Compounds > chlorambucil

chlorambucil and imatinib mesylate

chlorambucil has been researched along with imatinib mesylate in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Alaoui-Jamali, MA; Aloyz, R; Grzywacz, K; Loignon, M; Panasci, L; Xu, ZY1
Brahimi, F; Jean-Claude, BJ; Katsoulas, A; McNamee, J; Rachid, Z1
Alvarez, D; Chou, CJ; Druker, BJ; Eide, CA; Gottesfeld, JM; Lefebvre, S; O'Hare, T; Tyner, JW1
Aloyz, R; Amrein, L; Assouline, S; Caplan, S; Desjardins, P; Egorin, MJ; Hebb, J; Panasci, L; Rousseau, C1
Aloyz, R; Amrein, L; Davidson, D; Miller, WH; Panasci, L; Petruccelli, LA; Shawi, M1
Aloyz, R; Amrein, L; Jean-Claude, B; Panasci, L; Rachid, Z; Soulières, D1

Trials

1 trial(s) available for chlorambucil and imatinib mesylate

ArticleYear
A phase I study of imatinib mesylate in combination with chlorambucil in previously treated chronic lymphocytic leukemia patients.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:3

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Chlorambucil; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Imatinib Mesylate; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Pyrimidines; Rad51 Recombinase; Recombination, Genetic; Treatment Outcome; Vidarabine

2011

Other Studies

6 other study(ies) available for chlorambucil and imatinib mesylate

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Imatinib sensitizes CLL lymphocytes to chlorambucil.
    Leukemia, 2004, Volume: 18, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Cell Cycle; Chlorambucil; DNA-Binding Proteins; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Humans; Imatinib Mesylate; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Pyrimidines; Rad51 Recombinase; Tumor Cells, Cultured

2004
Cytokinetics and mechanism of action of AKO4: a novel nitrogen mustard targeted to bcr-abl.
    Leukemia research, 2005, Volume: 29, Issue:5

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Benzamides; Cell Proliferation; Chlorambucil; DNA Damage; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; Kinetics; Mechlorethamine; Megakaryocytes; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Pyrimidines

2005
Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate.
    PloS one, 2008, Volume: 3, Issue:10

    Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; Benzamides; Blood Cells; Bone Marrow Cells; Cell Proliferation; Cells, Cultured; Chlorambucil; Drug Evaluation, Preclinical; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Models, Biological; Nylons; Piperazines; Pyrimidines; Substrate Specificity; Transduction, Genetic

2008
Dual inhibition of the homologous recombinational repair and the nonhomologous end-joining repair pathways in chronic lymphocytic leukemia therapy.
    Leukemia research, 2011, Volume: 35, Issue:8

    Topics: Antineoplastic Agents, Alkylating; B-Lymphocytes; Benzamides; Blotting, Western; Chlorambucil; Comet Assay; DNA-Activated Protein Kinase; Drug Resistance, Neoplasm; Drug Synergism; Humans; Imatinib Mesylate; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Recombination, Genetic; Tumor Cells, Cultured

2011
ZRF4, a combi-molecule with increased efficacy as compared with the individual components in chronic lymphocytic leukemia lymphocytes in vitro.
    Leukemia, 2011, Volume: 25, Issue:9

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzamides; Cell Proliferation; Chlorambucil; DNA Damage; Humans; Imatinib Mesylate; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-abl; Pyrimidines; Triazenes; Tumor Cells, Cultured

2011