chlordiazepoxide and clozapine

chlordiazepoxide has been researched along with clozapine in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199010 (34.48)18.7374
1990's4 (13.79)18.2507
2000's8 (27.59)29.6817
2010's7 (24.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chakrabarti, JK; Hotten, TM; Pullar, IA; Type, NC1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bruhwyler, J; Chleide, E; Delarge, J; Liégeois, JF; Mercier, M1
Barrett, JE; Harrod, C; Hoffmann, SM; Lei, Z; Mansbach, RS; Nader, MA; Witkin, JM1
Sanger, DJ2
Bergman, J; Spealman, RD1
Spealman, RD1
Dews, PB; Lehr, E; Morse, WH1
Ford, KE; Fowler, SC; Gramling, SE; Nail, GL1
Katz, JL; Spealman, RD1
DeWeese, J; Goldberg, DM; Goldberg, SR; Kelleher, RT; Spealman, RD1
Benvenga, MJ; Leander, JD1
Compton, AD; Porter, JH; Wiley, JL1
Cao, BJ; Rodgers, RJ1
Ferris, CF; King, JA; Messenger, T1
Fletcher, PJ; Kapur, S; Li, M; Parkes, J1
Kapur, S; Li, M; Mead, A1
Li, M; Zhao, C1
Body, S; Bradshaw, CM; Cassaday, HJ; Goudie, AJ; Olarte-Sánchez, CM; Szabadi, E; Valencia Torres, L1

Reviews

1 review(s) available for chlordiazepoxide and clozapine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

28 other study(ies) available for chlordiazepoxide and clozapine

ArticleYear
Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:12

    Topics: Animals; Anti-Anxiety Agents; Azepines; Behavior, Animal; Catalepsy; Chemical Phenomena; Chemistry; Male; Mice; Piperazines; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Muscarinic

1989
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Anxiolytic potential of sulpiride, clozapine and derivatives in the open-field test.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:1

    Topics: Animals; Chlordiazepoxide; Clozapine; Defecation; Dibenzazepines; Exploratory Behavior; Haloperidol; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulpiride

1990
Behavioral studies with anxiolytic drugs. V. Behavioral and in vivo neurochemical analyses in pigeons of drugs that increase punished responding.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Anxiety Agents; Buspirone; Chlordiazepoxide; Clozapine; Columbidae; Conditioning, Operant; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Punishment; Pyrimidines

1988
Response decrement patterns after neuroleptic and non-neuroleptic drugs.
    Psychopharmacology, 1986, Volume: 89, Issue:1

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Chlordiazepoxide; Clonidine; Clozapine; Conditioning, Operant; Electroshock; Food; Male; Methocarbamol; Morphine; Rats; Rats, Inbred Strains

1986
Some behavioral effects of histamine H1 antagonists in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:1

    Topics: Animals; Behavior, Animal; Chlordiazepoxide; Chlorpheniramine; Cimetidine; Clozapine; Cocaine; Conditioning, Operant; Dextroamphetamine; Diphenhydramine; Electroshock; Feeding Behavior; Histamine H1 Antagonists; Male; Promethazine; Saimiri; Self Administration; Tripelennamine

1986
Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azabicyclo Compounds; Barbital; Benzodiazepines; Benzodiazepinones; Buspirone; Caffeine; Chlordiazepoxide; Cinanserin; Clozapine; Conditioning, Operant; Cyproheptadine; Diazepam; Diphenhydramine; Discrimination Learning; Electroshock; Flumazenil; Male; Midazolam; Muscimol; Nordazepam; Pentobarbital; Piperazines; Pyridazines; Pyrimidines; Saimiri; Tripelennamine

1985
Effects of drugs on schedule-controlled running of mice in a circular runway.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:1A

    Topics: Amphetamine; Animals; Chlordiazepoxide; Chlorpromazine; Clozapine; Female; Food Deprivation; Imipramine; Mice; Morphine; Motor Activity; Pentobarbital; Reinforcement Schedule

1985
The effects of clozapine on shuttle-box avoidance responding in rats: comparisons with haloperidol and chlordiazepoxide.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:2

    Topics: Animals; Avoidance Learning; Chlordiazepoxide; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Electroshock; Haloperidol; Male; Rats; Rats, Inbred Strains

1985
Acute and subchronic effects of neuroleptics on quantitative measures of discriminative motor control in rats.
    Psychopharmacology, 1984, Volume: 84, Issue:3

    Topics: Animals; Antipsychotic Agents; Chlordiazepoxide; Chlorpromazine; Clozapine; Conditioning, Operant; Haloperidol; Male; Psychomotor Performance; Rats; Rats, Inbred Strains; Reinforcement Schedule

1984
Some effects of clozapine on punished responding by mice and squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 212, Issue:3

    Topics: Animals; Chlordiazepoxide; Chlorpromazine; Clozapine; Conditioning, Operant; Dibenzazepines; Dose-Response Relationship, Drug; Haplorhini; Male; Mice; Punishment; Reinforcement Schedule; Saimiri

1980
Behavioral effects of clozapine: comparison with thioridazine, chlorpromazine, haloperidol and chlordiazepoxide in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:1

    Topics: Animals; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Clozapine; Conditioning, Operant; Dibenzazepines; Electroshock; Food; Haloperidol; Male; Reinforcement Schedule; Saimiri; Thioridazine; Tranquilizing Agents

1983
Olanzapine, an atypical antipsychotic, increases rates of punished responding in pigeons.
    Psychopharmacology, 1995, Volume: 119, Issue:2

    Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Clozapine; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Haloperidol; Isoxazoles; Male; Olanzapine; Piperidines; Pirenzepine; Punishment; Risperidone

1995
Effects of four antipsychotics on punished responding in rats.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:2

    Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Clozapine; Conflict, Psychological; Drug Evaluation, Preclinical; Haloperidol; Male; Punishment; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Structure-Activity Relationship; Thioridazine

1993
Dopamine D4 receptor and anxiety: behavioural profiles of clozapine, L-745,870 and L-741,742 in the mouse plus-maze.
    European journal of pharmacology, 1997, Sep-24, Volume: 335, Issue:2-3

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Isoxazoles; Male; Maze Learning; Mice; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D4

1997
Seed finding in golden hamsters: a potential animal model for screening anxiolytic drugs.
    Neuropsychobiology, 2002, Volume: 45, Issue:3

    Topics: Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety; Appetitive Behavior; Behavior, Animal; Buspirone; Chlordiazepoxide; Clozapine; Cricetinae; Desipramine; Drug Evaluation, Preclinical; Fasting; Fluoxetine; Injections, Intraperitoneal; Male; Mesocricetus; Models, Animal; Stress, Psychological; Yohimbine

2002
Evaluation of the motor initiation hypothesis of APD-induced conditioned avoidance decreases.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 78, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Avoidance Learning; Chlordiazepoxide; Clozapine; Haloperidol; Male; Motor Activity; Rats; Rats, Sprague-Dawley

2004
Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: contrast with haloperidol and chlordiazepoxide.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Chlordiazepoxide; Clozapine; Conditioning, Psychological; Dose-Response Relationship, Drug; Fear; Haloperidol; Hypnotics and Sedatives; Male; Motor Activity; Olanzapine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Vocalization, Animal

2008
Sedation and disruption of maternal motivation underlie the disruptive effects of antipsychotic treatment on rat maternal behavior.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 92, Issue:1

    Topics: Animals; Antipsychotic Agents; Anxiety, Separation; Chlordiazepoxide; Clozapine; Data Interpretation, Statistical; Dopamine Antagonists; Female; Haloperidol; Hypnotics and Sedatives; Maternal Behavior; Motivation; Nesting Behavior; Rats; Rats, Sprague-Dawley

2009
A clozapine-like effect of cyproheptadine on progressive ratio schedule performance.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:6

    Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chlordiazepoxide; Clozapine; Conditioning, Operant; Cyproheptadine; Dronabinol; Eating; Female; Haloperidol; Motivation; Performance-Enhancing Substances; Psychomotor Performance; Rats; Rats, Wistar; Reinforcement Schedule; Reinforcement, Psychology

2012