chlorambucil has been researched along with proline in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harris, RB; Wilson, IB | 1 |
| Ainpour, PR; Reuben, MA; Wickstrom, E; Yager, TD | 1 |
| Wickstrom, E | 1 |
| Bielawska, A; Bielawski, K; Pałka, J | 1 |
| Bielawska, A; Bielawski, K; Chrzanowski, K; Pałka, J | 1 |
| Bosanquet, AG; Daniel, PT; Dörken, B; Hummel, M; Sturm, I | 1 |
| Amidon, GL; Mittal, S; Song, X; Vig, BS | 1 |
7 other study(ies) available for chlorambucil and proline
| Article | Year |
|---|---|
Irreversible inhibition of bovine lung angiotensin I-converting enzyme with p-[N,N-bis(chloroethyl)amino]phenylbutyric acid (chlorambucil) and chlorambucyl L-proline and with evidence that an active site carboxyl group is labeled.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Binding Sites; Carbon Radioisotopes; Cattle; Chlorambucil; Kinetics; Lung; Proline; Protein Binding; Radioisotope Dilution Technique; Structure-Activity Relationship | 1982 |
Molecular rulers with 5 or 11 prolines intramolecularly crosslink to G45 of yeast phenylalanine tRNA.
Topics: Alkylation; Chemical Phenomena; Chemistry; Chlorambucil; Cross-Linking Reagents; Oligopeptides; Proline; RNA, Transfer, Amino Acyl; Saccharomyces cerevisiae | 1981 |
Chlorambucil inhibition by dimethyl sulfoxide and thiosulfate: implications for chlorambucil chemotherapy.
Topics: Alkylation; Animals; Chlorambucil; Dimethyl Sulfoxide; Kinetics; Proline; RNA, Transfer; Thiosulfates | 1980 |
Prolidase as a prodrug converting enzyme I. Synthesis of proline analogue of chlorambucil and its susceptibility to the action of prolidase.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Dipeptidases; Dipeptides; Hydrogenation; Imides; Magnetic Resonance Spectroscopy; Methanol; Molecular Structure; Prodrugs; Proline; Solubility; Substrate Specificity | 1997 |
Decreased cytotoxicity and increased antimitotic activity of proline analogue of chlorambucil as a prodrug in breast cancer MCF-7 cells.
Topics: Antineoplastic Agents, Alkylating; Breast Neoplasms; Chlorambucil; Dipeptidases; DNA; Dose-Response Relationship, Drug; Female; Humans; Mitosis; Prodrugs; Proline; Tumor Cells, Cultured | 2000 |
In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis.
Topics: Aged; Antineoplastic Agents; Apoptosis; Arginine; Chlorambucil; Codon; Cyclophosphamide; DNA Mutational Analysis; Doxorubicin; Drug Resistance, Neoplasm; Female; Gamma Rays; Gene Expression Regulation, Neoplastic; Genes, p53; Homozygote; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Methylprednisolone; Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Polymorphism, Single-Stranded Conformational; Prognosis; Proline; Vidarabine Phosphate; Vincristine | 2005 |
Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma.
Topics: Antineoplastic Agents, Alkylating; Biological Transport; Biotransformation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chlorambucil; Dipeptidases; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydrolysis; Inhibitory Concentration 50; Melanoma; Melphalan; Prodrugs; Proline; Protease Inhibitors; RNA, Messenger; Stereoisomerism | 2007 |