 as a negative regulator in ATG5 dependent autophagy.
Topics: Adenine; Adipogenesis; Ammonium Chloride; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Cycle; Cell Differentiation; Chloroquine; HEK293 Cells; Humans; Repressor Proteins; RNA-Binding Proteins; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; Ubiquitination; Up-Regulation | 2017 |
Effect of Multipurpose Solution Combined With Autophagy Inhibitors on Adhesion of Acanthamoeba trophozoites to Silicone Hydrogel Contact Lenses.
Topics: Acanthamoeba castellanii; Adenine; Amebicides; Autophagy; Bacterial Adhesion; Chloroquine; Contact Lens Solutions; Contact Lenses, Hydrophilic; Hydrogel, Polyethylene Glycol Dimethacrylate; Microscopy, Electron; Silicones; Trophozoites | 2017 |
HSF1 upregulates ATG4B expression and enhances epirubicin-induced protective autophagy in hepatocellular carcinoma cells.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Autophagy; Autophagy-Related Proteins; Carcinoma, Hepatocellular; Cell Line, Tumor; Chloroquine; Cysteine Endopeptidases; DNA-Binding Proteins; Drug Synergism; Epirubicin; Heat Shock Transcription Factors; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; RNA, Messenger; Transcription Factors; Transfection; Up-Regulation; Xenograft Model Antitumor Assays | 2017 |
Gambogic acid improves non-small cell lung cancer progression by inhibition of mTOR signaling pathway.
Topics: A549 Cells; Adenine; Antineoplastic Agents, Phytogenic; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Cisplatin; Drug Combinations; Drug Synergism; Garcinia; Gene Expression Regulation, Neoplastic; Humans; Microtubule-Associated Proteins; Plant Extracts; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Xanthones | 2017 |
Gelatin promotes cell aggregation and pro-inflammatory cytokine production in PMA-stimulated U937 cells by augmenting endocytosis-autophagy pathway.
Topics: Adenine; Animals; Autophagy; Beclin-1; Carcinogens; Cell Aggregation; Cell Differentiation; Cell Line, Tumor; Chloroquine; Cytokines; Endocytosis; Extracellular Matrix; Gelatin; Humans; Macrophages; Mannose-Binding Lectins; Membrane Glycoproteins; Monocytes; Pseudopodia; Receptors, Cell Surface; RNA Interference; Skin; Sus scrofa; Tetradecanoylphorbol Acetate | 2018 |
[Inhibition of autophagy initiation stage enhances camptothecin-induced apoptosis in NCI-H1975 cells].
Topics: Adenine; Apoptosis; Autophagy; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chloroquine; Humans; Lung Neoplasms; Transforming Growth Factor beta1 | 2017 |
Targeting mTOR by CZ415 Inhibits Head and Neck Squamous Cell Carcinoma Cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Carcinoma, Squamous Cell; Cell Proliferation; Cell Survival; Chloroquine; Cyclic S-Oxides; Extracellular Signal-Regulated MAP Kinases; Female; Head and Neck Neoplasms; Humans; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Nude; Phenylurea Compounds; Protein Kinase Inhibitors; RNA Interference; RNA, Small Interfering; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Tumor Cells, Cultured | 2018 |
The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells induced by bufalin.
Topics: Adenine; Autophagy; Beclin-1; Bufanolides; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chloroquine; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Microtubule-Associated Proteins | 2018 |
Mulberry anthocyanins improves thyroid cancer progression mainly by inducing apoptosis and autophagy cell death.
Topics: Adenine; Anthocyanins; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Morus; Plant Extracts; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6; Signal Transduction; Thyroid Gland; TOR Serine-Threonine Kinases | 2018 |
Inhibition of autophagy significantly increases the antitumor effect of Abiraterone in prostate cancer.
Topics: Abiraterone Acetate; Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Death; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Resistance, Neoplasm; Humans; Male; Prostatic Neoplasms, Castration-Resistant | 2019 |
The anticancer effects of pharmacological inhibition of autophagy in acute erythroid leukemia cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Autophagy; Cell Line, Tumor; Chloroquine; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cytarabine; Down-Regulation; G1 Phase; Humans; Leukemia, Erythroblastic, Acute; MicroRNAs; Resting Phase, Cell Cycle; Up-Regulation | 2018 |
Ganoderma tsugae induced ROS-independent apoptosis and cytoprotective autophagy in human chronic myeloid leukemia cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Drugs, Chinese Herbal; G2 Phase Cell Cycle Checkpoints; Ganoderma; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Signal Transduction | 2019 |
Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway.
Topics: Acetylcysteine; Adenine; Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Chloroquine; Cisplatin; Gene Expression Regulation; Genes, Reporter; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; Red Fluorescent Protein; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; TOR Serine-Threonine Kinases; Virus Activation; Virus Replication | 2019 |
Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux.
Topics: Adenine; Animals; Antioxidants; Apoptosis; Autophagy; Autophagy-Related Protein 5; Benzofurans; Cell Line, Tumor; Chloroquine; Flavonoids; Hepatocytes; Humans; Mice; Mitophagy; Molecular Structure; Reactive Oxygen Species; Structure-Activity Relationship | 2019 |
Autophagy induced by enterovirus 71 regulates the production of IL-6 through the p38MAPK and ERK signaling pathways.
Topics: Adenine; Autophagy; Cell Line; Cell Proliferation; Chloroquine; Enterovirus A, Human; Enterovirus Infections; Gene Expression Regulation; Humans; Interleukin-6; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation | 2019 |
Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling.
Topics: Adenine; AMP-Activated Protein Kinases; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Chloroquine; Glucosides; Humans; Laryngeal Neoplasms; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Caseins; Cathepsin D; Cell Death; Cell Line, Tumor; Cell Proliferation; Chloroquine; Humans; Lysosomes; MCF-7 Cells; Mice; Microtubule-Associated Proteins; Morpholines; Neoplasms; Pyrones; Reactive Oxygen Species; Sequestosome-1 Protein | 2019 |
Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chloroquine; Cytokines; Free Radical Scavengers; Inflammation; Interleukin-6; Mice; Microtubule-Associated Proteins; Muscle, Skeletal; Oxidative Stress; Palmitates; Reactive Oxygen Species; Sequestosome-1 Protein; Sirolimus; Tumor Necrosis Factor-alpha | 2020 |
Chloroquine and 3-Methyladenine Attenuates Periodontal Inflammation and Bone Loss in Experimental Periodontitis.
Topics: Adenine; Alveolar Bone Loss; Alveolar Process; Animals; Anti-Inflammatory Agents; Autophagy; Autophagy-Related Proteins; Cells, Cultured; Chloroquine; Disease Models, Animal; Male; Osteoclasts; Osteogenesis; Periodontitis; Porphyromonas gingivalis; Rats, Sprague-Dawley; Transcription Factor RelA | 2020 |
NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway.
Topics: Adenine; Apoptosis; Autophagy; Basic Helix-Loop-Helix Transcription Factors; Bone Marrow Cells; Cell Line, Tumor; Chloroquine; Gene Silencing; Humans; Multiple Myeloma; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Nbr1-regulated autophagy in Lactoferrin-induced osteoblastic differentiation.
Topics: Adenine; Animals; Autophagy; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Chloroquine; Intracellular Signaling Peptides and Proteins; Lactoferrin; Mice; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Sirolimus | 2020 |
Arctigenin suppresses cell proliferation via autophagy inhibition in hepatocellular carcinoma cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Arctium; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Forsythia; Furans; Hep G2 Cells; Humans; Lignans; Liver Neoplasms; Sequestosome-1 Protein | 2020 |
Effect of Oleanolic Acid on Apoptosis and Autophagy of SMMC-7721 Hepatoma Cells.
Topics: Adenine; Adenosine Triphosphate; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Oleanolic Acid | 2020 |
Apalutamide in combination with autophagy inhibitors improves treatment effects in prostate cancer cells.
Topics: Adenine; Autophagy; Chloroquine; Drug Combinations; Drug Screening Assays, Antitumor; Humans; Male; Prostatic Neoplasms; Thiohydantoins; Treatment Outcome; Tumor Cells, Cultured | 2020 |
Pharmacological and nutritional modulation of autophagy in a rainbow trout (Oncorhynchus mykiss) gill cell line, RTgill-W1.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Cell Survival; Chloroquine; Fish Proteins; Gene Expression Regulation; Gills; Microtubule-Associated Proteins; Nutrients; Oncorhynchus mykiss; Pharmaceutical Preparations; Serum; Sirolimus; Time Factors; Trichothecenes | 2020 |
Autophagy inhibition protects from alveolar barrier dysfunction in LPS-induced ALI mice by targeting alveolar epithelial cells.
Topics: Acute Lung Injury; Adenine; Alveolar Epithelial Cells; Animals; Autophagy; Bronchoalveolar Lavage Fluid; Chloroquine; Disease Models, Animal; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL | 2021 |
Inhibition of autophagy by 3-methyladenine restricts murine cytomegalovirus replication.
Topics: Adenine; Animals; Antigens, Viral; Apoptosis; Autophagy; Caspase 3; Chloroquine; Herpesviridae Infections; Mice; Mice, Inbred C57BL; Muromegalovirus; Virus Replication | 2021 |
Systematic identification of autophagy-related proteins in Aedes albopictus.
Topics: Adenine; Aedes; Animals; Arbovirus Infections; Arboviruses; Autophagy; Autophagy-Related Proteins; Beclin-1; Cell Line; Chloroquine; Female; Gene Expression Regulation; Male; Phylogeny; Real-Time Polymerase Chain Reaction; RNA, Small Interfering | 2021 |
PINK1/Parkin-mediated mitophagy inhibits warangalone-induced mitochondrial apoptosis in breast cancer cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Neoplastic; Humans; Isoflavones; Membrane Potential, Mitochondrial; Mitochondria; Mitophagy; Protein Kinases; Reactive Oxygen Species; Ubiquitin-Protein Ligases | 2021 |
Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling.
Topics: Adenine; Autophagy; Autophagy-Related Protein 5; Cancer-Associated Fibroblasts; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chloroquine; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; HMGB1 Protein; Humans; Lung Neoplasms; Microtubule-Associated Proteins; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Recombinant Proteins; Signal Transduction | 2021 |