chloroacetaldehyde and ifosfamide

chloroacetaldehyde has been researched along with ifosfamide in 45 studies

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (6.67)	18.7374
1990's	13 (28.89)	18.2507
2000's	21 (46.67)	29.6817
2010's	8 (17.78)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cerny, T; Küpfer, A	1
Cerny, T; Küpfer, A; Kurowski, V; Wagner, T	1
Hilgard, P; Pohl, J; Stekar, J	1
Crowther, D; Fox, BW; Hadfield, JA; Lind, MJ; McGown, AT; Thatcher, N	1
Goren, MP; Pell, FE; Pratt, CB; Wright, RK	1
Ansorge, S; Brandis, M; Mohrmann, M; Schmich, U; Schönfeld, B	1
Allenbacher, A; Botzler, C; Issels, R; Meier, T; Mueller, E; Multhoff, G; Wiesnet, M	1
Morris, ME; Springate, JE; Zamlauski-Tucker, MJ	1
Kurowski, V; Wagner, T	1
Beijnen, JH; Bult, A; de Kraker, J; Jeunink, EL; Kaijser, GP; Keizer, HJ; Underberg, WJ	1
O'Brien, PJ; Sood, C	1
Brüggemann, SK; Kisro, J; Wagner, T	1
Loqueviel, C; Malet-Martino, M; Martino, R	1
Blaschke, G; Boos, J; Hohenlöchter, B; Jürgens, H; Rossi, R; Silies, H	1
Huang, Z; Waxman, DJ	1
Chan, K; Davies, S; Lu, H; Springate, J; Taub, M	1
Börner, K; Brüggemann, SK; Hagenah, W; Kisro, J; Peters, SO; Wagner, T	1
Bolanowska-Higdon, W; Creaven, PJ; Meropol, NJ; Murphy, M; Pendyala, L; Perez, R; Schwartz, G; Zdanowicz, J	1
Baverel, G; Cochat, P; Dubourg, L; Michoudet, C	1
Brueggemann, SK; Deeken, M; Klich, S; Peters, SO; Schlenke, P; Wagner, T	1
Springate, JE; Taub, M; Zaki, EL	1
Giometto, B; Nicolao, P	1
Aleksa, K; Ito, S; Koren, G	1
Aleksa, K; Halachmi, N; Ito, S; Koren, G	1
Chen, CS; Jounaidi, Y; Waxman, DJ	1
Braasch, K; Brüggemann, SK; Hagenah, W; Hinrichs, J; Kisro, J; Peters, SO; Radike, K; Wagner, T	1
Benesic, A; Freudinger, R; Gekle, M; Gordjani, N; Mildenberger, S; Schwerdt, G	1
Daikhin, Y; Horyn, O; Luhovyy, B; Nissim, I; Phillips, PC; Yudkoff, M	1
Beck-Schimmer, B; Biber, J; Hernando, N; Murer, H; Patzer, L; Ziegler, U	1
Benesic, A; Freudinger, R; Gekle, M; Groezinger, F; Kirchhoff, A; Mildenberger, S; Schwerdt, G; Wollny, B	1
Springate, J; Taub, M	1
Fujimoto, Y; Sakurai, K; Takahashi, K; Tanaka, H	1
Dolan, ME; Hansen, RJ; Ludeman, SM; Paikoff, SJ; Pegg, AE	1
Brüggemann, SK; Peters, SO; Pfäffle, S; Wagner, T	1
Baverel, G; Dubourg, L; Michoudet, C; Yaseen, Z	1
Aleksa, K; Koren, G; Nava-Ocampo, A	1
Chen, N; Hanly, L; Koren, G; Rieder, M	1
Baverel, G; Dubourg, L; Knouzy, B; Michoudet, C	1
Gonzalez, FJ; Höfer, CC; Idle, JR; Krausz, KW; Li, F; Patterson, AD	1
Aninat, C; Brochot, C; Choucha-Snouber, L; Corlu, A; Grsicom, L; Guillouzo, CG; Leclerc, E; Legallais, C; Madalinski, G; Poleni, PE; Razan, F	1
Baverel, G; Duplany, A; El Hage, M; Ferrier, B; Gauthier, C; Knouzy, B; Martin, G	1
Lau, V; MacAllister, SL; Martin-Brisac, N; O'Brien, PJ; Yang, K	1
Górska, A; Hładoń, B; Misiura, K; Sikorska, M; Sloderbach, A	1
Benesic, A; Gekle, M; Hennemeier, I; Mildenberger, S; Sauvant, C; Schwerdt, G	1
Bois, FY; Hamon, J; Leclerc, E	1

Reviews

4 review(s) available for chloroacetaldehyde and ifosfamide

Article	Year
Neurological toxicity of ifosfamide. Oncology, 2003, Volume: 65 Suppl 2 Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Brain; Carbocysteine; Central Nervous System; Glutarates; Glutathione; Humans; Ifosfamide; Neurotoxicity Syndromes	2003
Ifosfamide nephrotoxicity in children: a mechanistic base for pharmacological prevention. Expert opinion on drug safety, 2009, Volume: 8, Issue:2 Topics: Acetaldehyde; Acetylcysteine; Age Factors; Antineoplastic Agents, Alkylating; Antioxidants; Child; Humans; Ifosfamide; Kidney Diseases; Oxidative Stress; Risk Factors	2009
Use of precision-cut renal cortical slices in nephrotoxicity studies. Xenobiotica; the fate of foreign compounds in biological systems, 2013, Volume: 43, Issue:1 Topics: Acetaldehyde; Animals; Anticonvulsants; Antineoplastic Agents, Alkylating; Cobalt; Humans; Ifosfamide; Kidney Cortex; Metal Nanoparticles; Microdissection; Organ Culture Techniques; Valproic Acid	2013
[Classical oxazaphosphorines--metabolism and therapeutic properties--new implications]. Postepy higieny i medycyny doswiadczalnej (Online), 2013, Dec-10, Volume: 67 Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Antineoplastic Agents; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Drug Resistance, Neoplasm; Glutathione; Glutathione Transferase; Humans; Hydroxylation; Ifosfamide; Neoplasms	2013

Trials

3 trial(s) available for chloroacetaldehyde and ifosfamide

Article	Year
Metabolism and pharmacokinetics of oral and intravenous ifosfamide. Journal of cancer research and clinical oncology, 1991, Volume: 117 Suppl 4 Topics: Acetaldehyde; Administration, Oral; Adult; Aged; Female; Humans; Ifosfamide; Infusions, Intravenous; Male; Middle Aged; Neoplasms	1991
Intravenous ifosfamide/mesna is associated with depletion of plasma thiols without depletion of leukocyte glutathione. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:4 Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Cysteine; Dose-Response Relationship, Drug; Glutathione; Homocysteine; Humans; Ifosfamide; Infusions, Intravenous; Leukocytes; Mesna; Neoplasms; Oxidation-Reduction; Protective Agents; Sulfhydryl Compounds	2000
Influence of short-term use of dexamethasone on the pharmacokinetics of ifosfamide in patients. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:10 Topics: Acetaldehyde; Adolescent; Adult; Aged; Antiemetics; Antineoplastic Agents, Alkylating; Dexamethasone; Female; Humans; Ifosfamide; Male; Middle Aged; Neoplasms	2007

Other Studies

38 other study(ies) available for chloroacetaldehyde and ifosfamide

Article	Year
The enigma of ifosfamide encephalopathy. Annals of oncology : official journal of the European Society for Medical Oncology, 1992, Volume: 3, Issue:9 Topics: Acetaldehyde; Brain; Brain Diseases; Drug Administration Schedule; Female; Humans; Ifosfamide	1992
Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication. Arzneimittel-Forschung, 1989, Volume: 39, Issue:6 Topics: Acetaldehyde; Animals; Cyclophosphamide; Cystitis; Female; Hemorrhage; Ifosfamide; Male; Mesna; Rats; Rats, Inbred Strains	1989
The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo. Biochemical pharmacology, 1989, Jun-01, Volume: 38, Issue:11 Topics: Acetaldehyde; Cell Line; Glutathione; Glutathione Transferase; Humans; Ifosfamide; In Vitro Techniques; Macrophages; Placenta; Time Factors	1989
Dechloroethylation of ifosfamide and neurotoxicity. Lancet (London, England), 1986, Nov-22, Volume: 2, Issue:8517 Topics: Acetaldehyde; Humans; Ifosfamide; Nervous System Diseases	1986
Toxicity of ifosfamide, cyclophosphamide and their metabolites in renal tubular cells in culture. Pediatric nephrology (Berlin, Germany), 1994, Volume: 8, Issue:2 Topics: Acetaldehyde; Acrolein; Animals; Cell Line; Cells, Cultured; Cyclophosphamide; DNA; DNA Replication; Epithelial Cells; Epithelium; Ifosfamide; Kidney Tubules, Proximal; RNA; Swine; Thymidine; Uridine	1994
Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna. Anti-cancer drugs, 1994, Volume: 5, Issue:4 Topics: Acetaldehyde; Acrolein; Animals; CHO Cells; Cricetinae; Glutathione; Humans; Ifosfamide; Intracellular Fluid; Lymphocytes; Mesna	1994
Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney. Toxicology and applied pharmacology, 1994, Volume: 129, Issue:1 Topics: Absorption; Acetaldehyde; Acrolein; Animals; Chemotherapy, Cancer, Regional Perfusion; Disease Models, Animal; Fanconi Syndrome; Glucose; Ifosfamide; Kidney; Kidney Tubules, Proximal; Male; Organ Size; Phosphates; Prodrugs; Rats; Rats, Inbred Lew; Sodium; Sulfates	1994
Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy. Cancer chemotherapy and pharmacology, 1993, Volume: 33, Issue:1 Topics: Acetaldehyde; Adult; Aged; Carcinoma, Bronchogenic; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyclophosphamide; Drug Administration Schedule; Female; Humans; Ifosfamide; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged	1993
Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma. Journal of chromatography, 1993, May-05, Volume: 614, Issue:2 Topics: Acetaldehyde; Aged; Biotransformation; Chromatography, High Pressure Liquid; Drug Stability; Formaldehyde; Humans; Ifosfamide	1993
2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity. The British journal of cancer. Supplement, 1996, Volume: 27 Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Brain; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Glutathione; Ifosfamide; Liver; Male; Mice	1996
Ifosfamide cytotoxicity on human tumor and renal cells: role of chloroacetaldehyde in comparison to 4-hydroxyifosfamide. Cancer research, 1997, Jul-01, Volume: 57, Issue:13 Topics: Acetaldehyde; Carcinoma, Non-Small-Cell Lung; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Ifosfamide; Kidney Tubules; Lung Neoplasms; Tumor Cells, Cultured	1997
A 13C NMR study of 2-(13)C-chloroacetaldehyde, a metabolite of ifosfamide and cyclophosphamide, in the isolated perfused rabbit heart model. Initial observations on its cardiotoxicity and cardiac metabolism. Cellular and molecular biology (Noisy-le-Grand, France), 1997, Volume: 43, Issue:5 Topics: Acetaldehyde; Acetates; Animals; Carbon Isotopes; Cyclophosphamide; Glutathione; Glycolates; Heart; Ifosfamide; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Myocardium; Perfusion; Rabbits	1997
Excretion kinetics of ifosfamide side-chain metabolites in children on continuous and short-term infusion. International journal of clinical pharmacology and therapeutics, 1998, Volume: 36, Issue:5 Topics: Acetaldehyde; Acrolein; Adolescent; Adult; Antineoplastic Agents, Alkylating; Child; Female; Humans; Ifosfamide; Infusions, Intravenous; Kidney; Male; Neoplasms; Phosphoramide Mustards	1998
High-performance liquid chromatographic-fluorescent method to determine chloroacetaldehyde, a neurotoxic metabolite of the anticancer drug ifosfamide, in plasma and in liver microsomal incubations. Analytical biochemistry, 1999, Aug-15, Volume: 273, Issue:1 Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Cells, Cultured; Chromatography, High Pressure Liquid; Ifosfamide; Male; Microsomes, Liver; Rats; Rats, Inbred F344; Spectrometry, Fluorescence	1999
Toxicity of ifosfamide and its metabolite chloroacetaldehyde in cultured renal tubule cells. In vitro cellular & developmental biology. Animal, 1999, Volume: 35, Issue:6 Topics: Acetaldehyde; Adenosine Triphosphate; Animals; Antineoplastic Agents, Alkylating; Cell Division; Cells, Cultured; Glucose; Glutathione; Ifosfamide; Kidney Tubules, Proximal; Male; Mesna; Rabbits	1999
Metabolism of ifosfamide to chloroacetaldehyde contributes to antitumor activity in vivo. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:5 Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Humans; Ifosfamide; Mice; Mice, Nude; Neoplasm Transplantation; Prodrugs; Transplantation, Heterologous; Tumor Cells, Cultured	2000
Human kidney tubules detoxify chloroacetaldehyde, a presumed nephrotoxic metabolite of ifosfamide. Journal of the American Society of Nephrology : JASN, 2001, Volume: 12, Issue:8 Topics: Acetaldehyde; Aldehyde Dehydrogenase; Antineoplastic Agents, Alkylating; Humans; Ifosfamide; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Tubules; Lactic Acid; Osmolar Concentration; Sulfhydryl Compounds	2001
Stem cell toxicity of oxazaphosphorine metabolites in comparison to their antileukemic activity. Biochemical pharmacology, 2002, Apr-01, Volume: 63, Issue:7 Topics: Acetaldehyde; Alkylating Agents; Antineoplastic Agents; Cyclophosphamide; Drug Screening Assays, Antitumor; Hematopoietic Stem Cells; Humans; Ifosfamide; Tumor Cells, Cultured; Tumor Stem Cell Assay	2002
Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells. Toxicology in vitro : an international journal published in association with BIBRA, 2003, Volume: 17, Issue:4 Topics: Acetaldehyde; Acrolein; Amifostine; Animals; Antineoplastic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Glutathione; Ifosfamide; Kidney Tubules; Mesna; Neutral Red; Rabbits	2003
Renal-tubule metabolism of ifosfamide to the nephrotoxic chloroacetaldehyde: pharmacokinetic modeling for estimation of intracellular levels. The Journal of laboratory and clinical medicine, 2004, Volume: 143, Issue:3 Topics: Acetaldehyde; Animals; Biotransformation; Cell Line; Ifosfamide; Kidney; Kidney Tubules; Kinetics	2004
Renal ontogeny of ifosfamide nephrotoxicity. The Journal of laboratory and clinical medicine, 2004, Volume: 144, Issue:6 Topics: Acetaldehyde; Age Factors; Animals; Antineoplastic Agents, Alkylating; Aryl Hydrocarbon Hydroxylases; Child; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Disease Models, Animal; Female; Humans; Ifosfamide; Kidney; Kidney Diseases; Male; Microsomes; Oxidoreductases, N-Demethylating; Steroid Hydroxylases; Swine	2004
Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:9 Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Proliferation; Cricetinae; Cricetulus; Cyclophosphamide; Cytochrome P-450 Enzyme System; DNA, Complementary; Gene Expression; Humans; Ifosfamide; NADPH-Ferrihemoprotein Reductase; Prodrugs; Rats; Stereoisomerism	2005
Chloroacetaldehyde: mode of antitumor action of the ifosfamide metabolite. Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:3 Topics: Acetaldehyde; Adenosine Triphosphate; Antineoplastic Agents, Alkylating; Bromodeoxyuridine; Cell Line, Tumor; Comet Assay; Cross-Linking Reagents; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Ifosfamide; Nucleic Acid Synthesis Inhibitors	2006
Disturbed Ca2+-signaling by chloroacetaldehyde: a possible cause for chronic ifosfamide nephrotoxicity. Kidney international, 2005, Volume: 68, Issue:5 Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Cation Transport Proteins; Cell Line; Cytosol; Extracellular Space; Homeostasis; Humans; Hydrogen-Ion Concentration; Ifosfamide; Kidney Diseases; Kidney Tubules, Proximal; Plasma Membrane Calcium-Transporting ATPases; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium; Sodium-Calcium Exchanger	2005
Ifosfamide-induced nephrotoxicity: mechanism and prevention. Cancer research, 2006, Aug-01, Volume: 66, Issue:15 Topics: Acetaldehyde; Agmatine; Animals; Antineoplastic Agents, Alkylating; Drug Interactions; Electron Transport Complex I; Ifosfamide; Kidney Cortex; Kidney Diseases; Male; Oxidative Phosphorylation; Rats	2006
Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells. Kidney international, 2006, Volume: 70, Issue:10 Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Biological Transport; Cell Death; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation; Ifosfamide; Kidney; Mesna; Opossums; Phosphates; Phosphoramide Mustards; RNA, Messenger; Sodium-Phosphate Cotransporter Proteins, Type IIa	2006
Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy. Kidney & blood pressure research, 2006, Volume: 29, Issue:5 Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Biomarkers; Caspase 3; Caspase 8; Cathepsin B; Cell Count; Cell Death; Cells, Cultured; Coloring Agents; Cysteine Endopeptidases; gamma-Glutamyltransferase; Humans; Ifosfamide; Kidney Diseases; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Microscopy, Fluorescence; Necrosis; Sulfhydryl Compounds; Sulfhydryl Reagents; Trypan Blue	2006
Ifosfamide toxicity in cultured proximal renal tubule cells. Pediatric nephrology (Berlin, Germany), 2007, Volume: 22, Issue:3 Topics: Acetaldehyde; Acrolein; Amifostine; Animals; Cell Culture Techniques; Cells, Cultured; Dose-Response Relationship, Drug; Ifosfamide; Inulin; Ion Transport; Kidney Tubules, Proximal; Male; Mesna; p-Aminohippuric Acid; Protective Agents; Rabbits; Tetraethylammonium	2007
Necrotic pathway in human osteosarcoma Saos-2 cell death induced by chloroacetaldehyde. Anti-cancer drugs, 2007, Volume: 18, Issue:5 Topics: Acetaldehyde; Adenosine Triphosphate; Annexin A5; Antineoplastic Agents, Alkylating; Blotting, Western; Bone Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Flow Cytometry; Humans; Ifosfamide; Membrane Potentials; Mitochondrial Membranes; Necrosis; Osteosarcoma; Propidium; Sulfhydryl Compounds	2007
Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals. DNA repair, 2007, Aug-01, Volume: 6, Issue:8 Topics: Acetaldehyde; Acrolein; Alkylating Agents; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclophosphamide; DNA Repair; Drug Resistance, Neoplasm; Ifosfamide; Mice; Mice, Knockout; Mutation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Transfection; Transplantation, Heterologous	2007
Mechanisms of the ifosfamide-induced inhibition of endocytosis in the rat proximal kidney tubule. Archives of toxicology, 2008, Volume: 82, Issue:9 Topics: Acetaldehyde; Adenosine Triphosphatases; Animals; Antineoplastic Agents, Alkylating; Endocytosis; Glutathione; Horseradish Peroxidase; Ifosfamide; In Vitro Techniques; Kidney Tubules, Proximal; Male; Rats; Sodium-Potassium-Exchanging ATPase	2008
Detection and quantification of (R) and (S)-dechloroethylifosfamide metabolites in plasma from children by enantioselective LC/MS/MS. Chirality, 2009, Volume: 21, Issue:7 Topics: Acetaldehyde; Adolescent; Child; Child, Preschool; Chromatography, Liquid; Cyclophosphamide; Humans; Ifosfamide; Infant; Mass Spectrometry; Pediatrics; Plasma Cells; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism	2009
Ifosfamide metabolite chloroacetaldehyde inhibits cell proliferation and glucose metabolism without decreasing cellular ATP content in human breast cancer cells MCF-7. Journal of applied toxicology : JAT, 2010, Volume: 30, Issue:3 Topics: Acetaldehyde; Adenosine Triphosphate; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Female; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Glycolysis; Hexokinase; Humans; Ifosfamide; Lactic Acid; Osmolar Concentration; Pyruvate Kinase	2010
Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochemical pharmacology, 2010, Oct-01, Volume: 80, Issue:7 Topics: Acetaldehyde; Animals; Carbocysteine; Chromatography, Liquid; Cyclophosphamide; Ifosfamide; Male; Mass Spectrometry; Metabolomics; Mice; Mice, Inbred C57BL; Pharmaceutical Preparations	2010
Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip. Biotechnology and bioengineering, 2013, Volume: 110, Issue:2 Topics: Acetaldehyde; Animals; Calcium; Cell Cycle; Cell Proliferation; Cell Shape; Coculture Techniques; Dogs; Fluorescent Dyes; Gene Expression; Hep G2 Cells; Humans; Ifosfamide; Kidney; Liver; Madin Darby Canine Kidney Cells; Microfluidic Analytical Techniques; Real-Time Polymerase Chain Reaction; Tissue Array Analysis	2013
Acrolein and chloroacetaldehyde: an examination of the cell and cell-free biomarkers of toxicity. Chemico-biological interactions, 2013, Feb-25, Volume: 202, Issue:1-3 Topics: Acetaldehyde; Acrolein; Aldehyde Dehydrogenase; Animals; Biomarkers; Cell-Free System; Cyclophosphamide; Hepatocytes; Hydrogen Peroxide; Ifosfamide; Inactivation, Metabolic; Male; Microsomes, Liver; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serum Albumin, Bovine	2013
The nephrotoxic Ifosfamide-metabolite chloroacetaldehyde interferes with renal extracellular matrix homeostasis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2014, Volume: 33, Issue:4 Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Calcium; Cells, Cultured; Collagen Type III; Collagen Type IV; Cyclic AMP; Egtazic Acid; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Homeostasis; Humans; Ifosfamide; Isoquinolines; Kidney Tubules, Proximal; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction; Sulfonamides	2014
Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver-kidney microfluidic data and pharmacokinetic-system biology models. Journal of applied toxicology : JAT, 2016, Volume: 36, Issue:2 Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Bayes Theorem; Cells, Cultured; Hepatocytes; Ifosfamide; Kidney; Microfluidics; Models, Biological; Neoplasms	2016