chlorambucil and km 2210

chlorambucil has been researched along with km 2210 in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199024 (66.67)18.7374
1990's12 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asano, S; Matsudaira, T; Ozawa, K; Shirato, R; Tani, K; Tojo, A; Tsurumi, H; Tsuruta, T; Uchida, H; Wada, C1
Asano, K; Asano, S; Kodo, H; Matsudaira, T; Okamoto, S; Ozawa, K; Tani, K; Tojo, A1
Abe, O; Inagaki, H; Kosano, H; Kubota, T; Nagata, N; Ohsawa, N; Yamamori, S1
Ezaki, K; Hirano, M; Hirota, Y; Kimura, K; Naito, K; Ohno, R; Shirakawa, S; Yamada, K1
Arisawa, Y; Fujita, S; Inoue, S; Ishibiki, K; Josui, K; Kubota, T; Kuzuoka, M; Oka, S; Suto, A; Yamamoto, T1
Asano, K; Bannai, K; Egawa, H; Maki, A; Mitsuhashi, S; Mori, K; Ozawa, K; Yamamoto, Y1
Asano, K; Bannai, K; Egawa, H; Mitsuhashi, S; Mori, K; Ozawa, K1
Ohsawa, N2
Kodo, H1
Akao, Y; Hiraiwa, A; Kubo, K; Naito, K; Naoe, T; Yamada, K1
Naito, K; Ogawa, T; Yamada, K1
Abe, O; Asano, K; Enomoto, K; Ishibiki, K; Koh, J; Kubota, T; Masui, O; Oka, S; Yamada, Y1
Katayama, N; Komada, F; Nishikawa, M; Ohno, T; Shirakawa, S; Uemura, Y1
Kanemura, M1
Ohsawa, N; Yamazaki, Z1
Akao, Y; Ezaki, K; Nagura, E; Naito, K; Nishikawa, M; Ohno, R; Ono, Y; Shirakawa, S; Tanaka, H; Yamada, K1
Katayama, N; Kita, K; Kobayashi, T; Matsuoka, N; Minami, N; Nishikawa, M; Ohno, T; Tanaka, H; Tomeoku, M; Uemura, Y1
Hirano, M; Shirakawa, S1
Akagi, T; Hara, M; Matsumura, Y; Nasu, Y; Obama, T; Ochi, J; Ozaki, Y; Saegusa, M; Tsushima, T; Yoshimoto, J1
Hashimoto, M; Imai, T; Inoue, K; Kawabata, M; Masuda, T; Okayasu, T; Tanabe, T1
Kawamura, E; Kubota, T; Kurokawa, T; Miyagawa, T; Toyoda, H; Yamada, Y1
Baba, H; Haraguchi, M; Hiramoto, Y; Korenaga, D; Okamura, T; Sugimachi, K; Tsujitani, S1
Akagi, T; Hara, M; Matsumura, Y; Nasu, Y; Obama, T; Ochi, J; Ohmori, H; Saegusa, M; Tsushima, T; Yoshimoto, J1
Morimoto, K; Nakatani, S; Sakai, K; Ueda, T1
Agatsuma, T; Fugiwara, A; Fujita, K; Goto, T; Isurugi, K; Kamei, H; Kubota, T; Nakao, I; Suga, S; Takenaka, K1
Kawamura, E; Kubota, T; Kurokawa, T; Miyagawa, T; Suzuki, T; Toyoda, H; Yamada, T1
Isurugi, K1
Isurugi, K; Ohsawa, N; Wagatsuma, T; Yamazaki, Z1
Fukayama, M; Ikebuchi, K; Kaise, M; Miwa, A; Mori, M; Murai, Y; Nakamura, N1
Karbe, S; Koike, N; Miwa, A; Mori, M; Murai, Y; Nagata, Y; Yamamoto, T1
Asano, S; Han, CW; Hashino, S; Imai, K; Imamura, M; Matsudaira, T; Tanaka, J; Zhu, X1
Akaza, H; Imada, S; Koiso, K; Tsukamoto, S1
Furusawa, M; Matsuoka, H; Sugimachi, K1
Asaka, M; Asano, S; Hashino, S; Imamura, M; Kasai, M; Kobayashi, S; Matsudaira, T; Tanaka, J; Tao, HR; Zhu, X1
Kita, K; Miwa, H; Mizuno, T; Morita, K; Nishikawa, M; Shiku, H; Suzuki, H; Tanaka, I1

Reviews

2 review(s) available for chlorambucil and km 2210

ArticleYear
Graft-versus-host disease.
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1987, Volume: 50, Issue:8

    Topics: Bone Marrow Transplantation; Cardiac Surgical Procedures; Chlorambucil; Cytomegalovirus Infections; Estradiol; Graft vs Host Disease; Humans; Immunosuppressive Agents; Postoperative Complications; Pulmonary Fibrosis; Transfusion Reaction

1987
[Tumor-oriented anti-cancer agent with estrogen as a carrier].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:4 Pt 2-1

    Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Chlorambucil; Drug Carriers; Estradiol; Estramustine; Estrogens; Humans; Male; Prostatic Neoplasms; Rats

1988

Trials

2 trial(s) available for chlorambucil and km 2210

ArticleYear
A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia-lymphoma.
    Cancer, 1991, Aug-15, Volume: 68, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Estradiol; Female; Humans; Interferon Type I; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Pilot Projects; Tumor Cells, Cultured

1991
[Clinical trial of bestrabucil (KM 2210) on hematopoietic malignancies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:6

    Topics: Aged; Chlorambucil; Clinical Trials as Topic; Drug Administration Schedule; Estradiol; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Male; Middle Aged; Multiple Myeloma

1986

Other Studies

32 other study(ies) available for chlorambucil and km 2210

ArticleYear
Adult T-cell leukemia developing during immunosuppressive treatment in a renal transplant recipient.
    American journal of hematology, 1992, Volume: 41, Issue:4

    Topics: Adult; Antineoplastic Agents; Carrier State; Chlorambucil; Estradiol; Humans; Immunosuppression Therapy; Kidney Transplantation; Leukemia-Lymphoma, Adult T-Cell; Male

1992
The alloantigen-specific immunosuppressive activity of estradiol-chlorambucil conjugate (KM2210) and its beneficial effect on allogeneic bone marrow transplantation in mice.
    Transplantation, 1992, Volume: 54, Issue:4

    Topics: Animals; Bone Marrow Transplantation; Cell Division; Cell Survival; Chlorambucil; Epitopes; Estradiol; Flow Cytometry; Immunosuppressive Agents; Isoantigens; Knee Joint; Leukocyte Count; Lymph Nodes; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Mice; Organ Size; Transplantation, Homologous

1992
Growth-inhibitory action of an estrogen-chlorambucil conjugate (KM2210) in human breast cancer cell line MCF-7: its relation to reduction of estrogen receptor and transforming growth factor-alpha secretion.
    Cancer research, 1992, Mar-01, Volume: 52, Issue:5

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Chlorambucil; Drug Screening Assays, Antitumor; Estradiol; Humans; Receptors, Estrogen; Transforming Growth Factor alpha; Tumor Cells, Cultured

1992
[Enhancement of antitumor activity of mitomycin C against human breast carcinoma xenografts by pretreatment with KM 2210].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Estradiol; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Transplantation, Heterologous

1990
Effects of intra-arterial chemotherapy with a new lipophilic anticancer agent, estradiol-chlorambucil (KM2210), dissolved in lipiodol on experimental liver tumor in rats.
    Journal of surgical oncology, 1990, Volume: 44, Issue:2

    Topics: Animals; Antineoplastic Agents; Carbon Radioisotopes; Chlorambucil; Dose-Response Relationship, Drug; Embolization, Therapeutic; Estradiol; Female; Injections, Intra-Arterial; Iodized Oil; Liver Neoplasms, Experimental; Rats; Rats, Inbred Strains; Tritium

1990
Effects of intraarterial chemotherapy using the new lipophilic anticancer agent 'KM2210' (estradiol-chlorambucil) dissolved in lipiodol on Walker 256 carcinosarcoma in Wistar rats--a preliminary report.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1990, Volume: 22, Issue:4

    Topics: Animals; Antineoplastic Agents; Carcinosarcoma; Chlorambucil; Dose-Response Relationship, Drug; Estradiol; Extremities; Female; Infusions, Intra-Arterial; Iodized Oil; Necrosis; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Solutions

1990
[Targeting therapy of cancer, using hormones as carriers].
    Nihon rinsho. Japanese journal of clinical medicine, 1989, Volume: 47, Issue:6

    Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Carriers; Estradiol; Estramustine; Humans; Immunosuppressive Agents

1989
[Clinical experiences in tumor-oriented anti-cancer drugs].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1988, Volume: 77, Issue:3

    Topics: Administration, Oral; Antibodies, Monoclonal; Chlorambucil; Estradiol; Estramustine; Humans; Neoplasms; Prednimustine; Receptors, Cell Surface

1988
[Clinical trial of bestrabucil (KM 2210) in hematopoietic malignancies].
    Gan no rinsho. Japan journal of cancer clinics, 1986, Volume: 32, Issue:11

    Topics: Aged; Chlorambucil; Deltaretrovirus Infections; Estradiol; Female; Humans; Lymphoma; Male; Middle Aged; Multiple Myeloma; Thrombocytosis

1986
[A case of adult T cell leukemia treated with a new chemotherapeutic agent, KM2210].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:1

    Topics: Antigens, Viral; Chlorambucil; Deltaretrovirus Infections; Estradiol; HIV Antigens; Humans; Lymphocyte Activation; Male; Middle Aged

1987
Mode of action of estra-1,3,5(10)-triene-3,17 beta-diol 3-benzoate 17-[4-(4-bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acet ate) on human breast carcinoma xenografts in nude mice.
    Japanese journal of cancer research : Gann, 1988, Volume: 79, Issue:11

    Topics: Animals; Antineoplastic Agents; Chlorambucil; Estradiol; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Organ Size; Receptors, Estrogen; Receptors, Progesterone; Transplantation, Heterologous

1988
Clinical response to busramustine (KM-2210) in chronic lymphocytic leukemia: a pilot evaluation of estrogen receptor in relation to its therapeutic effect.
    Japanese journal of clinical oncology, 1988, Volume: 18, Issue:4

    Topics: Adult; Aged; Blood Coagulation; Chlorambucil; Estradiol; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Receptors, Estrogen

1988
[An experimental study of cancer therapy through the augmented foreign body reaction].
    Nihon Gan Chiryo Gakkai shi, 1988, Jan-20, Volume: 23, Issue:1

    Topics: Animals; Carcinoma 256, Walker; Chlorambucil; Estradiol; Foreign-Body Reaction; Rats; Rats, Inbred Strains; T-Lymphocytes

1988
[Early phase II trial of bestrabucil in hematological malignancies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:6

    Topics: Adult; Aged; Chlorambucil; Drug Administration Schedule; Drug Evaluation; Estradiol; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukopenia; Lymphoma; Male; Middle Aged; Thrombocytopenia

1986
[Bestrabucil-induced complete remission in a case of follicular lymphoma, medium-sized cell type, stage IV (leukemic)].
    Gan no rinsho. Japan journal of cancer clinics, 1986, Volume: 32, Issue:11

    Topics: Adult; Chlorambucil; Estradiol; Humans; Lymph Nodes; Lymphoma, Follicular; Male; Neoplasm Staging

1986
[A new anti-cancer agent, bestrabucil (KM 2210): I. Concentration in the serum and tissue in urogenital tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:4

    Topics: Administration, Oral; Chlorambucil; Estradiol; Humans; Kidney Neoplasms; Male; Prostatic Neoplasms; Testicular Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms

1987
[A case of breast carcinoma with lung metastasis].
    Gan no rinsho. Japan journal of cancer clinics, 1987, Volume: 33, Issue:6

    Topics: Adenocarcinoma; Adult; Breast Neoplasms; Chlorambucil; Drug Evaluation; Estradiol; Female; Humans; Lung Neoplasms

1987
[Two cases of recurrent breast carcinoma achieving CR (complete response) with KM2210].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:8

    Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Papillary; Chlorambucil; Drug Combinations; Drug Evaluation; Estradiol; Female; Humans; Middle Aged; Neoplasm Recurrence, Local

1987
[A case of carcinoma in the lower abdomen treated successfully with oral administration of bestrabucil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:10

    Topics: Aged; Carcinoma, Transitional Cell; Chlorambucil; Estradiol; Female; Humans; Pelvic Neoplasms; Prognosis; Retroperitoneal Neoplasms

1987
[Clinical effects of bestrabucil (KM2210) in bladder cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:11

    Topics: Chlorambucil; Drug Administration Schedule; Estradiol; Humans; Male; Middle Aged; Urinary Bladder Neoplasms

1987
[Therapeutic results in recurrent breast cancer with the use of Bestrabucil (KM2210)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:12

    Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Drug Evaluation; Estradiol; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Recurrence

1987
[Phase I study of bestrabucil (KM 2210)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:6

    Topics: Adult; Aged; Animals; Anorexia; Chlorambucil; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Estradiol; Female; Humans; Leukocyte Count; Leukopenia; Male; Middle Aged; Neoplasms; Pain; Rats

1986
Antitumor activity and pharmacokinetics of estra-1,3,5 (10)-triene-3,17 beta-diol, 3-benzoate, 17-((4-(4-bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy) acetate) (Bestrabucil) in human tumor xenografts serially transplanted into nude mice.
    Japanese journal of clinical oncology, 1986, Volume: 16, Issue:4

    Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Evaluation, Preclinical; Estradiol; Female; Humans; Kinetics; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental

1986
[Clinical application of KM 2210 (estradiol-chlorambucil) in patients with advanced prostatic carcinoma].
    Gan no rinsho. Japan journal of cancer clinics, 1984, Volume: 30, Issue:7

    Topics: Aged; Animals; Child; Chlorambucil; Estradiol; Humans; Male; Middle Aged; Prostate; Prostatic Neoplasms; Rats

1984
[Bestrabacil: a possible target-oriented anticancer agent].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:10

    Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Chlorambucil; Estradiol; Female; Humans; Male; Mice; Middle Aged; Neoplasms; Prostatic Neoplasms; Rats; Rats, Inbred Strains

1984
[KM 2210 therapy for chronic lymphocytic leukemia].
    Gan no rinsho. Japan journal of cancer clinics, 1983, Volume: 29, Issue:15

    Topics: Aged; Chlorambucil; Estradiol; Humans; Leukemia, Lymphoid; Male

1983
[A case of Hand-Schüller-Christian disease with foam cells in the pericardial effusion treated effectively by KM 2210].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1982, Volume: 23, Issue:9

    Topics: Adult; Chlorambucil; Estradiol; Female; Foam Cells; Histiocytosis, Langerhans-Cell; Humans; Macrophages; Pericardial Effusion

1982
Differential effects of the immunosuppressants cyclosporin A, FK506 and KM2210 on cytokine gene expression.
    Bone marrow transplantation, 1995, Volume: 15, Issue:5

    Topics: Animals; Base Sequence; Cells, Cultured; Chlorambucil; Cyclosporine; Cytokines; DNA Primers; Estradiol; Gene Expression Regulation; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Molecular Sequence Data; Polymerase Chain Reaction; RNA, Messenger; Spleen; Tacrolimus

1995
Inhibitory effects of bestrabucil, a conjugate of chlorambucil and estradiol, on the production of androgen-induced growth factor(s) by Shionogi carcinoma 115 cells.
    International journal of urology : official journal of the Japanese Urological Association, 1994, Volume: 1, Issue:1

    Topics: Androgens; Animals; Antineoplastic Agents; Carcinoma; Cell Count; Chlorambucil; Culture Media, Conditioned; Estradiol; Growth Substances; Male; Mice; Mice, Inbred BALB C; Prostatic Neoplasms; Tumor Cells, Cultured

1994
[Quantitative assay of growth response of clinical breast cancer cells against E2 or E2-conjugated drugs].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:10

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Chlorambucil; Drug Screening Assays, Antitumor; Estradiol; Estramustine; Humans; Receptors, Estrogen; Tumor Cells, Cultured

1994
Enhancing and suppressive effects of immunosuppressants cyclosporin A, FK506, and KM2210 on the colony formation of murine bone marrow cells.
    Annals of hematology, 1995, Volume: 71, Issue:6

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Chlorambucil; Colony-Forming Units Assay; Cyclosporine; Estradiol; Hematopoietic Stem Cells; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Tacrolimus

1995
[Acute myelogenous leukemia (M4) occurring during chronic lymphocytic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1997, Volume: 38, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Estradiol; Etoposide; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelomonocytic, Acute; Male; Neoplasms, Second Primary

1997