chloral hydrate has been researched along with trichloroacetic acid in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (50.00) | 18.7374 |
| 1990's | 17 (25.00) | 18.2507 |
| 2000's | 14 (20.59) | 29.6817 |
| 2010's | 3 (4.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Dallmeier, E; Fetz, H; Henschler, D; Hoos, WR; Metzler, M | 1 |
| Nomiyama, H; Nomiyama, K; Uchiki, H | 1 |
| Koch-Weser, J; Lang-Sellers, M; Sellers, EM | 1 |
| Gubéran, E | 1 |
| Laseter, JL; McDonald, LK; Politzer, IR | 1 |
| Brodersen, R; Onks, DL; Robertson, AF | 1 |
| Harrison, SP | 1 |
| Clemens, M; Schöler, HF | 1 |
| Deyashiki, Y; Hara, A; Nakayama, T; Oritani, H; Sawada, H; Yamamoto, H | 1 |
| Gorecki, DK; Hall, CA; Hindmarsh, KW; Mayers, DJ; Sankaran, K | 1 |
| Klaunig, JE; Lin, EL; Ruch, RJ | 1 |
| Hobara, T; Iwamoto, S; Kawamoto, T; Kobayashi, H; Sakai, T | 4 |
| Buur, T; Larsson, R; Norlander, B | 1 |
| Hobara, T; Iwamoto, S; Kawamoto, T; Kobayashi, H; Ogino, K; Sakai, T | 1 |
| Hobara, T; Imamura, A; Iwamoto, S; Kawamoto, T; Kobayashi, H; Koshiro, A; Sakai, T | 1 |
| Brown, BR; Kelley, JM | 1 |
| Müller, G; Urban, T | 1 |
| Henschler, D; Müller, G; Spassovski, M | 1 |
| Cascorbi, HF | 1 |
| Ertle, T; Henschler, D; Müller, G; Spassowski, M | 1 |
| Eben, A; Kimmerle, G | 2 |
| Garrett, ER; Lambert, HJ | 1 |
| Ogata, M; Saeki, T | 1 |
| Yllner, S | 1 |
| Koch-Weser, J; Sellers, EM | 2 |
| Cabana, BE; Gessner, PK | 2 |
| Alexander, F; Horner, MW; Moss, MS | 1 |
| Buchel, L; Tanguy, O | 1 |
| Ikeda, M; Miyake, Y; Ogata, M; Ohmori, S | 1 |
| Fu, PP; Kadlubar, FF; Ni, YC | 1 |
| Benane, SG; Blackman, CF; House, DE | 1 |
| Langonné, I; Sabaté, JP; Saillenfait, AM | 1 |
| Casciano, D; Fu, PP; Heinze, TM; Kadlubar, FF; Lloyd, RV; Ni, YC; Shelton, S; Wong, TY | 1 |
| Abbas, RR; Fisher, JW; Kidney, JK; Seckel, CS | 1 |
| Abbas, R; Fisher, JW | 1 |
| Doerr, CL; Harrington-Brock, K; Moore, MM | 1 |
| Dawson, BV; Goldberg, SJ; Johnson, PD | 1 |
| Bull, RJ; Gonzalez-Leon, A; Merdink, JL; Schultz, IR | 1 |
| Burton, GA; Fisher, JW; Greenberg, MS | 1 |
| Bull, RJ; Merdink, JL; Parker, JC; Stenner, RD; Stevens, DK | 1 |
| Henderson, GN; James, MO; Stacpoole, PW; Yan, Z | 1 |
| Bucci, TJ; Chou, MW; Fu, PP; Kadlubar, FF; Samokyszyn, VM; Von Tungeln, LS; Yi, P | 1 |
| Forkert, PG; Lash, LH; Nadeau, V; Simmonds, A; Tardif, R | 1 |
| Deng, YY; Huang, JX; Li, LY; Tang, XJ | 1 |
| MARSHALL, EK; OWENS, AH | 1 |
| IASNITSKII, VB; ZAITSEV, AP | 1 |
| BUCHEL, L; LEVY, J | 1 |
| BUCHEL, L | 1 |
| Agrawal, N; Allaben, WT; Horsley, ET; Leakey, JE; Leakey, TI; Scherer, EM; Seng, JE; Xia, S | 1 |
| Blossom, SJ; Gilbert, KM; Pumford, NR | 1 |
| Bartlett, MG; Bruckner, JV; Delinsky, AD | 1 |
| Bronley-DeLancey, A; Hoel, DG; Jollow, DJ; McMillan, DC; McMillan, JM; Mohr, LC | 1 |
| Chiu, WA; Clewell, HJ; Hack, CE; Jay Zhao, Q | 1 |
| Caldwell, JC; Keshava, N | 1 |
| Lock, EA; McMillan, JM; Oatis, JE; Reed, CJ; Schnellmann, RG | 1 |
| Bull, RJ; Hu, M; Merdink, JL; Parker, JC; Robison, LM; Stevens, DK | 1 |
| Arndt, T; Gierten, B; Grüner, J; Güssregen, B; Werle, A | 1 |
| Hashimoto, S; Inoue, M; Ito, Y; Kamijima, M; Nakahira, Y; Nakajima, T; Sato, H | 1 |
3 review(s) available for chloral hydrate and trichloroacetic acid
| Article | Year |
|---|---|
Biotransformation of trichloroethylene.
Topics: Anesthesia, Inhalation; Animals; Biotransformation; Carbon Monoxide; Chloral Hydrate; Chlorine; Cytochrome P-450 Enzyme System; Disulfiram; Drug Interactions; Drug Synergism; Enzyme Induction; Ethanol; Humans; In Vitro Techniques; Liver; Microsomes, Liver; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Partial Pressure; Protein Binding; Radioisotopes; Trichloroacetic Acid; Trichloroethylene | 1974 |
A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid.
Topics: Animals; Chloral Hydrate; Chromatography, Gas; Chromatography, Liquid; Dichloroacetic Acid; Humans; Mass Spectrometry; Trichloroacetic Acid; Trichloroethylene | 2005 |
Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.
Topics: Animals; Carcinogenicity Tests; Chloral Hydrate; Cysteine; Dichloroacetic Acid; Environmental Pollutants; History, 21st Century; Humans; Kidney Neoplasms; Liver Neoplasms; Risk Assessment; Risk Factors; Signal Transduction; Trichloroacetic Acid; Trichloroethylene; United States | 2006 |
65 other study(ies) available for chloral hydrate and trichloroacetic acid
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Reactions of trichloroethylene epoxide in aqueous systems.
Topics: Carbon Monoxide; Chemical Phenomena; Chemistry; Chloral Hydrate; Drug Stability; Epoxy Compounds; Formates; Glyoxylates; Trichloroacetic Acid; Trichloroethylene; Water | 1979 |
Gas-liquid chromatographic determination of trichloroethylene metabolites in urine.
Topics: Air Pollutants, Occupational; Animals; Chloral Hydrate; Chromatography, Gas; Environmental Exposure; Rats; Trichloroacetic Acid; Trichloroethylene | 1978 |
Comparative metabolism of chloral hydrate and triclofos.
Topics: Blood Proteins; Chloral Hydrate; Half-Life; Humans; Hydrocarbons, Chlorinated; Hypnotics and Sedatives; Male; Organophosphates; Organophosphorus Compounds; Protein Binding; Time Factors; Trichloroacetic Acid | 1978 |
Proposed biological threshold limit values for industrial exposure to trichloroethylene vapor.
Topics: Chloral Hydrate; Environmental Exposure; Ethanol; Humans; Mathematics; Models, Biological; Occupational Medicine; Trichloroacetic Acid; Trichloroethylene | 1977 |
Identification of some volatile endogenous constituents in rat brain tissue and the effects of lithium carbonate and chloral hydrate.
Topics: Animals; Brain; Brain Chemistry; Chloral Hydrate; Chromatography, Gas; Lithium; Male; Mass Spectrometry; Rats; Trichloroacetic Acid | 1976 |
The effect of chloral hydrate and its metabolites, trichloroethanol and trichloroacetic acid, on bilirubin-albumin binding.
Topics: Bilirubin; Chloral Hydrate; Ethylene Chlorohydrin; Humans; Oxidation-Reduction; Protein Binding; Regression Analysis; Serum Albumin; Spectrophotometry, Ultraviolet; Trichloroacetic Acid | 1992 |
Positive interference.
Topics: Blood Gas Analysis; Carbon Dioxide; Carboxylic Acids; Chloral Hydrate; Humans; Infant, Newborn; Trichloroacetic Acid | 1992 |
[Halogenated organic compounds in swimming pool water].
Topics: Acetonitriles; Chloral Hydrate; Chloroform; Dichloroacetic Acid; Germany; Hydrocarbons, Halogenated; Swimming Pools; Trichloroacetic Acid; Trihalomethanes; Water Pollution | 1992 |
Aldehyde dismutation catalyzed by pulmonary carbonyl reductase: kinetic studies of chloral hydrate metabolism to trichloroacetic acid and trichloroethanol.
Topics: Alcohol Oxidoreductases; Aldehydes; Animals; Catalysis; Chloral Hydrate; Ethylene Chlorohydrin; Guinea Pigs; Kinetics; Liver; Lung; Male; Mice; Oxidation-Reduction; Trichloroacetic Acid | 1991 |
Determination of chloral hydrate metabolism in adult and neonate biological fluids after single-dose administration.
Topics: Adult; Body Fluids; Chloral Hydrate; Chromatography, Gas; Ethylene Chlorohydrin; Humans; Infant; Male; Trichloroacetic Acid | 1990 |
Effects of trichloroethylene and its metabolites on rodent hepatocyte intercellular communication.
Topics: Animals; Cell Communication; Cells, Cultured; Chloral Hydrate; Liver; Male; Mice; Mice, Inbred Strains; Pyridines; Rats; Rats, Inbred F344; Species Specificity; Trichloroacetic Acid; Trichloroethylene | 1989 |
The absorption of trichloroethylene and its metabolites from the urinary bladder of anesthetized dogs.
Topics: Animals; Bile; Chloral Hydrate; Dogs; Dose-Response Relationship, Drug; Ethylene Chlorohydrin; Female; Male; Trichloroacetic Acid; Trichloroethylene; Urinary Bladder | 1988 |
Pharmacokinetics of chloral hydrate poisoning treated with hemodialysis and hemoperfusion.
Topics: Adult; Chloral Hydrate; Ethylene Chlorohydrin; Female; Hemoperfusion; Humans; Renal Dialysis; Trichloroacetic Acid | 1988 |
Intestinal absorption of chloral hydrate, free trichloroethanol and trichloroacetic acid in dogs.
Topics: Animals; Chloral Hydrate; Chlorohydrins; Colon; Dogs; Ethylene Chlorohydrin; Female; Ileum; Intestinal Absorption; Jejunum; Male; Trichloroacetic Acid | 1988 |
The cholecystohepatic circulation of trichloroethylene and its metabolites in dogs.
Topics: Absorption; Animals; Bile; Chloral Hydrate; Dogs; Ethylene Chlorohydrin; Female; Gallbladder; Inactivation, Metabolic; Liver; Male; Trichloroacetic Acid; Trichloroethylene | 1987 |
Alteration of chloral hydrate metabolism in rats with carbon tetrachloride-induced liver damage.
Topics: Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Ethylene Chlorohydrin; Liver Diseases; Male; Metabolic Clearance Rate; Perfusion; Rats; Rats, Inbred Strains; Trichloroacetic Acid | 1987 |
The metabolism of trichloroethylene and its metabolites in the perfused liver.
Topics: Animals; Bile; Chloral Hydrate; Ethylene Chlorohydrin; Liver; Male; Perfusion; Rats; Rats, Inbred Strains; Trichloroacetic Acid; Trichloroethylene | 1987 |
Extrahepatic metabolism of chloral hydrate, trichloroethanol and trichloroacetic acid in dogs.
Topics: Animals; Chloral Hydrate; Chlorohydrins; Dogs; Ethylene Chlorohydrin; Male; Trichloroacetic Acid | 1987 |
Proceedings: Metabolization of trichloroethylene and its metabolites in rat liver.
Topics: Animals; Bile; Chloral Hydrate; Ethanol; Glucuronates; In Vitro Techniques; Liver; Oxidation-Reduction; Perfusion; Rats; Trichloroacetic Acid; Trichloroethylene | 1974 |
Metabolism of trichloroethylene in man. II. Pharmacokinetics of metabolites.
Topics: Adult; Chloral Hydrate; Environmental Exposure; Ethanol; Half-Life; Humans; Hydrocarbons, Chlorinated; Kinetics; Male; Respiration; Trichloroacetic Acid; Trichloroethylene | 1974 |
Letter: A historical note on the biotransformation of chloroform.
Topics: Administration, Oral; Anesthesia, Inhalation; Animals; Berlin; Biotransformation; Carbon Tetrachloride; Chloral Hydrate; Chlorides; Chloroform; Diet, Sodium-Restricted; Dogs; Germany; History, 19th Century; Humans; Methyl Chloride; Sodium Chloride; Trichloroacetic Acid | 1974 |
Metabolism of trichloroethylene in man. I. The significance of trichloroethanol in long-term exposure conditions.
Topics: Administration, Oral; Adult; Chloral Hydrate; Chlorine; Chromatography, Gas; Colorimetry; Environmental Exposure; Ethanol; Half-Life; Humans; Male; Neurocognitive Disorders; Respiration; Time Factors; Trichloroacetic Acid; Trichloroethylene | 1972 |
Metabolism, excretion and toxicology of trichloroethylene after inhalation. 1. Experimental exposure on rats.
Topics: Air; Animals; Chloral Hydrate; Ethanol; Hydrocarbons, Halogenated; Liver; Male; Methods; Organ Size; Rats; Trichloroacetic Acid; Trichloroethylene | 1973 |
Metabolism, excretion and toxicology of trichloroethylene after inhalation. 2. Experimental human exposure.
Topics: Adult; Air; Chloral Hydrate; Ethanol; Female; Humans; Hydrocarbons, Halogenated; Male; Middle Aged; Respiration; Time Factors; Trichloroacetic Acid; Trichloroethylene | 1973 |
Pharmacokinetics of trichloroethanol and metabolites and interconversions among variously referenced pharmacokinetic parameters.
Topics: Animals; Chloral Hydrate; Chlorine; Chromatography, Gas; Computers; Computers, Analog; Dogs; Dose-Response Relationship, Drug; Ethanol; Glucuronates; Half-Life; Protein Binding; Sulfobromophthalein; Trichloroacetic Acid | 1973 |
Measurement of chloral hydrate, trichloroethanol, trichloroacetic acid and monochloroacetic acid in the serum and the urine by gas chromatography.
Topics: Acetates; Animals; Chloral Hydrate; Chromatography, Gas; Ethanol; Hydrocarbons, Chlorinated; Methods; Rabbits; Trichloroacetic Acid; Trichloroethylene | 1974 |
Metabolism of pentachloroethane in the mouse.
Topics: Animals; Chloral Hydrate; Chromatography, Gas; Chromatography, Paper; Ethanol; Female; Hydrocarbons, Halogenated; Mice; Mice, Inbred Strains; Spectrum Analysis; Tetrachloroethylene; Time Factors; Trichloroacetic Acid; Trichloroethylene | 1971 |
Kinetics and clinical importance of displacement of warfarin from albumin by acidic drugs.
Topics: Chemical Phenomena; Chemistry; Chloral Hydrate; Computers, Analog; Diazoxide; Drug Synergism; Ethacrynic Acid; Humans; Mathematics; Mefenamic Acid; Nalidixic Acid; Phenylbutazone; Protein Binding; Prothrombin; Prothrombin Time; Serum Albumin; Trichloroacetic Acid; Warfarin | 1971 |
The kinetics of chloral hydrate metabolism in mice and the effect thereon of ethanol.
Topics: Animals; Chloral Hydrate; Dogs; Drug Synergism; Ethanol; Injections, Intraperitoneal; Kinetics; Male; Mice; Species Specificity; Trichloroacetic Acid | 1970 |
Potentiation of warfarin-induced hypoprothrombinemia by chloral hydrate.
Topics: Binding Sites; Blood Coagulation; Chloral Hydrate; Depression, Chemical; Drug Synergism; Humans; Hypoprothrombinemias; Male; Protein Binding; Prothrombin; Prothrombin Time; Serum Albumin; Trichloroacetic Acid; Warfarin | 1970 |
The salivary secretion and clearance in the horse of chloral hydrate and its metabolites.
Topics: Animals; Chloral Hydrate; Chromatography, Gas; Ethanol; Horses; Male; Parotid Gland; Saliva; Trichloroacetic Acid | 1967 |
Determination of chloral hydrate, trichloroacetic acid, trichloroethanol, and urochloralic acid in the presence of each other and in tissue homogenates.
Topics: Alcohols; Animals; Chemical Phenomena; Chemistry; Chloral Hydrate; Mice; Tissue Extracts; Trichloroacetic Acid | 1967 |
[Influence of environmental temperature on the duration of experimental sleep and cerebral metabolism of hypnotics in rodents].
Topics: Alcohols; Animals; Brain; Chloral Hydrate; Hexobarbital; Hypothermia; Mice; Pentobarbital; Rats; Sleep; Temperature; Time Factors; Trichloroacetic Acid | 1967 |
Metabolism of trichloroethylene.
Topics: Animals; Chloral Hydrate; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Proteins; Rats; Subcellular Fractions; Trichloroacetic Acid; Trichloroethylene | 1980 |
Formation of malondialdehyde-modified 2'-deoxyguanosinyl adduct from metabolism of chloral hydrate by mouse liver microsomes.
Topics: Animals; Cattle; Chloral Hydrate; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; Ethylene Chlorohydrin; Isotope Labeling; Lipid Peroxidation; Male; Malondialdehyde; Mice; Microsomes, Liver; Phosphorus Radioisotopes; Trichloroacetic Acid | 1995 |
Effect of perchloroethylene and its metabolites on intercellular communication in clone 9 rat liver cells.
Topics: Analysis of Variance; Animals; Chloral Hydrate; Clone Cells; Dichloroacetic Acid; Ethylene Chlorohydrin; Gap Junctions; Liver; Male; Rats; Rats, Sprague-Dawley; Tetrachloroethylene; Trichloroacetic Acid; Water Pollutants | 1996 |
Developmental toxicity of trichloroethylene, tetrachloroethylene and four of their metabolites in rat whole embryo culture.
Topics: Animals; Chloral Hydrate; Chloroacetates; Culture Techniques; Dichloroacetic Acid; Embryo, Mammalian; Embryonic and Fetal Development; Liver; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Tetrachloroethylene; Trichloroacetic Acid; Trichloroethylene | 1995 |
Mouse liver microsomal metabolism of chloral hydrate, trichloroacetic acid, and trichloroethanol leading to induction of lipid peroxidation via a free radical mechanism.
Topics: Allopurinol; Animals; Catalysis; Cell Line; Chloral Hydrate; Ethylene Chlorohydrin; Free Radicals; Gas Chromatography-Mass Spectrometry; Horseradish Peroxidase; Humans; Lipid Peroxidation; Male; Mice; Microsomes, Liver; NAD; NADP; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Trichloroacetic Acid; Xanthine Oxidase | 1996 |
Pharmacokinetic analysis of chloral hydrate and its metabolism in B6C3F1 mice.
Topics: Animals; Area Under Curve; Biotransformation; Chloral Hydrate; Dichloroacetic Acid; Glucuronates; Half-Life; Hypnotics and Sedatives; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred Strains; Trichloroacetic Acid | 1996 |
A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice.
Topics: Administration, Oral; Animals; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Feces; Glucuronates; Liver; Male; Mice; Mice, Inbred Strains; Models, Biological; Solvents; Tissue Distribution; Trichloroacetic Acid; Trichloroethylene | 1997 |
Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK +/- (-)3.7.2C mouse lymphoma cells.
Topics: Animals; Chloral Hydrate; Chromosome Aberrations; Dichloroacetic Acid; Disinfectants; Leukemia L5178; Mice; Mutagenicity Tests; Mutagens; Thymidine Kinase; Trichloroacetic Acid; Tumor Cells, Cultured; Water Purification | 1998 |
Cardiac teratogenicity of trichloroethylene metabolites.
Topics: Abnormalities, Drug-Induced; Acetaldehyde; Acetates; Animals; Chloral Hydrate; Cystine; Dichloroethylenes; Embryonic and Fetal Development; Environmental Pollutants; Ethylene Chlorohydrin; Female; Heart; Heart Defects, Congenital; Humans; Maternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Teratogens; Trichloroacetic Acid; Trichloroethylene; Water Pollutants, Chemical; Water Supply | 1998 |
The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol in B6C3F1 mice.
Topics: Animals; Biological Availability; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Half-Life; Male; Metabolic Clearance Rate; Mice; Models, Biological; Trichloroacetic Acid; Trichloroethylene | 1998 |
Physiologically based pharmacokinetic modeling of inhaled trichloroethylene and its oxidative metabolites in B6C3F1 mice.
Topics: Adipose Tissue; Administration, Inhalation; Animals; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Kidney; Liver; Lung; Male; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Models, Biological; Oxidation-Reduction; Sensitivity and Specificity; Solvents; Tissue Distribution; Trichloroacetic Acid; Trichloroethylene | 1999 |
Effect of enterohepatic circulation on the pharmacokinetics of chloral hydrate and its metabolites in F344 rats.
Topics: Animals; Area Under Curve; Bile; Chloral Hydrate; Dichloroacetic Acid; Disinfectants; Hypnotics and Sedatives; Intestine, Small; Liver; Male; Random Allocation; Rats; Rats, Inbred F344; Trichloroacetic Acid | 1999 |
Determination of chloral hydrate metabolites in human plasma by gas chromatography-mass spectrometry.
Topics: Acetals; Acetates; Acidosis, Lactic; Administration, Oral; Child; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Evaluation Studies as Topic; Gas Chromatography-Mass Spectrometry; Glucuronates; Glucuronides; Humans; Hydroxamic Acids; Reproducibility of Results; Sensitivity and Specificity; Trichloroacetic Acid | 1999 |
Tumorigenicity of chloral hydrate, trichloroacetic acid, trichloroethanol, malondialdehyde, 4-hydroxy-2-nonenal, crotonaldehyde, and acrolein in the B6C3F(1) neonatal mouse.
Topics: Acrolein; Aldehydes; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Chloral Hydrate; Chromatography, High Pressure Liquid; Crosses, Genetic; DNA; DNA Adducts; Electrochemistry; Ethylene Chlorohydrin; Female; Lipid Peroxidation; Liver; Liver Neoplasms, Experimental; Male; Malondialdehyde; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Phosphorus Radioisotopes; Trichloroacetic Acid | 2002 |
Metabolism and toxicity of trichloroethylene in epididymis and testis.
Topics: Administration, Inhalation; Animals; Blotting, Western; Chloral Hydrate; Cytochrome P-450 CYP2E1; Epididymis; Ethylene Chlorohydrin; Immunohistochemistry; Male; Mice; Microsomes; Occupational Exposure; Testis; Trichloroacetic Acid; Trichloroethylene | 2002 |
Guinea pig maximization test for trichloroethylene and its metabolites.
Topics: Allergens; Animals; Chloral Hydrate; Dermatitis, Allergic Contact; Dermatitis, Irritant; Ethylene Chlorohydrin; Guinea Pigs; Skin; Toxicity Tests; Trichloroacetic Acid; Trichloroethylene | 2002 |
Further studies on the metabolic fate of chloral hydrate and trichloroethanol.
Topics: Biochemical Phenomena; Blood; Chloral Hydrate; Ethanol; Ethylene Chlorohydrin; Humans; Trichloroacetic Acid; Trichloroethylene | 1955 |
[Isolation of trichloroacetic acid from the reaction batch in chloral oxidation].
Topics: Aldehydes; Chloral Hydrate; Oxidation-Reduction; Trichloroacetic Acid | 1962 |
[Duration of the presence of chloral hydrate and its metabolites in rat brain. Consequences].
Topics: Alcohols; Animals; Brain; Chloral Hydrate; Iproniazid; Rats; Trichloroacetic Acid | 1963 |
[CONTRIBUTION TO THE STUDY OF CHLORAL HYDRATE METABOLISM IN RODENTS. II. IN MICE].
Topics: Alcohols; Animals; Chloral Hydrate; Ethyl Chloride; Metabolism; Mice; Research; Trichloroacetic Acid | 1964 |
Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure.
Topics: Animals; Area Under Curve; Body Weight; Caloric Restriction; Chloral Hydrate; Chromatography, Gas; Cytochrome P-450 CYP4A; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Induction; Feeding Methods; Food Deprivation; Hypnotics and Sedatives; Liver; Longevity; Male; Mice; Mice, Inbred Strains; Microchemistry; Microsomes, Liver; Trichloroacetic Acid | 2003 |
Activation and attenuation of apoptosis of CD4+ T cells following in vivo exposure to two common environmental toxicants, trichloroacetaldehyde hydrate and trichloroacetic acid.
Topics: Animals; Annexin A5; Apoptosis; Autoantibodies; CD4-Positive T-Lymphocytes; Chloral Hydrate; Female; Interferon-gamma; L-Selectin; Lymphocyte Activation; Mice; Phenotype; Trichloroacetic Acid | 2004 |
Some drinking-water disinfectants and contaminants, including arsenic.
Topics: Animals; Arsenic; Carcinogens, Environmental; Chloral Hydrate; Chloramines; Dichloroacetic Acid; Disinfectants; Furans; Humans; Trichloroacetic Acid; Water Pollutants, Chemical; Water Supply | 2004 |
Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.
Topics: Animals; Carcinogens; Chloral Hydrate; Chloramines; Dichloroacetic Acid; Furans; Humans; Trichloroacetic Acid; Water Supply | 2004 |
Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol.
Topics: Adult; Aged; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Animals; Chloral Hydrate; Cryopreservation; Ethylene Chlorohydrin; Female; Genotype; Hepatocytes; Humans; In Vitro Techniques; Kinetics; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Risk Assessment; Solvents; Trichloroacetic Acid; Trichloroethylene | 2006 |
Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites.
Topics: Animals; Bayes Theorem; Chloral Hydrate; Dichloroacetic Acid; Dose-Response Relationship, Drug; Ethylene Chlorohydrin; Humans; Kinetics; Markov Chains; Mice; Models, Biological; Monte Carlo Method; Rats; Sulfhydryl Compounds; Trichloroacetic Acid; Trichloroethylene | 2006 |
Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid.
Topics: Adolescent; Adult; Animals; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Chromatography, Gas; Ethylene Chlorohydrin; Formates; Hepatocytes; Humans; Kidney Diseases; Kidney Tubules, Proximal; Liver Diseases; Magnetic Resonance Spectroscopy; Male; Rats; Trichloroacetic Acid | 2007 |
Kinetics of chloral hydrate and its metabolites in male human volunteers.
Topics: Adult; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Glucuronates; Humans; Liver; Male; Middle Aged; Time Factors; Trichloroacetic Acid | 2008 |
False-positive ethyl glucuronide immunoassay screening associated with chloral hydrate medication as confirmed by LC-MS/MS and self-medication.
Topics: Adult; Biomarkers; Chloral Hydrate; Chromatography, Liquid; Cross Reactions; Ethylene Chlorohydrin; False Positive Reactions; Female; Forensic Toxicology; Glucuronates; Humans; Hypnotics and Sedatives; Immunoassay; Mass Spectrometry; Self Medication; Trichloroacetic Acid | 2009 |
TRICHLOROETHYLENE, TETRACHLOROETHYLENE, AND SOME OTHER CHLORINATED AGENTS.
Topics: Animals; Carcinogenicity Tests; Carcinogens, Environmental; Chloral Hydrate; Dichloroacetic Acid; Ethane; Humans; Hydrocarbons, Chlorinated; Neoplasms; Risk Assessment; Tetrachloroethylene; Trichloroacetic Acid; Trichloroethylene | 2014 |
Simple method to detect triclofos and its metabolites in plasma of children by combined use of liquid chromatography tandem-mass spectrometry and gas chromatography-mass spectrometry.
Topics: Child, Preschool; Chloral Hydrate; Chromatography, Liquid; Ethylene Chlorohydrin; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Hypnotics and Sedatives; Infant; Japan; Limit of Detection; Male; Mass Spectrometry; Organophosphates; Reproducibility of Results; Tandem Mass Spectrometry; Trichloroacetic Acid | 2019 |