chlorambucil has been researched along with melphalan in 211 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 134 (63.51) | 18.7374 |
| 1990's | 34 (16.11) | 18.2507 |
| 2000's | 26 (12.32) | 29.6817 |
| 2010's | 15 (7.11) | 24.3611 |
| 2020's | 2 (0.95) | 2.80 |
| Authors | Studies |
|---|---|
| Hall, IH; Loeffler, LJ; Sajadi, Z | 2 |
| Hansch, C; Khwaja, TA; Selassie, CD | 1 |
| Giraud, I; Madelmont, JC; Maurizis, JC; Rapp, M | 1 |
| Bingham, JP; Caddick, S; Hartley, JA; Urbaniak, MD; Woolfson, DN | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Balzarini, J; Das, U; De Clercq, E; Dimmock, JR; Kawase, M; Lorand, T; Perjési, P; Rozmer, Z; Sakagami, H; Stables, JP | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Benfenati, E; Raska, I; Toropov, AA; Toropova, AP | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, ZS; Li, D; Pei, L; Sun, Y; Wang, C; Wu, X; Xu, J; Xu, S; Yao, H; Zhang, YK | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Hu, W; Huang, XS; Li, X; Li, ZY; Shen, YM; Wu, JF; Yang, L; Zheng, YT | 1 |
| Arnold, LA; Balakrishnan, K; Chen, W; Fan, H; Fan, Y; Gandhi, V; Peng, X; Sun, H; Wang, Y | 1 |
| Merrin, C | 1 |
| Davies, DA; Dowd, P; Everall, KD; O'Neill, GJ; Rowland, GF | 1 |
| Firusian, N; Hossfeld, DK; John, V | 1 |
| Casey, AE; Griswold, DP; Prejean, JD; Weisburger, EK; Weisburger, JH; Wood, HB | 1 |
| Hirschberg, H; Rowland, G; Thorsby, E | 1 |
| Phillips, BJ; Tisdale, MJ | 1 |
| Bezwoda, WR; Gilich, GC; Lynch, SR; Shulman, G | 1 |
| Cinotti, A; Romanini, D; Spanedda, R | 1 |
| Howard, JG; Shand, FL | 1 |
| Drings, P; Kaufmann, M; Kubli, F; Lammers, G | 1 |
| Fraumeni, JF; Hoover, R; Reimer, RR; Young, RC | 1 |
| Bruntsch, U; Gallmeier, WM | 1 |
| Millar, JL; Powles, TJ | 1 |
| Morley, AA; Seshadri, RS; Trainor, KJ | 1 |
| Godenech, D; Meyniel, G | 1 |
| Silverstein, MN | 1 |
| Kossard, S; Winkelmann, RK | 1 |
| Górska, B; Pawelski, S; Rechowicz, K; Sylwestrowicz, T; Zupańska, B | 1 |
| Barlow, JJ; Chung, WS; Lee, FT; Piver, S; Vongtama, V | 1 |
| Allt, WE; Beale, FA; Bean, H; Bush, RS; Pringle, JF; Sturgeon, J | 1 |
| Ehrhart, H; Fateh-Moghadam, A; Knedel, M; Sandel, P | 1 |
| Goldenberg, GJ | 1 |
| Loeb, V | 1 |
| Rutledge, F; Smith, JP | 1 |
| Barlow, JJ; Lee, FJ; Piver, MS; Vongtama, V | 1 |
| Azam, L; Campbell, AE; De Vine, J; Delamore, IW; Hamid, J; McFarlane, H | 1 |
| Andersen, O; Berlin, G; Ernerudh, JH; Lindberg, C; Vrethem, M | 1 |
| Hunsicker, PR; Russell, LB; Shelby, MD | 1 |
| Weiss, RB | 1 |
| Alaoui-Jamali, MA; Batist, G; Centurioni, GM; Lehnert, S; Panasci, L; Schecter, R | 1 |
| Dedrick, RL; Morrison, PF | 1 |
| Bagshawe, KD; Hartley, JA; Souhami, RL; Springer, CJ; Sunters, A | 1 |
| Bauer, GB; Bennett, RA; Povirk, LF; Wang, P | 1 |
| Basu, A; Lazo, JS | 1 |
| Benz, CC; Ford, JM; Hait, WN; Matlin, SA | 1 |
| Barranco, SC; Beasley, EG; Jenkins, VK; MacLean, KK; Townsend, CM; Weintraub, B | 1 |
| Bell, J; Clarke, EA; Day, NE; Høst, H; Kaldor, JM; Karjalainen, S; Mehnert, W; Pedersen, D; Pettersson, F; Prior, P | 1 |
| Bungo, M; Fujiwara, Y; Kasahara, K; Saijo, N; Sugimoto, Y; Tew, KD; Yamakido, M | 1 |
| Frei, H; Tripathy, NK; Würgler, FE | 1 |
| Erickson, LC; Pieper, RO | 1 |
| Bellet, AJ; Favier, D; Holmes, RS; Hurst, T; Kable, EP; Khoo, SK; Lean, J; Parsons, PG | 1 |
| Ehrsson, H; Eksborg, S | 1 |
| Bajusz, S; Bokser, L; Csernus, VJ; Fekete, M; Janaky, T; Redding, TW; Schally, AV; Srkalovic, G | 1 |
| Glüsenkamp, KH; Hülser, DF; Jähde, E; Klünder, I; Rajewsky, MF; Tietze, LF | 1 |
| Erickson, LC; Futscher, BW; Pieper, RO | 1 |
| Ehrsson, H; Ringborg, U; Wallin, I | 1 |
| Horikoshi, N | 1 |
| Daunter, B; Khoo, SK; Maynard, K; Musk, P; Parsons, PG | 1 |
| Alcalá, A; Alonso, C; Besalduch, J; García-Conde, J; Garijo, J; Gomis, F; Gutierrez, M; Guzmán, MC; Montserrat, E; Moraleda, JM | 1 |
| Greig, NH; Rapoport, SI; Sweeney, DJ | 1 |
| Bennett, JM; Boice, JD; Greene, MH; Moloney, WC | 1 |
| Mouridsen, HT | 1 |
| Adair, CG; McElnay, JC | 2 |
| Sladek, NE; Smith, PC | 1 |
| Bosanquet, AG | 1 |
| Bleehen, NM; Honess, DJ | 1 |
| Wilms, K | 1 |
| Abendroth, K; Siering, VH | 1 |
| Astrakhan, VI; Monul, FA | 1 |
| Fomina, IP; Navashin, SM; Osokina, LI | 1 |
| Lemmel, EM; Motycka, K; Nouza, K; Soucek, J | 1 |
| Leĭkina, FI; Smolianskaia, AZ | 1 |
| Alexanian, R; Ruiz, VG | 1 |
| Patakfalvi, A | 1 |
| Berenbaum, MC; Bundick, RV; Reittie, JR; Sheard, CE | 1 |
| Cardamone, JM; Kimmerle, RI; Marshall, EY | 1 |
| Buckham, S; Davies, DA; Manstone, AJ | 1 |
| Bradley, SG; Munson, AE; Rose, WC | 1 |
| Dendy, PP | 1 |
| Jacobs, EM; Johnson, FD | 1 |
| Bhuyan, BK; Fraser, TJ; Scheidt, LG | 1 |
| Du Priest, RW; Fletcher, WS | 1 |
| Jordon, RE; Muller, SA; Perry, HO; Rogers, RS; Schroeter, AL; Winkelmann, RK | 1 |
| Fetherston, WC; Grueninger, AJ; Hurley, JD; Speckhard, ME | 1 |
| Donelli, MG; Garattini, S; Rosso, R | 1 |
| Stoltz, DR | 1 |
| Stevenson, AC | 1 |
| Davies, DA | 1 |
| Piver, MS | 1 |
| Carter, SK | 1 |
| Dunn, CD | 1 |
| Haddow, A | 1 |
| Laszlo, J | 1 |
| Tolen, SJ; Valeriote, FA | 1 |
| Greenwald, ES | 1 |
| Hartwich, G | 1 |
| Waldenström, JG | 1 |
| Delobel, J; Dresch, C; Najean, Y; Pecking, A; Rain, JD | 1 |
| Patel, CR; Roman, CS; Stevenson, AC | 1 |
| Sonntag, RW | 1 |
| Astaldi, G; Meardi, G; Yalçin, B | 1 |
| Griggs, LJ; Jarman, M; Tisdale, MJ | 1 |
| Berndt, H; Rieche, K | 1 |
| Graham, JB; Hreshchyshyn, MM | 1 |
| Klemm, D; Merker, H; Westerhausen, M | 1 |
| Nechaeva, ID | 1 |
| Klemm, D | 1 |
| Lewis, TL | 1 |
| Clément, F | 1 |
| Schmidt, CG | 1 |
| Netschajewa, ID | 1 |
| Górkiewicz, A; Kostanecki, W; Mazurkiewicz, W; Zborzil, J | 1 |
| Khristov, IS | 1 |
| Bihler, I; Goldenberg, GJ; Iise, D; Israels, LG; Vanstone, CL | 1 |
| Bernier, JJ; Bognel, C; Bognel, JC; Ferrier, JP; Hurez, D; Matuchansky, C; Mihaesco, E; Perol, C; Rambaud, JC; Scotto, J; Seligmann, M | 1 |
| Harrap, KR; Hill, BT | 3 |
| Karaivanova, MKh | 1 |
| Lelieveld, P; van Putten, LM | 1 |
| Bishop, RC | 1 |
| Abraham, D; Bowie, M; Carbone, PP; Teller, MN | 1 |
| Williamson, CE; Witten, B | 1 |
| Hills, WJ; Rufino, C; Stehlin, JS | 1 |
| Brunner, KW | 1 |
| Clifford, P; Klein, G; Singh, S; Stjernswärd, J | 1 |
| Collis, CH | 1 |
| Gráf, F; Raposa, T; Várkonyi, J | 1 |
| Kehrberg, G; Moldenhauer, H; Rose, H; Saul, G; Wolf, G | 1 |
| Twentyman, PR | 1 |
| Cochi, S; De Laurenzi, A; Ferraro, P; Pacilli, L | 1 |
| Emmerich, B | 1 |
| Davis, TE; Gilchrist, KW; Neville, AJ | 1 |
| Parsons, PG | 1 |
| Blessing, JA; Boice, JD; Dembo, AJ; Greene, MH; Greer, BE | 1 |
| Syrkin, AB | 1 |
| Adamson, RH; Seiber, SM | 1 |
| Janisch, H; Szalay, S | 1 |
| Begleiter, A; Goldenberg, GJ | 1 |
| Arcese, W; Colombo, R; Franchii, A; Pastore, S; Tribalto, M | 1 |
| Sporny, S | 1 |
| Dresch, C; Najean, Y | 1 |
| Benckhuysen, C; van der Steen, J; van Wichen, BH | 1 |
| Twentyman, P; Workman, P | 1 |
| Gerster, JC; Métrailler, A; Saudan, Y | 1 |
| Frank, GJ; Millar, JL; Powles, TJ | 1 |
| Alberts, DS; Chang, SY; Chen, HS; Evans, TL; Larcom, BJ | 1 |
| Godenèche, D; Madelmont, JC; Meyniel, G; Moreau, MF; Plagne, R | 1 |
| Povirk, LF; Shuker, DE | 1 |
| Bosanquet, AG; Catovsky, D; Crotty, GM; McCann, SR; Mills, MJ | 1 |
| Gouyette, A | 1 |
| Alaoui-Jamali, M; Aubin, R; Batist, G; Bramson, J; Christodoulopoulos, G; McQuillan, A; Panasci, LC | 1 |
| Cotter, TG; Fernandes, RS | 1 |
| Ardiet, C; Lind, MJ | 1 |
| Alaoui-Jamali, MA; Batist, G; Fahl, WE; Schecter, RL; Woo, A | 1 |
| Cacheiro, NL; Cain, KT; Generoso, WM; Hughes, L; Lockhart, AM; Shelby, MD; Witt, KL | 1 |
| Doi, T; Nagai, H; Suzuki, T; Tsukuda, R | 1 |
| Laval, J; Lee, CS; Mattes, WB; O'Connor, TR | 1 |
| Fisher, SG; Godwin, J; Nand, S; Stock, W | 1 |
| Akimaru, K; Bao, JJ; Frindrich, K; Ishikawa, T; Kuo, MT; Wright, CD; Yamane, Y | 1 |
| Luedtke, NW; Millard, JT; Spencer, RJ | 1 |
| Barnouin, K; Jedlitschky, G; Keppler, D; König, J; Lehmann, WD; Leier, I; Pourtier-Manzanedo, A | 1 |
| Hopkins, PB; Millard, JT; Spencer, RJ | 1 |
| Dreger, P; Glass, B; Kuse, R; Löffler, H; Schmitz, N; Schoch, R; Sonnen, R; Uharek, L; von Neuhoff, N | 1 |
| Aalders, M; Beijnen, JH; Essers, M; Kuin, A; Lamfers, M; Smets, LA; van Zuidam, DJ | 1 |
| Devereux, S; Goldstone, AH; Gregory, W; Hancock, B; Harrison, CN; Hoskin, P; Hudson, GV; Linch, DC; MacMillan, AK; Milligan, D; Newland, AC; Winfield, D | 1 |
| Fenselau, C; Szilágyi, Z | 1 |
| Ledford, BG; Morrow, CS; Paumi, CM; Smitherman, PK; Townsend, AJ | 1 |
| Martin, AM; McCartney, H; Middleton, PG; Tilby, MJ | 1 |
| Baum, C; Fodstad, Ø; Hildinger, M; Lorico, A; Rappa, G | 1 |
| Hulst, AG; Jansen, R; Noort, D | 1 |
| Ellis, EM; Kazi, S | 1 |
| Cai, Y; Chung, AB; Dolan, ME; Ludeman, SM; Wilson, LR | 1 |
| Goon, AT; McCann, M; McFadden, JP; Royds, C; Rycroft, RJ | 1 |
| WALDENSTROEM, J | 1 |
| VIGI, F | 1 |
| IGLESIAS, F; KOKAME, GM; KREMENTZ, ET | 1 |
| CHUMAKOV, VM; SYRKIN, AB | 1 |
| BOYLAND, E; KINDER, CH; WILLIAMS, K | 1 |
| Annibali, O; Avvisati, G; Del Bianco, P; Foa, R; Fossati, C; Levi, A; Mandelli, F; Martini, V; Petrucci, MT; Tirindelli, MC | 1 |
| Anestål, K; Arnér, ES; Ehrsson, H; Jerremalm, E; Witte, AB | 1 |
| Brody, JR; Cunningham, SC; DeMarzo, AM; Dezentje, DA; Gallmeier, E; Hruban, RH; Isacoff, WH; Kern, SE; Offerhaus, GJ; Swartz, MJ; van der Heijden, MS | 1 |
| Oumeish, I; Oumeish, OY; Salman, T; Sharaiha, A; Tarawneh, M | 1 |
| Dörken, B; Dreyling, M; Forstpointner, R; Freund, M; Ganser, A; Hiddemann, W; Hoster, E; Huber, C; Ludwig, WD; Nickenig, C; Trümper, L; Unterhalt, M | 1 |
| Andrianopoulos, C; Demopoulos, NA; Efthimiou, M; Nikolaropoulos, SS; Stephanou, G | 1 |
| Amidon, GL; Mittal, S; Song, X; Vig, BS | 1 |
| Liu, G; Wang, W; Zheng, J | 1 |
| Bielawska, A; Bielawski, K | 1 |
| Lan, M; Meng, X; Yuan, H; Zhao, H | 1 |
| Demopoulos, NA; Efthimiou, M; Nikolaropoulos, SS; Stephanou, G | 1 |
| Avlasevich, SL; Bemis, JC; Cottom, J; Dertinger, SD; Macgregor, JT; Mereness, J; Phonethepswath, S; Torous, DK | 1 |
| Daw, S; Hayward, J; Hewitt, M; Kirkwood, A; McCarthy, K; Morland, B; Shankar, A | 1 |
| Burckhardt, G; Hagos, Y; Hundertmark, P; Marada, VV; Shnitsar, V; Wulf, G | 1 |
| Garman, B; Glickson, JD; Leeper, DB; Nath, K; Nathanson, KL; Nelson, DS; Putt, ME | 1 |
| Burton, JH; Knych, HK; Rebhun, RB; Stanley, SD | 1 |
| Andersson, BS; Hassan, M; Valdez, BC | 1 |
| Avlasevich, SL; Bemis, JC; Dertinger, SD; Elhajouji, A; Hove, TT; Martus, H; O'Connell, O; Torous, DK | 1 |
| Dertinger, SD; Elhajouji, A; Hove, TT; Martus, H; O'Connell, O | 1 |
32 review(s) available for chlorambucil and melphalan
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.
Topics: Animals; Biocatalysis; Chemistry, Pharmaceutical; DNA Topoisomerases, Type II; Drug Discovery; Humans; Topoisomerase II Inhibitors | 2018 |
Seminoma.
Topics: Adult; Aging; Castration; Chlorambucil; Cryptorchidism; Cyclophosphamide; Dysgerminoma; Humans; Male; Melphalan; Middle Aged; Mumps; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Testicular Neoplasms; Testis | 1977 |
[Adjuvant (preventive) postoperative chemotherapy in breast carcinoma].
Topics: Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; Humans; Melphalan; Menopause; Methotrexate; Postoperative Care | 1978 |
Treatment of polycythaemia vera.
Topics: Bloodletting; Busulfan; Chlorambucil; Cyclophosphamide; Humans; Injections, Intravenous; International Cooperation; Melphalan; Phosphorus Radioisotopes; Polycythemia Vera | 1975 |
Hypersensitivity reactions.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Aziridines; Benzoquinones; Bleomycin; Chlorambucil; Cisplatin; Cyclophosphamide; Cytarabine; Dacarbazine; Drug Hypersensitivity; Etoposide; Fluorouracil; Humans; Ifosfamide; Melphalan; Methotrexate; Mitomycins; Neoplasms; Paclitaxel; Pentostatin; Procarbazine; Teniposide | 1992 |
Metallothionein expression and transient resistance to electrophilic antineoplastic drugs.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Doxorubicin; Drug Resistance; Humans; Melphalan; Metallothionein; Mitomycin; Prednimustine | 1991 |
Drug level monitoring: cytostatics.
Topics: Alkylating Agents; Aminoacridines; Amsacrine; Anthraquinones; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Bleomycin; Busulfan; Chlorambucil; Chromatography, Gas; Chromatography, Liquid; Cisplatin; Cyclophosphamide; Cytarabine; Fluorouracil; Humans; Mass Spectrometry; Melphalan; Methotrexate; Mitomycins; Monitoring, Physiologic; Nitrosourea Compounds; Podophyllotoxin; Purines; Thiotepa; Vinca Alkaloids | 1985 |
Prednimustine in advanced breast cancer: a review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Drug Evaluation; Female; Fluorouracil; Humans; Leukocyte Count; Melphalan; Methotrexate; Prednimustine; Time Factors | 1986 |
Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. General considerations, the nitrosoureas and alkylating agents.
Topics: Alkylation; Antineoplastic Agents; Carmustine; Chlorambucil; Colony-Forming Units Assay; Cyclophosphamide; Drug Storage; Hydrogen-Ion Concentration; Lomustine; Mathematics; Melphalan; Nimustine; Nitrosourea Compounds; Solutions; Temperature; Tumor Stem Cell Assay | 1985 |
[Principles of the effect of cytostatics].
Topics: Antineoplastic Agents; Asparaginase; Cell Division; Chlorambucil; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Fluorouracil; Folic Acid Antagonists; Humans; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Triaziquone; Triethylenephosphoramide; Vincristine | 1974 |
Multiple myeloma and macroglobulinemia. Advances in treatment.
Topics: Anemia; Blood Protein Electrophoresis; Blood Transfusion; Blood Viscosity; Chlorambucil; Drug Therapy, Combination; Humans; Melphalan; Multiple Myeloma; Plasmacytoma; Prednisolone; Waldenstrom Macroglobulinemia | 1974 |
Guidelines for the management of patients with ovarian adenocarcinoma.
Topics: Adenocarcinoma; Castration; Chlorambucil; Cobalt Isotopes; Female; Humans; Hysterectomy; Melphalan; Ovarian Neoplasms | 1972 |
Single and combination nonhormonal chemotherapy in breast cancer.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Drug Synergism; Female; Fluorouracil; Humans; Hydroxyurea; Melphalan; Menopause; Methotrexate; Mice; Vinblastine; Vincristine | 1972 |
On the biological alkylating agents.
Topics: Alkylating Agents; Busulfan; Carcinogens; Chlorambucil; Melphalan; Mustard Compounds; Mutation; Neoplasms; Nitrogen Mustard Compounds; Triethylenemelamine | 1973 |
Current management of polycythemia vera and related diseases.
Topics: Allopurinol; Bloodletting; Chlorambucil; Erythropoiesis; Gout; Humans; Melphalan; Phosphorus Radioisotopes; Polycythemia Vera; Uric Acid | 1974 |
Cancer chemotherapy. I.
Topics: Animals; Busulfan; Chlorambucil; Cyclophosphamide; Female; Humans; Male; Mechlorethamine; Melphalan; Methotrexate; Mice; Neoplasms; Thiotepa | 1972 |
[Current status of chemotherapy of malignant tumors of the ovaries].
Topics: Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Ovarian Neoplasms; Thiotepa; Triaziquone; Vinblastine | 1968 |
Trends in the treatment of pelvic malignant diseases.
Topics: Carcinoma; Chlorambucil; Cyclophosphamide; Female; Genital Neoplasms, Female; Humans; Hysterectomy; Lymph Node Excision; Melphalan; Ovarian Neoplasms; Progestins; Radiotherapy, High-Energy; Thiotepa; Uterine Cervical Neoplasms; Uterine Neoplasms | 1971 |
[Alkylating cytostatic agents].
Topics: Alkylating Agents; Alkylation; Animals; Busulfan; Cell Division; Chemical Phenomena; Chemistry; Chlorambucil; Cyclophosphamide; DNA Viruses; Ethers, Cyclic; Ethoglucid; Ethylamines; Humans; Mannomustine; Melphalan; Neoplasms; Nitrogen Mustard Compounds; Thiotepa; Triaziquone | 1971 |
Lung damage from cytotoxic drugs.
Topics: Antineoplastic Agents; Azathioprine; Bleomycin; Busulfan; Carmustine; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Humans; Lung; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; Oxygen Inhalation Therapy; Pneumonia; Procarbazine; Radiation Injuries | 1980 |
[Intensification of cytostatic action by radiosensitizers--a review of the present status of chemosensitization].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Cyclophosphamide; Doxorubicin; Etanidazole; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Design of cancer chemotherapy: tailored sensitivity assays.
Topics: Animals; Antineoplastic Agents; Body Weight; Chlorambucil; Melphalan; Nitrogen Mustard Compounds; Organ Size; Rats; Thiotepa; Uracil Mustard | 1980 |
Chemically induced leukemia in humans.
Topics: Benzene; Chlorambucil; Chloramphenicol; Cyclophosphamide; Humans; Leukemia; Melphalan; Phenylbutazone; Procarbazine; Thiotepa | 1981 |
[New trends in treatment of ovarian carcinoma (author's transl)].
Topics: Carcinoma; Chlorambucil; Cyclophosphamide; Cystadenocarcinoma; Female; Humans; Melphalan; Mesonephroma; Neoplasm Staging; Ovarian Neoplasms; Prognosis; Thiotepa | 1982 |
Membrane transport of alkylating agents.
Topics: Alkylating Agents; Animals; Biological Transport, Active; Chemical Phenomena; Chemistry; Chlorambucil; Diffusion; Drug Resistance; Humans; Kinetics; Melphalan; Membranes; Nitrogen Mustard Compounds | 1980 |
[Chemotherapy of multiple myeloma. Review of the recent trials].
Topics: Antineoplastic Agents; Azathioprine; Carmustine; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Humans; Melphalan; Multiple Myeloma; Prednisone; Procarbazine; Vincristine | 1981 |
[Current theories on the possibilities of treatment of amyloidosis].
Topics: Amyloidosis; Chlorambucil; Colchicine; Dimethyl Sulfoxide; Humans; Melphalan | 1981 |
DNA damage and mutagenesis induced by nitrogen mustards.
Topics: Animals; Base Sequence; Chlorambucil; Cyclophosphamide; DNA; DNA Damage; DNA Repair; Humans; Mechlorethamine; Melphalan; Molecular Sequence Data; Mutagenesis; Nitrogen Mustard Compounds; Phosphoramide Mustards | 1994 |
[Resistance associated with the glutathione system].
Topics: Alkylating Agents; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Drug Resistance, Multiple; Glutathione; Glutathione Transferase; Humans; Melphalan; Mitoxantrone; Nitrosourea Compounds | 1994 |
Pharmacokinetics of alkylating agents.
Topics: Alkylating Agents; Carmustine; Chlorambucil; Cyclophosphamide; Humans; Ifosfamide; Lomustine; Melphalan; Neoplasms; Nitrosourea Compounds; Organophosphorus Compounds; Thiotepa | 1993 |
Small-molecule based delivery systems for alkylating antineoplastic compounds.
Topics: Antineoplastic Agents, Alkylating; Benzimidazoles; Chlorambucil; Dipeptidases; Distamycins; DNA; Drug Delivery Systems; Enzyme Inhibitors; Melphalan; Prodrugs; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2008 |
10 trial(s) available for chlorambucil and melphalan
| Article | Year |
|---|---|
Primary treatment of advanced ovarian adenocarcinoma, stages III and IV.
Topics: Adenocarcinoma; Alkylating Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Ovarian Neoplasms; Thiotepa | 1975 |
Treatment of myeloma. Comparison of melphalan, chlorambucil, and azathioprine.
Topics: Azathioprine; Blood Urea Nitrogen; Bone Neoplasms; Chlorambucil; Drug Therapy, Combination; Fluoxymesterone; Humans; Melphalan; Multiple Myeloma; Prednisone; Remission, Spontaneous; Risk; Time Factors | 1975 |
Advances in chemotherapy for gynecologic cancer.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Middle Aged; Ovarian Neoplasms; Pelvic Neoplasms; Sarcoma; Teratoma; Vincristine | 1975 |
Leukemia following chemotherapy for ovarian cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Case-Control Studies; Chlorambucil; Combined Modality Therapy; Cyclophosphamide; Female; Humans; Leukemia; Melphalan; Multicenter Studies as Topic; Neoplasms, Multiple Primary; Ovarian Neoplasms; Registries; Risk Factors; Thiotepa | 1990 |
A randomized trial comparing chlorambucil plus prednisone vs cyclophosphamide, melphalan, and prednisone in the treatment of chronic lymphocytic leukemia stages B and C.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Melphalan; Middle Aged; Neoplasm Staging; Prednisone; Random Allocation; Spain | 1988 |
Prednimustine in advanced breast cancer: a review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Drug Evaluation; Female; Fluorouracil; Humans; Leukocyte Count; Melphalan; Methotrexate; Prednimustine; Time Factors | 1986 |
Acute nonlymphocytic leukemia after therapy with alkylating agents for ovarian cancer: a study of five randomized clinical trials.
Topics: Acute Disease; Adult; Aged; Alkylating Agents; Animals; Chlorambucil; Clinical Trials as Topic; Female; Humans; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Melphalan; Middle Aged; Ovarian Neoplasms; Random Allocation; Risk | 1982 |
Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Chlorambucil; Cyclophosphamide; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Fatal Outcome; Female; Humans; Ifosfamide; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Melphalan; Methylprednisolone; Middle Aged; Neoplastic Stem Cells; Palliative Care; Pilot Projects; Prednisolone; Prednisone; Remission Induction; Staining and Labeling; Survival Analysis; Treatment Outcome; Tumor Cells, Cultured; Vidarabine; Vinca Alkaloids; Vincristine | 1995 |
Early stem cell transplantation for chronic lymphocytic leukaemia: a chance for cure?
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chlorambucil; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dexamethasone; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Fluorouracil; Follow-Up Studies; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Hydrocortisone; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Melphalan; Methotrexate; Methylprednisolone; Middle Aged; Mitomycins; Prednisone; Prospective Studies; Treatment Outcome; Vincristine | 1998 |
Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chlorambucil; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Etoposide; Female; Germany; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Male; Melphalan; Middle Aged; Mitoxantrone; Prednisolone; Prednisone; Prospective Studies; Survival Rate; Treatment Outcome; Vincristine | 2007 |
170 other study(ies) available for chlorambucil and melphalan
| Article | Year |
|---|---|
Antineoplastic agents. 1. N-Protected vinyl, 1,2-dihaloethyl, and cyanomethyl esters of phenylalanine.
Topics: Acetonitriles; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Lethal Dose 50; Leukemia, Experimental; Male; Mice; Mice, Inbred DBA; Phenylalanine; Rats; Vinyl Compounds | 1977 |
Antineoplastic agents. 2. Structure-activity studies on N-protected vinyl, 1,2-dibromoethyl, and cyanomethyl esters of several amino acids.
Topics: Acetonitriles; Amino Acids; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Lethal Dose 50; Leukemia, Experimental; Mice; Structure-Activity Relationship; Vinyl Compounds | 1977 |
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
Synthesis and in vitro evaluation of quaternary ammonium derivatives of chlorambucil and melphalan, anticancer drugs designed for the chemotherapy of chondrosarcoma.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Chondrosarcoma; Drug Screening Assays, Antitumor; Humans; Melanoma; Melphalan; Mice; Quaternary Ammonium Compounds; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2002 |
Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin.
Topics: Antineoplastic Agents; Binding Sites; Chlorambucil; DNA Adducts; Drug Design; Hydrolysis; Magnetic Resonance Spectroscopy; Melphalan; Models, Molecular; Molecular Structure; Nitrogen Mustard Compounds; Protein Structure, Tertiary; Taq Polymerase; Zinostatin | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells.
Topics: Animals; Antineoplastic Agents; Benzopyrans; Cell Survival; Drug Design; Drug Screening Assays, Antitumor; Fibroblasts; Humans; Injections, Intraperitoneal; Leukemia L1210; Mice; Models, Molecular; Molecular Structure; Neoplasms; Neurons; Structure-Activity Relationship; Survival Rate; T-Lymphocytes; Tumor Cells, Cultured | 2008 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates.
Topics: | 2014 |
Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents.
Topics: Antineoplastic Agents, Alkylating; Boronic Acids; Cell Line, Tumor; Drug Design; Esters; Humans; Hydrogen Peroxide; Nitrogen Mustard Compounds | 2018 |
Treatment of melanoma by passive humoral immunotherapy using antibody drug synergism.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Synergism; Goats; Humans; Immunoglobulins; Immunotherapy; Melanoma; Melphalan; Neoplasm Metastasis; Nitrogen Mustard Compounds; Skin Neoplasms; Vincristine | 1977 |
[Chemotherapy as an adjuvant treatment in breast cancer (author's transl)].
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Fluorouracil; Humans; Melphalan; Methotrexate; Thiotepa | 1978 |
The carcinogenic properties of some of the principal drugs used in clinical cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Carcinogens; Chlorambucil; Cyclophosphamide; Dacarbazine; Dactinomycin; Diethylnitrosamine; Female; Humans; Male; Melphalan; Mice; Mitobronitol; Mitolactol; Mitomycins; Neoplasms, Experimental; Nitrogen Mustard Compounds; Picolinic Acids; Procarbazine; Rats; Streptozocin; Uracil Mustard | 1975 |
In vitro immunosuppressive effects of cytotoxic agents conjugated to antihuman lymphocyte globulin.
Topics: Antilymphocyte Serum; Chlorambucil; Cytotoxicity, Immunologic; Humans; Immunosuppressive Agents; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Melphalan; Polyglutamic Acid | 1978 |
Adenosine 3',5'-monophosphate phosphodiesterase activity in experimental animal tumours which are either sensitive or resistant to bifunctional alkylating agents.
Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Cells, Cultured; Chlorambucil; Cyclic AMP; Drug Resistance; Electrophoresis; Female; Kinetics; Lymphoma; Male; Melphalan; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Phosphoric Diester Hydrolases; Plasmacytoma; Rats; Time Factors; Transplantation, Homologous | 1975 |
Serum beta-lipoprotein and other specific protein concentrations in patients with immunocytoma.
Topics: Aged; Blood Protein Electrophoresis; Blood Proteins; Chlorambucil; Cholesterol; Female; Follow-Up Studies; Hemoglobinometry; Humans; Immunodiffusion; Lipoproteins, LDL; Male; Melphalan; Middle Aged; Multiple Myeloma; Paraproteinemias; Prednisolone; Ultracentrifugation; Waldenstrom Macroglobulinemia | 1976 |
[Evolutionary aspects of the picture of pulmonary pathology in the course of chronic blood diseases (a correlation with cytostatic treatment)].
Topics: Adult; Aged; Antineoplastic Agents; Busulfan; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Melphalan; Middle Aged; Multiple Myeloma; Pleural Effusion; Pulmonary Fibrosis | 1979 |
Cyclophosphamide inhibited B cell receptor regeneration as a basis for drug-induced tolerance;.
Topics: Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; Chlorambucil; Cyclophosphamide; Female; Immune Tolerance; Immunologic Capping; Male; Melphalan; Mice; Receptors, Antigen, B-Cell; Spleen; Time Factors | 1978 |
Acute leukemia after alkylating-agent therapy of ovarian cancer.
Topics: Acute Disease; Alkylating Agents; Altretamine; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Melphalan; Middle Aged; Neoplasm Metastasis; Ovarian Neoplasms; Risk; Thiotepa; Time Factors; Uracil Mustard | 1977 |
[Chemotherapy of the ovarian carcinoma (author's transl)].
Topics: Altretamine; Antineoplastic Agents; Chlorambucil; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Hydroxyprogesterones; Mechlorethamine; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; Nitrosourea Compounds; Ovarian Neoplasms; Thiotepa; Vinblastine; Vincristine | 1977 |
Non-steroidal anti-inflammatory drugs and cytotoxics.
Topics: Animals; Bone Marrow; Carcinoma 256, Walker; Chlorambucil; Digestive System; Flurbiprofen; Indomethacin; Melphalan; Mice; Propionates; Rats | 1979 |
Residual marrow injury following cytotoxic drugs.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Chlorambucil; Dacarbazine; Doxorubicin; Female; Granulocytes; Hematopoietic Stem Cells; Mechlorethamine; Melphalan; Mice; Mice, Inbred BALB C; Mitomycins | 1979 |
[Relationship of labeled molecules in the pharmacokinetic study of alkylating agents (chlorambucil, melphalan, mitoclomine) and glycosyl nitrosoureas (RFCNU and RPCNU)].
Topics: 1-Naphthylamine; Alkylating Agents; Carbon Radioisotopes; Chlorambucil; Humans; Kinetics; Melphalan; Nitrogen Mustard Compounds; Nitrosourea Compounds | 1979 |
Myeloproliferative diseases.
Topics: Adult; Aged; Chlorambucil; Female; Humans; Male; Melphalan; Middle Aged; Myeloproliferative Disorders; Phosphorus Radioisotopes; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential | 1977 |
Response of generalized granuloma annulare to alkylating agents.
Topics: Aged; Alkylating Agents; Chlorambucil; Female; Granuloma; Humans; Male; Melphalan; Middle Aged; Prednisone; Skin Diseases | 1978 |
[Results of treatment of autoimmune hemolytic anemias].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Alkylating Agents; Anemia, Hemolytic, Autoimmune; Azathioprine; Chlorambucil; Cyclophosphamide; Drug Evaluation; Female; Follow-Up Studies; Humans; Male; Melphalan; Middle Aged; Prednisone; Splenectomy | 1978 |
Treatment of epithelial carcinoma of the ovary: operation, irradiation, and chemotherapy.
Topics: Abdomen; Castration; Chlorambucil; Cyclophosphamide; Fallopian Tubes; Female; Humans; Hysterectomy; Melphalan; Middle Aged; Ovarian Neoplasms; Pelvis; Prognosis; Prospective Studies | 1977 |
[Results of plasmacytoma therapy].
Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Melphalan; Middle Aged; Plasmacytoma; Prognosis; Remission, Spontaneous | 1976 |
The role of drug transport in resistance to nitrogen mustard and other alkylating agents in L518Y lymphoblsts.
Topics: Alkylating Agents; Animals; Binding, Competitive; Biological Transport; Carmustine; Cell Line; Chlorambucil; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Resistance; Female; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mechlorethamine; Melphalan; Mice; Mice, Inbred DBA; Mitomycins | 1975 |
Sequential therapy for advanced ovarian adenocarcinoma: operation, chemotherapy, second-look laparotomy, and radiation therapy.
Topics: Adenocarcinoma; Chlorambucil; Cyclophosphamide; Dactinomycin; Female; Fluorouracil; Laparotomy; Melphalan; Neoplasm Metastasis; Neoplasm Recurrence, Local; Ovarian Neoplasms | 1975 |
Lymphocyte transformation in patients with paraproteinaemia.
Topics: Chlorambucil; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Lymphocyte Activation; Melphalan; Paraproteinemias; Prednisolone; Time Factors | 1975 |
Immunochemical and clinical effects of immunosuppressive treatment in monoclonal IgM neuropathy.
Topics: Adult; Aged; Blood Proteins; Chlorambucil; Demyelinating Diseases; Drug Therapy, Combination; Female; Humans; Immunoglobulin M; Immunoglobulins; Immunosuppressive Agents; Male; Melphalan; Middle Aged; Monoclonal Gammopathy of Undetermined Significance; Myelin Proteins; Myelin-Associated Glycoprotein; Neurologic Examination; Peripheral Nerves; Polyradiculoneuropathy; Prednisolone; Synaptic Transmission | 1992 |
Melphalan, a second chemical for which specific-locus mutation induction in the mouse is maximum in early spermatids.
Topics: Animals; Chlorambucil; Female; Fertility; Injections, Intraperitoneal; Male; Melphalan; Mice; Mice, Inbred C3H; Mutagenicity Tests; Mutagens; Spermatids; Survival Analysis | 1992 |
Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Survival; Chlorambucil; DNA; Drug Interactions; Drug Resistance; Glutathione; Glutathione Transferase; Mammary Neoplasms, Experimental; Mechlorethamine; Melphalan; Methionine Sulfoximine; Rats; RNA, Messenger; Tumor Cells, Cultured | 1992 |
Carcinogenic potency of alkylating agents in rodents and humans.
Topics: Animals; Carcinogenicity Tests; Chlorambucil; Cyclophosphamide; Humans; Melphalan; Mice; Neoplasms, Second Primary; Rats | 1992 |
The cytotoxicity, DNA crosslinking ability and DNA sequence selectivity of the aniline mustards melphalan, chlorambucil and 4-[bis(2-chloroethyl)amino] benzoic acid.
Topics: 4-Aminobenzoic Acid; Alkylation; Binding Sites; Cell Survival; Chlorambucil; Cross-Linking Reagents; DNA; Humans; Melphalan; Nitrogen Mustard Compounds; para-Aminobenzoates; Tumor Cells, Cultured | 1992 |
Thermolabile adenine adducts and A.T base pair substitutions induced by nitrogen mustard analogues in an SV40-based shuttle plasmid.
Topics: Adenine Nucleotides; Alkylating Agents; Base Composition; Base Sequence; Chlorambucil; Genetic Vectors; Hot Temperature; Mechlorethamine; Melphalan; Molecular Sequence Data; Mutagenesis; Plasmids; Simian virus 40; Thymine Nucleotides | 1991 |
Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers.
Topics: Alkylating Agents; Animals; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma 256, Walker; Carmustine; Cell Division; Cell Line; Chlorambucil; Cisplatin; Drug Antagonism; Drug Resistance; Glutathione Transferase; Gossypol; Humans; In Vitro Techniques; Isomerism; Melphalan; Methionine Sulfoximine; Rats | 1991 |
Relationship between glutathione levels and drug or radiation sensitivities in human gastric cancer cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Chlorambucil; Cyclophosphamide; Doxorubicin; Drug Resistance; Fluorouracil; Glutathione; Humans; Melphalan; Radiation Tolerance; Semustine; Stomach Neoplasms; Tumor Cells, Cultured | 1991 |
Determinants of drug response in a cisplatin-resistant human lung cancer cell line.
Topics: Adenocarcinoma; Blotting, Northern; Cell Survival; Chlorambucil; Cisplatin; Drug Resistance; Glutathione Transferase; Humans; Lung Neoplasms; Melphalan; Nimustine; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1990 |
Genetic toxicity of six carcinogens and six non-carcinogens in the Drosophila wing spot test.
Topics: Aminobiphenyl Compounds; Amitrole; Animals; Arsenates; Arsenic; Arsenites; Carcinogens; Chlorambucil; Drosophila melanogaster; Genes, Recessive; Melphalan; Mutagenicity Tests; Mutagens; Phenotype; Sodium Compounds | 1990 |
DNA adenine adducts induced by nitrogen mustards and their role in transcription termination in vitro.
Topics: Amino Acid Sequence; Chlorambucil; DNA; DNA Damage; Genes, myc; Mechlorethamine; Melphalan; Molecular Sequence Data; Templates, Genetic; Transcription, Genetic | 1990 |
Relationships between resistance to cross-linking agents and glutathione metabolism, aldehyde dehydrogenase isozymes and adenovirus replication in human tumour cell lines.
Topics: Adenoviruses, Human; Aldehyde Dehydrogenase; Cadmium; Cadmium Chloride; Chlorambucil; Cisplatin; Cross-Linking Reagents; Cyclophosphamide; DNA Damage; Drug Resistance; Glutathione; Humans; Isoenzymes; Melphalan; Metallothionein; Tumor Cells, Cultured; Virus Replication | 1990 |
Highly potent analogues of luteinizing hormone-releasing hormone containing D-phenylalanine nitrogen mustard in position 6.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Membrane; Chlorambucil; Female; Gonadotropin-Releasing Hormone; Humans; Luteinizing Hormone; Male; Melphalan; Molecular Sequence Data; Ovulation; Pituitary Gland; Prostatic Neoplasms; Rats; Receptors, LHRH | 1989 |
Hydrogen ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro.
Topics: Alkylating Agents; Animals; Chlorambucil; Cyclophosphamide; Hydrogen-Ion Concentration; Mammary Neoplasms, Experimental; Melphalan; Nitrogen Mustard Compounds; Rats; Structure-Activity Relationship; Tumor Stem Cell Assay | 1989 |
Transcription-terminating lesions induced by bifunctional alkylating agents in vitro.
Topics: Alkylating Agents; Alkylation; Base Sequence; Chlorambucil; Cyclophosphamide; DNA; DNA Damage; Exons; Genetic Vectors; Guanine; Humans; Mechlorethamine; Melphalan; Molecular Sequence Data; Plasmids; Proto-Oncogenes; Templates, Genetic; Transcription, Genetic | 1989 |
Concentration and time-dependent inter-relationships for cytotoxicities of nitrogen mustard drugs against lymphoblasts in-vitro.
Topics: Cell Survival; Chlorambucil; Humans; In Vitro Techniques; Lymphocytes; Melphalan; Nitrogen Mustard Compounds; Time Factors | 1988 |
[Second malignancies and cancer chemotherapy].
Topics: Antineoplastic Agents; Chlorambucil; Hodgkin Disease; Humans; Leukemia; Melphalan; Neoplasms; Risk Factors | 1989 |
Melphalan-resistant lymphoblastoid cell lines established from patients with ovarian cancer treated with cross-linking agents.
Topics: B-Lymphocytes; Cell Line; Cell Survival; Cell Transformation, Viral; Cells, Cultured; Chlorambucil; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Resistance; Female; Herpesvirus 4, Human; Humans; Melphalan; Ovarian Neoplasms; Prognosis; Time Factors | 1985 |
Comparative brain and plasma pharmacokinetics and anticancer activities of chlorambucil and melphalan in the rat.
Topics: Amino Acids; Animals; Blood Proteins; Brain; Carcinoma 256, Walker; Chlorambucil; Half-Life; Male; Melphalan; Protein Binding; Rats | 1988 |
Acute myeloid leukemia and other myelopathic disorders following treatment with alkylating agents.
Topics: Adolescent; Adult; Aged; Alkylating Agents; Anemia, Aplastic; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Female; Gastrointestinal Neoplasms; Humans; Infant; Karyotyping; Leukemia, Myeloid, Acute; Male; Melphalan; Middle Aged; Myelodysplastic Syndromes; Ovarian Neoplasms | 1987 |
The effect of dietary amino acids on the gastrointestinal absorption of melphalan and chlorambucil.
Topics: Amino Acids; Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Chlorambucil; Diet; Intestinal Absorption; Melphalan; Models, Biological; Perfusion; Rats; Statistics as Topic | 1987 |
Studies on the mechanism of gastrointestinal absorption of melphalan and chlorambucil.
Topics: 2,4-Dinitrophenol; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chlorambucil; Dinitrophenols; Hydrolysis; Intestinal Absorption; Kinetics; Melphalan; Rats; Rats, Inbred Strains | 1986 |
Sensitivity of murine B- and T-lymphocytes to oxazaphosphorine and non-oxazaphosphorine nitrogen mustards.
Topics: Animals; B-Lymphocytes; Chlorambucil; Concanavalin A; Cyclophosphamide; Lipopolysaccharides; Lymphocyte Activation; Male; Melphalan; Mice; Nitrogen Mustard Compounds; Organophosphorus Compounds; Phytohemagglutinins; T-Lymphocytes | 1985 |
Thermochemotherapy with cis-platinum, CCNU, BCNU, chlorambucil and melphalan on murine marrow and two tumours: therapeutic gain for melphalan only.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Carmustine; Chlorambucil; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Hyperthermia, Induced; Lomustine; Melphalan; Mice; Mice, Inbred C3H; Neoplasms, Experimental | 1985 |
[Cytostatic treatment of malignant testicular neoplasms].
Topics: Adult; Antibiotics, Antineoplastic; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dysgerminoma; Humans; Male; Melphalan; Methotrexate; Plicamycin; Prognosis; Teratoma; Testicular Neoplasms | 1971 |
[The combined chemotherapy of testicular tumors resistant to sarcolysin].
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Drug Synergism; Dysgerminoma; Humans; Male; Melphalan; Methotrexate; Olivomycins; Teratoma; Testicular Neoplasms | 1967 |
[Use of different modifications of human cell culture method in the study of antineoplastic antibiotics].
Topics: Agar; Antibiotics, Antineoplastic; Chlorambucil; Clone Cells; Culture Techniques; Flavonoids; HeLa Cells; Humans; Melphalan; Methods; Mitomycins; Olivomycins | 1966 |
[The influence of age and experimentally-induced disease on the tolerance of cytostatically-active materials in mice].
Topics: Age Factors; Aminopterin; Animals; Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Tolerance; Graft vs Host Disease; Immunosuppressive Agents; Leukemia; Melphalan; Mercaptopurine; Methotrexate; Mice; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Skin Transplantation; Thioguanine; Transplantation, Homologous | 1967 |
[Detection of a moderate staphylococcal phage by means of antineoplastic agents].
Topics: Aminopterin; Antibiotics, Antineoplastic; Anticholesteremic Agents; Antimetabolites; Antineoplastic Agents; Chlorambucil; Colchicine; Cyclophosphamide; Dactinomycin; Drug Resistance, Microbial; Flavonoids; Fluorouracil; Lysogeny; Mechlorethamine; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; Nitrogen Mustard Compounds; Olivomycins; Staphylococcus; Staphylococcus Phages; Thiotepa; Ultraviolet Rays; Uracil; Vinblastine; Vincristine | 1970 |
Secondary antibody deficiency syndrome in haemoblastosis.
Topics: Agammaglobulinemia; Antibodies; Antigens, Bacterial; Blood Protein Disorders; Blood Proteins; Busulfan; Chlorambucil; Electrophoresis, Paper; Hodgkin Disease; Humans; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulins; Immunosuppression Therapy; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mannomustine; Melphalan; Primary Myelofibrosis; Radiation Effects; Saliva; Skin Tests; Spleen; Time Factors | 1972 |
The growth of human tumours in immunosuppressed mice and their response to chemotherapy.
Topics: Animals; Chlorambucil; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Immunosuppression Therapy; Male; Melphalan; Methotrexate; Mice; Mice, Inbred CBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Ovarian Neoplasms; Thiotepa; Thymectomy; Transplantation, Heterologous; Triaziquone; Urinary Bladder Neoplasms; Vinblastine; Vincristine | 1974 |
Development of acute erythroleukemia in B-cell immunoproliferative disorders after prolonged therapy with alkylating drugs.
Topics: Aged; Alkylating Agents; Biopsy; Bone Marrow; Chlorambucil; Female; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Male; Melphalan; Middle Aged; Multiple Myeloma; Uracil Mustard; Waldenstrom Macroglobulinemia | 1974 |
Protection of mice against syngeneic lymphomata: II. Collaboration between drugs and antibodies.
Topics: Animals; Antibodies, Neoplasm; Antineoplastic Agents; Carcinoembryonic Antigen; Cell Line; Chlorambucil; Cyclophosphamide; Immunization, Passive; Immunodiffusion; Lymphoma; Melphalan; Mice; Mice, Inbred C57BL; Models, Biological; Neoplasms, Experimental; Rabbits; Time Factors | 1974 |
Synergistic lethal action of alkylating agents and sodium pentobarbital in the mouse.
Topics: Alkylating Agents; Animals; Atropine; Chlorambucil; Cyclophosphamide; Decamethonium Compounds; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Hexamethonium Compounds; Injections, Intraperitoneal; Injections, Intravenous; Lethal Dose 50; Male; Mechlorethamine; Melphalan; Mice; Pentobarbital; Thiotepa; Time Factors | 1974 |
Responses of freshly cultured tumour cells to certain selected chemotherapeutic agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Chlorambucil; Colchicine; Culture Techniques; Cyclophosphamide; Dactinomycin; Female; Floxuridine; Fluorouracil; Hodgkin Disease; Humans; Melphalan; Mercaptopurine; Methotrexate; Nandrolone; Neoplasms; Nitrogen Mustard Compounds; Norethindrone; Prednisolone; Progesterone; Testosterone; Thiotepa; Uterine Neoplasms; Vinblastine | 1968 |
Chemotherapy of metastatic malignant melanoma. Experience with 73 patients.
Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Eye Neoplasms; Female; Floxuridine; Humans; Hydroxyurea; Idoxuridine; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Metastasis; Nitrogen Mustard Compounds; Nitrosourea Compounds; Skin Neoplasms; Vinblastine; Vincristine; Vulvar Neoplasms | 1971 |
Cell cycle phase specificity of antitumor agents.
Topics: Alkaloids; Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carbazoles; Cell Line; Chlorambucil; Cricetinae; Cytarabine; Dactinomycin; Depression, Chemical; DNA; Fibroblasts; Floxuridine; In Vitro Techniques; Lung; Melphalan; Mitosis; Neoplasms, Experimental; Nitrosourea Compounds; Nucleosides; Protein Biosynthesis; RNA; Streptozocin; Thiosemicarbazones | 1972 |
Chemotherapy of testicular germinal tumors.
Topics: Alkylating Agents; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Dysgerminoma; Humans; Male; Mechlorethamine; Melphalan; Methotrexate; Nitrofurazone; Pharmaceutic Aids; Plicamycin; Prognosis; Testicular Neoplasms; Testis; Vincristine | 1973 |
Treatment of Sezary syndrome.
Topics: Chlorambucil; Cyclophosphamide; Dermatitis, Exfoliative; Humans; Keratoderma, Palmoplantar; Lymphatic Diseases; Lymphoma; Melphalan; Methotrexate; Nitrogen Mustard Compounds; Prednisone; Pruritus; Remission, Spontaneous; Syndrome; Time Factors; Triethylenemelamine; Vinblastine | 1974 |
Integrated therapy in the treatment of ovarian cancer with surgery, radiation and chemotherapy.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Ascites; Chlorambucil; Cobalt Isotopes; Cyclophosphamide; Cystadenocarcinoma; Dactinomycin; Endometriosis; Female; Fluorouracil; Humans; Melphalan; Ovarian Neoplasms; Radiotherapy, High-Energy; Thiotepa; Vinblastine; Vincristine | 1972 |
On the neurotoxic effects induced by alkylating agents.
Topics: Alanine; Animals; Anti-Bacterial Agents; Antimetabolites; Azaserine; Behavior, Animal; Central Nervous System; Chlorambucil; Cyclophosphamide; Cysteine; Drug Antagonism; Glycine; Male; Mannitol; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds; Phenobarbital; Phenytoin; Rats; Seizures; Spasm; Thiourea; Triethylenemelamine; Tryptophan | 1966 |
Letter: Effects of amylobarbitone on the frequency of chromosomal aberrations in human lymphocytes determined by chlorambucil and melphalan in vitro.
Topics: Amobarbital; Chlorambucil; Chromosome Aberrations; Humans; In Vitro Techniques; Lymphocytes; Melphalan | 1974 |
Letter: Effects of amylobarbitone on the frequency of chromosomal aberrations in human lymphocytes determined by chlorambucil and melphalan in vitro.
Topics: Amobarbital; Chlorambucil; Chromosome Aberrations; Humans; In Vitro Techniques; Lymphocytes; Melphalan | 1974 |
The combined effect of drugs and tumor-specific antibodies in protection against a mouse lymphoma.
Topics: Animals; Antibodies, Neoplasm; Chlorambucil; Cytarabine; Immune Sera; Immunotherapy; Lymphoma; Melphalan; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Rabbits; Time Factors | 1974 |
The effect of certain nitrogen mustard derivatives on bone marrow colony-forming units and erythroid repopulating ability. I. Rats.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chlorambucil; Depression, Chemical; Erythrocytes; Female; Hematopoietic Stem Cells; Iron Isotopes; Melphalan; Mitosis; Nitrogen Mustard Compounds; Rats; Spleen; Transplantation, Homologous | 1972 |
Survival of hematopoietic and lymphoma colony-forming cells in vivo following the administration of a variety of alkylating agents.
Topics: Alkylating Agents; Animals; Cell Line; Cell Survival; Chlorambucil; Clone Cells; Cyclophosphamide; Female; Hematopoietic Stem Cells; Lethal Dose 50; Lymphoma; Mechlorethamine; Melphalan; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Nitrosourea Compounds; Thiotepa; Triethylenemelamine | 1972 |
[Side-effects of cytostatic and immunosuppressive therapy].
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Chromosomes; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Male; Melphalan; Spermatogenesis; Thiotepa; Triaziquone | 1973 |
From bad to worse? Treatment and leukemogenesis.
Topics: Antibiotics, Antineoplastic; Busulfan; Chlorambucil; Chromosome Aberrations; Chromosome Disorders; Humans; Leukemia; Melphalan; Phosphorus Isotopes; Polycythemia Vera | 1973 |
[Choice of treatment in polycythemia vera. 1. Efficacy of chemotherapy].
Topics: Chlorambucil; Humans; Hydroxyurea; Melphalan; Phosphorus Isotopes; Polycythemia Vera; Remission, Spontaneous; Time Factors | 1973 |
Effects of amylobarbitone on the frequency of chromosomal aberrations in human lymphocytes determined by chlorambucil and melphalan in vitro.
Topics: Amobarbital; Cells, Cultured; Chlorambucil; Chromosome Aberrations; Humans; In Vitro Techniques; Lymphocytes; Melphalan | 1973 |
[Rules of current therapy in multiple myeloma].
Topics: Chlorambucil; Cyclophosphamide; Humans; Melphalan; Multiple Myeloma; Prednisone; Purpura, Hyperglobulinemic; Remission, Spontaneous; Time Factors | 1973 |
[Medical treatment of multiple myeloma].
Topics: Antineoplastic Agents; Bone Neoplasms; Chlorambucil; Humans; Melphalan; Multiple Myeloma | 1973 |
Synthesis of tritium-labeled chlorambucil and aniline mustard of high specific activity.
Topics: Aniline Compounds; Chlorambucil; Isotope Labeling; Mass Spectrometry; Melphalan; Methods; Nitrogen Mustard Compounds; Phenylbutyrates; Tritium | 1974 |
[Chemotherapy of cancer. Hints for continuing medical education].
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Cytarabine; Daunorubicin; Education, Medical, Continuing; Fluorouracil; Humans; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Procarbazine; Triaziquone; Vinblastine; Vincristine | 1974 |
Chemotherapy of ovarian cancer.
Topics: Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Female; Humans; Melphalan; Nitrogen Mustard Compounds; Ovarian Neoplasms; Thiotepa | 1967 |
[Acute new proliferation inparaproteinemic hemoblastoses during long-term treatment with cytostatic agents].
Topics: Aged; Blood Sedimentation; Chlorambucil; Cyclophosphamide; Female; Humans; Immunoelectrophoresis; Male; Melphalan; Methods; Middle Aged; Plasmacytoma; Waldenstrom Macroglobulinemia | 1968 |
Cytotoxic agents in the treatment of malignant disease.
Topics: Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Female; Fluorouracil; Hodgkin Disease; Humans; Hydrazines; Intestinal Neoplasms; Melphalan; Methotrexate; Multiple Myeloma; Ovarian Neoplasms; Pregnancy; Thiotepa; Vinblastine | 1968 |
[Paraproteinemic diseases].
Topics: Anemia, Hemolytic; Blood Protein Disorders; Chlorambucil; Cryoglobulins; Cyclophosphamide; Diagnosis, Differential; Heavy Chain Disease; Humans; Melphalan; Neoplasms; Plasmacytoma; Waldenstrom Macroglobulinemia | 1969 |
[Modern hematology. Sidero-achrestic anemias, polyglobulias, chemotherapy].
Topics: Adenoma; Adolescent; Adult; Aged; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Sideroblastic; Blood Protein Disorders; Chlorambucil; Female; Hemoglobinometry; Humans; Immunosuppressive Agents; Kidney Neoplasms; Leukemia; Lupus Erythematosus, Systemic; Male; Melphalan; Multiple Myeloma; Polycythemia; Pyridoxine; Waldenstrom Macroglobulinemia | 1971 |
[Role of chemotherapy in the treatment of malignant ovarian tumors].
Topics: Ambulatory Care; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Drug Combinations; Estrogens; Female; Hospitalization; Humans; Melphalan; Methotrexate; Ovarian Neoplasms; Prognosis; Remission, Spontaneous; Thiotepa; Triaziquone | 1971 |
[Hair changes in immunosuppressive therapy].
Topics: Antineoplastic Agents; Azathioprine; Chlorambucil; Cyclophosphamide; Hair; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Scleroderma, Systemic; Skin Diseases; Vinblastine | 1971 |
[Chemotherapy of malignant testicular tumors].
Topics: Chlorambucil; Dactinomycin; Drug Synergism; Humans; Male; Melphalan; Methotrexate; Oral Manifestations; Testicular Neoplasms | 1971 |
Evidence for a transport carrier of nitrogen mustard in nitrogen mustard-sensitive and -resistant L5178Y lymphoblasts.
Topics: Biological Transport, Active; Carbon Isotopes; Cell Line; Chlorambucil; Culture Techniques; Cyclophosphamide; Kinetics; Lymphocytes; Mechlorethamine; Melphalan; Nitrophenols; Ouabain; Protein Binding | 1970 |
[A further case of alpha chain disease in a Eurasian].
Topics: Adrenal Cortex Hormones; Adult; Age Factors; Blood Protein Disorders; Chlorambucil; Humans; Immunity, Cellular; Immunoelectrophoresis; Immunoglobulin G; Immunoglobulins; Intestinal Absorption; Intestine, Small; Jejunum; Lymphoma; Malabsorption Syndromes; Male; Melphalan; Microscopy, Electron; Racial Groups; Saliva | 1970 |
The selectivity of action of alkylating agents and drug resistance. 3. The uptake and degradation of alkylating drugs by Yoshida ascites sarcoma cells in vitro.
Topics: Animals; Busulfan; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Chlorambucil; Culture Techniques; Hydrolysis; Melphalan; Rats; Sarcoma, Yoshida; Solvents; Time Factors | 1970 |
[A method of primary selection of antitumor agents].
Topics: Adenocarcinoma; Animals; Carcinoma 256, Walker; Chlorambucil; Cyclophosphamide; Melphalan; Mercaptopurine; Mice; Neoplasms, Experimental; Sarcoma, Experimental | 1971 |
Factors determining cell killing by chemotherapeutic agents in vivo. II. Melphalan, chlorambucil and nitrogen mustard.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Survival; Chlorambucil; Cyclophosphamide; DNA; Female; Hematopoietic Stem Cells; Male; Mechlorethamine; Melphalan; Mice; Spleen | 1971 |
Chemotherapy of Hodgkin's disease, lymphoma, and leukemia.
Topics: Adult; Antineoplastic Agents; Busulfan; Chlorambucil; Hodgkin Disease; Humans; Leukemia; Lymphoma; Male; Mechlorethamine; Melphalan; Vinblastine | 1968 |
The selectivity of action of alkylating agents and drug resistance. I. Biochemical changes occurring in sensitive and resistant strains of the Yoshida ascites sarcoma following chemotherapy.
Topics: Animals; Busulfan; Chlorambucil; DNA; Female; Glutamates; Glutathione; Glycine; Melphalan; Neoplasm Proteins; Neoplasm Transplantation; Rats; RNA; Sarcoma, Yoshida; Transplantation, Homologous | 1969 |
The selectivity of action of alkylating agents and drug resistance. II. A comparison of the effects of alkylating drugs on growth inhibition and cell size in sensitive and resistant strains of the Yoshida ascites sarcoma.
Topics: Animals; Busulfan; Cell Division; Chlorambucil; Female; Growth; Lymphocytes; Macrophages; Melphalan; Neoplasm Transplantation; Neutrophils; Rats; Sarcoma, Yoshida; Transplantation, Homologous | 1969 |
Transplantable mouse plasma cell tumors in experimental chemotherapy.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Blood Protein Electrophoresis; Blood Proteins; Chlorambucil; Cyclophosphamide; Erythrocyte Count; Female; Fluorouracil; Hemoglobinometry; Humans; Leukocyte Count; Melphalan; Mercaptopurine; Methods; Methotrexate; Mice; Models, Biological; Mustard Compounds; Neoplasm Transplantation; Neoplasms, Experimental; Peritoneum; Plasma Cells; Plasmacytoma; Time Factors; Transplantation, Homologous; Triethylenemelamine | 1969 |
Reaction mechanism of some aromatic nitrogen mustards.
Topics: Azirines; Chemical Phenomena; Chemistry; Chlorambucil; Kinetics; Mechlorethamine; Melphalan; Mercaptoethanol; Solutions | 1967 |
Disseminated melanoma. Biologic behavior and treatment.
Topics: Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Fluorouracil; Humans; Hydrazines; Hydroxyurea; Lymph Node Excision; Lymphatic Metastasis; Melanoma; Melphalan; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Perfusion; Vincristine | 1967 |
[Therapy of plasmocytoma].
Topics: Anemia; Blood Protein Disorders; Chlorambucil; Humans; Hypercalcemia; Leukopenia; Melphalan; Plasmacytoma; Thrombocytopenia | 1967 |
Long-term survival of patients with Burkitt's lymphoma: an assessment of treatment and other factors which may relate to survival.
Topics: Adolescent; Antineoplastic Agents; Burkitt Lymphoma; Busulfan; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Cytarabine; Female; Humans; Immunotherapy; Infant; Kenya; Male; Mannitol; Melphalan; Methotrexate; Nitrogen Mustard Compounds; Nitroso Compounds; Urea | 1967 |
Characteristics of secondary acute nonlymphocytic leukemias. Cytological aspects (a review).
Topics: Alkylating Agents; Cell Differentiation; Chlorambucil; Combined Modality Therapy; Cyclophosphamide; Esterases; Humans; Leukemia; Leukemia, Radiation-Induced; Melphalan; Peroxidases | 1984 |
Modification by WR 2721 of the response to chemotherapy of tumours and normal tissues in the mouse.
Topics: Amifostine; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cyclophosphamide; Female; Leukocyte Count; Lomustine; Male; Melphalan; Mice; Mice, Inbred C3H; Organothiophosphorus Compounds; Sarcoma, Experimental | 1983 |
Plasma cell leukemia: a report on three patients.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Female; Humans; Leukemia, Plasma Cell; Male; Melphalan; Middle Aged; Multiple Myeloma; Prednisone; Time Factors; Vincristine; Whole-Body Irradiation | 1983 |
[Therapy of malignant gammopathies].
Topics: Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Humans; Hypergammaglobulinemia; Melphalan; Multiple Myeloma; Nitrosourea Compounds; Orthopedic Equipment; Paraproteins; Plasmacytoma; Prednisone; Prognosis; Vincristine; Waldenstrom Macroglobulinemia | 1984 |
The chemotherapy of granulosa cell tumors of the ovary: experience of the Wisconsin Clinical Cancer Center.
Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Granulosa Cell Tumor; Humans; Melphalan; Methotrexate; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Prednisone; Retrospective Studies; Vincristine | 1984 |
Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines.
Topics: Caffeine; Cell Line; Cell Survival; Chlorambucil; DNA, Neoplasm; Drug Resistance; Drug Synergism; Hot Temperature; Humans; Kinetics; Mechlorethamine; Melanoma; Melphalan; Methyl Methanesulfonate; Thymidine | 1984 |
Myelosuppression in polycythemia vera: chemotherapy or radiotherapy?
Topics: Bone Marrow; Busulfan; Chlorambucil; Cyclophosphamide; Humans; Melphalan; Phosphorus Radioisotopes; Polycythemia Vera | 1982 |
Effects of alkylating agents on the DNA replication of cultured Yoshida sarcoma cells.
Topics: Alkylating Agents; Animals; Carmustine; Cell Division; Cell Survival; Chlorambucil; Cyclophosphamide; DNA Replication; Doxorubicin; Kinetics; Mechlorethamine; Melphalan; Mice; Sarcoma, Yoshida; Structure-Activity Relationship | 1982 |
Effect of misonidazole or metronidazole pretreatment on the response of the RIF-1 mouse sarcoma to melphalan, cyclophosphamide, chlorambucil and CCNU.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chlorambucil; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Female; Lethal Dose 50; Leukocyte Count; Lomustine; Male; Melphalan; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1982 |
[Malignant lymphoma in a case of disseminated lupus erythematosus treated with cytotoxic agents].
Topics: Adult; Chlorambucil; Female; Humans; Lupus Erythematosus, Systemic; Lymphoma; Melphalan | 1982 |
Interactions of cytotoxic and anti-inflammatory agents on normal and neoplastic tissue.
Topics: Animals; Carcinoma 256, Walker; Cell Survival; Chlorambucil; Flurbiprofen; Hematopoietic Stem Cells; Indomethacin; Melphalan; Mice; Propionates | 1980 |
Comparative pharmacokinetics of chlorambucil and melphalan in man.
Topics: Biotransformation; Chlorambucil; Humans; Kinetics; Melphalan | 1980 |
Comparative physico-chemical properties, biological effects, and disposition in mice of four nitrogen mustards.
Topics: 1-Naphthylamine; Alkylation; Animals; Chemical Phenomena; Chemistry; Chlorambucil; DNA, Neoplasm; Hydrolysis; In Vitro Techniques; Melphalan; Mice; Moloney murine leukemia virus; Nitrogen Mustard Compounds; Phenylacetates; Sarcoma, Experimental | 1980 |
Nitrogen mustard drug resistant B-cell chronic lymphocytic leukemia as an in vivo model for crosslinking agent resistance.
Topics: B-Lymphocytes; Chlorambucil; Cisplatin; Cross-Linking Reagents; DNA Adducts; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Humans; Inactivation, Metabolic; Leukemia, Lymphocytic, Chronic, B-Cell; Melphalan; Methyl Methanesulfonate; Mitomycin; Nitrogen Mustard Compounds; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1995 |
Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death.
Topics: Alkylating Agents; Apoptosis; Camptothecin; Cell Death; Cell Line; Chlorambucil; Dactinomycin; DNA; Glutathione; Humans; Melphalan; Necrosis | 1994 |
Expression of a rat glutathione-S-transferase complementary DNA in rat mammary carcinoma cells: impact upon alkylator-induced toxicity.
Topics: Alkylating Agents; Animals; Biological Transport; Cell Line; Cell Nucleus; Chlorambucil; Cisplatin; DNA, Complementary; Gene Expression; Genetic Vectors; Glutathione Transferase; Macromolecular Substances; Mammary Neoplasms, Experimental; Mechlorethamine; Melphalan; Rats; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice.
Topics: Animals; Antineoplastic Agents, Alkylating; Chlorambucil; Female; Genes, Dominant; Genes, Lethal; Germ-Line Mutation; Male; Melphalan; Mice; Mutagenicity Tests; Mutagens; Pregnancy; Spermatids; Translocation, Genetic | 1995 |
Dose-response relationships of cytotoxicity, PFC response and histology in the spleen in rats treated with alkylating agents.
Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Cell Count; Cell Survival; Chlorambucil; Cyclophosphamide; Dose-Response Relationship, Drug; Hemolytic Plaque Technique; Immune System; Injections, Intravenous; Male; Mechlorethamine; Melphalan; Organ Size; Rats; Rats, Inbred F344; Sensitivity and Specificity; Spleen | 1996 |
Excision of DNA adducts of nitrogen mustards by bacterial and mammalian 3-methyladenine-DNA glycosylases.
Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; Chlorambucil; DNA Adducts; DNA Glycosylases; Escherichia coli; Guanine; Humans; Mechlorethamine; Melphalan; Molecular Sequence Data; N-Glycosyl Hydrolases; Rats | 1996 |
Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Topics: Acute Disease; Anemia, Refractory, with Excess of Blasts; Busulfan; Cell Transformation, Neoplastic; Chlorambucil; Cohort Studies; Disease Progression; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Hydroxyurea; Incidence; Interferon-alpha; Leukemia; Leukemia, Radiation-Induced; Male; Melphalan; Middle Aged; Phlebotomy; Phosphorus Radioisotopes; Polycythemia Vera; Preleukemia; Primary Myelofibrosis; Retrospective Studies; Ribonucleotide Reductases; Risk; Thrombocythemia, Essential | 1996 |
Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells.
Topics: Antineoplastic Agents; Arsenites; ATP-Binding Cassette Transporters; Base Sequence; Cadmium; Carrier Proteins; Cell Division; Chlorambucil; Cisplatin; DNA Primers; Drug Resistance, Multiple; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione; HL-60 Cells; Humans; Kinetics; Melphalan; Membrane Transport Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Zinc | 1996 |
The 5'-GNC preference for mustard cross-linking is preserved in a restriction fragment.
Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; Chlorambucil; Cross-Linking Reagents; Deoxyribonuclease EcoRI; DNA; DNA Damage; Mechlorethamine; Melphalan; Molecular Sequence Data; Nitrogen Mustard Compounds; Oligodeoxyribonucleotides; Structure-Activity Relationship; Substrate Specificity; Xenopus | 1996 |
Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Alkylating; Biological Transport, Active; Buthionine Sulfoximine; Cell Membrane; Chlorambucil; CHO Cells; Cricetinae; DNA-Binding Proteins; Drug Resistance; Glutathione; HeLa Cells; Humans; Leukotriene C4; Mass Spectrometry; Melphalan; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; MutS Homolog 3 Protein; Sequence Alignment; Tumor Cells, Cultured | 1998 |
Effect of nucleosome structure on DNA interstrand cross-linking reactions.
Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; Chlorambucil; Cross-Linking Reagents; DNA, Ribosomal; Mechlorethamine; Melphalan; Molecular Sequence Data; Nitrogen Mustard Compounds; Nucleosomes; RNA, Ribosomal, 5S; Xenopus | 1998 |
Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG).
Topics: 3-Iodobenzylguanidine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Antineoplastic Agents; Cell Division; Cell Survival; Chlorambucil; Chromium Radioisotopes; Doxorubicin; Drug Synergism; Edetic Acid; Glucose; Guanidines; Hydrogen-Ion Concentration; Kidney; Leukemia L1210; Melphalan; Mice; Mitomycin; Tumor Cells, Cultured | 1999 |
High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Child; Child, Preschool; Chlorambucil; Cohort Studies; Combined Modality Therapy; Cytarabine; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Incidence; Infant; Leukemia, Myeloid; Life Tables; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Myelodysplastic Syndromes; Neoplasms, Second Primary; Podophyllotoxin; Prednisolone; Prednisone; Procarbazine; Retrospective Studies; Risk; Salvage Therapy; Vinblastine; Vincristine | 1999 |
Molecular dynamics simulation of metallothionein-drug complexes.
Topics: Binding Sites; Chemical Phenomena; Chemistry, Physical; Chlorambucil; Computer Simulation; Crystallography, X-Ray; Cysteine; Mechlorethamine; Melphalan; Metallothionein; Models, Structural; Nitrogen Mustard Compounds; Protein Binding; Zinc | 2000 |
Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity.
Topics: Antineoplastic Agents, Alkylating; ATP-Binding Cassette Transporters; Chlorambucil; Drug Resistance; Female; Glutathione; Glutathione Transferase; Humans; Isoenzymes; Kinetics; Melphalan; Multidrug Resistance-Associated Proteins; Tumor Cells, Cultured | 2001 |
Antibody recognition of melphalan adducts characterized using immobilized DNA: enhanced alkylation of G-Rich regions in cells compared to in vitro.
Topics: Alkylation; Animals; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Base Sequence; Cattle; Chlorambucil; Cross-Linking Reagents; DNA; DNA Adducts; Drug Stability; Enzyme-Linked Immunosorbent Assay; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Melphalan; Molecular Sequence Data | 2001 |
Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents.
Topics: 3T3 Cells; Alkylating Agents; Animals; Antimony; Blotting, Southern; Cells, Cultured; Chlorambucil; Cisplatin; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Fibroblasts; Flow Cytometry; Friend murine leukemia virus; Genetic Therapy; Genetic Vectors; Genome, Viral; Glutamate-Cysteine Ligase; Glutathione; Hematopoietic Stem Cells; Humans; Inhibitory Concentration 50; Male; Melphalan; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Multidrug Resistance-Associated Proteins; Retroviridae; RNA; RNA, Messenger; Terminal Repeat Sequences; Transduction, Genetic; Viral Envelope Proteins | 2001 |
Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin.
Topics: Binding Sites; Chlorambucil; Cyclophosphamide; Cysteine; Drug Monitoring; Humans; In Vitro Techniques; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds; Protein Binding; Serum Albumin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
Expression of rat liver glutathione-S-transferase GSTA5 in cell lines provides increased resistance to alkylating agents and toxic aldehydes.
Topics: Aldehydes; Alkylating Agents; Animals; Cell Line; Cell Survival; Chlorambucil; Cricetinae; Glutathione Transferase; Isoenzymes; Lipid Peroxidation; Liver; Melphalan; Pyruvaldehyde; Rats | 2002 |
Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Cycle; Cell Division; Chlorambucil; CHO Cells; Cricetinae; Enzyme Inhibitors; Guanine; Melphalan; O(6)-Methylguanine-DNA Methyltransferase; Phosphoramide Mustards | 2001 |
Allergic contact dermatitis from melphalan and chlorambucil: cross-sensitivity or cosensitization?
Topics: Adult; Allergens; Chlorambucil; Cross Reactions; Dermatitis, Allergic Contact; Dermatitis, Occupational; Diagnosis, Differential; Facial Dermatoses; Humans; Male; Medical Laboratory Personnel; Melphalan; Patch Tests | 2002 |
CHEMOTHERAPY IN RETICULOSES.
Topics: Chlorambucil; Cyclophosphamide; Genetic Diseases, X-Linked; Hodgkin Disease; Humans; Leukemia, Hairy Cell; Lymphatic Diseases; Melphalan; Nitrogen Mustard Compounds; Peptide Nucleic Acids; Prednisolone; Prednisone; Severe Combined Immunodeficiency; Thiotepa | 1963 |
MELPHALAN THERAPY IN MYELOMATOSIS.
Topics: Chlorambucil; Erythrocyte Count; Geriatrics; Humans; Melphalan; Multiple Myeloma; Prognosis; Proteins; Serum Globulins; Statistics as Topic; Urethane; Waldenstrom Macroglobulinemia | 1964 |
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES].
Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Dactinomycin; Fibrosarcoma; Fluoresceins; Humans; Infusions, Parenteral; Injections, Intra-Arterial; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Melphalan; Neoplasms; Pharmacology; Thiotepa; Toxicology | 1963 |
CURRENT STATUS OF CHEMOTHERAPY OF CANCER.
Topics: Alkylating Agents; Anti-Bacterial Agents; Antineoplastic Agents; Black People; Chemotherapy, Cancer, Regional Perfusion; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Dermatologic Agents; DNA; DNA, Neoplasm; Fluorouracil; Geriatrics; Humans; Mechlorethamine; Melphalan; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Pharmacology; Thiotepa; Toxicology; Triethylenemelamine; Vinblastine; Vincristine | 1964 |
INFLUENCE OF SOME ANTITUMOR DRUGS ON BODY AND ORGANS GROWTH IN RATS.
Topics: Adrenal Glands; Antineoplastic Agents; Body Weight; Bone and Bones; Brain; Chlorambucil; Diaphragm; Esophagus; Gastrointestinal Tract; Growth; Heart; Humans; Kidney; Liver; Lung; Male; Mechlorethamine; Melphalan; Pharmacology; Prostate; Rats; Research; Spleen; Testis; Thiotepa; Thymus Gland; Urinary Bladder | 1964 |
THE TREATMENT OF CARCINOMA IN DOGS' BLADDERS WITH CYTOTOXIC DRUGS.
Topics: Alkylating Agents; Antineoplastic Agents; Carcinogens; Carcinoma; Chlorambucil; Cyclophosphamide; Dogs; Melphalan; Methotrexate; Naphthalenes; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Pharmacology; Research; Toxicology; Urinary Bladder Neoplasms | 1965 |
Treatment of 72 newly diagnosed Waldenstrom macroglobulinemia cases with oral melphalan, cyclophosphamide, and prednisone: results and cost analysis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cost-Benefit Analysis; Cyclophosphamide; Disease-Free Survival; Drug Administration Schedule; Drug Costs; Female; Follow-Up Studies; Humans; Italy; Male; Melphalan; Middle Aged; Prednisone; Survival Analysis; Treatment Outcome; Waldenstrom Macroglobulinemia | 2005 |
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antioxidants; Binding Sites; Busulfan; Chlorambucil; Cisplatin; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Screening Assays, Antitumor; Glutathione Reductase; Melphalan; Organoplatinum Compounds; Oxaliplatin; Rats; Spectrophotometry; Substrate Specificity; Thioredoxin-Disulfide Reductase; Time Factors | 2005 |
In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor.
Topics: Animals; Antineoplastic Agents; Apoptosis; BRCA2 Protein; Caspases; Cell Cycle; Cell Line, Tumor; Cell Survival; Chlorambucil; Cisplatin; Cross-Linking Reagents; Deoxycytidine; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group G Protein; Fanconi Anemia Complementation Group Proteins; Female; Fluorouracil; Gemcitabine; Humans; Inhibitory Concentration 50; Melphalan; Mice; Mice, Nude; Mitomycin; Mutation; Paclitaxel; Pancreatic Neoplasms; Time Factors; Vinblastine; Xenograft Model Antitumor Assays | 2005 |
Necrobiotic xanthogranuloma associated with paraproteinemia and non-Hodgkin's lymphoma developing into chronic lymphocytic leukemia: the first case reported in the literature and review of the literature.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Female; Glucocorticoids; Granuloma; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Melphalan; Middle Aged; Necrobiotic Disorders; Paraproteinemias; Skin Diseases; Treatment Failure; Treatment Outcome; Xanthomatosis | 2006 |
Aneugenic potential of the nitrogen mustard analogues melphalan, chlorambucil and p-N,N-bis(2-chloroethyl)aminophenylacetic acid in cell cultures in vitro.
Topics: Adult; Aneugens; Aneuploidy; Animals; Antineoplastic Agents, Alkylating; Azasteroids; Cells, Cultured; Centromere; Chlorambucil; Chromosome Aberrations; Female; Humans; In Situ Hybridization, Fluorescence; In Vitro Techniques; Lymphocytes; Male; Melphalan; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Nondisjunction, Genetic; Phenylacetates | 2007 |
Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma.
Topics: Antineoplastic Agents, Alkylating; Biological Transport; Biotransformation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chlorambucil; Dipeptidases; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydrolysis; Inhibitory Concentration 50; Melanoma; Melphalan; Prodrugs; Proline; Protease Inhibitors; RNA, Messenger; Stereoisomerism | 2007 |
Human renal UOK130 tumor cells: a drug resistant cell line with highly selective over-expression of glutathione S-transferase-pi isozyme.
Topics: 4-Butyrolactone; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Chlorambucil; Cisplatin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glutathione; Glutathione S-Transferase pi; Humans; Isoenzymes; Kidney Neoplasms; Melphalan; Transfection | 2007 |
Novel melphalan and chlorambucil derivatives of 2,2,6,6-tetramethyl-1-piperidinyloxy radicals: synthesis, characterization, and biological evaluation in vitro.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Chlorambucil; Cyclic N-Oxides; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Free Radicals; Humans; Hydrolysis; Kinetics; Melphalan; Structure-Activity Relationship | 2010 |
Aneugenic potential of the anticancer drugs melphalan and chlorambucil. The involvement of apoptosis and chromosome segregation regulating proteins.
Topics: Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Antineoplastic Agents, Alkylating; Apoptosis; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Blotting, Western; Centrosome; Chlorambucil; Chromosome Breakage; Chromosome Segregation; Fibroblasts; Fluorescent Antibody Technique; Inhibitor of Apoptosis Proteins; Melphalan; Mice; Microscopy, Fluorescence; Microtubules; Neuroprotective Agents; Propidium; Protein Serine-Threonine Kinases; Repressor Proteins; Survivin; Tubulin | 2013 |
Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.
Topics: Animals; Antineoplastic Agents, Alkylating; Chlorambucil; Comet Assay; Dose-Response Relationship, Drug; Flow Cytometry; Male; Melphalan; Membrane Proteins; Micronucleus Tests; Mutagenicity Tests; Mutation; Rats; Rats, Sprague-Dawley; Reticulocytes; Thiophenes; Thiotepa | 2014 |
Treatment outcome in children and adolescents with relapsed Hodgkin lymphoma--results of the UK HD3 relapse treatment strategy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carmustine; Child; Chlorambucil; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dacarbazine; Dexamethasone; Disease-Free Survival; Doxorubicin; Epirubicin; Etoposide; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Ifosfamide; Kaplan-Meier Estimate; Melphalan; Multicenter Studies as Topic; Neoplasm Staging; Prednisolone; Prednisone; Procarbazine; Prognosis; Radiotherapy, Adjuvant; Recurrence; Remission Induction; Retrospective Studies; Salvage Therapy; Treatment Outcome; Vinblastine; Vincristine | 2014 |
Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Bendamustine Hydrochloride; Cell Proliferation; Chlorambucil; Dose-Response Relationship, Drug; Estrone; HEK293 Cells; Humans; Jurkat Cells; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, T-Cell; Melphalan; Nitrogen Mustard Compounds; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Transfection; Tumor Cells, Cultured | 2015 |
Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice.
Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Chlorambucil; Cyclophosphamide; Doxorubicin; Drug Synergism; Humans; Indazoles; Male; Mechlorethamine; Melanoma; Melphalan; Mice; Mice, Nude; Mice, SCID; Xenograft Model Antitumor Assays | 2016 |
Potency and stability of compounded formulations of chlorambucil, melphalan and cyclophosphamide.
Topics: Animals; Chlorambucil; Cyclophosphamide; Drug Compounding; Drug Stability; Melphalan; Time Factors; Veterinary Medicine | 2017 |
Development of an assay for cellular efflux of pharmaceutically active agents and its relevance to understanding drug interactions.
Topics: Antineoplastic Agents, Alkylating; Biological Transport; Busulfan; Cell Line, Tumor; Cell Survival; Chlorambucil; Cyclophosphamide; Drug Interactions; Ethacrynic Acid; Everolimus; Flow Cytometry; Fluoresceins; Humans; Ketoconazole; Melphalan; Multidrug Resistance-Associated Proteins; Reproducibility of Results; Sirolimus | 2017 |
Intra- and inter-laboratory reproducibility of the rat blood Pig-a gene mutation assay.
Topics: Animals; Biological Assay; Chlorambucil; Erythrocytes; Laboratories; Male; Melphalan; Mutation; Rats, Sprague-Dawley; Reproducibility of Results; Reticulocytes | 2020 |
Pig-a gene mutation assay study design: critical assessment of 3- versus 28-day repeat-dose treatment schedules.
Topics: Animals; Aristolochic Acids; Chlorambucil; Erythrocytes; Male; Melphalan; Membrane Proteins; Mutagenicity Tests; Mutagens; Mutation; Rats; Rats, Wistar; Reticulocytes; Thiophenes; Thiotepa; Time Factors | 2020 |