chloral hydrate has been researched along with dichloroacetic acid in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (61.90) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clemens, M; Schöler, HF | 1 |
| Daniel, FB; DeAngelo, AB; Olson, GR; Page, NP; Stober, JA | 1 |
| Benane, SG; Blackman, CF; House, DE | 1 |
| Langonné, I; Sabaté, JP; Saillenfait, AM | 1 |
| Abbas, RR; Fisher, JW; Kidney, JK; Seckel, CS | 1 |
| Davydova, N; Henderson, GN; James, MO; Stacpoole, PW; Yan, Z | 1 |
| Abbas, R; Fisher, JW | 1 |
| Doerr, CL; Harrington-Brock, K; Moore, MM | 1 |
| Elfarra, AA; Krause, RJ; Lash, LH; Last, AR; Parker, JC | 1 |
| Bull, RJ; Gonzalez-Leon, A; Merdink, JL; Schultz, IR | 1 |
| Burton, GA; Fisher, JW; Greenberg, MS | 1 |
| Bull, RJ; Merdink, JL; Parker, JC; Stenner, RD; Stevens, DK | 1 |
| Henderson, GN; James, MO; Stacpoole, PW; Yan, Z | 1 |
| Bartlett, MG; Bruckner, JV; Delinsky, AD | 1 |
| Chiu, WA; Clewell, HJ; Hack, CE; Jay Zhao, Q | 1 |
| Caldwell, JC; Keshava, N | 1 |
| Bull, RJ; Hu, M; Merdink, JL; Parker, JC; Robison, LM; Stevens, DK | 1 |
| Coats, BS; Langaee, T; Shroads, AL; Shuster, JJ; Stacpoole, PW | 1 |
2 review(s) available for chloral hydrate and dichloroacetic acid
| Article | Year |
|---|---|
A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid.
Topics: Animals; Chloral Hydrate; Chromatography, Gas; Chromatography, Liquid; Dichloroacetic Acid; Humans; Mass Spectrometry; Trichloroacetic Acid; Trichloroethylene | 2005 |
Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.
Topics: Animals; Carcinogenicity Tests; Chloral Hydrate; Cysteine; Dichloroacetic Acid; Environmental Pollutants; History, 21st Century; Humans; Kidney Neoplasms; Liver Neoplasms; Risk Assessment; Risk Factors; Signal Transduction; Trichloroacetic Acid; Trichloroethylene; United States | 2006 |
2 trial(s) available for chloral hydrate and dichloroacetic acid
| Article | Year |
|---|---|
Kinetics and metabolism of chloral hydrate in children: identification of dichloroacetate as a metabolite.
Topics: Acidosis, Lactic; Adolescent; Biotransformation; Child; Child, Preschool; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Gas Chromatography-Mass Spectrometry; Glucuronates; Humans; Hypnotics and Sedatives; Infant; Kinetics | 1997 |
Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.
Topics: Acetone; Adult; Biomarkers; Chloral Hydrate; cis-trans-Isomerases; Dichloroacetic Acid; Female; Glutathione Transferase; Healthy Volunteers; Humans; Hypnotics and Sedatives; Male; Maleates; Tyrosine; Young Adult | 2015 |
17 other study(ies) available for chloral hydrate and dichloroacetic acid
| Article | Year |
|---|---|
[Halogenated organic compounds in swimming pool water].
Topics: Acetonitriles; Chloral Hydrate; Chloroform; Dichloroacetic Acid; Germany; Hydrocarbons, Halogenated; Swimming Pools; Trichloroacetic Acid; Trihalomethanes; Water Pollution | 1992 |
Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse.
Topics: Acetaldehyde; Animals; Body Weight; Carcinogens; Chloral Hydrate; Dichloroacetic Acid; Drinking Behavior; Female; Kidney; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Organ Size; Spleen; Testis | 1992 |
Effect of perchloroethylene and its metabolites on intercellular communication in clone 9 rat liver cells.
Topics: Analysis of Variance; Animals; Chloral Hydrate; Clone Cells; Dichloroacetic Acid; Ethylene Chlorohydrin; Gap Junctions; Liver; Male; Rats; Rats, Sprague-Dawley; Tetrachloroethylene; Trichloroacetic Acid; Water Pollutants | 1996 |
Developmental toxicity of trichloroethylene, tetrachloroethylene and four of their metabolites in rat whole embryo culture.
Topics: Animals; Chloral Hydrate; Chloroacetates; Culture Techniques; Dichloroacetic Acid; Embryo, Mammalian; Embryonic and Fetal Development; Liver; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Tetrachloroethylene; Trichloroacetic Acid; Trichloroethylene | 1995 |
Pharmacokinetic analysis of chloral hydrate and its metabolism in B6C3F1 mice.
Topics: Animals; Area Under Curve; Biotransformation; Chloral Hydrate; Dichloroacetic Acid; Glucuronates; Half-Life; Hypnotics and Sedatives; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred Strains; Trichloroacetic Acid | 1996 |
A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice.
Topics: Administration, Oral; Animals; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Feces; Glucuronates; Liver; Male; Mice; Mice, Inbred Strains; Models, Biological; Solvents; Tissue Distribution; Trichloroacetic Acid; Trichloroethylene | 1997 |
Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK +/- (-)3.7.2C mouse lymphoma cells.
Topics: Animals; Chloral Hydrate; Chromosome Aberrations; Dichloroacetic Acid; Disinfectants; Leukemia L5178; Mice; Mutagenicity Tests; Mutagens; Thymidine Kinase; Trichloroacetic Acid; Tumor Cells, Cultured; Water Purification | 1998 |
Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes.
Topics: Acetates; Animals; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Female; Glyoxylates; Humans; Kinetics; Male; Mice; Microsomes, Liver; NADP; Oxalates; Oxalic Acid; Rats; Rats, Inbred F344; Sex Factors; Solvents; Species Specificity; Trichloroethylene | 1998 |
The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol in B6C3F1 mice.
Topics: Animals; Biological Availability; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Half-Life; Male; Metabolic Clearance Rate; Mice; Models, Biological; Trichloroacetic Acid; Trichloroethylene | 1998 |
Physiologically based pharmacokinetic modeling of inhaled trichloroethylene and its oxidative metabolites in B6C3F1 mice.
Topics: Adipose Tissue; Administration, Inhalation; Animals; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Kidney; Liver; Lung; Male; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Models, Biological; Oxidation-Reduction; Sensitivity and Specificity; Solvents; Tissue Distribution; Trichloroacetic Acid; Trichloroethylene | 1999 |
Effect of enterohepatic circulation on the pharmacokinetics of chloral hydrate and its metabolites in F344 rats.
Topics: Animals; Area Under Curve; Bile; Chloral Hydrate; Dichloroacetic Acid; Disinfectants; Hypnotics and Sedatives; Intestine, Small; Liver; Male; Random Allocation; Rats; Rats, Inbred F344; Trichloroacetic Acid | 1999 |
Determination of chloral hydrate metabolites in human plasma by gas chromatography-mass spectrometry.
Topics: Acetals; Acetates; Acidosis, Lactic; Administration, Oral; Child; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Evaluation Studies as Topic; Gas Chromatography-Mass Spectrometry; Glucuronates; Glucuronides; Humans; Hydroxamic Acids; Reproducibility of Results; Sensitivity and Specificity; Trichloroacetic Acid | 1999 |
Some drinking-water disinfectants and contaminants, including arsenic.
Topics: Animals; Arsenic; Carcinogens, Environmental; Chloral Hydrate; Chloramines; Dichloroacetic Acid; Disinfectants; Furans; Humans; Trichloroacetic Acid; Water Pollutants, Chemical; Water Supply | 2004 |
Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.
Topics: Animals; Carcinogens; Chloral Hydrate; Chloramines; Dichloroacetic Acid; Furans; Humans; Trichloroacetic Acid; Water Supply | 2004 |
Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites.
Topics: Animals; Bayes Theorem; Chloral Hydrate; Dichloroacetic Acid; Dose-Response Relationship, Drug; Ethylene Chlorohydrin; Humans; Kinetics; Markov Chains; Mice; Models, Biological; Monte Carlo Method; Rats; Sulfhydryl Compounds; Trichloroacetic Acid; Trichloroethylene | 2006 |
Kinetics of chloral hydrate and its metabolites in male human volunteers.
Topics: Adult; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Glucuronates; Humans; Liver; Male; Middle Aged; Time Factors; Trichloroacetic Acid | 2008 |
TRICHLOROETHYLENE, TETRACHLOROETHYLENE, AND SOME OTHER CHLORINATED AGENTS.
Topics: Animals; Carcinogenicity Tests; Carcinogens, Environmental; Chloral Hydrate; Dichloroacetic Acid; Ethane; Humans; Hydrocarbons, Chlorinated; Neoplasms; Risk Assessment; Tetrachloroethylene; Trichloroacetic Acid; Trichloroethylene | 2014 |