chloroacetaldehyde has been researched along with acetaldehyde in 199 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (24.62) | 18.7374 |
| 1990's | 68 (34.17) | 18.2507 |
| 2000's | 50 (25.13) | 29.6817 |
| 2010's | 30 (15.08) | 24.3611 |
| 2020's | 2 (1.01) | 2.80 |
| Authors | Studies |
|---|---|
| Boufadi, MY; Dufrasne, F; Furtmüller, PG; Gelbcke, M; Meyer, F; Nève, J; Obinger, C; Soubhye, J; Van Antwerpen, P; Zouaoui Boudjeltia, K | 1 |
| Crawford, WM; Guengerich, FP; Watanabe, PG | 1 |
| Chang, LW; Daniel, FB; DeAngelo, AB | 1 |
| Ludlum, DB; Matijasevic, Z; Sekiguchi, M | 1 |
| Cerny, T; Küpfer, A | 1 |
| Dobson, JG; Fenton, RA | 1 |
| Daniel, FB; DeAngelo, AB; Olson, GR; Page, NP; Stober, JA | 1 |
| Cerny, T; Küpfer, A; Kurowski, V; Wagner, T | 1 |
| Dayn, A; Duzhy, D; Lyamichev, V; Malkhosyan, S; Mirkin, S; Panchenko, Y | 1 |
| Kohwi, Y; Kohwi-Shigematsu, T | 3 |
| Carere, A; Conti, G; Conti, L; Crebelli, R | 1 |
| Ruenitz, PC; Ruzicka, JA | 1 |
| Barbin, A; Bartsch, H; Béréziat, JC; Croisy, A; O'Neill, IK | 1 |
| Daniel, FB; DeAngelo, A; Guntaka, RV; Kandala, JC; Mrema, JE | 1 |
| Anin, MF; Leng, M | 1 |
| Humayun, MZ; Jacobsen, JS | 1 |
| Laib, RJ | 1 |
| Hilgard, P; Pohl, J; Stekar, J | 1 |
| Callahan, JT; Humayun, MZ; Jacobsen, JS; Perkins, CP; Sambamurti, K | 1 |
| Leng, M; Marrot, L | 1 |
| Crowther, D; Fox, BW; Hadfield, JA; Lind, MJ; McGown, AT; Thatcher, N | 1 |
| Boublíková, P; Galazka, G; Klysik, J; Palecek, E | 1 |
| Kohwi-Shigematsu, T; Nelson, JA | 1 |
| Goren, MP; Pell, FE; Pratt, CB; Wright, RK | 1 |
| McLean, MJ; Wells, RD; Wohlrab, F | 1 |
| Leng, M; Malfoy, B; Marrot, L; Rousseau, N; Vogt, N | 1 |
| Landes, JP; Singhal, RP | 1 |
| Kohwi, Y; Kohwi-Shigematsu, T; Scribner, N | 1 |
| Heger, M; Kemena, A; Mohtashamipur, E; Müller, G; Norpoth, K; Witting, C | 2 |
| Santella, RM; Young, TL | 1 |
| Kitagawa, H; Maguire, MH; Slegel, P | 1 |
| Singer, B; Spengler, SJ | 1 |
| Kohwi, Y; Kohwi-Shigematsu, T; Manes, T | 1 |
| Barbin, A; Bartsch, H | 1 |
| Clark, DP; Cunningham, PR | 1 |
| Hall, JA; Saffhill, R | 1 |
| Adler, S; Doerjer, G; Oesch, F; Rettelbach, R | 1 |
| Ames, BN; Bartsch, H; Bochner, B; Hollstein, M; Nair, J | 1 |
| Fraenkel-Conrat, H; Holbrook, SR; Kuśmierek, JT; Singer, B | 1 |
| Barbin, A; Bartsch, H; Friesen, M; O'Neill, I | 1 |
| Jaskólski, M; Krzyzosiak, WJ; Wiewiórowski, M | 1 |
| Perrard, MH | 1 |
| Digweed, M; Erdmann, VA; Hardesty, B; Odom, OW | 1 |
| Abbott, LG; Singer, B; Spengler, SJ | 1 |
| Gentleman, S; Neff, NH; Olianas, M; Parenti, M; Wojcik, W | 1 |
| Ciesiołka, J; Krzyzosiak, WJ | 1 |
| Hussain, S; Osterman-Golkar, S | 1 |
| Cazenave, C; Chabbert, M; Hélène, C; Toulmé, JJ | 1 |
| Graham, MI; McLean, AE; Shaw, IC | 2 |
| Head, RJ; Levitt, B; Westfall, DP | 1 |
| Kuśmierek, JT; Singer, B | 2 |
| Garro, AJ; Phillips, RA | 1 |
| Addison, WR; Gillam, IC; Tener, GM | 1 |
| Neff, NH; Wojcik, WJ | 1 |
| Biernat, J; Ciesiołka, J; Gulewicz, K; Krzyzosiak, WJ; Wiewiórowski, M | 1 |
| Barbin, A; Bartsch, H; Leconte, P; Radman, M | 1 |
| Green, T; Hall, JA; Hathway, DE; Saffhill, R | 1 |
| Doerjer, G; Oesch, F | 1 |
| Williams, RG | 1 |
| Biernat, J; Ciesiołka, J; Górnicki, P; Krzyzosiak, WJ; Wiewiórowski, M | 1 |
| Ansorge, S; Brandis, M; Mohrmann, M; Schmich, U; Schönfeld, B | 1 |
| Kawanishi, M; Matsuda, T; Matsui, S; Takebe, H; Yagi, T | 1 |
| Bacolla, A; Larson, JE; Ley, TJ; Ulrich, MJ; Wells, RD | 1 |
| Dzierzgowska-Szmidt, A; Gajewska, M; Kazimierczuk, Z; Pawiński, T | 1 |
| Berthelier, V; Chinsky, L; Jollès, B; Laigle, A | 1 |
| Borys, E; Kuśmierek, JT; Mroczkowska-Słupska, MM | 1 |
| Dennis, MF; Stratford, MR | 1 |
| Gannett, P; Gold, B; Liang, G | 1 |
| Mandel, M; Mower, HF; Premaratne, S; Swenson, SD | 1 |
| Allenbacher, A; Botzler, C; Issels, R; Meier, T; Mueller, E; Multhoff, G; Wiesnet, M | 1 |
| Morris, ME; Springate, JE; Zamlauski-Tucker, MJ | 1 |
| Albert, AC; Bouche, G; Leng, M; Rahmouni, AR; Roman, AM | 1 |
| O'Brien, PJ; Sood, C | 3 |
| Gorski, J; Kladde, MP; Kohwi, Y; Kohwi-Shigematsu, T | 1 |
| Kuśmierek, JT; Mroczkowska-Słupska, MM | 1 |
| Helms, M; Mower, HF; Premaratne, S | 1 |
| Crane, AE; Steiner, S; Watson, WP | 1 |
| Carter, DE; Sharpe, AL | 1 |
| Kurowski, V; Wagner, T | 1 |
| Mandel, M; Mower, HF; Premaratne, S | 1 |
| Chenna, A; Dosanjh, MK; Fraenkel-Conrat, H; Kim, E; Samson, L; Singer, B | 1 |
| Balcarová, Z; Boudný, V; Brabec, V | 1 |
| Beijnen, JH; Bult, A; de Kraker, J; Jeunink, EL; Kaijser, GP; Keizer, HJ; Underberg, WJ | 1 |
| Kolasa, IK; Kusmierek, JT; Mroczkowska, MM | 1 |
| Lilley, DM; Nejedlý, K; Palecek, E | 1 |
| Chung, FL; Foiles, PG; Kuśmierek, JT; Miglietta, LM; Nishikawa, A; Singer, B | 1 |
| Bjur, RA; Mohri, K; Shinozuka, K; Takeuchi, K; Westfall, DP | 1 |
| Singer, B | 1 |
| Moriya, M; Pandya, GA | 1 |
| Beale, SC; McCann, WP; Wang, CC | 1 |
| Guérin, M; Leng, M; Rahmouni, AR | 1 |
| Chiang, SY; Skopek, TR; Swenberg, JA; Weisman, WH | 1 |
| Costa, M; Gargas, M; Harris, M; Paustenbach, D; Zhitkovich, A | 1 |
| Brüggemann, SK; Kisro, J; Wagner, T | 1 |
| Comendador, MA; Consuegra, S; Ferreiro, JA; Sierra, LM | 1 |
| Ni, L; Sheikh, S; Weiner, H | 1 |
| Lauterburg, BH; Stucki, JW; Visarius, TM | 2 |
| Loqueviel, C; Malet-Martino, M; Martino, R | 1 |
| Anderson, BM; Leskovac, V; Stancić, B; Trivić, S; Zeremski, J | 1 |
| Bergeron, H; Labbé, D; Lau, PC; Turmel, C | 1 |
| Blaschke, G; Boos, J; Hohenlöchter, B; Jürgens, H; Rossi, R; Silies, H | 1 |
| Capoor, S; Crooks, PA; Herfel, R; Howard, M; Jacobson, MK; Sen, HA | 1 |
| Haginaka, J; Kawamoto, Y; Kunitomo, M; Shinozuka, K | 1 |
| Dai, X; Kloster, M; Rothman-Denes, LB | 1 |
| Manzano, RG; Twentyman, PR; Wright, KA | 1 |
| Huang, Z; Waxman, DJ | 1 |
| Chan, K; Davies, S; Lu, H; Springate, J; Taub, M | 1 |
| Jost, JP; Oakeley, EJ; Schmitt, F | 1 |
| Cieśla, JM; Kowalczyk, P; Tudek, B | 1 |
| Beijnen, JH; Hoetelmans, RM; Sparidans, RW; Veldkamp, A | 1 |
| Börner, K; Brüggemann, SK; Hagenah, W; Kisro, J; Peters, SO; Wagner, T | 1 |
| Bolanowska-Higdon, W; Creaven, PJ; Meropol, NJ; Murphy, M; Pendyala, L; Perez, R; Schwartz, G; Zdanowicz, J | 1 |
| Baumann, W; Brischwein, M; Ehret, R; Freund, I; Henning, T; Kammerer, R; Lehmann, M; Schwinde, A; Wolf, B | 1 |
| Bunting, KD; Haynes, RL; Leone-Kabler, S; Szweda, L; Townsend, AJ; Wu, Y | 1 |
| Hergenhahn, M; Zielinski, B | 1 |
| Baverel, G; Cochat, P; Dubourg, L; Michoudet, C | 1 |
| Baverel, G; Cochat, P; Dubourg, L; Michoudet, C; Tanière, P | 1 |
| Balu, N; Colvin, ME; Colvin, OM; Dolan, ME; Gamcsik, MP; Ludeman, SM | 1 |
| Brueggemann, SK; Deeken, M; Klich, S; Peters, SO; Schlenke, P; Wagner, T | 1 |
| Brischwein, M; Grothe, H; Motrescu, E; Otto, AM; Wolf, B | 1 |
| Beijnen, JH; Crommentuyn, KM; Schellens, JH; Sparidans, RW | 1 |
| Springate, JE; Taub, M; Zaki, EL | 1 |
| Giometto, B; Nicolao, P | 1 |
| Aleksa, K; Ito, S; Koren, G | 1 |
| Brischwein, M; Cabala, E; Grothe, H; Motrescu, ER; Otto, AM; Wolf, B | 1 |
| Gold, B; Kisby, GE; Lesselroth, H; Olivas, A; Samson, L; Tanaka, K; Turker, MS | 1 |
| Bramanti, E; Raspi, G; Sbrana, E; Spinetti, MC | 1 |
| Bobalova, J; Lew, C; Mendoza, MG; Mutafova-Yambolieva, VN; Smyth, LM | 1 |
| Coote, ML; Radom, L; Sandala, GM; Smith, DM | 1 |
| Jurado, J; Krwawicz, J; Laval, J; Maciejewska, A; Saparbaev, MK | 1 |
| Choi, JH; Pfeifer, GP | 1 |
| Aleksa, K; Halachmi, N; Ito, S; Koren, G | 1 |
| Cai, H; Daniels, JS; Guengerich, FP; Marnett, LJ; Osheroff, N; Riggins, JN; Vélez-Cruz, R | 1 |
| Chen, CS; Jounaidi, Y; Waxman, DJ | 1 |
| Allali-Hassani, A; Ho, KK; Hurley, TD; Weiner, H | 1 |
| Desmond, RA; Devine, PN; Foster, BS; Gauthier, DR; Limanto, J; Szumigala, RH; Volante, RP | 1 |
| Brischwein, M; Motrescu, ER; Otto, AM; Wolf, B; Zahler, S | 1 |
| Braasch, K; Brüggemann, SK; Hagenah, W; Hinrichs, J; Kisro, J; Peters, SO; Radike, K; Wagner, T | 1 |
| Delaney, JC; Drennan, CL; Essigmann, JM; Frick, LE; Samson, LD; Smeester, L; Taghizadeh, K; Wishnok, JS; Wong, C | 1 |
| Benesic, A; Freudinger, R; Gekle, M; Gordjani, N; Mildenberger, S; Schwerdt, G | 1 |
| Benesic, A; Freudinger, R; Gekle, M; Gordjani, N; Kirchhoff, A; Schwerdt, G; Wollny, B | 1 |
| Coote, ML; Golding, BT; Radom, L; Sandala, GM; Smith, DM | 1 |
| Cieśla, JM; Kowalczyk, P; Laval, J; Saparbaev, M; Tudek, B | 1 |
| Kawamura, M; Oya, T; Tsuno, H | 1 |
| Daikhin, Y; Horyn, O; Luhovyy, B; Nissim, I; Phillips, PC; Yudkoff, M | 1 |
| Beck-Schimmer, B; Biber, J; Hernando, N; Murer, H; Patzer, L; Ziegler, U | 1 |
| Benesic, A; Freudinger, R; Gekle, M; Groezinger, F; Kirchhoff, A; Mildenberger, S; Schwerdt, G; Wollny, B | 1 |
| Springate, J; Taub, M | 1 |
| Benesic, A; Freudinger, R; Gekle, M; Kirchhoff, A; Schwerdt, G; Wollny, B | 1 |
| Fujimoto, Y; Sakurai, K; Takahashi, K; Tanaka, H | 1 |
| Dolan, ME; Hansen, RJ; Ludeman, SM; Paikoff, SJ; Pegg, AE | 1 |
| Dole, S; Madhusudan, S; Nagarajavel, V; Rahmouni, AR; Schnetz, K | 1 |
| Brüggemann, SK; Peters, SO; Pfäffle, S; Wagner, T | 1 |
| Dedon, PC; Delaney, JC; Essigmann, JM; Kim, MY; Taghizadeh, K; Wogan, GN; Zhou, X | 1 |
| Baverel, G; Dubourg, L; Michoudet, C; Yaseen, Z | 2 |
| Daujotyte, D; Klimasauskas, S; Liutkeviciūte, Z; Tamulaitis, G | 1 |
| Bekkelund, A; Bjelland, S; Dedon, PC; Falnes, PØ; Klungland, A; Meira, LB; Moen, MN; Nordstrand, LM; Pang, B; Ringvoll, J; Samson, LD | 1 |
| Aleksa, K; Koren, G; Nava-Ocampo, A | 1 |
| Chen, N; Hanly, L; Koren, G; Rieder, M | 1 |
| Baverel, G; Dubourg, L; Knouzy, B; Michoudet, C | 2 |
| Grzesiuk, E; Kuśmierek, JT; Lewicka, J; Maciejewska, AM; Nieminuszczy, J; Ruszel, KP; Sokołowska, B | 1 |
| Chen, YT; Hung, DZ; Liao, JW | 1 |
| Hurley, MD; Takahashi, K; Wallington, TJ; Xing, JH | 1 |
| Gonzalez, FJ; Höfer, CC; Idle, JR; Krausz, KW; Li, F; Patterson, AD | 1 |
| Kuśmierek, JT; Maciejewska, AM; Nowicki, A; Sokołowska, B | 1 |
| Chen, YT; Hsu, CI; Hung, DZ; Liao, JW; Matsuura, I | 1 |
| Bartsch, H; Godschalk, RW; Hull, WE; Nair, J; Nair, U; Owen, RW | 1 |
| Bhatt, DP; Chen, X; Geiger, JD; Rosenberger, TA | 1 |
| Aninat, C; Brochot, C; Choucha-Snouber, L; Corlu, A; Grsicom, L; Guillouzo, CG; Leclerc, E; Legallais, C; Madalinski, G; Poleni, PE; Razan, F | 1 |
| Baverel, G; Duplany, A; El Hage, M; Ferrier, B; Gauthier, C; Knouzy, B; Martin, G | 1 |
| Liu, ZQ; Shen, YC; You, ZY; Zheng, YG | 1 |
| Lau, V; MacAllister, SL; Martin-Brisac, N; O'Brien, PJ; Yang, K | 1 |
| Brischwein, M; Demmel, F; Kleinhans, R; Pfister, C; Schwarzenberger, T; Wolf, B; Wolf, P | 1 |
| Kimura, SY; Komaki, Y; Mariñas, BJ; Plewa, MJ | 1 |
| Górska, A; Hładoń, B; Misiura, K; Sikorska, M; Sloderbach, A | 1 |
| Benesic, A; Gekle, M; Hennemeier, I; Mildenberger, S; Sauvant, C; Schwerdt, G | 1 |
| Mosrin-Huaman, C; Rahmouni, AR | 1 |
| Dekant, W; Hewitt, P; Huber, CG; Jennings, P; Kohlbacher, O; Limonciel, A; Ranninger, C; Reischl, R; Rurik, M; Ruzek, S; Wilmes, A | 1 |
| Bois, FY; Hamon, J; Leclerc, E | 1 |
| Anders, LC; Anwar-Mohamed, A; Arteel, GE; Beier, JI; Bushau, AM; Cave, M; Douglas, AN; Falkner, KC; Hill, BG; Lang, AL; McClain, CJ; Warner, NL | 1 |
| Nasiri, F; Sabahi-Agabager, L | 1 |
| Chen, L; Chen, W; Feng, G; Gao, S; Yin, J; Zhai, J; Zhang, F | 1 |
| Chen, W; Gao, S; Huang, L; Jiang, B; Liang, Y; Yan, C; Yang, L; Zhang, F | 1 |
| Chen, L; Chen, W; Feng, G; Gao, S; Gong, X; Hou, X; Tao, X; Wei, H; Xia, T; Xiong, X; Zhai, J; Zhang, F | 1 |
| Aiken, A; Akanji, JO; Baig, S; Bellou, S; Beuning, PJ; Carlson, A; Conway, C; Cowell, CM; DeLateur, NA; Giese, RW; Gou, N; Gu, AZ; Hester, A; Hu, M; Joshi, C; Kramer, C; Leifer, BS; Muenter, MM; Nash, E; Qi, MH; Travers, M; Wong, KC | 1 |
| Mao, Y; Qi, S; Xie, YF; Yang, H; Zhao, E | 1 |
| Chess-Williams, R; McDermott, C; Mills, KA | 1 |
| Liu, YM; Ogungbe, IV; Pan, L; Zhang, H; Zhao, J; Zhao, S | 1 |
| Bzowska, A; Górka, M; Stachelska-Wierzchowska, A; Stolarski, R; Wielgus-Kutrowska, B; Wierzchowski, J | 1 |
7 review(s) available for chloroacetaldehyde and acetaldehyde
| Article | Year |
|---|---|
[Molecular basis of mutagenic activity of vinyl chloride].
Topics: Acetaldehyde; Animals; Carcinogens; Cytochrome P-450 Enzyme System; DNA Repair; Ethylene Oxide; Genetic Code; Humans; Mutagens; Nucleic Acids; Vinyl Chloride | 1994 |
DNA damage: chemistry, repair, and mutagenic potential.
Topics: Acetaldehyde; Alkylating Agents; Animals; Base Sequence; Benzene; Benzoquinones; Carcinogens; DNA; DNA Adducts; DNA Damage; DNA Repair; Humans; Molecular Sequence Data; Mutation; Nitrosourea Compounds; Structure-Activity Relationship; Vinyl Chloride | 1996 |
Multiparametric sensor chips for chemosensitivity testing of sensitive and resistant tumor cells.
Topics: Acetaldehyde; Antibiotics, Antineoplastic; Biosensing Techniques; Breast Neoplasms; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Mitochondria; Oxygen; Tumor Cells, Cultured | 2003 |
Neurological toxicity of ifosfamide.
Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Brain; Carbocysteine; Central Nervous System; Glutarates; Glutathione; Humans; Ifosfamide; Neurotoxicity Syndromes | 2003 |
Ifosfamide nephrotoxicity in children: a mechanistic base for pharmacological prevention.
Topics: Acetaldehyde; Acetylcysteine; Age Factors; Antineoplastic Agents, Alkylating; Antioxidants; Child; Humans; Ifosfamide; Kidney Diseases; Oxidative Stress; Risk Factors | 2009 |
Use of precision-cut renal cortical slices in nephrotoxicity studies.
Topics: Acetaldehyde; Animals; Anticonvulsants; Antineoplastic Agents, Alkylating; Cobalt; Humans; Ifosfamide; Kidney Cortex; Metal Nanoparticles; Microdissection; Organ Culture Techniques; Valproic Acid | 2013 |
[Classical oxazaphosphorines--metabolism and therapeutic properties--new implications].
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Antineoplastic Agents; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Drug Resistance, Neoplasm; Glutathione; Glutathione Transferase; Humans; Hydroxylation; Ifosfamide; Neoplasms | 2013 |
3 trial(s) available for chloroacetaldehyde and acetaldehyde
| Article | Year |
|---|---|
Metabolism and pharmacokinetics of oral and intravenous ifosfamide.
Topics: Acetaldehyde; Administration, Oral; Adult; Aged; Female; Humans; Ifosfamide; Infusions, Intravenous; Male; Middle Aged; Neoplasms | 1991 |
Intravenous ifosfamide/mesna is associated with depletion of plasma thiols without depletion of leukocyte glutathione.
Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Cysteine; Dose-Response Relationship, Drug; Glutathione; Homocysteine; Humans; Ifosfamide; Infusions, Intravenous; Leukocytes; Mesna; Neoplasms; Oxidation-Reduction; Protective Agents; Sulfhydryl Compounds | 2000 |
Influence of short-term use of dexamethasone on the pharmacokinetics of ifosfamide in patients.
Topics: Acetaldehyde; Adolescent; Adult; Aged; Antiemetics; Antineoplastic Agents, Alkylating; Dexamethasone; Female; Humans; Ifosfamide; Male; Middle Aged; Neoplasms | 2007 |
189 other study(ies) available for chloroacetaldehyde and acetaldehyde
| Article | Year |
|---|---|
From Dynamic Combinatorial Chemistry to
Topics: | 2017 |
Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Animals; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Ethylene Oxide; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats; Vinyl Chloride; Vinyl Compounds | 1979 |
Analysis of DNA strand breaks induced in rodent liver in vivo, hepatocytes in primary culture, and a human cell line by chlorinated acetic acids and chlorinated acetaldehydes.
Topics: Acetaldehyde; Acetates; Animals; Chloral Hydrate; Chlorine; DNA; DNA Damage; DNA Helicases; DNA Mutational Analysis; DNA Repair; Humans; Hydrocarbons, Chlorinated; Leukocytes; Liver; Male; Mice; Mice, Inbred Strains; Mutagens; Rats; Rats, Inbred F344; Tumor Cells, Cultured; Water Supply | 1992 |
Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II.
Topics: Acetaldehyde; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Deoxyguanine Nucleotides; DNA; DNA Glycosylases; DNA Repair; Escherichia coli; Guanine; Kinetics; Methylnitrosourea; N-Glycosyl Hydrolases; Time Factors; Tritium | 1992 |
The enigma of ifosfamide encephalopathy.
Topics: Acetaldehyde; Brain; Brain Diseases; Drug Administration Schedule; Female; Humans; Ifosfamide | 1992 |
Fluorometric quantitation of adenosine concentration in small samples of extracellular fluid.
Topics: Acetaldehyde; Adenosine; Animals; Ethenoadenosine Triphosphate; Extracellular Space; Exudates and Transudates; Fluorometry; Heart; Heart Ventricles; Hypoxia; Male; Rats; Rats, Sprague-Dawley; Ventricular Function | 1992 |
Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse.
Topics: Acetaldehyde; Animals; Body Weight; Carcinogens; Chloral Hydrate; Dichloroacetic Acid; Drinking Behavior; Female; Kidney; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Organ Size; Spleen; Testis | 1992 |
Formation of (dA-dT)n cruciforms in Escherichia coli cells under different environmental conditions.
Topics: Acetaldehyde; Chloramphenicol; DNA Topoisomerases, Type I; DNA, Superhelical; Electrophoresis, Agar Gel; Escherichia coli; Molecular Conformation; Oxygen; Plasmids; Sodium Chloride; Time Factors; Valine | 1991 |
Detection of triple-helix related structures adopted by poly(dG)-poly(dC) sequences in supercoiled plasmid DNA.
Topics: Acetaldehyde; Base Sequence; DNA, Superhelical; Hydrogen-Ion Concentration; Magnesium; Molecular Sequence Data; Nucleic Acid Conformation; Plasmids; Polydeoxyribonucleotides | 1991 |
Chloroacetaldehyde is a powerful inducer of mitotic aneuploidy in Aspergillus nidulans.
Topics: Acetaldehyde; Aneuploidy; Animals; Aspergillus nidulans; Cattle; Chromosomes, Fungal; Crossing Over, Genetic; In Vitro Techniques; Microtubules; Mutagens | 1990 |
Derivatization-liquid chromatographic assay of chloroacetaldehyde in biological samples.
Topics: Acetaldehyde; Animals; Chromatography, High Pressure Liquid; Female; Microsomes, Liver; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Thiazoles | 1990 |
Nucleophilic selectivity and reaction kinetics of chloroethylene oxide assessed by the 4-(p-nitrobenzyl)pyridine assay and proton nuclear magnetic resonance spectroscopy.
Topics: Acetaldehyde; Anions; Carcinogens; Chemical Phenomena; Chemistry; Chlorides; Deuterium; Ethylene Oxide; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Pyridines; Temperature; Thiosulfates | 1990 |
2-Chloroacetaldehyde and 2-chloroacetal are potent inhibitors of DNA synthesis in animal cells.
Topics: Acetaldehyde; Acetals; Animals; Cell Line; Cells, Cultured; DNA; DNA Replication; Kinetics; Mice; Thymidine; Tritium | 1990 |
Distortions induced in double-stranded oligonucleotides by the binding of cis- or trans-diammine-dichloroplatinum(II) to the d(GTG) sequence.
Topics: Acetaldehyde; Base Sequence; Binding Sites; Cisplatin; Copper; Diethyl Pyrocarbonate; Electrophoresis, Gel, Two-Dimensional; Isomerism; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Osmium Tetroxide; Phenanthrolines; Sodium Cyanide; Temperature | 1990 |
Mechanisms of mutagenesis by the vinyl chloride metabolite chloroacetaldehyde. Effect of gene-targeted in vitro adduction of M13 DNA on DNA template activity in vivo and in vitro.
Topics: Acetaldehyde; Bacteriophages; Base Sequence; DNA Damage; DNA Polymerase I; DNA Replication; DNA, Bacterial; DNA, Single-Stranded; Escherichia coli; Molecular Sequence Data; Mutation; SOS Response, Genetics; Templates, Genetic; Transfection | 1990 |
The role of cyclic base adducts in vinyl-chloride-induced carcinogenesis: studies on nucleic acid alkylation in vivo.
Topics: Acetaldehyde; Adenine; Alkylation; Animals; Carcinogens; Cytosine; DNA; DNA Damage; Ethylene Oxide; Guanine; Microsomes, Liver; Rats; RNA; Vinyl Chloride; Vinyl Compounds | 1986 |
Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication.
Topics: Acetaldehyde; Animals; Cyclophosphamide; Cystitis; Female; Hemorrhage; Ifosfamide; Male; Mesna; Rats; Rats, Inbred Strains | 1989 |
Mechanisms of mutagenesis by chloroacetaldehyde.
Topics: Acetaldehyde; Base Sequence; Cell Survival; Coliphages; Cytosine Nucleotides; DNA; DNA, Viral; Escherichia coli; Molecular Sequence Data; Mutation; Transfection | 1989 |
Chemical probes of the conformation of DNA modified by cis-diamminedichloroplatinum(II).
Topics: Acetaldehyde; Base Sequence; Circular Dichroism; Cisplatin; Diethyl Pyrocarbonate; DNA; Kinetics; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Osmium Tetroxide; Piperidines; Plasmids | 1989 |
The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo.
Topics: Acetaldehyde; Cell Line; Glutathione; Glutathione Transferase; Humans; Ifosfamide; In Vitro Techniques; Macrophages; Placenta; Time Factors | 1989 |
Inhibition of restriction endonuclease cleavage due to site-specific chemical modification of the B-Z junction in supercoiled DNA.
Topics: Acetaldehyde; Base Sequence; DNA Restriction Enzymes; DNA, Superhelical; Electrophoresis, Agar Gel; Nucleic Acid Conformation; Plasmids | 1987 |
The chemical carcinogen, chloroacetaldehyde, modifies a specific site within the regulatory sequence of human cytomegalovirus major immediate early gene in vivo.
Topics: Acetaldehyde; Antigens, Viral; Chromatin; Chromosome Mapping; Cytomegalovirus; DNA, Superhelical; DNA, Viral; Humans; Immediate-Early Proteins; Molecular Structure; Plasmids; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Tumor Cells, Cultured | 1988 |
Dechloroethylation of ifosfamide and neurotoxicity.
Topics: Acetaldehyde; Humans; Ifosfamide; Nervous System Diseases | 1986 |
The segment inversion site of herpes simplex virus type 1 adopts a novel DNA structure.
Topics: Acetaldehyde; Deoxyribonuclease BamHI; Deoxyribonuclease EcoRI; DNA Restriction Enzymes; DNA, Superhelical; DNA, Viral; Endonucleases; Hydrogen-Ion Concentration; Nucleic Acid Conformation; Plasmids; Repetitive Sequences, Nucleic Acid; Simplexvirus; Single-Strand Specific DNA and RNA Endonucleases | 1987 |
Chloroacetaldehyde reacts with Z-DNA.
Topics: Acetaldehyde; Base Sequence; DNA; Nucleotide Mapping; Piperidines | 1988 |
High-performance liquid chromatographic analysis of DNA composition and DNA modification by chloroacetaldehyde.
Topics: Acetaldehyde; Chromatography, High Pressure Liquid; DNA; Hydrogen-Ion Concentration; Indicators and Reagents; Nucleosides | 1988 |
An ultimate chemical carcinogen, N-acetoxy-2-acetylaminofluorene, detects non-B DNA structures that are reactive with chloroacetaldehyde in supercoiled plasmid DNA.
Topics: 2-Acetylaminofluorene; Acetaldehyde; Acetoxyacetylaminofluorene; Base Sequence; DNA, Superhelical; Magnesium; Nucleic Acid Conformation; Plasmids | 1988 |
Investigations on metabolism and carcinogenicity of 1,1,2-trichloroethane.
Topics: Acetaldehyde; Animals; DNA; Female; Hydrocarbons, Chlorinated; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Sarcoma, Experimental; Thioglycolates; Trichloroethanes | 1988 |
Development of techniques to monitor for exposure to vinyl chloride: monoclonal antibodies to ethenoadenosine and ethenocytidine.
Topics: Acetaldehyde; Adenosine; Antibodies, Monoclonal; Antigen-Antibody Complex; Binding, Competitive; Cytidine; DNA; Environmental Exposure; Enzyme-Linked Immunosorbent Assay; Structure-Activity Relationship; Vinyl Chloride; Vinyl Compounds | 1988 |
Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA.
Topics: Acetaldehyde; DNA, Bacterial; DNA, Superhelical; Hydrogen-Ion Concentration; Magnesium; Nucleic Acid Conformation; Plasmids; Polydeoxyribonucleotides | 1988 |
Determination of adenosine in fetal perfusates of human placental cotyledons using fluorescence derivatization and reversed-phase high-performance liquid chromatography.
Topics: Acetaldehyde; Adenosine; Chromatography, High Pressure Liquid; Female; Fetal Blood; Humans; Perfusion; Placenta; Pregnancy; Spectrometry, Fluorescence | 1988 |
Formation of interstrand cross-links in chloroacetaldehyde-treated DNA demonstrated by ethidium bromide fluorescence.
Topics: Acetaldehyde; Cross-Linking Reagents; DNA; Ethidium; Fluorescence; Poly dA-dT | 1988 |
Unusual conformational effect exerted by Z-DNA upon its neighboring sequences.
Topics: Acetaldehyde; Base Sequence; DNA, Superhelical; Nucleic Acid Conformation; Nucleotide Mapping; Plasmids | 1987 |
Mutagenic and promutagenic properties of DNA adducts formed by vinyl chloride metabolites.
Topics: Acetaldehyde; Adenine; Alkylating Agents; Animals; Carcinogens; Cytosine; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Escherichia coli; Ethylene Oxide; Guanine; Mutagens; Vinyl Chloride; Vinyl Compounds | 1986 |
The use of suicide substrates to select mutants of Escherichia coli lacking enzymes of alcohol fermentation.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Oxidoreductases; Chromosome Mapping; Drug Resistance, Microbial; Escherichia coli; Ethanol; Ethylene Chlorohydrin; Fermentation; Genes; Genes, Bacterial; Mutation; Temperature; Transduction, Genetic | 1986 |
Investigations on metabolism, genotoxic effects and carcinogenicity of 2,2'-dichlorodiethylether.
Topics: Acetaldehyde; Animals; Carcinogens; DNA; Dose-Response Relationship, Drug; Ether; Ethyl Ethers; Female; Light; Male; Mutagens; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Thioglycolates | 1986 |
Reaction of chloroacetaldehyde with poly(dA-dT) and poly(dC-dG) and its effect upon the accuracy of DNA synthesis.
Topics: Acetaldehyde; DNA Damage; DNA Replication; Poly dA-dT; Polydeoxyribonucleotides | 1986 |
Repair of etheno DNA adducts by N-glycosylases.
Topics: Acetaldehyde; Adenine; Adenosine; DNA Glycosylases; DNA Repair; Guanine; Guanosine; N-Glycosyl Hydrolases; Substrate Specificity | 1986 |
Detection of DNA base damage by 32P-postlabelling: TLC separation of 5'-deoxynucleoside monophosphates.
Topics: Acetaldehyde; Chromatography, Thin Layer; Deoxyribonucleotides; DNA Damage; Phosphorus Radioisotopes | 1986 |
Neutral reactions of haloacetaldehydes with polynucleotides: mechanisms, monomer and polymer products.
Topics: Acetaldehyde; Adenosine; Aldehydes; Alkylation; Cross-Linking Reagents; Cytosine; DNA Damage; Guanosine; Nucleic Acid Conformation; Nucleic Acids; Poly dA-dT; Spectrophotometry, Ultraviolet | 1986 |
Reaction kinetics and cytosine adducts of chloroethylene oxide and chloroacetaldehyde: direct observation of intermediates by FTNMR and GC-MS.
Topics: 5-Methylcytosine; Acetaldehyde; Chemical Phenomena; Chemistry; Cytidine; Cytosine; DNA; DNA Damage; Ethylene Oxide; Gas Chromatography-Mass Spectrometry; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Uridine | 1986 |
Chemical modification of adenine and cytosine residues with chloroacetaldehyde at the nucleoside and the tRNA level: the structural effect of chloroacetaldehyde modification.
Topics: Acetaldehyde; Adenine; Adenosine; Chemical Phenomena; Chemistry; Cytidine; Cytosine; Molecular Conformation; RNA, Transfer | 1986 |
Mutagenicity and toxicity of chloroethylene oxide and chloroacetaldehyde.
Topics: Acetaldehyde; Escherichia coli; Ethylene Oxide; Mutagens; Tryptophan | 1985 |
Fluorescence modification of Escherichia coli 5S RNA.
Topics: Acetaldehyde; Adenine; Base Composition; Escherichia coli; Geobacillus stearothermophilus; Kinetics; Nucleic Acid Conformation; Phosphoric Diester Hydrolases; Ribosomal Proteins; RNA; Spectrometry, Fluorescence | 1981 |
Assessment of mutagenic efficiency of two carcinogen-modified nucleosides, 1,N6-ethenodeoxyadenosine and O4-methyldeoxythymidine, using polymerases of varying fidelity.
Topics: Acetaldehyde; Deoxyadenosines; DNA Replication; Mutagens; Poly dA-dT; RNA-Directed DNA Polymerase; Thymidine; Transcription, Genetic | 1984 |
A simple fluorometric method for cAMP: application to studies of brain adenylate cyclase activity.
Topics: Acetaldehyde; Adenylyl Cyclases; Animals; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cyclic AMP; Guinea Pigs; Spectrometry, Fluorescence | 1981 |
Long-range conformational transition in yeast tRNAPhe, induced by the Y-base removal and detected by chloroacetaldehyde modification.
Topics: Acetaldehyde; Base Sequence; Guanine; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; RNA, Transfer, Amino Acyl; Saccharomyces cerevisiae | 1983 |
Dose-response relationships for mutations induced in E. coli by some model compounds. With an addendum: Reaction kinetics in water of chloroethylene oxide, chloroacetaldehyde, and chloroacetone.
Topics: Acetaldehyde; Acetone; Dose-Response Relationship, Drug; Escherichia coli; Ethylene Oxide; Kinetics; Mutagens; Water | 1984 |
Binding of gene 32 protein from phage T4 and recA gene product from E. coli to fluorescent single-stranded polynucleotides.
Topics: Acetaldehyde; Binding, Competitive; DNA, Single-Stranded; Fluorescence Polarization; Hydrogen-Ion Concentration; Poly A; Polynucleotides; Rec A Recombinases; Spectrometry, Fluorescence; T-Phages; Viral Proteins | 1984 |
2-Chloroacetaldehyde: a metabolite of cyclophosphamide in the rat.
Topics: Acetaldehyde; Animals; Cyclophosphamide; Kidney; Rats; Rats, Inbred Strains; Tritium | 1983 |
2-Chloroacetaldehyde, a metabolite of cyclophosphamide in the rat.
Topics: Acetaldehyde; Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cyclophosphamide; Male; Phenylhydrazines; Rats; Rats, Inbred Strains; Spectrophotometry; Tritium | 1983 |
High-pressure liquid chromatographic-fluorometric detection of adenosine and adenine nucleotides: application to endogenous content and electrically induced release of adenyl purines in guinea pig vas deferens.
Topics: Acetaldehyde; Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adrenergic Fibers; Animals; Chromatography, High Pressure Liquid; Electric Stimulation; Electrophysiology; Fluorometry; Guinea Pigs; In Vitro Techniques; Male; Vas Deferens | 1984 |
Chloroacetaldehyde-treated ribo- and deoxyribopolynucleotides. 2. Errors in transcription by different polymerases resulting from ethenocytosine and its hydrated intermediate.
Topics: Acetaldehyde; Animals; Base Sequence; Cattle; Cytosine; Deoxyribonucleotides; DNA-Directed RNA Polymerases; Escherichia coli; Poly C; Ribonucleotides; RNA, Messenger; Transcription, Genetic | 1982 |
Detection of mutagen-induced lesions in isolated DNA by marker rescue of Bacillus subtilis phage phi 105.
Topics: Acetaldehyde; Acetoxyacetylaminofluorene; Bacillus subtilis; Bacteriophages; DNA, Viral; Epoxy Compounds; Genetic Markers; Hydroxylamines; Lysogeny; Methylnitronitrosoguanidine; Mutagenicity Tests | 1980 |
The nucleotide sequence of tRNA4Val of Drosophila melanogaster. Chloroacetaldehyde modification as an aid to RNA sequencing.
Topics: Acetaldehyde; Animals; Base Sequence; Drosophila melanogaster; Nucleic Acid Conformation; RNA, Transfer, Amino Acyl | 1982 |
Adenosine measurement by a rapid HPLC-fluorometric method: induced changes of adenosine content in regions of rat brain.
Topics: Acetaldehyde; Adenosine; Animals; Brain; Brain Chemistry; Carbon Dioxide; Chromatography, High Pressure Liquid; Male; Microwaves; Rats; Rats, Inbred Strains; Specimen Handling; Tissue Distribution | 1982 |
The reaction of adenine and cytosine residues in tRNA with chloroacetaldehyde.
Topics: Acetaldehyde; Adenine; Cytosine; Hydrogen-Ion Concentration; Kinetics; Plants; RNA, Transfer; RNA, Transfer, Amino Acyl | 1981 |
Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis.
Topics: Acetaldehyde; Biotransformation; DNA Polymerase I; DNA Replication; DNA-Directed DNA Polymerase; Escherichia coli; Ethylene Oxide; Polydeoxyribonucleotides; Templates, Genetic; Vinyl Chloride; Vinyl Compounds | 1981 |
The induction of errors during in vitro DNA synthesis following chloroacetaldehyde-treatment of poly(dA-dT) and poly(dC-dG) templates.
Topics: Acetaldehyde; DNA; DNA Polymerase I; Escherichia coli; Poly dA-dT; Polydeoxyribonucleotides; Templates, Genetic | 1981 |
Detection of N2,3-ethanoguanine in DNA after treatment with chloroacetaldehyde in vitro.
Topics: Acetaldehyde; Alkylation; Animals; DNA; Guanine; Salmon; Vinyl Chloride | 1982 |
Determination of chloroacetaldehyde in air by differential pulse polarography.
Topics: Acetaldehyde; Air; Air Pollutants; Air Pollutants, Occupational; Polarography | 1982 |
Chloroacetaldehyde-treated ribo- and deoxyribopolynucleotides. 1. Reaction products.
Topics: Acetaldehyde; Adenosine; Chromatography, High Pressure Liquid; Cytosine; Deoxyribonucleotides; Hydrogen-Ion Concentration; Poly A; Poly C; Ribonucleotides; Temperature | 1982 |
The reactions of thiouridines and thiouracils with chloroacetaldehyde; mechanistic considerations.
Topics: Acetaldehyde; Adenosine; Alkylation; Cytidine; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Thiouracil; Thiouridine | 1980 |
Toxicity of ifosfamide, cyclophosphamide and their metabolites in renal tubular cells in culture.
Topics: Acetaldehyde; Acrolein; Animals; Cell Line; Cells, Cultured; Cyclophosphamide; DNA; DNA Replication; Epithelial Cells; Epithelium; Ifosfamide; Kidney Tubules, Proximal; RNA; Swine; Thymidine; Uridine | 1994 |
Molecular analysis of mutations induced by 2-chloroacetaldehyde, the ultimate carcinogenic form of vinyl chloride, in human cells using shuttle vectors.
Topics: Acetaldehyde; Base Composition; Base Sequence; Carcinogens; Cell Line, Transformed; DNA Primers; Dose-Response Relationship, Drug; Escherichia coli; Genes, Bacterial; Genetic Vectors; Humans; Molecular Sequence Data; Mutagenesis; Plasmids; Point Mutation; Simian virus 40; Vinyl Chloride | 1995 |
An intramolecular triplex in the human gamma-globin 5'-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin.
Topics: Acetaldehyde; Base Sequence; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 16; Diethyl Pyrocarbonate; DNA; Electrophoresis, Agar Gel; Fetal Hemoglobin; Globins; Hemoglobinopathies; Humans; Indicators and Reagents; Molecular Sequence Data; Nucleic Acid Conformation; Osmium Tetroxide; Plasmids; Point Mutation; Regulatory Sequences, Nucleic Acid; Restriction Mapping | 1995 |
Spectrofluorimetric determination of 2-chloro-2'-deoxyadenosine (cladribine) in human plasma by photochemical reaction and chloroacetaldehyde derivatization.
Topics: Acetaldehyde; Chromatography, High Pressure Liquid; Cladribine; Humans; Magnetic Resonance Spectroscopy; Photochemistry; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1995 |
Distortion after monofunctional alkylation by mitomycin C of a dodecamer containing its major binding site.
Topics: Acetaldehyde; Alkylation; Base Sequence; Binding Sites; DNA; DNA Probes; Guanine; Hydroxylamine; Hydroxylamines; Mitomycin; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; Osmium Compounds; Spectrum Analysis, Raman | 1995 |
The induction of adaptive response to alkylating agents in Escherichia coli reduces the frequency of specific C-->T mutations in chloroacetaldehyde-treated M13 glyU phage.
Topics: Acetaldehyde; Adaptation, Physiological; Alkylating Agents; Anticodon; Base Sequence; Coliphages; DNA Adducts; DNA Repair; DNA, Viral; Escherichia coli; Molecular Sequence Data; Point Mutation | 1994 |
Determination of adenine nucleotides by fluorescence detection using high-performance liquid chromatography and post-column derivatisation with chloroacetaldehyde.
Topics: Acetaldehyde; Adenine Nucleotides; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Liver; Mice; Perchlorates; Spectrometry, Fluorescence; Trichloroacetic Acid; Tumor Cells, Cultured | 1994 |
The use of 2-hydroperoxytetrahydrofuran as a reagent to sequence cytosine and to probe non-Watson-Crick DNA structures.
Topics: 5-Methylcytosine; Acetaldehyde; Base Sequence; Cytosine; DNA; DNA, Single-Stranded; Furans; Hot Temperature; Hydrogen-Ion Concentration; Hydroxylamines; Indicators and Reagents; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; Sequence Analysis, DNA | 1995 |
Detection of small quantities of double stranded DNA by enhanced fluorescence of substituted aldehyde modified polydeoxynucleotide-ethidium bromide complexes.
Topics: Acetaldehyde; DNA; DNA, Single-Stranded; Electrophoresis, Agar Gel; Ethidium; Spectrometry, Fluorescence | 1994 |
Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna.
Topics: Acetaldehyde; Acrolein; Animals; CHO Cells; Cricetinae; Glutathione; Humans; Ifosfamide; Intracellular Fluid; Lymphocytes; Mesna | 1994 |
Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney.
Topics: Absorption; Acetaldehyde; Acrolein; Animals; Chemotherapy, Cancer, Regional Perfusion; Disease Models, Animal; Fanconi Syndrome; Glucose; Ifosfamide; Kidney; Kidney Tubules, Proximal; Male; Organ Size; Phosphates; Prodrugs; Rats; Rats, Inbred Lew; Sodium; Sulfates | 1994 |
Gradual and oriented B-Z transition in 5'-untranscribed region of mouse ribosomal DNA.
Topics: Acetaldehyde; Animals; Base Composition; Base Sequence; Diethyl Pyrocarbonate; DNA, Bacterial; DNA, Recombinant; DNA, Ribosomal; Electrophoresis, Gel, Two-Dimensional; Escherichia coli; Hydroxylamine; Hydroxylamines; Mice; Models, Molecular; Molecular Probes; Molecular Sequence Data; Nucleic Acid Conformation; Osmium Tetroxide; Repetitive Sequences, Nucleic Acid | 1994 |
Chloroacetaldehyde-induced hepatocyte cytotoxicity. Mechanisms for cytoprotection.
Topics: Acetaldehyde; Adenosine Triphosphate; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Aminooxyacetic Acid; Animals; Aspartate Aminotransferases; Cell Survival; Drug Resistance; Homeostasis; Liver; Male; NAD; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 1994 |
The non-B-DNA structure of d(CA/TG)n differs from that of Z-DNA.
Topics: Acetaldehyde; Animals; Base Sequence; DNA; DNA, Superhelical; Electrophoresis, Gel, Two-Dimensional; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Prolactin; Rats; Repetitive Sequences, Nucleic Acid | 1994 |
Enhancement of ethidium bromide fluorescence in double-stranded DNA reacted with chloroacetaldehyde.
Topics: Acetaldehyde; DNA; Electrophoresis, Agar Gel; Ethidium; Fluorescent Dyes; Spectrometry, Fluorescence | 1993 |
32P-postlabelling methods for cyclic DNA adducts.
Topics: Acetaldehyde; Animals; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Damage; Male; Mice; Mice, Inbred C3H; Nucleotides, Cyclic; Phosphorus Radioisotopes; Skin | 1993 |
Molecular mechanisms of chloroacetaldehyde-induced cytotoxicity in isolated rat hepatocytes.
Topics: Acetaldehyde; Adenosine Triphosphate; Animals; Antioxidants; Calcium; Cell Survival; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; Glutathione; Lipid Peroxidation; Liver; Male; Malondialdehyde; Oxygen Consumption; Rats; Rats, Sprague-Dawley | 1993 |
Substrate specificity of rat liver aldehyde dehydrogenase with chloroacetaldehydes.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Cytosol; In Vitro Techniques; Isoenzymes; Kinetics; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Substrate Specificity | 1993 |
Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy.
Topics: Acetaldehyde; Adult; Aged; Carcinoma, Bronchogenic; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyclophosphamide; Drug Administration Schedule; Female; Humans; Ifosfamide; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged | 1993 |
Identification of DNA adducts at specific locations by sequencing techniques.
Topics: Acetaldehyde; Bacteriophage M13; Base Sequence; DNA Damage; DNA, Viral; Molecular Sequence Data; Sequence Analysis, DNA; Terminator Regions, Genetic | 1993 |
All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.
Topics: Acetaldehyde; Adenine; Animals; Base Sequence; Cattle; Cytosine; DNA; DNA Glycosylases; DNA-Binding Proteins; Guanine; HeLa Cells; Humans; Molecular Sequence Data; N-Glycosyl Hydrolases; Oligonucleotide Probes | 1994 |
Monofunctional adducts of platinum(II) produce in DNA a sequence-dependent local denaturation.
Topics: Acetaldehyde; Base Composition; Base Sequence; Chromosome Mapping; Cisplatin; Deoxyribonucleases, Type II Site-Specific; DNA; Enzyme-Linked Immunosorbent Assay; Hydrogen Bonding; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; Piperidines; Spectrometry, Fluorescence; Transcription, Genetic | 1994 |
Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma.
Topics: Acetaldehyde; Aged; Biotransformation; Chromatography, High Pressure Liquid; Drug Stability; Formaldehyde; Humans; Ifosfamide | 1993 |
Chloroacetaldehyde-induced mutagenesis in Escherichia coli: specificity of mutations and modulation by induction of the adaptive response to alkylating agents.
Topics: Acetaldehyde; Alkylating Agents; Carcinogens; DNA Damage; DNA Glycosylases; DNA Mutational Analysis; DNA Repair; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagenesis; N-Glycosyl Hydrolases; Vinyl Chloride | 1993 |
Conformational junctions between left-handed DNA in (dA-dT)16 and contiguous B-DNA in a supercoiled plasmid contain chemically reactive bases.
Topics: Acetaldehyde; Base Sequence; Diethyl Pyrocarbonate; DNA, Superhelical; Hydrogen-Ion Concentration; Indicators and Reagents; Molecular Probes; Molecular Sequence Data; Nucleic Acid Conformation; Plasmids; Poly dA-dT; Single-Strand Specific DNA and RNA Endonucleases | 1993 |
Development of monoclonal antibodies specific for 1,N2-ethenodeoxyguanosine and N2,3-ethenodeoxyguanosine and their use for quantitation of adducts in G12 cells exposed to chloroacetaldehyde.
Topics: Acetaldehyde; Animals; Antibodies, Monoclonal; Cells, Cultured; Cricetinae; Cricetulus; Deoxyguanosine; DNA Damage; DNA, Single-Stranded; Enzyme-Linked Immunosorbent Assay; Female; Lipid Peroxidation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL | 1993 |
Simultaneous determination of nerve-induced adenine nucleotides and nucleosides released from rabbit pulmonary artery.
Topics: Acetaldehyde; Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; Drug Stability; Electric Stimulation; Fluorescent Dyes; In Vitro Techniques; Male; Nucleosides; Pulmonary Artery; Rabbits; Reference Standards; Reproducibility of Results; Vidarabine | 1993 |
Structural polymorphism of homopurine-homopyrimidine sequences at neutral pH.
Topics: Acetaldehyde; Base Sequence; DNA; Hydrogen-Ion Concentration; Molecular Sequence Data; Nucleic Acid Conformation; Plasmids; Polydeoxyribonucleotides; Stereoisomerism; Zinc | 1993 |
2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity.
Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Brain; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Glutathione; Ifosfamide; Liver; Male; Mice | 1996 |
1,N6-ethenodeoxyadenosine, a DNA adduct highly mutagenic in mammalian cells.
Topics: Acetaldehyde; Animals; Base Sequence; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; Deoxyadenosines; Deoxycytidine; DNA Adducts; DNA, Single-Stranded; Escherichia coli; Ethylene Oxide; Humans; Molecular Sequence Data; Mutagens; Mutation; Nucleic Acid Conformation; Plasmids; Transformation, Genetic | 1996 |
Measurement of adenosine by capillary zone electrophoresis with on-column isotachophoretic preconcentration.
Topics: Acetaldehyde; Adenosine; Adult; Buffers; Electrophoresis; Electrophoresis, Capillary; Humans; Indicators and Reagents; Male; Spectrometry, Fluorescence | 1996 |
High resolution mapping of E.coli transcription elongation complex in situ reveals protein interactions with the non-transcribed strand.
Topics: Acetaldehyde; Bacterial Proteins; Base Sequence; DNA Footprinting; DNA-Directed RNA Polymerases; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Lac Operon; Lac Repressors; Molecular Sequence Data; Osmium Tetroxide; Repressor Proteins; RNA, Bacterial; RNA, Messenger; Sulfuric Acid Esters; Terminator Regions, Genetic; Transcription, Genetic; Trinucleotide Repeats; Ultraviolet Rays | 1996 |
Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line.
Topics: Acetaldehyde; B-Lymphocytes; Cell Line; Dose-Response Relationship, Drug; Ethylene Oxide; Humans; Hypoxanthine Phosphoribosyltransferase; Mutagenicity Tests; Mutation; Time Factors; Vinyl Chloride | 1997 |
DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells.
Topics: Acetaldehyde; Acrolein; Aldehydes; Arsenates; Carcinogens; Cell Death; Cell Division; Cell Survival; Cross-Linking Reagents; DNA; DNA-Binding Proteins; Epoxy Compounds; Formaldehyde; Furaldehyde; Humans; Lymphoma; Methane; Mutagens; Nitroparaffins; Polymers; Tumor Cells, Cultured | 1997 |
Ifosfamide cytotoxicity on human tumor and renal cells: role of chloroacetaldehyde in comparison to 4-hydroxyifosfamide.
Topics: Acetaldehyde; Carcinoma, Non-Small-Cell Lung; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Ifosfamide; Kidney Tubules; Lung Neoplasms; Tumor Cells, Cultured | 1997 |
Is the white-ivory assay of Drosophila melanogaster a useful tool in genetic toxicology?
Topics: Acetaldehyde; Animals; Antimetabolites; Cross-Linking Reagents; DNA Adducts; DNA Damage; Drosophila melanogaster; Enzyme Inhibitors; Evaluation Studies as Topic; Eye Color; Hydrocarbons, Halogenated; Intercalating Agents; Male; Mutagenicity Tests; Oxidative Stress; Recombination, Genetic; Sensitivity and Specificity; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1997 |
Involvement of glutamate 399 and lysine 192 in the mechanism of human liver mitochondrial aldehyde dehydrogenase.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Glutamic Acid; Humans; Isoelectric Point; Kinetics; Lysine; Magnesium; Mitochondria, Liver; Mutagenesis, Site-Directed; Structure-Activity Relationship | 1997 |
Stimulation of respiration by methylene blue in rat liver mitochondria.
Topics: Acetaldehyde; Animals; Antidotes; Coloring Agents; Male; Methylene Blue; Mitochondria, Liver; Mitochondrial Swelling; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rats, Wistar; Uncoupling Agents | 1997 |
A 13C NMR study of 2-(13)C-chloroacetaldehyde, a metabolite of ifosfamide and cyclophosphamide, in the isolated perfused rabbit heart model. Initial observations on its cardiotoxicity and cardiac metabolism.
Topics: Acetaldehyde; Acetates; Animals; Carbon Isotopes; Cyclophosphamide; Glutathione; Glycolates; Heart; Ifosfamide; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Myocardium; Perfusion; Rabbits | 1997 |
Novel substrates of yeast alcohol dehydrogenase-3. 4-dimethylamino-cinnamaldehyde and chloroacetaldehyde.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Cinnamates; Hydrogen-Ion Concentration; Kinetics; NAD; Polymers; Schiff Bases; Spectrophotometry; Substrate Specificity | 1997 |
Cloning, sequence and expression of a linear plasmid-based and a chromosomal homolog of chloroacetaldehyde dehydrogenase-encoding genes in Xanthobacter autotrophicus GJ10.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Amino Acid Sequence; Base Sequence; Biodegradation, Environmental; Carboxy-Lyases; Cloning, Molecular; Escherichia coli; Gene Expression; Genes, Bacterial; Gram-Negative Aerobic Rods and Cocci; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic | 1998 |
Excretion kinetics of ifosfamide side-chain metabolites in children on continuous and short-term infusion.
Topics: Acetaldehyde; Acrolein; Adolescent; Adult; Antineoplastic Agents, Alkylating; Child; Female; Humans; Ifosfamide; Infusions, Intravenous; Kidney; Male; Neoplasms; Phosphoramide Mustards | 1998 |
Measurement of adenosine concentration in aqueous and vitreous.
Topics: Acetaldehyde; Adenosine; Animals; Aqueous Humor; Cattle; Chromatography, High Pressure Liquid; Fluorometry; Swine; Vitreous Body | 1998 |
Determination of ATP and its metabolites released from rat caudal artery by isocratic ion-pair reversed-phase high-performance liquid chromatography.
Topics: Acetaldehyde; Adenine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arteries; Calibration; Chromatography, High Pressure Liquid; Fluorescence; Male; Norepinephrine; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity | 1998 |
Sequence-dependent extrusion of a small DNA hairpin at the N4 virion RNA polymerase promoters.
Topics: Acetaldehyde; Base Sequence; Conserved Sequence; DNA-Directed RNA Polymerases; DNA, Superhelical; DNA, Viral; Mutation; Nucleic Acid Conformation; Podoviridae; Potassium Permanganate; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; Single-Strand Specific DNA and RNA Endonucleases; Virion | 1998 |
Modulation by acrolein and chloroacetaldehyde of multidrug resistance mediated by the multidrug resistance-associated protein (MRP).
Topics: Acetaldehyde; Acrolein; ATP-Binding Cassette Transporters; Daunorubicin; Drug Resistance, Multiple; Glutathione; Humans; Multidrug Resistance-Associated Proteins; Tumor Cells, Cultured; Vinblastine | 1996 |
Inhibition and stimulation of long-chain fatty acid oxidation by chloroacetaldehyde and methylene blue in rats.
Topics: Acetaldehyde; Animals; Bile; Caprylates; Coloring Agents; Fatty Acids; Glutathione; Male; Methylene Blue; Mitochondria; Oxidation-Reduction; Palmitic Acid; Rats; Rats, Wistar; Succinic Acid | 1999 |
High-performance liquid chromatographic-fluorescent method to determine chloroacetaldehyde, a neurotoxic metabolite of the anticancer drug ifosfamide, in plasma and in liver microsomal incubations.
Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Cells, Cultured; Chromatography, High Pressure Liquid; Ifosfamide; Male; Microsomes, Liver; Rats; Rats, Inbred F344; Spectrometry, Fluorescence | 1999 |
Toxicity of ifosfamide and its metabolite chloroacetaldehyde in cultured renal tubule cells.
Topics: Acetaldehyde; Adenosine Triphosphate; Animals; Antineoplastic Agents, Alkylating; Cell Division; Cells, Cultured; Glucose; Glutathione; Ifosfamide; Kidney Tubules, Proximal; Male; Mesna; Rabbits | 1999 |
Quantification of 5-methylcytosine in DNA by the chloroacetaldehyde reaction.
Topics: 5-Methylcytosine; Acetaldehyde; Borohydrides; Chemical Precipitation; Chromatography, High Pressure Liquid; Cinnamates; Cytosine; DNA; DNA Methylation; Fluorescent Dyes; Hydrogen-Ion Concentration; Hydrolysis; Hygromycin B; Purines; Silver Nitrate; Solutions; Spectrometry, Fluorescence; Sulfites | 1999 |
Localization of chloroacetaldehyde-induced DNA damage in human p53 gene by DNA polymerase fingerprint analysis.
Topics: Acetaldehyde; Adenine; Animals; Cytosine; DNA Damage; DNA Fingerprinting; DNA Repair; Exons; Genes, p53; Guanine; Hemangiosarcoma; Humans; Liver Neoplasms; Mutation; Rats; Sequence Analysis, DNA | 1999 |
Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde.
Topics: Acetaldehyde; Adenine; Antiviral Agents; Chemical Precipitation; Chromatography, Liquid; Drug Stability; Fluorescent Dyes; Humans; Indicators and Reagents; Mass Spectrometry; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Trichloroacetic Acid | 1999 |
Metabolism of ifosfamide to chloroacetaldehyde contributes to antitumor activity in vivo.
Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Humans; Ifosfamide; Mice; Mice, Nude; Neoplasm Transplantation; Prodrugs; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Approach to a multiparametric sensor-chip-based tumor chemosensitivity assay.
Topics: Acetaldehyde; Antibiotics, Antineoplastic; Biosensing Techniques; Breast Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Lung Neoplasms; Mitochondria; Oxygen; Tumor Cells, Cultured | 2001 |
Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells.
Topics: Acetaldehyde; Acrolein; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehydes; Alkylation; Animals; Apoptosis; Benzaldehydes; Cell Division; Cell Line; Cricetinae; Drug Resistance; Humans; Inactivation, Metabolic; Isoenzymes; Lipid Peroxidation; Proteins; Rats; Retinal Dehydrogenase; Transfection | 2001 |
2-Chloroacetaldehyde induces epsilondA DNA adducts in DNA of Raji cells as demonstrated by an improved HPLC-fluorimetry method.
Topics: Acetaldehyde; Carcinogens; Chromatography, High Pressure Liquid; DNA; DNA Adducts; DNA Damage; Humans; Leukemia, B-Cell; Lipid Peroxidation; Nicotiana; Plants, Toxic; Smoke; Spectrometry, Fluorescence; Tumor Cells, Cultured; Urethane; Vinyl Chloride | 2001 |
Human kidney tubules detoxify chloroacetaldehyde, a presumed nephrotoxic metabolite of ifosfamide.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Antineoplastic Agents, Alkylating; Humans; Ifosfamide; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Tubules; Lactic Acid; Osmolar Concentration; Sulfhydryl Compounds | 2001 |
Toxicity of chloroacetaldehyde is similar in adult and pediatric kidney tubules.
Topics: Acetaldehyde; Aged; Cell Survival; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Infant; Kidney Tubules; Lactic Acid; Osmolar Concentration; Sulfhydryl Compounds | 2002 |
Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies.
Topics: Acetaldehyde; Acrolein; Alkylation; Antineoplastic Agents, Alkylating; Cyclophosphamide; DNA Damage; Guanine; Humans; Leukemia | 2002 |
Stem cell toxicity of oxazaphosphorine metabolites in comparison to their antileukemic activity.
Topics: Acetaldehyde; Alkylating Agents; Antineoplastic Agents; Cyclophosphamide; Drug Screening Assays, Antitumor; Hematopoietic Stem Cells; Humans; Ifosfamide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2002 |
Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde.
Topics: Acetaldehyde; Adenine; Chromatography, Liquid; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reproducibility of Results; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Spectrometry, Fluorescence; Tenofovir | 2003 |
Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells.
Topics: Acetaldehyde; Acrolein; Amifostine; Animals; Antineoplastic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Glutathione; Ifosfamide; Kidney Tubules; Mesna; Neutral Red; Rabbits | 2003 |
Renal-tubule metabolism of ifosfamide to the nephrotoxic chloroacetaldehyde: pharmacokinetic modeling for estimation of intracellular levels.
Topics: Acetaldehyde; Animals; Biotransformation; Cell Line; Ifosfamide; Kidney; Kidney Tubules; Kinetics | 2004 |
Functional cellular assays with multiparametric silicon sensor chips.
Topics: Acetaldehyde; Adenosine Triphosphate; Biosensing Techniques; Cell Division; Cell Line, Tumor; Cells; Cytochalasin B; Humans; Hydrogen-Ion Concentration; Luminescent Measurements; Microcomputers; Microscopy, Fluorescence; Oxygen Consumption; Silicon; Temperature | 2003 |
Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death.
Topics: Acetaldehyde; Adenine; Alkylating Agents; Animals; Apoptosis; Astrocytes; Cell Culture Techniques; Cerebellum; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Female; Glutathione; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagens; Netropsin; Neurons; Oxidation-Reduction; Xeroderma Pigmentosum Group A Protein | 2004 |
S-Adenosyl methionine/S-adenosyl-L-homocysteine ratio determination by capillary electrophoresis employed as a monitoring tool for the antiviral effectiveness of adenosine analogs.
Topics: Acetaldehyde; Antiviral Agents; Electrophoresis, Capillary; Humans; S-Adenosylhomocysteine; S-Adenosylmethionine | 2004 |
Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder.
Topics: Acetaldehyde; Adenine; Adenosine Triphosphate; Adrenergic Agents; Anesthetics, Local; Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cyclic ADP-Ribose; Dogs; Electrochemistry; Electrophysiology; Female; Guanethidine; Guinea Pigs; Hydrogen-Ion Concentration; Male; Mesenteric Arteries; Mice; Models, Chemical; Muscle, Smooth; NAD; Norepinephrine; omega-Conotoxin GVIA; Oxidopamine; Rabbits; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stress, Mechanical; Temperature; Tetrodotoxin; Time Factors; Urinary Bladder | 2004 |
Suicide inactivation of dioldehydratase by glycolaldehyde and chloroacetaldehyde: an examination of the reaction mechanism.
Topics: Acetaldehyde; Binding Sites; Electron Spin Resonance Spectroscopy; Enzyme Activation; Propanediol Dehydratase; Thermodynamics | 2004 |
Role of mismatch-specific uracil-DNA glycosylase in repair of 3,N4-ethenocytosine in vivo.
Topics: Acetaldehyde; Base Pair Mismatch; Cytosine; DNA Damage; DNA Repair; Escherichia coli; Genetic Complementation Test; Humans; Microbial Sensitivity Tests; Mutagenesis, Insertional; Mutagens; Mutation; Plasmids; Thymine DNA Glycosylase | 2004 |
DNA damage and mutations produced by chloroacetaldehyde in a CpG-methylated target gene.
Topics: Acetaldehyde; Base Sequence; Cell Line; CpG Islands; DNA Adducts; DNA Damage; DNA Methylation; DNA Mutational Analysis; DNA Primers; Genes, Suppressor; Genetic Vectors; Humans; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; RNA, Transfer; Taq Polymerase; Thymine DNA Glycosylase; Transfection | 2004 |
Renal ontogeny of ifosfamide nephrotoxicity.
Topics: Acetaldehyde; Age Factors; Animals; Antineoplastic Agents, Alkylating; Aryl Hydrocarbon Hydroxylases; Child; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Disease Models, Animal; Female; Humans; Ifosfamide; Kidney; Kidney Diseases; Male; Microsomes; Oxidoreductases, N-Demethylating; Steroid Hydroxylases; Swine | 2004 |
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.
Topics: Acetaldehyde; Alkylating Agents; Antigens, Neoplasm; Cell Line, Tumor; Cell Survival; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Humans; Myeloid-Lymphoid Leukemia Protein; Proto-Oncogenes; Transcription Factors | 2005 |
Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450.
Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Proliferation; Cricetinae; Cricetulus; Cyclophosphamide; Cytochrome P-450 Enzyme System; DNA, Complementary; Gene Expression; Humans; Ifosfamide; NADPH-Ferrihemoprotein Reductase; Prodrugs; Rats; Stereoisomerism | 2005 |
Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases.
Topics: Acetaldehyde; Acylation; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitochondrial; Cations, Divalent; Cytosol; Deuterium Exchange Measurement; Humans; Isoenzymes; Kinetics; Liver; Magnesium; Mitochondria; NAD; Retinal Dehydrogenase; Substrate Specificity | 2005 |
Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4]triazine: synthesis of an alpha 2/3-selective GABA agonist.
Topics: Acetaldehyde; Bromides; Catalysis; GABA Agonists; Hydrocarbons, Aromatic; Imidazoles; Palladium; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship; Triazines; Triazoles | 2005 |
Dynamic analysis of metabolic effects of chloroacetaldehyde and cytochalasin B on tumor cells using bioelectronic sensor chips.
Topics: Acetaldehyde; Adenocarcinoma; Biosensing Techniques; Cell Line, Tumor; Colorectal Neoplasms; Cytochalasin B; Energy Metabolism; Humans; Membrane Potentials; Mitochondria; Oxygen Consumption; Reactive Oxygen Species | 2005 |
Chloroacetaldehyde: mode of antitumor action of the ifosfamide metabolite.
Topics: Acetaldehyde; Adenosine Triphosphate; Antineoplastic Agents, Alkylating; Bromodeoxyuridine; Cell Line, Tumor; Comet Assay; Cross-Linking Reagents; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Ifosfamide; Nucleic Acid Synthesis Inhibitors | 2006 |
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo.
Topics: Acetaldehyde; Adenine; Cytosine; DNA Adducts; DNA Damage; DNA Glycosylases; DNA Repair; Escherichia coli; Escherichia coli Proteins; Lipid Peroxidation; Mixed Function Oxygenases; Mutagenesis | 2005 |
Disturbed Ca2+-signaling by chloroacetaldehyde: a possible cause for chronic ifosfamide nephrotoxicity.
Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Cation Transport Proteins; Cell Line; Cytosol; Extracellular Space; Homeostasis; Humans; Hydrogen-Ion Concentration; Ifosfamide; Kidney Diseases; Kidney Tubules, Proximal; Plasma Membrane Calcium-Transporting ATPases; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium; Sodium-Calcium Exchanger | 2005 |
Chloroacetaldehyde- and acrolein-induced death of human proximal tubule cells.
Topics: Acetaldehyde; Acrolein; Cell Death; Cells, Cultured; Glutathione; Humans; Kidney Tubules, Proximal; Oxidation-Reduction | 2006 |
Insights into the hydrogen-abstraction reactions of diol dehydratase: relevance to the catalytic mechanism and suicide inactivation.
Topics: Acetaldehyde; Catalysis; Electron Spin Resonance Spectroscopy; Enzyme Activation; Ethylene Glycol; Free Radicals; Glyoxal; Hydrogen; Kinetics; Propanediol Dehydratase; Propylene Glycol; Quantum Theory; Thermodynamics | 2006 |
Sequence-specific p53 gene damage by chloroacetaldehyde and its repair kinetics in Escherichia coli.
Topics: Acetaldehyde; DNA Adducts; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; DNA, Bacterial; Escherichia coli; Exons; Genes, p53; Humans; Kinetics; Models, Chemical; Molecular Structure; Polymerase Chain Reaction; Time Factors; Vinyl Chloride | 2006 |
Application of biological activated carbon anaerobic reactor for treatment of hazardous chemicals.
Topics: Acetaldehyde; Adsorption; Bacteria, Anaerobic; Biodegradation, Environmental; Bioreactors; Carbon; Hazardous Substances; Pentachlorophenol; Phenols; Tetrachloroethylene; Time Factors; Waste Disposal, Fluid; Water Purification | 2006 |
Ifosfamide-induced nephrotoxicity: mechanism and prevention.
Topics: Acetaldehyde; Agmatine; Animals; Antineoplastic Agents, Alkylating; Drug Interactions; Electron Transport Complex I; Ifosfamide; Kidney Cortex; Kidney Diseases; Male; Oxidative Phosphorylation; Rats | 2006 |
Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells.
Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Biological Transport; Cell Death; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation; Ifosfamide; Kidney; Mesna; Opossums; Phosphates; Phosphoramide Mustards; RNA, Messenger; Sodium-Phosphate Cotransporter Proteins, Type IIa | 2006 |
Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.
Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Biomarkers; Caspase 3; Caspase 8; Cathepsin B; Cell Count; Cell Death; Cells, Cultured; Coloring Agents; Cysteine Endopeptidases; gamma-Glutamyltransferase; Humans; Ifosfamide; Kidney Diseases; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Microscopy, Fluorescence; Necrosis; Sulfhydryl Compounds; Sulfhydryl Reagents; Trypan Blue | 2006 |
Ifosfamide toxicity in cultured proximal renal tubule cells.
Topics: Acetaldehyde; Acrolein; Amifostine; Animals; Cell Culture Techniques; Cells, Cultured; Dose-Response Relationship, Drug; Ifosfamide; Inulin; Ion Transport; Kidney Tubules, Proximal; Male; Mesna; p-Aminohippuric Acid; Protective Agents; Rabbits; Tetraethylammonium | 2007 |
Mesna or cysteine prevents chloroacetaldehyde-induced cell death of human proximal tubule cells.
Topics: Acetaldehyde; Apoptosis; Cell Line; Cysteine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Therapy, Combination; Glutathione; Humans; Kidney Tubules, Proximal; Mesna; Necrosis; Protective Agents | 2007 |
Necrotic pathway in human osteosarcoma Saos-2 cell death induced by chloroacetaldehyde.
Topics: Acetaldehyde; Adenosine Triphosphate; Annexin A5; Antineoplastic Agents, Alkylating; Blotting, Western; Bone Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Flow Cytometry; Humans; Ifosfamide; Membrane Potentials; Mitochondrial Membranes; Necrosis; Osteosarcoma; Propidium; Sulfhydryl Compounds | 2007 |
Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.
Topics: Acetaldehyde; Acrolein; Alkylating Agents; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclophosphamide; DNA Repair; Drug Resistance, Neoplasm; Ifosfamide; Mice; Mice, Knockout; Mutation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Transfection; Transplantation, Heterologous | 2007 |
Repression by binding of H-NS within the transcription unit.
Topics: Acetaldehyde; Bacterial Proteins; Binding Sites; DNA-Binding Proteins; DNA-Directed RNA Polymerases; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Models, Genetic; Operon; Plasmids; Promoter Regions, Genetic; Protein Structure, Tertiary; Transcription, Genetic | 2007 |
AlkB influences the chloroacetaldehyde-induced mutation spectra and toxicity in the pSP189 supF shuttle vector.
Topics: Acetaldehyde; Base Sequence; Chromatography, Liquid; DNA Damage; DNA Mutational Analysis; DNA, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Escherichia coli Proteins; Genes, Suppressor; Genetic Vectors; Genome; Mass Spectrometry; Mixed Function Oxygenases; Molecular Sequence Data; Mutagenesis; Plasmids | 2007 |
In vivo mesna and amifostine do not prevent chloroacetaldehyde nephrotoxicity in vitro.
Topics: Acetaldehyde; Acetyl Coenzyme A; Adenosine Triphosphate; Amifostine; Animals; Disease Models, Animal; Drug Therapy, Combination; Glutathione; Glutathione Disulfide; Injections, Intraperitoneal; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Mesna; Organ Culture Techniques; Radiation-Protective Agents; Rats; Rats, Wistar | 2008 |
Mechanisms of the ifosfamide-induced inhibition of endocytosis in the rat proximal kidney tubule.
Topics: Acetaldehyde; Adenosine Triphosphatases; Animals; Antineoplastic Agents, Alkylating; Endocytosis; Glutathione; Horseradish Peroxidase; Ifosfamide; In Vitro Techniques; Kidney Tubules, Proximal; Male; Rats; Sodium-Potassium-Exchanging ATPase | 2008 |
Chemical mapping of cytosines enzymatically flipped out of the DNA helix.
Topics: Acetaldehyde; Biochemistry; Cytosine; Deoxyribonucleases, Type II Site-Specific; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Restriction Enzymes; DNA-Cytosine Methylases | 2008 |
AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.
Topics: Acetaldehyde; Adenine; Age Factors; Animals; Base Sequence; DNA Adducts; DNA Primers; DNA Repair; Escherichia coli Proteins; Kinetics; Mass Spectrometry; Mice; Mixed Function Oxygenases | 2008 |
Detection and quantification of (R) and (S)-dechloroethylifosfamide metabolites in plasma from children by enantioselective LC/MS/MS.
Topics: Acetaldehyde; Adolescent; Child; Child, Preschool; Chromatography, Liquid; Cyclophosphamide; Humans; Ifosfamide; Infant; Mass Spectrometry; Pediatrics; Plasma Cells; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2009 |
Targets of chloroacetaldehyde-induced nephrotoxicity.
Topics: Acetaldehyde; Adenosine Triphosphate; Animals; Biotransformation; Enzyme Inhibitors; Enzymes; Gluconeogenesis; Glutathione; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Diseases; Kinetics; Lactic Acid; Male; Mitochondria; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Wistar; Sulfhydryl Compounds | 2010 |
Ifosfamide metabolite chloroacetaldehyde inhibits cell proliferation and glucose metabolism without decreasing cellular ATP content in human breast cancer cells MCF-7.
Topics: Acetaldehyde; Adenosine Triphosphate; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Female; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Glycolysis; Hexokinase; Humans; Ifosfamide; Lactic Acid; Osmolar Concentration; Pyruvate Kinase | 2010 |
Chloroacetaldehyde-induced mutagenesis in Escherichia coli: the role of AlkB protein in repair of 3,N(4)-ethenocytosine and 3,N(4)-alpha-hydroxyethanocytosine.
Topics: Acetaldehyde; Cytosine; DNA Repair; Escherichia coli; Escherichia coli Proteins; Mixed Function Oxygenases; Mutagenesis; Mutagenicity Tests; Mutagens; Transformation, Bacterial | 2010 |
Protective effects of fomepizole on 2-chloroethanol toxicity.
Topics: Acetaldehyde; Acetylcysteine; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Animals; Antidotes; Antioxidants; Disulfiram; Drug Synergism; Enzyme Inhibitors; Ethylene Chlorohydrin; Fomepizole; Glutathione; Kidney; Lethal Dose 50; Liver; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Solvents | 2010 |
Kinetics and mechanism of chlorine-atom-initiated oxidation of allyl alcohol, 3-buten-2-ol, and 2-methyl-3-buten-2-ol.
Topics: Acetaldehyde; Acetone; Butanols; Carbon; Chlorine; Formaldehyde; Kinetics; Lasers; Oxidation-Reduction; Pentanols; Photolysis; Propanols; Spectroscopy, Fourier Transform Infrared | 2010 |
Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.
Topics: Acetaldehyde; Animals; Carbocysteine; Chromatography, Liquid; Cyclophosphamide; Ifosfamide; Male; Mass Spectrometry; Metabolomics; Mice; Mice, Inbred C57BL; Pharmaceutical Preparations | 2010 |
The role of AlkB protein in repair of 1,N⁶-ethenoadenine in Escherichia coli cells.
Topics: Acetaldehyde; Adenine; Colony-Forming Units Assay; DNA Adducts; DNA Glycosylases; DNA Repair; Electroporation; Escherichia coli; Escherichia coli Proteins; Mixed Function Oxygenases; Molecular Structure; Mutagenesis; Plasmids; Statistics, Nonparametric; Thymine DNA Glycosylase | 2011 |
Effects of chloroacetaldehyde in 2-chloroethanol-induced cardiotoxicity.
Topics: Acetaldehyde; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calmodulin; Cardiotoxins; Ethylene Chlorohydrin; Heart Atria; Heart Diseases; Male; Myocardium; Nifedipine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley | 2011 |
Identification of 3,N(4)-etheno-5-methyl-2'-deoxycytidine in human DNA: a new modified nucleoside which may perturb genome methylation.
Topics: Acetaldehyde; Arachidonic Acid; Deoxycytidine; DNA; DNA Adducts; DNA Methylation; Female; Genome; Humans; Leukocytes; Lipid Peroxidation; Liver; Lung | 2012 |
A sensitive HPLC-based method to quantify adenine nucleotides in primary astrocyte cell cultures.
Topics: Acetaldehyde; Adenine Nucleotides; Animals; Astrocytes; Chromatography, High Pressure Liquid; Fluorescent Dyes; Limit of Detection; Linear Models; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Fluorescence; Temperature | 2012 |
Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.
Topics: Acetaldehyde; Animals; Calcium; Cell Cycle; Cell Proliferation; Cell Shape; Coculture Techniques; Dogs; Fluorescent Dyes; Gene Expression; Hep G2 Cells; Humans; Ifosfamide; Kidney; Liver; Madin Darby Canine Kidney Cells; Microfluidic Analytical Techniques; Real-Time Polymerase Chain Reaction; Tissue Array Analysis | 2013 |
Characterization and application of a newly synthesized 2-deoxyribose-5-phosphate aldolase.
Topics: Acetaldehyde; Aldehyde-Lyases; Amino Acid Sequence; Biocatalysis; Escherichia coli; Hydrogen-Ion Concentration; Molecular Sequence Data; Temperature | 2013 |
Acrolein and chloroacetaldehyde: an examination of the cell and cell-free biomarkers of toxicity.
Topics: Acetaldehyde; Acrolein; Aldehyde Dehydrogenase; Animals; Biomarkers; Cell-Free System; Cyclophosphamide; Hepatocytes; Hydrogen Peroxide; Ifosfamide; Inactivation, Metabolic; Male; Microsomes, Liver; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serum Albumin, Bovine | 2013 |
Automated platform for sensor-based monitoring and controlled assays of living cells and tissues.
Topics: Acetaldehyde; Biosensing Techniques; Breast; Breast Neoplasms; Cell Line, Tumor; Cytotoxins; Electric Impedance; Equipment Design; Female; Humans | 2013 |
Chloroacetonitrile and n,2-dichloroacetamide formation from the reaction of chloroacetaldehyde and monochloramine in water.
Topics: Acetaldehyde; Acetamides; Acetonitriles; Animals; Catalysis; Cell Death; Chloramines; CHO Cells; Cricetinae; Cricetulus; Drinking Water; Hydrogen-Ion Concentration; Kinetics; Spectrum Analysis; Water; Water Pollutants, Chemical | 2013 |
The nephrotoxic Ifosfamide-metabolite chloroacetaldehyde interferes with renal extracellular matrix homeostasis.
Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Calcium; Cells, Cultured; Collagen Type III; Collagen Type IV; Cyclic AMP; Egtazic Acid; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Homeostasis; Humans; Ifosfamide; Isoquinolines; Kidney Tubules, Proximal; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction; Sulfonamides | 2014 |
In situ footprinting of E. coli transcription elongation complex with chloroacetaldehyde.
Topics: Acetaldehyde; DNA Footprinting; Escherichia coli; Transcription Elongation, Genetic | 2015 |
Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline.
Topics: Acetaldehyde; Antineoplastic Agents; Cell Line; Chromatography, High Pressure Liquid; Humans; Metabolome; Nephrons; Software; Tandem Mass Spectrometry | 2015 |
Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver-kidney microfluidic data and pharmacokinetic-system biology models.
Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Bayes Theorem; Cells, Cultured; Hepatocytes; Ifosfamide; Kidney; Microfluidics; Models, Biological; Neoplasms | 2016 |
Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice.
Topics: Acetaldehyde; AMP-Activated Protein Kinases; Animals; Carbohydrate Metabolism; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Hep G2 Cells; Humans; Lipid Metabolism; Lipopolysaccharides; Liver; Male; Mice, Inbred C57BL; Mitochondria, Liver; Phosphorylation; Time Factors; TOR Serine-Threonine Kinases; Vinyl Chloride | 2016 |
Efficient One-Pot Synthesis of Thiazol-2-imine Derivatives through Regioselective Reaction Between Primary Amines, Phenylisothiocyanate, and α-Chloroacetaldehyde.
Topics: Acetaldehyde; Combinatorial Chemistry Techniques; Imines; Isocyanates; Isothiocyanates; Stereoisomerism; Thiazoles; Thiourea | 2017 |
Schisandra chinensis extract decreases chloroacetaldehyde production in rats and attenuates cyclophosphamide toxicity in liver, kidney and brain.
Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Area Under Curve; Brain; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cyclophosphamide; Drugs, Chinese Herbal; Glutathione; Herb-Drug Interactions; Kidney; Male; Malondialdehyde; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Schisandra; Tandem Mass Spectrometry | 2018 |
Effects of ketoconazole on cyclophosphamide metabolism: evaluation of CYP3A4 inhibition effect using the in vitro and in vivo models.
Topics: Acetaldehyde; Animals; Chromatography, High Pressure Liquid; Cyclophosphamide; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; In Vitro Techniques; Ketoconazole; Male; Microsomes, Liver; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2018 |
Wuzhi capsule regulates chloroacetaldehyde pharmacokinetics behaviour and alleviates high-dose cyclophosphamide-induced nephrotoxicity and neurotoxicity in rats.
Topics: Acetaldehyde; Animals; Brain; Cyclophosphamide; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Kidney; Male; Neurotoxicity Syndromes; Oxidative Stress; Rats; Renal Insufficiency | 2019 |
The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide.
Topics: Acetaldehyde; Alkylating Agents; DNA Damage; DNA, Bacterial; Epoxy Compounds; Escherichia coli; Esterases; Rec A Recombinases; SOS Response, Genetics | 2019 |
Mechanism of ozonation enhanced formation of haloacetaldehydes during subsequent chlorination.
Topics: Acetaldehyde; Chlorine; Disinfection; Drinking Water; Halogenation; Kinetics; Ozone; Water Pollutants, Chemical; Water Purification | 2019 |
Novel insights into the mechanism of cyclophosphamide-induced bladder toxicity: chloroacetaldehyde's contribution to urothelial dysfunction in vitro.
Topics: Acetaldehyde; Acrolein; Antineoplastic Agents, Alkylating; Cell Culture Techniques; Cell Line; Cell Survival; Cyclophosphamide; Epithelial Cells; Humans; Oxidative Stress; Reactive Oxygen Species; Urinary Bladder; Urothelium | 2019 |
A New One-Pot Fluorescence Derivatization Strategy for Highly Sensitive MicroRNA Analysis.
Topics: Acetaldehyde; Adenine; Chromatography, High Pressure Liquid; Fluorescence; Humans; Mass Spectrometry; MicroRNAs; Spectrometry, Fluorescence; Water | 2020 |
Tricyclic Nucleobase Analogs and Their Ribosides as Substrates and Inhibitors of Purine-Nucleoside Phosphorylases III. Aminopurine Derivatives.
Topics: 2-Aminopurine; Acetaldehyde; Anti-Bacterial Agents; Escherichia coli; Purine-Nucleoside Phosphorylase; Pyrimidines; Tubercidin | 2020 |