chlorambucil has been researched along with km 2210 in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (66.67) | 18.7374 |
| 1990's | 12 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Asano, S; Matsudaira, T; Ozawa, K; Shirato, R; Tani, K; Tojo, A; Tsurumi, H; Tsuruta, T; Uchida, H; Wada, C | 1 |
| Asano, K; Asano, S; Kodo, H; Matsudaira, T; Okamoto, S; Ozawa, K; Tani, K; Tojo, A | 1 |
| Abe, O; Inagaki, H; Kosano, H; Kubota, T; Nagata, N; Ohsawa, N; Yamamori, S | 1 |
| Ezaki, K; Hirano, M; Hirota, Y; Kimura, K; Naito, K; Ohno, R; Shirakawa, S; Yamada, K | 1 |
| Arisawa, Y; Fujita, S; Inoue, S; Ishibiki, K; Josui, K; Kubota, T; Kuzuoka, M; Oka, S; Suto, A; Yamamoto, T | 1 |
| Asano, K; Bannai, K; Egawa, H; Maki, A; Mitsuhashi, S; Mori, K; Ozawa, K; Yamamoto, Y | 1 |
| Asano, K; Bannai, K; Egawa, H; Mitsuhashi, S; Mori, K; Ozawa, K | 1 |
| Ohsawa, N | 2 |
| Kodo, H | 1 |
| Akao, Y; Hiraiwa, A; Kubo, K; Naito, K; Naoe, T; Yamada, K | 1 |
| Naito, K; Ogawa, T; Yamada, K | 1 |
| Abe, O; Asano, K; Enomoto, K; Ishibiki, K; Koh, J; Kubota, T; Masui, O; Oka, S; Yamada, Y | 1 |
| Katayama, N; Komada, F; Nishikawa, M; Ohno, T; Shirakawa, S; Uemura, Y | 1 |
| Kanemura, M | 1 |
| Ohsawa, N; Yamazaki, Z | 1 |
| Akao, Y; Ezaki, K; Nagura, E; Naito, K; Nishikawa, M; Ohno, R; Ono, Y; Shirakawa, S; Tanaka, H; Yamada, K | 1 |
| Katayama, N; Kita, K; Kobayashi, T; Matsuoka, N; Minami, N; Nishikawa, M; Ohno, T; Tanaka, H; Tomeoku, M; Uemura, Y | 1 |
| Hirano, M; Shirakawa, S | 1 |
| Akagi, T; Hara, M; Matsumura, Y; Nasu, Y; Obama, T; Ochi, J; Ozaki, Y; Saegusa, M; Tsushima, T; Yoshimoto, J | 1 |
| Hashimoto, M; Imai, T; Inoue, K; Kawabata, M; Masuda, T; Okayasu, T; Tanabe, T | 1 |
| Kawamura, E; Kubota, T; Kurokawa, T; Miyagawa, T; Toyoda, H; Yamada, Y | 1 |
| Baba, H; Haraguchi, M; Hiramoto, Y; Korenaga, D; Okamura, T; Sugimachi, K; Tsujitani, S | 1 |
| Akagi, T; Hara, M; Matsumura, Y; Nasu, Y; Obama, T; Ochi, J; Ohmori, H; Saegusa, M; Tsushima, T; Yoshimoto, J | 1 |
| Morimoto, K; Nakatani, S; Sakai, K; Ueda, T | 1 |
| Agatsuma, T; Fugiwara, A; Fujita, K; Goto, T; Isurugi, K; Kamei, H; Kubota, T; Nakao, I; Suga, S; Takenaka, K | 1 |
| Kawamura, E; Kubota, T; Kurokawa, T; Miyagawa, T; Suzuki, T; Toyoda, H; Yamada, T | 1 |
| Isurugi, K | 1 |
| Isurugi, K; Ohsawa, N; Wagatsuma, T; Yamazaki, Z | 1 |
| Fukayama, M; Ikebuchi, K; Kaise, M; Miwa, A; Mori, M; Murai, Y; Nakamura, N | 1 |
| Karbe, S; Koike, N; Miwa, A; Mori, M; Murai, Y; Nagata, Y; Yamamoto, T | 1 |
| Asano, S; Han, CW; Hashino, S; Imai, K; Imamura, M; Matsudaira, T; Tanaka, J; Zhu, X | 1 |
| Akaza, H; Imada, S; Koiso, K; Tsukamoto, S | 1 |
| Furusawa, M; Matsuoka, H; Sugimachi, K | 1 |
| Asaka, M; Asano, S; Hashino, S; Imamura, M; Kasai, M; Kobayashi, S; Matsudaira, T; Tanaka, J; Tao, HR; Zhu, X | 1 |
| Kita, K; Miwa, H; Mizuno, T; Morita, K; Nishikawa, M; Shiku, H; Suzuki, H; Tanaka, I | 1 |
2 review(s) available for chlorambucil and km 2210
| Article | Year |
|---|---|
Graft-versus-host disease.
Topics: Bone Marrow Transplantation; Cardiac Surgical Procedures; Chlorambucil; Cytomegalovirus Infections; Estradiol; Graft vs Host Disease; Humans; Immunosuppressive Agents; Postoperative Complications; Pulmonary Fibrosis; Transfusion Reaction | 1987 |
[Tumor-oriented anti-cancer agent with estrogen as a carrier].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Chlorambucil; Drug Carriers; Estradiol; Estramustine; Estrogens; Humans; Male; Prostatic Neoplasms; Rats | 1988 |
2 trial(s) available for chlorambucil and km 2210
| Article | Year |
|---|---|
A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia-lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Estradiol; Female; Humans; Interferon Type I; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Pilot Projects; Tumor Cells, Cultured | 1991 |
[Clinical trial of bestrabucil (KM 2210) on hematopoietic malignancies].
Topics: Aged; Chlorambucil; Clinical Trials as Topic; Drug Administration Schedule; Estradiol; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Male; Middle Aged; Multiple Myeloma | 1986 |
32 other study(ies) available for chlorambucil and km 2210
| Article | Year |
|---|---|
Adult T-cell leukemia developing during immunosuppressive treatment in a renal transplant recipient.
Topics: Adult; Antineoplastic Agents; Carrier State; Chlorambucil; Estradiol; Humans; Immunosuppression Therapy; Kidney Transplantation; Leukemia-Lymphoma, Adult T-Cell; Male | 1992 |
The alloantigen-specific immunosuppressive activity of estradiol-chlorambucil conjugate (KM2210) and its beneficial effect on allogeneic bone marrow transplantation in mice.
Topics: Animals; Bone Marrow Transplantation; Cell Division; Cell Survival; Chlorambucil; Epitopes; Estradiol; Flow Cytometry; Immunosuppressive Agents; Isoantigens; Knee Joint; Leukocyte Count; Lymph Nodes; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Mice; Organ Size; Transplantation, Homologous | 1992 |
Growth-inhibitory action of an estrogen-chlorambucil conjugate (KM2210) in human breast cancer cell line MCF-7: its relation to reduction of estrogen receptor and transforming growth factor-alpha secretion.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Chlorambucil; Drug Screening Assays, Antitumor; Estradiol; Humans; Receptors, Estrogen; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1992 |
[Enhancement of antitumor activity of mitomycin C against human breast carcinoma xenografts by pretreatment with KM 2210].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Estradiol; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Transplantation, Heterologous | 1990 |
Effects of intra-arterial chemotherapy with a new lipophilic anticancer agent, estradiol-chlorambucil (KM2210), dissolved in lipiodol on experimental liver tumor in rats.
Topics: Animals; Antineoplastic Agents; Carbon Radioisotopes; Chlorambucil; Dose-Response Relationship, Drug; Embolization, Therapeutic; Estradiol; Female; Injections, Intra-Arterial; Iodized Oil; Liver Neoplasms, Experimental; Rats; Rats, Inbred Strains; Tritium | 1990 |
Effects of intraarterial chemotherapy using the new lipophilic anticancer agent 'KM2210' (estradiol-chlorambucil) dissolved in lipiodol on Walker 256 carcinosarcoma in Wistar rats--a preliminary report.
Topics: Animals; Antineoplastic Agents; Carcinosarcoma; Chlorambucil; Dose-Response Relationship, Drug; Estradiol; Extremities; Female; Infusions, Intra-Arterial; Iodized Oil; Necrosis; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Solutions | 1990 |
[Targeting therapy of cancer, using hormones as carriers].
Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Carriers; Estradiol; Estramustine; Humans; Immunosuppressive Agents | 1989 |
[Clinical experiences in tumor-oriented anti-cancer drugs].
Topics: Administration, Oral; Antibodies, Monoclonal; Chlorambucil; Estradiol; Estramustine; Humans; Neoplasms; Prednimustine; Receptors, Cell Surface | 1988 |
[Clinical trial of bestrabucil (KM 2210) in hematopoietic malignancies].
Topics: Aged; Chlorambucil; Deltaretrovirus Infections; Estradiol; Female; Humans; Lymphoma; Male; Middle Aged; Multiple Myeloma; Thrombocytosis | 1986 |
[A case of adult T cell leukemia treated with a new chemotherapeutic agent, KM2210].
Topics: Antigens, Viral; Chlorambucil; Deltaretrovirus Infections; Estradiol; HIV Antigens; Humans; Lymphocyte Activation; Male; Middle Aged | 1987 |
Mode of action of estra-1,3,5(10)-triene-3,17 beta-diol 3-benzoate 17-[4-(4-bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acet ate) on human breast carcinoma xenografts in nude mice.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Estradiol; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Organ Size; Receptors, Estrogen; Receptors, Progesterone; Transplantation, Heterologous | 1988 |
Clinical response to busramustine (KM-2210) in chronic lymphocytic leukemia: a pilot evaluation of estrogen receptor in relation to its therapeutic effect.
Topics: Adult; Aged; Blood Coagulation; Chlorambucil; Estradiol; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Receptors, Estrogen | 1988 |
[An experimental study of cancer therapy through the augmented foreign body reaction].
Topics: Animals; Carcinoma 256, Walker; Chlorambucil; Estradiol; Foreign-Body Reaction; Rats; Rats, Inbred Strains; T-Lymphocytes | 1988 |
[Early phase II trial of bestrabucil in hematological malignancies].
Topics: Adult; Aged; Chlorambucil; Drug Administration Schedule; Drug Evaluation; Estradiol; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukopenia; Lymphoma; Male; Middle Aged; Thrombocytopenia | 1986 |
[Bestrabucil-induced complete remission in a case of follicular lymphoma, medium-sized cell type, stage IV (leukemic)].
Topics: Adult; Chlorambucil; Estradiol; Humans; Lymph Nodes; Lymphoma, Follicular; Male; Neoplasm Staging | 1986 |
[A new anti-cancer agent, bestrabucil (KM 2210): I. Concentration in the serum and tissue in urogenital tumors].
Topics: Administration, Oral; Chlorambucil; Estradiol; Humans; Kidney Neoplasms; Male; Prostatic Neoplasms; Testicular Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms | 1987 |
[A case of breast carcinoma with lung metastasis].
Topics: Adenocarcinoma; Adult; Breast Neoplasms; Chlorambucil; Drug Evaluation; Estradiol; Female; Humans; Lung Neoplasms | 1987 |
[Two cases of recurrent breast carcinoma achieving CR (complete response) with KM2210].
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Papillary; Chlorambucil; Drug Combinations; Drug Evaluation; Estradiol; Female; Humans; Middle Aged; Neoplasm Recurrence, Local | 1987 |
[A case of carcinoma in the lower abdomen treated successfully with oral administration of bestrabucil].
Topics: Aged; Carcinoma, Transitional Cell; Chlorambucil; Estradiol; Female; Humans; Pelvic Neoplasms; Prognosis; Retroperitoneal Neoplasms | 1987 |
[Clinical effects of bestrabucil (KM2210) in bladder cancer].
Topics: Chlorambucil; Drug Administration Schedule; Estradiol; Humans; Male; Middle Aged; Urinary Bladder Neoplasms | 1987 |
[Therapeutic results in recurrent breast cancer with the use of Bestrabucil (KM2210)].
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Drug Evaluation; Estradiol; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Recurrence | 1987 |
[Phase I study of bestrabucil (KM 2210)].
Topics: Adult; Aged; Animals; Anorexia; Chlorambucil; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Estradiol; Female; Humans; Leukocyte Count; Leukopenia; Male; Middle Aged; Neoplasms; Pain; Rats | 1986 |
Antitumor activity and pharmacokinetics of estra-1,3,5 (10)-triene-3,17 beta-diol, 3-benzoate, 17-((4-(4-bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy) acetate) (Bestrabucil) in human tumor xenografts serially transplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Evaluation, Preclinical; Estradiol; Female; Humans; Kinetics; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental | 1986 |
[Clinical application of KM 2210 (estradiol-chlorambucil) in patients with advanced prostatic carcinoma].
Topics: Aged; Animals; Child; Chlorambucil; Estradiol; Humans; Male; Middle Aged; Prostate; Prostatic Neoplasms; Rats | 1984 |
[Bestrabacil: a possible target-oriented anticancer agent].
Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Chlorambucil; Estradiol; Female; Humans; Male; Mice; Middle Aged; Neoplasms; Prostatic Neoplasms; Rats; Rats, Inbred Strains | 1984 |
[KM 2210 therapy for chronic lymphocytic leukemia].
Topics: Aged; Chlorambucil; Estradiol; Humans; Leukemia, Lymphoid; Male | 1983 |
[A case of Hand-Schüller-Christian disease with foam cells in the pericardial effusion treated effectively by KM 2210].
Topics: Adult; Chlorambucil; Estradiol; Female; Foam Cells; Histiocytosis, Langerhans-Cell; Humans; Macrophages; Pericardial Effusion | 1982 |
Differential effects of the immunosuppressants cyclosporin A, FK506 and KM2210 on cytokine gene expression.
Topics: Animals; Base Sequence; Cells, Cultured; Chlorambucil; Cyclosporine; Cytokines; DNA Primers; Estradiol; Gene Expression Regulation; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Molecular Sequence Data; Polymerase Chain Reaction; RNA, Messenger; Spleen; Tacrolimus | 1995 |
Inhibitory effects of bestrabucil, a conjugate of chlorambucil and estradiol, on the production of androgen-induced growth factor(s) by Shionogi carcinoma 115 cells.
Topics: Androgens; Animals; Antineoplastic Agents; Carcinoma; Cell Count; Chlorambucil; Culture Media, Conditioned; Estradiol; Growth Substances; Male; Mice; Mice, Inbred BALB C; Prostatic Neoplasms; Tumor Cells, Cultured | 1994 |
[Quantitative assay of growth response of clinical breast cancer cells against E2 or E2-conjugated drugs].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Chlorambucil; Drug Screening Assays, Antitumor; Estradiol; Estramustine; Humans; Receptors, Estrogen; Tumor Cells, Cultured | 1994 |
Enhancing and suppressive effects of immunosuppressants cyclosporin A, FK506, and KM2210 on the colony formation of murine bone marrow cells.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Chlorambucil; Colony-Forming Units Assay; Cyclosporine; Estradiol; Hematopoietic Stem Cells; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Tacrolimus | 1995 |
[Acute myelogenous leukemia (M4) occurring during chronic lymphocytic leukemia].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Estradiol; Etoposide; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelomonocytic, Acute; Male; Neoplasms, Second Primary | 1997 |