chlorine and tetrachlorodecaoxide

chlorine has been researched along with tetrachlorodecaoxide in 55 studies

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-199022 (40.00)18.7374
1990's14 (25.45)18.2507
2000's13 (23.64)29.6817
2010's5 (9.09)24.3611
2020's1 (1.82)2.80

Authors

AuthorsStudies
Blazsek, I; Breard, J; Comisso, M; Liu, XH; Mathe, G; Misset, JL1
Giroud, JP; Mathieu, J; Roch-Arveiller, M; Stahl, KW; Tissot, M1
Breiter, N; Sassy, T; Trott, KR2
Lerch, MM; Schumpelick, V; Stadel, R; Treutner, KH; Winkeltau, G1
Harding, KG; Hughes, LE; Marks, J1
Ehrlich, HP; Hatz, RA; Kelley, SF1
Friederich, HC; Horn, W; Issing, K; Weiler-Mithoff, EM1
Elstner, E1
Hautzinger, H; Hinz, J; Stahl, KW1
Evers, KH; Weise, K1
Habermann, E; Müller, B1
Gupta, MA; Schallreuter, KU1
Hinz, J; Ivankovic, S; Kempf, SR; Kolarić, K; Stahl, KW; Zupanc, D1
Ivankovic, S; Kempf, SR1
Chastang, C; Stahl, KW1
Elstner, EF; Kühne, FW; Wagner, GR; Youngman, RJ1
Dommes, M; Thiede, A; Ullmann, U; Zenker, W1
Breuer-Werle, M; Gillissen, G; Kühne, FW; Melzer, B; Ostendorp, H1
Kühne, FW; Stahl, KW; Weiler, EM1
Mueller-Klieser, W; Vaupel, P2
Kühne, FW; Ullmann, U1
Hinz, J; Kühne, FW; Stahl, KW1
Hautzinger, H; Helling, J; Hinz, J; Kühne, FW; Schirren, G; Sell, G; Stahl, KW1
Elstner, EF; Kleber, E; Mohazzab, KM; Wolin, MS1
Ivankovic, S; Kempf, SR; Port, RE1
Blaszkiewitz, K; Ivankovic, S; Kempf, SR; Reim, M1
Ennen, J; Kühne, FW; Kurth, R; Werner, K1
Mason, KA; Milas, L; Murphy, S1
Huber, H; Pelz, K; Stoll, P; Weingart, D1
Haq, S; Malik, IA; Moid, I; Sabih, M1
Benike, C; Engleman, E; Kuehne, FW; McGrath, MS1
Bondartschuk, M; Danzer, E; Schier, F2
Chingskol, K; Kraiphibul, P; Linasmita, V; Sangruchi, S; Srisupundit, S; Veerasarn, V1
Kodelja, V; McGrath, MS1
Dieperink, H; Freilow, E; Horn, T; Jensen, J; Johansen, A; Kemp, E; Kemp, G; Kemp, K; Kuhlmann, I; Larsen, S; Lillevang, S; Svendsen, M1
Dornisch, K; Elstner, EF; Reim, M; Schempp, H1
Bouchelouche, K; Bouchelouche, P; Dieperink, H; Hansen, A; Horn, T; Kemp, E; Kemp, K; Larsen, S1
Allegra, M; Avellone, G; Ceraulo, L; D'Arpa, D; Livrea, MA; Tesoriere, L1
Deby, CM; Deby-Dupont, GP; Kohnen, SL; Lamy, ML; Mouithys-Mickalad, AA; Noels, AF1
Herndier, BG; Kahn, JO; McGrath, MS1
Dieperink, H; Freilow, E; Hansen, A; Horn, T; Jensen, J; Johansen, A; Kemp, E; Kemp, G; Kemp, K; Kuhlmann, IL; Larsen, S; Lillevang, S; Svendsen, M1
Elstner, E; Giese, T; McGrath, MS; Meuer, SC; Schempp, H; Stumm, S1
Chitapanarux, I; Khorprasert, C; Kongthanarat, Y; Lertsanguansinchai, P; Lojanapiwat, B; Lorvidhaya, V; Narkwong, L; Ngampanprasert, P; Panichevaluk, A; Phromratanapongse, P; Puribhat, S; Ruangdilokrat, S; Rungpoka, P; Sangkittipaiboon, S; Sangruchi, S; Sookpreedee, L; Tantivatana, T; Tesavibul, C; Trithratipvikul, S; Veerasarn, V1
Boonnuch, W; Kakanaporn, C; Veerasarn, V1
Penpattanagul, S1
Giese, T; Konstandin, M; Kühne, L; Meuer, S; Samstag, Y; Watzl, C1
Yingsakmongkol, N1
Bryant, CM; Costa, JA; Dagan, R; Harris, SE; Henderson, RH; Hoppe, BS; Mendenhall, NP; Mendenhall, WM; Nichols, RC; Williams, CR1
Arnhold, J; Pichert, A1
Samstag, Y; Wabnitz, GH1
Burusapat, C; Sringkarawat, S1

Reviews

3 review(s) available for chlorine and tetrachlorodecaoxide

ArticleYear
Balanced macrophage activation hypothesis: a biological model for development of drugs targeted at macrophage functional states.
    Pathobiology : journal of immunopathology, molecular and cellular biology, 1999, Volume: 67, Issue:5-6

    Topics: Antigen Presentation; Chlorine; Humans; In Vitro Techniques; Macrophage Activation; Macrophages; Models, Biological; Oxides; Phagocytosis; Th1 Cells; Th2 Cells

1999
WF 10: Macrokine, TCDO, tetrachlorodecaoxide.
    Drugs in R&D, 2004, Volume: 5, Issue:4

    Topics: Adjuvants, Immunologic; Administration, Cutaneous; Chlorine; Clinical Trials, Phase II as Topic; HIV Infections; Humans; Injections, Intravenous; Oxides; Randomized Controlled Trials as Topic

2004
Hemorrhagic radiation cystitis.
    American journal of clinical oncology, 2015, Volume: 38, Issue:3

    Topics: Administration, Intravenous; Administration, Intravesical; Administration, Oral; Anticoagulants; Chlorine; Cystitis; Formaldehyde; Hematuria; Humans; Hyaluronic Acid; Hyperbaric Oxygenation; Laser Coagulation; Oxides; Pentosan Sulfuric Polyester; Radiation Injuries; Radiation-Protective Agents; Radiotherapy; Urinary Bladder

2015

Trials

12 trial(s) available for chlorine and tetrachlorodecaoxide

ArticleYear
Failure of tetrachlorodecaoxygen anion complex to assist wound healing.
    Lancet (London, England), 1989, Nov-25, Volume: 2, Issue:8674

    Topics: Chlorine; Double-Blind Method; Drug Evaluation; Humans; Oxides; Randomized Controlled Trials as Topic; Time Factors; Wound Healing

1989
Rationale for and results from a randomised, double-blind trial of tetrachlorodecaoxygen anion complex in wound healing.
    Lancet (London, England), 1986, Apr-12, Volume: 1, Issue:8485

    Topics: Administration, Topical; Aged; Biological Dressings; Chlorine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Oxides; Random Allocation; Regression Analysis; Skin Ulcer; Surgical Wound Infection; Time Factors; Varicose Ulcer; Wound Healing

1986
[Prevention of extravasation necroses as a complication following intravenous cytostatic drug therapy. Results of an open pilot study].
    Onkologie, 1988, Volume: 11, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Chlorine; Clinical Trials as Topic; Extravasation of Diagnostic and Therapeutic Materials; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Necrosis; Neoplasms; Oxides; Pilot Projects; Skin; Skin Ulcer; Wound Healing

1988
[Effectiveness of tetrachlorodecaoxide (TCDO) in the treatment of complicated disorders of wound healing. A controlled study: TCDO versus PVP-iodine complex].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1986, Volume: 57, Issue:5

    Topics: Adolescent; Adult; Aged; Chlorine; Clinical Trials as Topic; Epithelium; Female; Granulation Tissue; Humans; Male; Middle Aged; Oxides; Povidone; Povidone-Iodine; Random Allocation; Surgical Wound Infection; Wound Healing; Wound Infection

1986
[Stimulation of wound healing by tetrachlordecaoxide. Results of a randomized double-blind study].
    Fortschritte der Medizin, 1984, May-10, Volume: 102, Issue:18

    Topics: Aged; Chlorine; Clinical Trials as Topic; Double-Blind Method; Female; Granulation Tissue; Humans; Male; Middle Aged; Oxides; Random Allocation; Wound Healing; Wound Infection

1984
A double-blind, placebo-controlled, randomized trial to evaluate the role of tetrachlorodecaoxide in the management of chemotherapy-induced oral mucositis.
    Journal of pain and symptom management, 1997, Volume: 14, Issue:2

    Topics: Adult; Antineoplastic Agents; Chlorine; Double-Blind Method; Female; Humans; Male; Middle Aged; Mouth Mucosa; Oxides; Placebos; Stomatitis

1997
The efficacy of chemically-stabilized chlorite-matrix (TCDO) in the management of late postradiation cystitis.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1999, Volume: 82, Issue:8

    Topics: Adult; Aged; Chlorine; Cystitis; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Middle Aged; Oxides; Radiation Injuries; Radiation-Protective Agents; Treatment Outcome; Uterine Cervical Neoplasms

1999
Reduced recurrence of late hemorrhagic radiation cystitis by WF10 therapy in cervical cancer patients: a multicenter, randomized, two-arm, open-label trial.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2004, Volume: 73, Issue:2

    Topics: Adult; Aged; Chi-Square Distribution; Chlorine; Cystitis; Cystoscopy; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Hemorrhage; Humans; Infusions, Intravenous; Middle Aged; Oxides; Probability; Radiation Injuries; Reference Values; Risk Assessment; Secondary Prevention; Severity of Illness Index; Single-Blind Method; Statistics, Nonparametric; Treatment Outcome; Uterine Cervical Neoplasms

2004
A phase II study to evaluate WF10 in patients with late hemorrhagic radiation cystitis and proctitis.
    Gynecologic oncology, 2006, Volume: 100, Issue:1

    Topics: Chlorine; Cystitis; Female; Follow-Up Studies; Genital Neoplasms, Female; Hemorrhage; Humans; Middle Aged; Oxides; Proctitis; Radiation Injuries; Radiation-Protective Agents; Radiotherapy

2006
Reduced incidence and severity of acute radiation mucositis by WF10 (IMMUNOKINE) as adjunct to standard of cure in the management of head & neck cancer patients.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:8

    Topics: Adult; Chlorine; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Mouth Mucosa; Mucositis; Nasopharyngeal Neoplasms; Oxides; Radiation Injuries; Radiation-Protective Agents

2007
Clinical outcomes of WF10 adjunct to standard treatment of diabetic foot ulcers.
    Journal of wound care, 2013, Volume: 22, Issue:3

    Topics: Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Chlorine; Combined Modality Therapy; Diabetic Foot; Drug Administration Schedule; Female; Humans; Injury Severity Score; Male; Middle Aged; Oxides; Prospective Studies; Treatment Outcome; Wound Healing

2013
Efficacy of Negative-Pressure Wound Therapy with Tetrachlorodecaoxygen-Anion Complex Instillation Compared with Standard Negative-Pressure Wound Therapy for Accelerated Wound Healing: A Prospective, Randomized, Controlled Trial.
    Plastic and reconstructive surgery, 2021, Aug-01, Volume: 148, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Bacteria; Biopsy; Chlorine; Female; Humans; Male; Middle Aged; Negative-Pressure Wound Therapy; Oxides; Prospective Studies; Therapeutic Irrigation; Time Factors; Treatment Outcome; Wound Healing; Wound Infection; Young Adult

2021

Other Studies

40 other study(ies) available for chlorine and tetrachlorodecaoxide

ArticleYear
Elliptinium, norcantharidin and tetrachlordecaoxide in combined chemo-immunotherapy prolong the survival of Friend-virus-infected mice.
    Drugs under experimental and clinical research, 1991, Volume: 17, Issue:9

    Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorine; Combined Modality Therapy; Drug Synergism; Ellipticines; Friend murine leukemia virus; Immunotherapy; Leukemia, Experimental; Leukocytosis; Male; Mice; Mice, Inbred DBA; Oxides; Splenomegaly; Time Factors

1991
Anti-inflammatory properties of a novel wound healing and immunomodulating agent, tetrachlorodecaoxygen complex (TCDO).
    Agents and actions, 1990, Volume: 31, Issue:3-4

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Chlorine; Dinoprostone; Leukotriene B4; Luminescent Measurements; Male; Neutrophils; Oxidation-Reduction; Oxides; Pleura; Pleurisy; Rats; Rats, Inbred Strains; Superoxides; Wound Healing

1990
[Effects of tetrachlorodecaoxide (TCDO) in chronic radiation lesions of the rat colon].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1991, Volume: 167, Issue:3

    Topics: Animals; Chlorine; Colon; Endoscopy; Female; Oxides; Radiation Injuries, Experimental; Rats; Rats, Inbred Strains; Wound Healing

1991
[Postoperative, intra-abdominal adhesions--a new standardized and objective animal model and testing of substances for the prevention of adhesions].
    Langenbecks Archiv fur Chirurgie, 1989, Volume: 374, Issue:2

    Topics: Abdomen; Animals; Bacitracin; Chlorine; Dextrans; Injections, Intraperitoneal; Male; Neomycin; Oxides; Postoperative Complications; Rats; Rats, Inbred Strains; Sodium Chloride; Streptodornase and Streptokinase; Tissue Adhesions

1989
The tetrachlorodecaoxygen complex reverses the effect of cortisone on wound healing.
    Plastic and reconstructive surgery, 1989, Volume: 84, Issue:6

    Topics: Animals; Burns; Chlorine; Collagen; Cortisone; Male; Oxides; Polyvinyls; Prostheses and Implants; Rats; Rats, Inbred Strains; Tensile Strength; Wound Healing

1989
Tetrachlorodecaoxygen anion complex treatment after localized X irradiation of the rat colon.
    The British journal of radiology, 1989, Volume: 62, Issue:736

    Topics: Animals; Chlorine; Colon; Female; Oxides; Pilot Projects; Radiation Injuries, Experimental; Rats; Rats, Inbred Strains; Wound Healing

1989
[Increase of oxygen partial pressure and acceleration of wound healing by tetrachlorodecaoxide].
    Zeitschrift fur Hautkrankheiten, 1989, Mar-15, Volume: 64, Issue:3

    Topics: Adult; Aged; Amputation, Surgical; Blood Gas Monitoring, Transcutaneous; Chlorine; Female; Foot Diseases; Humans; Male; Middle Aged; Oxides; Postoperative Complications; Skin Temperature; Skin Ulcer; Telemetry; Thermography; Varicose Ulcer; Wound Healing

1989
[Damage to blood cells caused by oxoferin?].
    Klinische Wochenschrift, 1989, Jul-17, Volume: 67, Issue:14

    Topics: Chlorine; Erythrocytes; Humans; Oxides; Wound Healing

1989
[Clinical experiences with tetrachlorodecaoxide in the local treatment of difficult-to-heal wounds].
    Aktuelle Traumatologie, 1988, Volume: 18, Issue:5

    Topics: Adolescent; Adult; Aged; Chlorine; Combined Modality Therapy; Debridement; Extremities; Female; Fluorocarbon Polymers; Humans; Male; Middle Aged; Oxides; Wound Healing; Wound Infection

1988
[Oxoferin and sodium chlorite--a comparison].
    Klinische Wochenschrift, 1989, Jan-04, Volume: 67, Issue:1

    Topics: Animals; Cells, Cultured; Chick Embryo; Chlorides; Chlorine; Endothelium, Vascular; Erythrocytes; Fibroblasts; Humans; Methemoglobin; Oxidation-Reduction; Oxides; Swine; Wound Healing

1989
Allergic contact dermatitis from tetrachlordecaoxide (Oxofèrin).
    Contact dermatitis, 1987, Volume: 17, Issue:4

    Topics: Aged; Chlorine; Dermatitis, Contact; Drug Eruptions; Female; Humans; Leg Ulcer; Oxides; Patch Tests; Wound Healing

1987
Regenerative effects of tetrachlorodecaoxide in BD IX rats after total-body gamma irradiation.
    Radiation research, 1988, Volume: 115, Issue:1

    Topics: Agranulocytosis; Animals; Bone Marrow; Chlorine; Drug Administration Schedule; Gamma Rays; Male; Oxides; Pilot Projects; Rats; Rats, Inbred Strains; Skin; Whole-Body Irradiation

1988
[Healing of arterial and venous ulcers with TCDO. Insight into the mechanisms of tissue repair].
    Fortschritte der Medizin, 1988, Jan-10, Volume: 106, Issue:1

    Topics: Chlorine; Humans; Oxides; Ulcer; Wound Healing

1988
Time kinetics of hemoglobin and myoglobin activation by tetrachlorodecaoxide (TCDO).
    Free radical research communications, 1986, Volume: 1, Issue:5

    Topics: Anti-Bacterial Agents; Chlorine; Ethylenes; Free Radicals; Heme; Hemoglobins; Kinetics; Myoglobin; Oxides; Oxygen; Peroxidases

1986
Increased resistance towards two systemic experimental infections by tetrachlorodecaoxygen anion complex. Possible implications of cellular and humoral immunity.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:12

    Topics: Animals; Anti-Infective Agents; Antibody Formation; Bacterial Infections; Chlorine; Immunity, Cellular; Male; Mice; Mice, Inbred BALB C; Oxides

1986
Recent findings limiting immunological and photosensitizing hazards of the tetrachlorodecaoxygen anion complex (TCDO) in wound healing promotion.
    The British journal of dermatology, 1986, Volume: 115 Suppl 31

    Topics: Adolescent; Adult; Aged; Animals; Chlorine; Female; Guinea Pigs; Humans; Leg Ulcer; Male; Middle Aged; Oxides; Patch Tests; Photosensitivity Disorders; Wound Healing

1986
Tetrachlorodecaoxide improves the oxygenation status of multicellular tumor spheroids.
    Advances in experimental medicine and biology, 1986, Volume: 200

    Topics: Animals; Chlorine; Female; Kinetics; Mammary Neoplasms, Experimental; Mice; Oxides; Oxygen; Oxygen Consumption; Partial Pressure

1986
Improvement of tumor spheroid oxygenation by tetrachlorodecaoxide.
    International journal of radiation oncology, biology, physics, 1987, Volume: 13, Issue:1

    Topics: Cell Line; Chlorine; In Vitro Techniques; Neoplasms, Experimental; Oxides; Oxygen

1987
In vitro investigations on the antibacterial action and the influence on the phagocytic chemiluminescence of tetrachlorodecaoxide--a new, non-metallic oxygen complex.
    Infection, 1985, Volume: 13 Suppl 2

    Topics: Bacteria; Bacteriological Techniques; Chlorine; Dose-Response Relationship, Drug; Granulocytes; Humans; Luminescent Measurements; Oxides; Phagocytosis

1985
Local tetrachlorodecaoxide treatment to improve oxygen supply to non-healing wounds.
    Lancet (London, England), 1984, Sep-15, Volume: 2, Issue:8403

    Topics: Aged; Arterial Occlusive Diseases; Chlorine; Female; Humans; Leg Injuries; Oxides; Oxygen; Wound Healing

1984
Tetrachlorodecaoxygen, a wound healing agent, produces vascular relaxation through hemoglobulin-dependent inactivation of serotonin and norepinephrine.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:4

    Topics: Animals; Aorta, Thoracic; Cattle; Chlorine; Guanylate Cyclase; Hemoglobins; In Vitro Techniques; Norepinephrine; Oxidation-Reduction; Oxides; Pulmonary Artery; Rabbits; Serotonin; Vasodilator Agents; Wound Healing

1994
Anticarcinogenic effect of tetrachlorodecaoxide after total-body gamma irradiation in rats.
    Radiation research, 1994, Volume: 139, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Chlorine; Female; Gamma Rays; Male; Neoplasms, Radiation-Induced; Oxides; Radiation-Protective Agents; Rats; Whole-Body Irradiation

1994
Comparative study on the effects of chlorite oxygen reaction product TCDO (tetrachlorodecaoxygen) and sodium chlorite solution (NaClO2) with equimolar chlorite content on bone marrow and peripheral blood of BDIX rats.
    Drugs under experimental and clinical research, 1993, Volume: 19, Issue:4

    Topics: Animals; Blood; Bone Marrow; Cell Division; Chlorides; Chlorine; Injections, Intraperitoneal; Male; Organ Size; Oxides; Rats; Spleen

1993
Inactivation of HIV infectivity by the chlorite-oxygen reaction product tetrachlorodecaoxygen.
    AIDS (London, England), 1993, Volume: 7, Issue:9

    Topics: Antiviral Agents; Cells, Cultured; Chlorine; Didanosine; Drug Interactions; HIV Envelope Protein gp120; HIV-1; HIV-2; Humans; Oxides; Tumor Cells, Cultured; Virus Replication; Zidovudine

1993
Stimulation of hematopoietic cell recovery by tetrachlorodecaoxide in sublethally irradiated mice.
    Radiation research, 1993, Volume: 136, Issue:2

    Topics: Animals; Chlorine; Female; Hematopoiesis; Hematopoietic Stem Cells; Hematopoietic System; Mice; Mice, Inbred C3H; Oxides; Regeneration; Whole-Body Irradiation; Wound Healing

1993
Antimicrobial effects of the tetrachlorodecaoxygen-anion complex on oropharyngeal bacterial flora: an in vitro study.
    Chemotherapy, 1993, Volume: 39, Issue:1

    Topics: Bacteria; Candida; Chlorine; Humans; Microbial Sensitivity Tests; Oropharynx; Oxides; Wound Healing

1993
Effect of WF10 (TCDO) on antigen presentation.
    Transplantation proceedings, 1998, Volume: 30, Issue:8

    Topics: Antigens, CD; CD4-Positive T-Lymphocytes; Cells, Cultured; Chlorine; Dendritic Cells; Flow Cytometry; Humans; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Monocytes; Oxides; Radiation-Protective Agents; T-Lymphocytes

1998
Hyaluronate, tetrachlorodecaoxide, and galactolipid prevent adhesions after implantation of Gore-Tex and dura mater into the abdominal wall in rats.
    Pediatric surgery international, 1999, Volume: 15, Issue:3-4

    Topics: Abdominal Muscles; Animals; Chlorine; Dura Mater; Galactolipids; Glycolipids; Hyaluronic Acid; Implants, Experimental; Male; Oxides; Polytetrafluoroethylene; Rats; Tissue Adhesions

1999
WF10 in xenotransplantation-a potential new approach.
    Transplantation proceedings, 2000, Volume: 32, Issue:5

    Topics: Animals; Chlorine; Cricetinae; Graft Survival; Heart Transplantation; Immunosuppression Therapy; Oxides; Rats; Time Factors; Transplantation, Heterologous

2000
Tetrachlorodecaoxide does not jeopardize anastomotic healing: an experimental study in animals.
    Pediatric surgery international, 2001, Volume: 17, Issue:2-3

    Topics: Anastomosis, Surgical; Animals; Biomechanical Phenomena; Chlorine; Intestine, Small; Male; Oxides; Rats; Surgical Wound Dehiscence; Wound Healing

2001
Chlorite-hemoprotein interaction as key role for the pharmacological activity of the chlorite-based drug WF10.
    Arzneimittel-Forschung, 2001, Volume: 51, Issue:7

    Topics: Amino Acids, Cyclic; Animals; Cattle; Chlorides; Chlorine; Chromatography, Gas; Chromatography, Gel; Electron Spin Resonance Spectroscopy; Ethylenes; Hemeproteins; Hemin; Hydrogen Peroxide; Luminescent Measurements; Oxidants; Oxidation-Reduction; Oxides; Spectrophotometry, Ultraviolet; Taurine

2001
High-dose stabilized chlorite matrix WF10 prolongs cardiac xenograft survival in the hamster-to-rat model without inducing ultrastructural or biochemical signs of cardiotoxicity.
    Pharmacology & toxicology, 2001, Volume: 89, Issue:2

    Topics: Animals; Chlorine; Creatine Kinase; Creatine Kinase, MB Form; Cricetinae; Dose-Response Relationship, Drug; Graft Survival; Heart Transplantation; Heart Ventricles; Isoenzymes; Mesocricetus; Myocardium; Myofibrils; Myoglobin; Oxides; Rats; Rats, Inbred Lew; Transplantation, Heterologous; Troponin I

2001
Oxidation of melatonin by oxoferryl hemoglobin: a mechanistic study.
    Free radical research, 2001, Volume: 35, Issue:6

    Topics: Animals; Cattle; Chlorine; Gas Chromatography-Mass Spectrometry; Hemoglobins; Hydrogen Peroxide; Kinetics; Kynuramine; Magnetic Resonance Spectroscopy; Melatonin; Methemoglobin; Oxidation-Reduction; Oxides; Spectrophotometry, Ultraviolet; Time Factors

2001
Oxidation of tetrahydrobiopterin by peroxynitrite or oxoferryl species occurs by a radical pathway.
    Free radical research, 2001, Volume: 35, Issue:6

    Topics: Biopterins; Chlorine; Electron Spin Resonance Spectroscopy; Free Radicals; Oxidation-Reduction; Oxides; Peroxynitrous Acid; Signal Transduction; Spectrophotometry, Ultraviolet; Time Factors

2001
Development of WF10, a novel macrophage-regulating agent.
    Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:3

    Topics: Chlorine; Clinical Trials, Phase III as Topic; Drug Approval; Gene Expression; HIV Infections; Humans; Immunity, Cellular; Legislation, Drug; Macrophage Activation; Macrophages; Oxides; United States

2002
Immunosuppression in xenotransplantation with Wf10.
    Pharmacology & toxicology, 2002, Volume: 90, Issue:6

    Topics: Analysis of Variance; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chlorine; Cricetinae; Flow Cytometry; Graft Rejection; Heart Transplantation; Immunosuppression Therapy; Immunosuppressive Agents; Injections, Intraperitoneal; Mesocricetus; Oxides; Rats; Rats, Inbred Lew; Survival Rate; Transplantation, Heterologous

2002
Differential effects on innate versus adaptive immune responses by WF10.
    Cellular immunology, 2004, Volume: 229, Issue:2

    Topics: Chlorine; Cytokines; DNA-Binding Proteins; Humans; Immunity, Cellular; Immunity, Innate; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; NF-kappa B; NFATC Transcription Factors; Nuclear Proteins; Oxidants; Oxides; T-Lymphocytes; Taurine; Transcription Factor AP-1; Transcription Factors

2004
WF10 stimulates NK cell cytotoxicity by increasing LFA-1-mediated adhesion to tumor cells.
    Journal of biomedicine & biotechnology, 2011, Volume: 2011

    Topics: Cell Adhesion; Cell Survival; Cells, Cultured; Chlorine; Humans; Killer Cells, Natural; Lymphocyte Function-Associated Antigen-1; Neoplasms; Oxides

2011
Interaction of the chlorite-based drug WF10 and chlorite with hemoglobin, methemoglobin and ferryl hemoglobin.
    Archives of biochemistry and biophysics, 2015, Nov-01, Volume: 585

    Topics: Cells, Cultured; Chlorides; Chlorine; Erythrocytes; Heme; Hemoglobins; Hemolysis; Humans; Hydrogen Peroxide; Kinetics; Methemoglobin; Oxidation-Reduction; Oxides; Spectrophotometry

2015
Oxidative downmodulation of T cell-mediated cytotoxicity.
    Cell death & disease, 2016, 09-22, Volume: 7, Issue:9

    Topics: CD4-Positive T-Lymphocytes; Chlorine; Cytotoxicity, Immunologic; Down-Regulation; Humans; Models, Immunological; Oxidation-Reduction; Oxides

2016