chlorogenic-acid and salvianolic-acid-B

chlorogenic-acid has been researched along with salvianolic-acid-B* in 1 studies

Other Studies

1 other study(ies) available for chlorogenic-acid and salvianolic-acid-B

Article	Year
Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains. Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12 In this Letter, we report the natural products salvianolic acid A, salvianolic acid B, and caftaric acid as inhibitors of the protein-protein interactions mediated by the SH2 domains of the Src-family kinases Src and Lck, two established disease targets. Moreover, we propose a binding mode for the inhibitors based on molecular modeling, which will facilitate chemical optimization efforts of these important lead structures for drug discovery. Topics: Benzofurans; Biological Products; Caffeic Acids; Drug Discovery; Humans; Lactates; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Models, Molecular; Phenols; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); src Homology Domains; src-Family Kinases	2009

Article

Year

Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.

Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12

In this Letter, we report the natural products salvianolic acid A, salvianolic acid B, and caftaric acid as inhibitors of the protein-protein interactions mediated by the SH2 domains of the Src-family kinases Src and Lck, two established disease targets. Moreover, we propose a binding mode for the inhibitors based on molecular modeling, which will facilitate chemical optimization efforts of these important lead structures for drug discovery.

Topics: Benzofurans; Biological Products; Caffeic Acids; Drug Discovery; Humans; Lactates; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Models, Molecular; Phenols; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); src Homology Domains; src-Family Kinases

2009