chlordiazepoxide and valproic acid

chlordiazepoxide has been researched along with valproic acid in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199012 (46.15)18.7374
1990's3 (11.54)18.2507
2000's7 (26.92)29.6817
2010's4 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Johnson, DN; Kilpatrick, BF; Kinnier, WB; Lo, YS; Moses, LM; Sutherland, DB; Taylor, CR; Tomczuk, BE1
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Araki, Y; Ueki, S; Watanabe, S1
Albengres, E; Bree, F; Hamberger, C; Riant, P; Tillement, JP; Urien, S1
Bossut, D; Frenk, H; Mayer, DJ1
Hamilton, MS; Shephard, RA1
Aranko, K; File, SE2
Brucato, AF; Cannizzaro, G; Provenzano, PM1
Birbeck, KA; Willner, P1
Cannizzaro, G; Flugy, A; Novara, V; Provenzano, PM1
Estall, LB; Shephard, RA1
Vellucci, SV; Webster, RA1
Breese, GR; Frye, GD; Greenwood, RS; McCown, TJ1
Kuruvilla, A; Uretsky, N1
Cao, BJ; Peng, NA1
Campbell, T; Hubatch, S; Longo, LP1
Rekling, JC1
Arban, R; Brackenborough, K; Gerrard, P; Large, C; Maraia, G; Wilson, A; Winyard, L1
Adedoyin, A; Beyer, CE; Cai, Z; Comery, TA; Dwyer, JM; Kelly, MP; Liu, Z; Logue, SF; Majchrowski, H; Rosenzweig-Lipson, S1
Douma, TN; Groenink, L; Kolarz, A; Olivier, B; Postma, Y1

Reviews

1 review(s) available for chlordiazepoxide and valproic acid

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for chlordiazepoxide and valproic acid

ArticleYear
Divalproex sodium (Depakote) for alcohol withdrawal and relapse prevention.
    Journal of addictive diseases, 2002, Volume: 21, Issue:2

    Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; Anticonvulsants; Chlordiazepoxide; Female; Follow-Up Studies; Humans; Lorazepam; Male; Middle Aged; Patient Admission; Pilot Projects; Recurrence; Substance Abuse Treatment Centers; Treatment Outcome; Valproic Acid

2002

Other Studies

24 other study(ies) available for chlordiazepoxide and valproic acid

ArticleYear
2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:10

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding, Competitive; Cerebral Cortex; gamma-Aminobutyric Acid; Imidazoles; Mice; Mice, Inbred ICR; Molecular Structure; Pyridines; Rats; Receptors, GABA-A; Seizures

1991
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Changes in sensitivity of mice to anticonvulsant drugs following bilateral olfactory bulb ablations.
    Japanese journal of pharmacology, 1977, Volume: 27, Issue:2

    Topics: Acetazolamide; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Nitrazepam; Olfactory Bulb; Phenobarbital; Phenylacetates; Phenytoin; Trimethadione; Urea; Valproic Acid

1977
How chronically administered valproate increases chlordiazepoxide transfer through the blood-brain barrier.
    Fundamental & clinical pharmacology, 1990, Volume: 4, Issue:1

    Topics: Animals; Blood Proteins; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Chlordiazepoxide; Humans; Male; Rats; Rats, Inbred Strains; Valproic Acid

1990
Is substance P a primary afferent neurotransmitter for nociceptive input? III. Valproic acid and chlordiazepoxide decrease behaviors elicited by intrathecal injection of substance P and excitatory compounds.
    Brain research, 1988, Jul-12, Volume: 455, Issue:2

    Topics: Animals; Anticonvulsants; Chlordiazepoxide; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P; Valproic Acid

1988
Chlordiazepoxide and valproate enhancement of saline drinking by nondeprived rats: effects of bicuculline, picrotoxin and Ro15-1788.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:2

    Topics: Animals; Bicuculline; Chlordiazepoxide; Dose-Response Relationship, Drug; Drinking Behavior; Drug Combinations; Drug Interactions; Flumazenil; Male; Picrotoxin; Rats; Rats, Inbred Strains; Sodium Chloride; Valproic Acid

1989
Sodium valproate decreases exploratory behaviour in mice: development of tolerance and cross-tolerance with chlordiazepoxide.
    European journal of pharmacology, 1988, Jul-07, Volume: 151, Issue:2

    Topics: Animals; Chlordiazepoxide; Drug Tolerance; Exploratory Behavior; Flumazenil; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Receptors, GABA-A; Valproic Acid

1988
Effect of single and repeated treatment of chlordiazepoxide and sodium valproate on water intake in the rat and their influence on the antidipsogenic action of naloxone.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:4

    Topics: Animals; Chlordiazepoxide; Drinking; Drug Interactions; Male; Naloxone; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid

1986
Effects of chlordiazepoxide and sodium valproate in two tests of spatial behaviour.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:4

    Topics: Animals; Chlordiazepoxide; Dose-Response Relationship, Drug; Male; Memory; Rats; Spatial Behavior; Valproic Acid

1986
Interaction between naloxone, chlordiazepoxide and valproic acid evaluated by emotional operant behaviour in the rat.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:1

    Topics: Animals; Chlordiazepoxide; Conditioning, Operant; Emotions; Male; Naloxone; Rats; Rats, Inbred Strains; Reinforcement Schedule; Valproic Acid

1987
Sodium valproate and chlordiazepoxide in the elevated plus-maze test of anxiety in the rat.
    Neuropsychobiology, 1988, Volume: 20, Issue:2

    Topics: Animals; Arousal; Attention; Chlordiazepoxide; Discrimination Learning; Dose-Response Relationship, Drug; Male; Orientation; Rats; Valproic Acid

1988
Effects of chlordiazepoxide and of valproate on hyponeophagia in rats. Evidence for a mutual antagonism between their anxiolytic properties.
    Neuropharmacology, 1984, Volume: 23, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Drug Interactions; Eating; Food Preferences; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Time Factors; Valproic Acid

1984
The role of GABA in the anticonflict action of sodium valproate and chlordiazepoxide.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:6

    Topics: Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conflict, Psychological; Drug Interactions; gamma-Aminobutyric Acid; Ion Channels; Male; Muscimol; Rats; Receptors, GABA-A; Synaptic Transmission; Valproic Acid

1984
Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy?
    Experimental neurology, 1984, Volume: 86, Issue:3

    Topics: Animals; Chlordiazepoxide; Electric Stimulation; Electrophysiology; Epilepsy; Inferior Colliculi; Male; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Valproic Acid

1984
The interaction of chlordiazepoxide and sodium valproate in the nucleus accumbens of the rat.
    Life sciences, 1981, Jan-26, Volume: 28, Issue:4

    Topics: Animals; Bicuculline; Chlordiazepoxide; Dopamine; Drug Synergism; Motor Activity; Nucleus Accumbens; Rats; Septal Nuclei; Valproic Acid

1981
Magnesium valproate attenuates hyperactivity induced by dexamphetamine-chlordiazepoxide mixture in rodents.
    European journal of pharmacology, 1993, Jun-24, Volume: 237, Issue:2-3

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Bicuculline; Chlordiazepoxide; Dextroamphetamine; Drug Interactions; Female; GABA-A Receptor Antagonists; Isoniazid; Mice; Motor Activity; Picrotoxin; Rats; Rats, Sprague-Dawley; Valproic Acid

1993
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
    Neuroscience letters, 2003, Jan-02, Volume: 335, Issue:3

    Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glucose; Hippocampus; Hypoxia; Ischemia; Lamotrigine; Levetiracetam; Midazolam; Neurons; Neuroprotective Agents; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Rats; Rats, Wistar; Tiagabine; Triazines; Valproic Acid

2003
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania.
    Behavioural brain research, 2005, Mar-07, Volume: 158, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Carbamazepine; Central Nervous System Stimulants; Chlordiazepoxide; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Lamotrigine; Mice; Motor Activity; Pentylenetetrazole; Psychomotor Agitation; Seizures; Triazines; Valproic Acid

2005
The supra-additive hyperactivity caused by an amphetamine-chlordiazepoxide mixture exhibits an inverted-U dose response: negative implications for the use of a model in screening for mood stabilizers.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 92, Issue:4

    Topics: Affect; Amphetamine; Animals; Antimanic Agents; Anxiety; Bipolar Disorder; Chlordiazepoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Male; Mice; Mice, Inbred C57BL; Models, Neurological; Motor Activity; Valproic Acid

2009
The amphetamine-chlordiazepoxide mixture, a pharmacological screen for mood stabilizers, does not enhance amphetamine-induced disruption of prepulse inhibition.
    Behavioural brain research, 2011, Nov-20, Volume: 225, Issue:1

    Topics: Acoustic Stimulation; Affect; Amphetamine; Analysis of Variance; Animals; Anticonvulsants; Antimanic Agents; Behavior, Animal; Chlordiazepoxide; Drug Evaluation, Preclinical; Drug Synergism; Hyperkinesis; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperazines; Reflex, Startle; Valproic Acid

2011
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