chlorhexidine and 4-chloroaniline

chlorhexidine has been researched along with 4-chloroaniline in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19905 (20.00)18.7374
1990's1 (4.00)18.2507
2000's4 (16.00)29.6817
2010's13 (52.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Ackermann, B; Lingens, F; Suessmuth, R1
Brougham, LR; Cheng, HY; Pittman, KA1
Bauer, M; Degude, C; Mailhe, L1
Gelderblom, WC; Thiel, PG; Van der Bijl, P1
Dreyer, WP; van der Bijl, P1
Liang, H; Rao, G; Zeng, J; Zhang, D1
Hájková, R; Havlíková, L; Matysová, L; Nováková, L; Solich, P1
Basrani, BR; Fillery, E; Manek, S; Manzur, A; Sodhi, RN1
Barbin, LE; Estrela, C; Guedes, DF; Pécora, JD; Saquy, PC; Sousa-Neto, MD1
Deutsch, AS; Hladek, MM; Musikant, BL; Nekich, M; Rasimick, BJ1
Basrani, BR; Fillery, E; Manek, S; Mathers, D; Sodhi, RN1
Sem, DS; Thomas, JE1
Krishnamurthy, S; Sudhakaran, S1
Bae, KS; Baek, SH; Chang, SW; Cho, K; Gu, Y; Hong, ST; Jung, IY; Kim, HS; Kim, JW; Kum, KY; Lee, W; Lee, Y; Son, WJ; Zhu, Q1
Cohenca, N; Flake, NM; Heling, I; Johnson, JD; Mortenson, D; Paranjpe, A; Sadilek, M1
Kirsch, LE; Zong, Z1
Barbin, LE; Estrela, C; Guedes, DF; Pécora, JD; Sousa-Neto, MD; Spanó, JC1
Câmara De Bem, SH; Estrela, C; Guedes, DF; Pécora, JD; Sousa-Neto, MD1
Basrani, BR; Kishen, A; Kolosowski, KP; Sodhi, RN1
Arslan, H; Karatas, E; Keskin, A; Seçkin, F; Uygun, AD; Yıldırım, A1
Hür, D; Irmak, Ö; Karabucak, B; Orhan, EO; Yaman, BC1
Assadian, O; Baguhl, R; Below, H; Hildebrandt, U; Jäger, B; Kramer, A; Leaper, DJ; Meissner, K1
Ahmed, HMA; Callà, C; Gambarini, G; Martorana, GE; Nocca, G; Rengo, S; Spagnuolo, G1
Buyukozer Ozkan, H; Orhan, EO; Terlemez, A1
Czopik, B; Świętoniowska, N; Woźniakiewicz, A; Woźniakiewicz, M; Zarzecka, J1

Trials

2 trial(s) available for chlorhexidine and 4-chloroaniline

ArticleYear
The effect of using an alternative irrigant between sodium hypochlorite and chlorhexidine to prevent the formation of para-chloroaniline within the root canal system.
    International endodontic journal, 2012, Volume: 45, Issue:9

    Topics: Aniline Compounds; Anti-Infective Agents, Local; Chemical Precipitation; Chlorhexidine; Citric Acid; Dental Pulp Cavity; Edetic Acid; Gas Chromatography-Mass Spectrometry; Humans; Materials Testing; Root Canal Irrigants; Root Canal Preparation; Sodium Chloride; Sodium Hypochlorite; Tryptophan Hydroxylase

2012
Measurements of chlorhexidine, p-chloroaniline, and p-chloronitrobenzene in saliva after mouth wash before and after operation with 0.2% chlorhexidine digluconate in maxillofacial surgery: a randomised controlled trial.
    The British journal of oral & maxillofacial surgery, 2017, Volume: 55, Issue:2

    Topics: Adult; Aniline Compounds; Chlorhexidine; Female; Humans; Male; Middle Aged; Mouthwashes; Nitrobenzenes; Oral Surgical Procedures; Saliva; Single-Blind Method

2017

Other Studies

23 other study(ies) available for chlorhexidine and 4-chloroaniline

ArticleYear
Mutagenic effect of 1.1'-hexamethylene-bis-[(5-p-chlorophenyl)-biguanide].
    Chemico-biological interactions, 1979, Volume: 28, Issue:2-3

    Topics: Aniline Compounds; Buformin; Chlorhexidine; Escherichia coli; Mutagens; Phenformin; Salmonella typhimurium

1979
Sensitive high-performance liquid chromatographic method for the determination of chlorhexidine in human serum and urine.
    Journal of chromatography, 1986, Dec-19, Volume: 383, Issue:2

    Topics: Aniline Compounds; Chlorhexidine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Solvents

1986
Simultaneous determination of chlorhexidine, tetracaine and their degradation products by ion-pair liquid chromatography.
    Journal of chromatography, 1984, Dec-19, Volume: 315

    Topics: 4-Aminobenzoic Acid; Aniline Compounds; Chemical Phenomena; Chemistry; Chlorhexidine; Chromatography, Liquid; Hydrogen-Ion Concentration; para-Aminobenzoates; Quaternary Ammonium Compounds; Tetracaine

1984
On the mutagenicity of parachloroaniline, a breakdown product of chlorhexidine.
    The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika, 1984, Volume: 39, Issue:8

    Topics: Aniline Compounds; Animals; Cell Line; Chlorhexidine; Female; Liver; Male; Mutagens; Rats; Rats, Inbred Strains; Salmonella

1984
Chlorhexidine gluconate mouthrinse--further aspects concerning its chemical compatibility, stability and detection of potentially harmful degradation products.
    The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika, 1982, Volume: 37, Issue:11

    Topics: Aniline Compounds; Anti-Infective Agents, Local; Chemical Phenomena; Chemistry, Physical; Chlorhexidine; Chromatography, Thin Layer; Mouthwashes

1982
[A study on the simultaneous HPLC determination of chlorhexidine and its impurity 4-chloroaniline].
    Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1995, Volume: 26, Issue:4

    Topics: Aniline Compounds; Chlorhexidine; Chromatography, High Pressure Liquid

1995
HPLC determination of chlorhexidine gluconate and p-chloroaniline in topical ointment.
    Journal of pharmaceutical and biomedical analysis, 2007, Feb-19, Volume: 43, Issue:3

    Topics: Acetonitriles; Administration, Topical; Aniline Compounds; Buffers; Chlorhexidine; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Indicators and Reagents; Ointments; Quality Control; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Veterinary Drugs

2007
Interaction between sodium hypochlorite and chlorhexidine gluconate.
    Journal of endodontics, 2007, Volume: 33, Issue:8

    Topics: Aniline Compounds; Chemical Precipitation; Chlorhexidine; Color; Dose-Response Relationship, Drug; Drug Interactions; Dye Dilution Technique; Root Canal Irrigants; Sodium Hypochlorite; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrometry, X-Ray Emission

2007
Determination of para-chloroaniline and reactive oxygen species in chlorhexidine and chlorhexidine associated with calcium hydroxide.
    Journal of endodontics, 2008, Volume: 34, Issue:12

    Topics: Aniline Compounds; Calcium Hydroxide; Chlorhexidine; Chromatography, High Pressure Liquid; Humans; Humidity; Mass Spectrometry; Materials Testing; Reactive Oxygen Species; Root Canal Irrigants; Spectrometry, Mass, Electrospray Ionization; Temperature; Time Factors

2008
Interaction between chlorhexidine digluconate and EDTA.
    Journal of endodontics, 2008, Volume: 34, Issue:12

    Topics: Aniline Compounds; Chelating Agents; Chemical Precipitation; Chlorhexidine; Chromatography, High Pressure Liquid; Edetic Acid; Gluconates; Humans; Materials Testing; Root Canal Irrigants; Sodium; Solubility; Solvents; Trifluoroacetic Acid; Water

2008
Determination of 4-chloroaniline and its derivatives formed in the interaction of sodium hypochlorite and chlorhexidine by using gas chromatography.
    Journal of endodontics, 2010, Volume: 36, Issue:2

    Topics: Aniline Compounds; Chemical Precipitation; Chlorhexidine; Drug Interactions; Gas Chromatography-Mass Spectrometry; Root Canal Irrigants; Sodium Hypochlorite

2010
An in vitro spectroscopic analysis to determine whether para-chloroaniline is produced from mixing sodium hypochlorite and chlorhexidine.
    Journal of endodontics, 2010, Volume: 36, Issue:2

    Topics: Aniline Compounds; Chemical Precipitation; Chlorhexidine; Drug Interactions; Magnetic Resonance Spectroscopy; Root Canal Irrigants; Sodium Hypochlorite

2010
Evaluation and prevention of the precipitate formed on interaction between sodium hypochlorite and chlorhexidine.
    Journal of endodontics, 2010, Volume: 36, Issue:7

    Topics: Aniline Compounds; Chelating Agents; Chemical Precipitation; Chlorhexidine; Color; Dental Pulp Cavity; Edetic Acid; Ethanol; Humans; Materials Testing; Root Canal Irrigants; Root Canal Preparation; Sodium Chloride; Sodium Hypochlorite; Surface Properties; Water

2010
Chemical interaction of alexidine and sodium hypochlorite.
    Journal of endodontics, 2012, Volume: 38, Issue:1

    Topics: Aniline Compounds; Bicuspid; Biguanides; Chemical Precipitation; Chlorhexidine; Color; Dental Disinfectants; Dental Pulp Cavity; Dentin; Humans; Materials Testing; Microscopy, Electron, Scanning; Root Canal Irrigants; Sodium Hypochlorite; Spectrometry, Mass, Electrospray Ionization

2012
Studies on the instability of chlorhexidine, part I: kinetics and mechanisms.
    Journal of pharmaceutical sciences, 2012, Volume: 101, Issue:7

    Topics: Aniline Compounds; Anti-Infective Agents, Local; Chlorhexidine; Chromatography, High Pressure Liquid; Drug Stability; Hydrogen-Ion Concentration; Hydrolysis; Kinetics

2012
Detection of para-chloroaniline, reactive oxygen species, and 1-chloro-4-nitrobenzene in high concentrations of chlorhexidine and in a mixture of chlorhexidine and calcium hydroxide.
    Journal of endodontics, 2013, Volume: 39, Issue:5

    Topics: Aniline Compounds; Anti-Infective Agents, Local; Calcium Hydroxide; Chlorhexidine; Gas Chromatography-Mass Spectrometry; Humans; Humidity; Materials Testing; Nitrobenzenes; Reactive Oxygen Species; Temperature; Time Factors; Tryptophan Hydroxylase

2013
Determination of chemical components derived from 2% chlorhexidine gel degradation using gas chromatography-mass spectrometry.
    Acta odontologica Scandinavica, 2014, Volume: 72, Issue:8

    Topics: Aniline Compounds; Anti-Infective Agents, Local; Cellulose; Chlorhexidine; Chromatography; Cold Temperature; Darkness; Drug Compounding; Drug Storage; Gas Chromatography-Mass Spectrometry; Gels; Hot Temperature; Humans; Isocyanates; Light; Materials Testing; Nitriles; Reactive Oxygen Species; Root Canal Irrigants; Solutions; Spectrophotometry, Ultraviolet; Time Factors

2014
Qualitative analysis of precipitate formation on the surface and in the tubules of dentin irrigated with sodium hypochlorite and a final rinse of chlorhexidine or QMiX.
    Journal of endodontics, 2014, Volume: 40, Issue:12

    Topics: Aniline Compounds; Biguanides; Chemical Precipitation; Chlorhexidine; Color; Dentin; Edetic Acid; Humans; Materials Testing; Polymers; Root Canal Irrigants; Sodium Chloride; Sodium Hypochlorite; Spectrometry, Mass, Secondary Ion

2014
Evaluation of orange-brown precipitate formed in root canals after irrigation with chlorhexidine and QMix and spectroscopic analysis of precipitates produced by a mixture of chlorhexidine/NaOCl and QMix/NaOCl.
    International endodontic journal, 2015, Volume: 48, Issue:12

    Topics: Aniline Compounds; Biguanides; Chemical Precipitation; Chlorhexidine; Dental Pulp Cavity; Humans; In Vitro Techniques; Polymers; Root Canal Irrigants; Sodium Hypochlorite

2015
Does Para-chloroaniline Really Form after Mixing Sodium Hypochlorite and Chlorhexidine?
    Journal of endodontics, 2016, Volume: 42, Issue:3

    Topics: Aniline Compounds; Chemical Precipitation; Chlorhexidine; Chromatography, High Pressure Liquid; Drug Interactions; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Root Canal Irrigants; Sodium Hypochlorite

2016
Chromographic Analysis and Cytotoxic Effects of Chlorhexidine and Sodium Hypochlorite Reaction Mixtures.
    Journal of endodontics, 2017, Volume: 43, Issue:9

    Topics: Aniline Compounds; Cell Line; Chlorhexidine; Chromatography, High Pressure Liquid; Humans; Sodium Hypochlorite; Toxicity Tests

2017
Proton Nuclear Magnetic Resonance Spectroscopy Analysis of Mixtures of Chlorhexidine with Different Oxidizing Agents Activated by Photon-Induced Photoacoustic Streaming for Root Canal Irrigation.
    Photobiomodulation, photomedicine, and laser surgery, 2020, Volume: 38, Issue:6

    Topics: Aniline Compounds; Anti-Infective Agents, Local; Chlorhexidine; Lasers, Solid-State; Low-Level Light Therapy; Oxidants; Photoacoustic Techniques; Proton Magnetic Resonance Spectroscopy; Root Canal Irrigants; Root Canal Preparation; Sodium Hypochlorite

2020
Quantitative Insight into PCA Formation following Different Chlorhexidine Activation Methods in Endodontic Treatment.
    Molecules (Basel, Switzerland), 2023, Aug-21, Volume: 28, Issue:16

    Topics: Aniline Compounds; Chlorhexidine; Chromatography, High Pressure Liquid; Dental Care; Humans

2023