chlorine has been researched along with methotrexate in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (64.71) | 18.7374 |
| 1990's | 4 (11.76) | 18.2507 |
| 2000's | 4 (11.76) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Rosowsky, A | 1 |
| McHenry, CS; Santi, DV; Sommer, H | 1 |
| Chen, KK; Rosowsky, A | 1 |
| Adamson, RH; DeVita, VT; Johns, DG; Kyalwazi, SK; Vogel, CL | 1 |
| Faĭnshteĭn, FE | 1 |
| Band, PR; Holland, JF; Ross, CA | 1 |
| Goodman, L; Lee, WW; Martinez, AP | 1 |
| Adamson, RH | 1 |
| Kisliuk, RL; Leary, RP | 1 |
| Denyer, SP; Garner, ST; Melia, CD; Wren, AE | 1 |
| Goto, E; Hirose, J; Ijiri, Y; Kato, R; Kobayashi, T; Nakano, T; Sano, K; Takiuchi, H; Tamai, H; Tanaka, K | 1 |
| Feng, M; Manoli, K; Yin, Q; Yu, X; Zhang, L; Zhang, S | 1 |
| Ivanova, RD; Savitskiĭ, GA | 1 |
| Bentley, PJ; Yorio, T | 1 |
| Dedrick, RL | 2 |
| Gang, M; Kline, I; Sirica, AE; Venditti, JM; Woodman, RJ | 1 |
| Erickson, JS; Mathews, CK | 1 |
| Fyfe, MJ; Goldman, ID | 1 |
| Goldman, ID | 1 |
| Fry, DW; Goldman, ID; Yalowich, JC | 1 |
| Dembo, M; Moccio, DM; Sirotnak, FM | 1 |
| Barry, DI; Paulson, OB | 1 |
| Henderson, GB; Zevely, EM | 1 |
| Belfroid, L; Beukers, H; Driessen, O; Emonds, A | 1 |
| Faenza, S; Fini, M; Giardino, R; Giavaresi, G; Martini, L; Morrone, G; Spighi, M | 1 |
| Gao, XP; Rubinstein, I | 1 |
| Gao, F; Goldman, ID; Zhao, R | 1 |
| Assaraf, YG; Drori, S; Jansen, G; Mauritz, R; Peters, GJ | 1 |
| Gabriëls, G; Greven, J; Stockem, E | 1 |
| Horne, DW; Reed, KA | 1 |
| de la Peña, L; Gil, L; Laqué-Rupérez, E; Martínez-Morillo, M; Ruiz-Gómez, MJ | 1 |
| Barrett, KE; Hoda, MR; Keely, SJ; McCole, DF; Scharl, M | 1 |
| Severin, MJ; Torres, AM | 1 |
2 review(s) available for chlorine and methotrexate
| Article | Year |
|---|---|
[Clinical aspects of the problem of treating leukemias].
Topics: Acute Disease; Antineoplastic Agents; Chlorambucil; Chlorine; Chronic Disease; Daunorubicin; Dimethoate; Drug Therapy, Combination; Ethylamines; Glucocorticoids; Humans; Immunoglobulins; Immunosuppression Therapy; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Lymphocytosis; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous | 1973 |
Pharmacokinetic and pharmacodynamic considerations for chronic hemodialysis.
Topics: Animals; Antineoplastic Agents; Biological Transport; Chlorides; Deoxyuridine; Humans; Kinetics; Methotrexate; Models, Biological; Renal Dialysis | 1975 |
32 other study(ies) available for chlorine and methotrexate
| Article | Year |
|---|---|
Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3',5'-dichloromethotrexate by direct esterification.
Topics: Animals; Chlorine; Enterococcus faecalis; Esters; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1973 |
Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.
Topics: Chlorine; Chromatography; Chromatography, Ion Exchange; Deoxyribonucleotides; Drug Resistance, Microbial; Drug Stability; Enzyme Activation; Fluorine; Folic Acid; Guanidines; Kinetics; Lacticaseibacillus casei; Methotrexate; Methyltransferases; Peptide Fragments; Pronase; Protein Binding; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Tritium; Uracil Nucleotides | 1974 |
Methotrexate analogs. 4.7-Methyl derivatives of methotrexate and dichloromethotrexate. A new synthesis and some biological studies.
Topics: Animals; Cell Line; Chlorine; Enterococcus faecalis; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Magnetic Resonance Spectroscopy; Methane; Methotrexate; Mice; Spectrophotometry, Ultraviolet | 1974 |
Preliminary clinical trials of dichloromethotrexate (NSC-29630) in hepatocellular carcinoma.
Topics: Adolescent; Adult; Aged; Aldehydes; Carcinoma, Hepatocellular; Chlorine; Diarrhea; Erythrocyte Count; Female; Hepatic Artery; Humans; Infusions, Parenteral; Injections, Intravenous; Leukocyte Count; Liver; Liver Function Tests; Liver Neoplasms; Male; Methotrexate; Middle Aged; Oxidoreductases | 1972 |
Comparison of two dose schedules of dichloromethotrexate (NSC-29630) in lung cancer.
Topics: Blood Cell Count; Carcinoma, Bronchogenic; Chlorine; Female; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis | 1973 |
Folic acid antagonists. Methotrexate analogs containing spurious amino acids. Dichlorohomofolic acid.
Topics: Animals; Chlorine; Folic Acid Antagonists; Glutamates; Humans; Leukemia; Leukemia L1210; Methotrexate; Mice; Pteridines | 1974 |
Metabolism of anticancer agents in man.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Bile; Burkitt Lymphoma; Child; Child, Preschool; Chlorine; Cyclophosphamide; Feces; Half-Life; Humans; Injections, Intravenous; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Nitrosourea Compounds; Radioisotopes; Retinoblastoma; Tritium | 1971 |
Crystalline thymidylate synthetase from dichloromethotrexate resistant Lactobacillus casei.
Topics: Ammonium Sulfate; Chemical Precipitation; Chlorine; Chromatography; Crystallization; Drug Resistance, Microbial; Electrophoresis, Disc; Genetics, Microbial; Hydroxyapatites; Lacticaseibacillus casei; Lactobacillus; Methotrexate; Methyltransferases; Mutation; Thymine Nucleotides; Uracil Nucleotides | 1971 |
Decontamination methods for cytotoxic drugs. 1. Use of a bioluminescent technique to monitor the inactivation of methotrexate with chlorine-based agents.
Topics: Biological Assay; Chlorine; Decontamination; Luminescent Measurements; Methotrexate; Mutagenicity Tests; Sodium Hypochlorite; Solutions; Triazines | 1993 |
Application of electrolysis for detoxification of an antineoplastic in urine.
Topics: Antineoplastic Agents; Chlorine; Electrodes; Electrolysis; Humans; Methotrexate; Mutagens; Oxidation-Reduction; Sodium Chloride; Urine; Waste Disposal, Fluid; Water Pollutants; Water Purification | 2012 |
Chlorination of methotrexate in water revisited: Deciphering the kinetics, novel reaction mechanisms, and unexpected microbial risks.
Topics: Amides; Amines; Bromine; Chlorine; Halogenation; Halogens; Humic Substances; Kinetics; Methotrexate; Wastewater; Water; Water Pollutants, Chemical; Water Purification | 2022 |
[Quantitative evaluation of the permeability of the hematofollicular barrier in rats].
Topics: Animals; Cadmium; Cell Membrane Permeability; Chlorides; Female; Fluorescent Dyes; Methotrexate; Ovarian Follicle; Ovary; Rats | 1978 |
Permeability of the rabbit colon in vitro.
Topics: Amiloride; Animals; Biological Transport, Active; Chlorides; Colon; In Vitro Techniques; Membrane Potentials; Methotrexate; Permeability; Potassium; Rabbits; Sodium; Water | 1977 |
The enhanced therapeutic effect of cis-platinum (II) diamminodichloride against L1210 leukemia when combined with cyclophosphamide or 1,2-bis(3,5-dioxopiperazine-1-yl)propane or several other antitumor agents.
Topics: Amines; Animals; Antineoplastic Agents; Azacitidine; Camptothecin; Carmustine; Chlorides; Cyclophosphamide; Cytarabine; Drug Synergism; Emetine; Fluorouracil; Ketones; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperazines; Platinum; Propane; Time Factors | 1973 |
Dihydrofolate reductases of Escherichia coli and bacteriophage Tr. A spectrofluorometric study.
Topics: Amino Acids; Binding Sites; Chlorides; Chromatography, Affinity; Coliphages; Electrophoresis, Disc; Escherichia coli; Fluorides; Folic Acid; Folic Acid Antagonists; Kinetics; Methotrexate; NADP; Osmolar Concentration; Peptides; Perchlorates; Sodium Dodecyl Sulfate; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Streptomycin; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thiocyanates | 1973 |
Characteristics of the vincristine-induced augmentation of methotrexate uptake in Ehrlich ascites tumor cells.
Topics: Animals; Azides; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Division; Cells, Cultured; Chlorides; DNA; Dose-Response Relationship, Drug; Drug Synergism; Glucose; Kinetics; L Cells; Leukemia L1210; Membrane Potentials; Methotrexate; Mice; Tritium; Vincristine; Water | 1973 |
Animal scale-up.
Topics: Animals; Biological Transport; Biotransformation; Body Weight; Chlorides; Cytarabine; Dialysis; Diffusion; Humans; Kinetics; Mammals; Methotrexate; Models, Biological; Organ Specificity; Pharmaceutical Preparations; Pharmacology; Species Specificity; Thermodynamics; Thiopental; Time Factors | 1973 |
The characteristics of the membrane transport of amethopterin and the naturally occurring folates.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Aspirin; Azides; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane; Cells, Cultured; Chlorides; Erythrocytes; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Nitrates; Organophosphorus Compounds; Phosphates; Rabbits; Sulfates; Time Factors | 1971 |
Teniposide (VM-26)- and etoposide (VP-16-213)-induced augmentation of methotrexate transport and polyglutamylation in Ehrlich ascites tumor cells in vitro.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chlorides; Etoposide; Glucose; Kinetics; Methotrexate; Mice; Peptides; Podophyllotoxin; Polyglutamic Acid; Teniposide; Vincristine; Water | 1982 |
Effects of metabolic deprivation on methotrexate transport in L1210 leukemia cells: further evidence for separate influx and efflux systems with different energetic requirements.
Topics: Animals; Azides; Biological Transport, Active; Carrier Proteins; Chlorides; Energy Metabolism; Glucose; Kinetics; Leukemia L1210; Methotrexate; Mice; Models, Biological; Sodium Azide; Tetrahydrofolate Dehydrogenase | 1984 |
Amphotericin B and the blood-brain barrier to methotrexate.
Topics: Amphotericin B; Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Chlorides; Drug Therapy, Combination; Male; Methotrexate; Rats; Rats, Inbred Strains; Sodium | 1982 |
Transport of methotrexate in L1210 cells: effect of ions on the rate and extent of uptake.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Calcium; Chlorides; Kinetics; Leukemia L1210; Magnesium; Methotrexate; Mice; Phosphates; Sodium | 1980 |
Analysis of methotrexate by isotachophoresis.
Topics: Anions; Blood Proteins; Chlorides; Electrophoresis; Humans; Hydrogen-Ion Concentration; Methotrexate; Silver Nitrate; Trichloroacetic Acid | 1980 |
In vivo experimental models on the evaluation of haemoperfusion.
Topics: Alkalosis; Animals; Chlorides; Disease Models, Animal; Female; Hemoperfusion; Male; Methotrexate; Partial Thromboplastin Time; Poisoning; Pyloric Stenosis; Rabbits; Swine; Uremia | 1993 |
Methotrexate potentiates bradykinin-induced increase in macromolecular efflux from the hamster oral mucosa.
Topics: Adenosine; Animals; Bradykinin; Chlorides; Cricetinae; Enzyme Inhibitors; Indomethacin; Ionomycin; Macromolecular Substances; Male; Mesocricetus; Methotrexate; Mouth Mucosa; NG-Nitroarginine Methyl Ester; Zinc Compounds | 1997 |
Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.
Topics: Amino Acid Substitution; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Division; Chlorides; DNA Mutational Analysis; DNA, Complementary; DNA, Neoplasm; Drug Resistance, Neoplasm; Kinetics; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Phenotype; Phenylalanine; Reduced Folate Carrier Protein; Serine; Transfection; Tumor Cells, Cultured | 1999 |
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Blotting, Northern; Blotting, Southern; Blotting, Western; Carrier Proteins; Cell Division; Cell Membrane; Chlorides; DNA Mutational Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Exons; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Kinetics; Leucovorin; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mutagenesis, Site-Directed; Mutation; Polymorphism, Single-Stranded Conformational; Protein Structure, Secondary; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins; Reduced Folate Carrier Protein; Thymidylate Synthase; Time Factors; Transfection; Trimetrexate; Tumor Cells, Cultured | 2000 |
Potassium-sparing renal effects of trimethoprim and structural analogues.
Topics: Animals; Anti-Infective Agents; Blood Pressure; Chlorides; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glomerular Filtration Rate; Kidney; Male; Methotrexate; Potassium; Pyrimethamine; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium; Time Factors; Trimethoprim | 2000 |
Transport of methotrexate into PC-3 human prostate cancer cells.
Topics: Binding, Competitive; Biological Transport, Active; Buffers; Carrier Proteins; Chlorides; Folic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Methotrexate; Prostatic Neoplasms; Tumor Cells, Cultured | 2001 |
Methotrexate cytotoxicity on MCF-7 breast cancer cells is not altered by exposure to 25 Hz, 1.5 mT magnetic field and iron (III) chloride hexahydrate.
Topics: Breast Neoplasms; Cell Death; Cell Line, Tumor; Chlorides; Ferric Compounds; Humans; Magnetics; Methotrexate | 2003 |
Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis.
Topics: Androstadienes; Animals; Carbachol; Cell Line; Chlorides; Colforsin; Enterocolitis; Epithelial Cells; Flavonoids; Humans; Leptin; Male; MAP Kinase Signaling System; Methotrexate; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Wortmannin | 2010 |
Time course effects of methotrexate on renal handling of water and electrolytes in rats. Role of aquaporin-2 and Na-K-2Cl-cotransporter.
Topics: Animals; Aquaporin 2; Biomarkers; Chlorides; Electrolytes; Kidney Diseases; Kidney Tubules; Male; Methotrexate; Potassium; Rats, Wistar; Renal Reabsorption; Sodium; Solute Carrier Family 12, Member 1; Time Factors; Urodynamics; Water | 2019 |