chlorophyll-a and akuammicine

Catharanthus roseus is a medicinal plant that produces an abundance of monoterpenoid indole alkaloids (MIAs), notably including the anticancer compounds vinblastine and vincristine. While the canonical pathway leading to these drugs has been resolved, the regulatory and catalytic mechanisms controlling many lateral branches of MIA biosynthesis remain largely unknown. Here, we describe an ethyl methanesulfonate (EMS) C. roseus mutant (M

Topics: Alkaloids; Analgesics, Opioid; Catharanthus; Chlorophyll; Ethyl Methanesulfonate; Gene Expression Regulation, Plant; Indoles; Plant Proteins; Receptors, Opioid; Secologanin Tryptamine Alkaloids; Transcription Factors; Vinblastine; Vincristine