chitosan has been researched along with methotrexate in 87 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.15) | 18.2507 |
| 2000's | 8 (9.20) | 29.6817 |
| 2010's | 50 (57.47) | 24.3611 |
| 2020's | 28 (32.18) | 2.80 |
| Authors | Studies |
|---|---|
| Blanton, CD; Gallo, JM; Sanzgiri, YD | 1 |
| Hu, FQ; Ye, YQ; Yuan, H | 1 |
| Chan, WC; Kumacheva, E; Mardyani, S; Zhang, H | 1 |
| Oungbho, K; Tangtrakulwanich, B; Vechasilp, J; Yuenyongsawad, S | 1 |
| Chen, H; Gao, F; Liu, L; Wang, Y; Yang, X; Zhang, H; Zhang, Q | 1 |
| Cui, F; Ma, R; Niu, M; Shi, K; Sun, Y; Wang, J | 1 |
| Jang, MJ; Jang, MK; Jeong, YI; Kim, DG; Nah, JW; Seo, DH | 1 |
| Chen, F; Ni, J; Zhang, X | 1 |
| He, C; He, X; Tan, W; Wang, K; Wu, P; Zheng, M | 1 |
| Danjun, W; Jingou, J; Shilei, H; Tengfei, W; Weiqi, L; Yi, X | 1 |
| Hagesaether, E | 1 |
| Maharramov, A; Ramazanov, MA; Saboktakin, MR; Tabatabaie, RM | 1 |
| Bakowsky, U; Denora, N; Iacobellis, G; Kissel, T; Sitterberg, J; Trapani, A | 1 |
| Koland, M; Nairy, MH; Nisha, GS; Prabhu, P; Shetty, R; Vijayalakshmi, KK; Vijayanarayana, K | 1 |
| Infante, MR; Mitjans, M; Nogueira, DR; Pérez, L; Tavano, L; Vinardell, MP | 1 |
| Chen, Z; Du, LB; He, Z; Huang, SP; Jia, HY; Leng, ZH; Li, YC; Liu, Y; Zhou, JW; Zhuang, QF | 1 |
| Azadi, A; Hamidi, M; Rouini, MR | 2 |
| Chen, J; Fang, M; Huang, L; Lai, H; Lu, C; Luo, X; Zhang, Q | 1 |
| Augsburger, JJ; Banerjee, RK; Correa, ZM; Landero, JA; Manna, S | 1 |
| Bader, RA; Wardwell, PR; Zhang, N | 1 |
| Hou, Z; Huang, Y; Jia, M; Li, Y; Lin, J; Wu, H; Yang, X; Zhang, Q | 1 |
| Dang, Y; Gao, C; Guo, J; He, G; Kong, X; Liu, T; Wang, W; Yin, Y; Yu, Z; Zhang, X; Zheng, H | 1 |
| Aruna, P; Chinnathambi, S; Ganesan, S; Mangaiyarkarasi, R | 1 |
| Asgarshamsi, M; Fattahi, A; Hasanzadeh, F; Mirian, M; Rostami, M; Sadeghi-aliabadi, H; Varshosaz, J | 1 |
| Al-Rjoub, MF; Augsburger, JJ; Banerjee, RK; Correa, ZM; Donnell, A; Manna, S | 1 |
| Alvarez-Lorenzo, C; Blanco-Fernández, B; Concheiro, A; Costoya, A; Curcio, M; Puoci, F | 1 |
| Hou, Z; Li, Y; Lin, C; Lin, J; Luo, F; Wu, H; Xie, L; Yu, F; Zhou, S | 1 |
| Farooqi, AA; Macedo, LB; Marcolino, AI; Mitjans, M; Nogueira, DR; Pilar Vinardell, M; Rolim, CM; Rosa Infante, M; Scheeren, LE | 1 |
| Prabu, P; Sastry, TP; Vedakumari, WS | 1 |
| Bader, RA; Forstner, MB; Wardwell, PR | 1 |
| Dang, Q; Fan, B; Liu, C; Wan, H; Wang, Y; Yan, J | 1 |
| Li, M; Liu, BM; Wang, SY; Yin, BS; Zhang, WG; Zou, JY | 1 |
| Ashrafi, H; Azadi, A | 1 |
| Dorkoosh, FA; Ghaffarzadegan, R; Ghazizadeh, L; Mirzakhanlouei, S; Naghibi Beidokhti, HR | 1 |
| Al-Rjoub, MF; Augsburger, JJ; Banerjee, RK; Correa, ZM; Manna, S | 1 |
| Geneidi, AS; Hashad, RA; Ishak, RA; Mansour, S | 2 |
| Jiang, W; Shen, Y; Tian, R; Wu, J | 1 |
| Al-Rjoub, MF; Augsburger, JJ; Banerjee, RK; Correa, ZM; Manna, S; Rao, MB | 1 |
| Abbasi, S; Fahham, M; Firuzi, O; Karimi, L; Karimi, Z; Shokrollahi, H; Yousefi, G | 1 |
| Mahdavinia, GR; Mosallanezhad, A; Sabzi, M; Soleymani, M | 1 |
| Kaul, A; Kumar, V; Leekha, A; Mishra, AK; Tyagi, A; Verma, AK | 1 |
| Fan, Z; Hou, Z; Jiang, Y; Li, Y; Lu, Y; Wu, S; Yang, X | 1 |
| Asmatulu, R; Berndt, M; Cluff, K; Saeednia, L; Yao, L | 1 |
| Li, S; Xiong, Y; Zhang, X | 1 |
| Chatterjee, B; Ghosh, SS; Raza, A | 1 |
| Gowthaman, MK; Gunadharini, DN; Hemalatha, T; Prabu, P | 1 |
| Fattahi, A; Sadrjavadi, K; Shahbazi, B | 1 |
| Du, L; Guo, X; Ji, T; Jia, H; Li, C; Li, H; Liu, Y; Wang, Y; Zhang, Y; Zhuang, Q | 1 |
| Al-Rjoub, MF; Augsburger, JJ; Banerjee, RK; Donnell, AM; Kaval, N; Manna, S | 1 |
| Choonara, YE; Clift, SJ; du Toit, LC; Kumar, P; Pantshwa, JM; Penny, C; Pillay, V; Pradeep, P; Rhoda, K | 1 |
| Ait Bachir, Z; Chen, R; Gao, F; He, M; Hou, X; Huang, L; Huang, Y | 1 |
| Damodharan, N; Teja, SPS | 1 |
| Chen, J; Gan, C; Huang, L; Lai, H; Luo, X; Yang, X | 1 |
| Barbosa, AI; Costa Lima, SA; Reis, S | 1 |
| Ashrafi, H; Azadi, A; Moghaddam Panah, F; Pourtalebi Jahromi, L | 1 |
| Ghorbani, M; Jannat, B; Mahmoodzadeh, F | 1 |
| Chen, J; He, X; Jiang, Y; Li, X; Qu, J; Zhang, T | 1 |
| Barar, J; Erfan-Niya, H; Fathi, M; Omidi, Y | 1 |
| Chen, L; Fan, X; Fei, Z; Han, Q; Luo, Q; Wang, Y; Zhang, H | 1 |
| Kaul, A; Kumar, V; Leekha, A; Mishra, AK; Verma, AK | 1 |
| Mohammed, AM; Osman, SK; Saleh, KI; Samy, AM | 1 |
| Eftekhari, Z; Jabbari, N; Parivar, K; Roodbari, NH | 1 |
| Alhajj, MJ; Carabali, GA; Ciro, Y; Di Virgilio, AL; Rojas, J; Salamanca, CH | 1 |
| Chen, H; Chen, Q; Han, D | 1 |
| Keyhanfar, M; Shakeran, Z; Sutherland, DS; Varshosaz, J | 1 |
| Boni, FI; Cury, BSF; Ferreira, NN; Gremião, MPD; Teixeira, DA | 1 |
| Augsburger, JJ; Banerjee, RK; Caixeta Faraj, RQ; Correa, ZM; Manna, S; Nair, V; Rao, MB; Riemann, B; Riemann, CD | 1 |
| Ai, Y; Chen, MM; Liu, D; Liu, F; Wang, J; Zhang, Z | 1 |
| Fu, S; Lai, R; Liu, Z; Lu, Y; Luo, W; Wang, Y; Xu, Y | 1 |
| Aykac, A; Bilginaylar, K; Özkayalar, H; Sayiner, S; Şehirli, AÖ | 1 |
| Aslam, A; Bukhari, SNA; Ejaz, H; Elsherif, MAM; Ghumman, SA; Hameed, H; Hasan, S; Ijaz, B; Iqbal, H; Noreen, S; Noureen, S | 1 |
| Akhtar, B; Akhtar, K; Arshad, MI; Javed, Y; Muhammad, F; Saleem, MU; Sharif, A | 1 |
| Bruckmann, FDS; Dorneles, LS; Fagan, SB; Garcia, WJDS; Oliveira, AH; Rhoden, CRB; Roberto Mortari, S; Rossato Viana, A; Silva, IZD; Silva, WLD; Tonel, MZ | 1 |
| Khan, S; Madni, A; Nawaz, M; Rehman, S; Shafiq, A; Shah, H; Sultana, H | 1 |
| Ashrafi, H; Azadi, A; Heidari, R; Mirzaei, E; Ourani-Pourdashti, S | 1 |
| Kim, HJ; Kim, MA; Lee, CM; Lee, JS; Shin, SR | 1 |
| Cai, W; Gao, J; Kong, Y; Li, J; Rui, Q; Wu, D; Yin, ZZ | 1 |
| Hamed, AA; Hanna, DH; Saad, GR | 1 |
| Kumar, M; Rani, V; Verma, R | 1 |
| Al-Nemrawi, NK; Alzoubi, KH; Khafajah, AS | 1 |
| Al-Nemrawi, N; Alzoubi, KH; Wahsheh, Y | 1 |
| Ambre, P; Coutinho, E; Gupta, C; Singh, P; Vaidya, S | 1 |
| Asaad, GF; El-Dakroury, WA; El-Gizawy, SA; Shabana, ME; Zewail, MB | 1 |
| De Wael, K; Detamornrat, U; Domínguez-Robles, J; Donnelly, RF; Parrilla, M; Tunca, S | 1 |
| Gaber, M; Ghareeb, D; Hamed, A; Hamed, M; Mohamed, TM; Nofal, MS | 1 |
1 review(s) available for chitosan and methotrexate
| Article | Year |
|---|---|
Food-Derived Nanoscopic Drug Delivery Systems for Treatment of Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chitosan; Drug Carriers; Flavonoids; Humans; Methotrexate; Nanostructures; Plant Oils; Polyphenols | 2020 |
86 other study(ies) available for chitosan and methotrexate
| Article | Year |
|---|---|
Synthesis, characterization, and in vitro stability of chitosan-methotrexate conjugates.
Topics: Binding, Competitive; Chemistry, Pharmaceutical; Chitin; Chitosan; Dialysis; Drug Stability; Methotrexate; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1990 |
[Preparation and characterization of stearic acid-grafted chitosan oligosaccharide polymeric micelles].
Topics: Chitosan; Drug Carriers; Drug Delivery Systems; Hydrogen-Ion Concentration; Methotrexate; Micelles; Oligosaccharides; Particle Size; Polymers; Polyphosphates; Solubility; Stearic Acids | 2004 |
Design of biocompatible chitosan microgels for targeted pH-mediated intracellular release of cancer therapeutics.
Topics: Antineoplastic Agents; Biocompatible Materials; Biological Transport; Cell Survival; Chitosan; Gels; HeLa Cells; Humans; Hydrogen-Ion Concentration; Methotrexate; Microchemistry; Molecular Conformation | 2006 |
The efficacy of methotrexate-impregnated hydroxyapatite composites on human mammary carcinoma cells.
Topics: Alginates; Antimetabolites, Antineoplastic; Biocompatible Materials; Breast Neoplasms; Calcium Sulfate; Chitosan; Drug Carriers; Drug Combinations; Humans; Hydroxyapatites; In Vitro Techniques; Methotrexate; Spectroscopy, Fourier Transform Infrared; Tumor Cells, Cultured | 2007 |
Self-aggregated nanoparticles from methoxy poly(ethylene glycol)-modified chitosan: synthesis; characterization; aggregation and methotrexate release in vitro.
Topics: Chitosan; Drug Delivery Systems; Magnetic Resonance Spectroscopy; Methotrexate; Nanoparticles; Polyethylene Glycols; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2008 |
The effect of chitosan molecular weight on the characteristics of spray-dried methotrexate-loaded chitosan microspheres for nasal administration.
Topics: Adhesiveness; Administration, Intranasal; Animals; Antimetabolites, Antineoplastic; Anura; Calorimetry, Differential Scanning; Chitosan; Cilia; Delayed-Action Preparations; Drug Carriers; Methotrexate; Microspheres; Molecular Weight; Particle Size; Toxicity Tests | 2009 |
Methotrexate-incorporated polymeric nanoparticles of methoxy poly(ethylene glycol)-grafted chitosan.
Topics: Chitosan; Drug Carriers; Drug Delivery Systems; Methotrexate; Microscopy, Electron, Transmission; Nanoparticles; Nuclear Magnetic Resonance, Biomolecular; Particle Size; Polyethylene Glycols | 2009 |
A novel method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system.
Topics: Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Drug Compounding; Drug Delivery Systems; Ferrosoferric Oxide; Glutaral; Methotrexate; Microspheres; Particle Size; Static Electricity; Technology, Pharmaceutical | 2009 |
A novel methotrexate delivery system based on chitosan-methotrexate covalently conjugated nanoparticles.
Topics: Breast Neoplasms; Cell Line, Tumor; Chitosan; Crystallization; Diffusion; Humans; Macromolecular Substances; Materials Testing; Methotrexate; Molecular Conformation; Nanocapsules; Nanomedicine; Particle Size; Surface Properties | 2009 |
Preparation, characterization of hydrophilic and hydrophobic drug in combine loaded chitosan/cyclodextrin nanoparticles and in vitro release study.
Topics: beta-Cyclodextrins; Chitosan; Hydrophobic and Hydrophilic Interactions; Kinetics; Leucovorin; Methotrexate; Nanoparticles; Solubility; Spectroscopy, Fourier Transform Infrared; Water; X-Ray Diffraction | 2011 |
Permeation modulating properties of natural polymers--effect of molecular weight and mucus.
Topics: Chitosan; Excipients; Fluoresceins; Fluorescent Dyes; Goblet Cells; HT29 Cells; Humans; Hyaluronic Acid; Methotrexate; Molecular Weight; Mucus; Pectins; Permeability; Polymers | 2011 |
Synthesis and characterization of pH-dependent glycol chitosan and dextran sulfate nanoparticles for effective brain cancer treatment.
Topics: Brain Neoplasms; Chitosan; Dextran Sulfate; Drug Compounding; Hydrogen-Ion Concentration; Methotrexate; Molecular Weight; Nanoparticles; Temperature | 2011 |
Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors.
Topics: Animals; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Cell Line; Cell Survival; Chemistry, Pharmaceutical; Chitosan; Dogs; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Glycols; Kinetics; Methotrexate; Microscopy, Atomic Force; Microscopy, Confocal; Nanoparticles; Nanotechnology; Particle Size; Polysorbates; Rats; Solubility; Technology, Pharmaceutical; Transfection | 2011 |
Investigation of nano lipid vesicles of methotrexate for anti-rheumatoid activity.
Topics: Analysis of Variance; Animals; Antirheumatic Agents; Arthritis, Experimental; Calorimetry, Differential Scanning; Chitosan; Drug Stability; Inflammation; Liposomes; Male; Methotrexate; Nanoparticles; Particle Size; Rats; Rats, Wistar | 2012 |
In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Cycle; Cell Survival; Chemical Phenomena; Chitosan; Drug Delivery Systems; Feasibility Studies; Fluoresceins; HeLa Cells; Humans; Hydrogen-Ion Concentration; Lysine; MCF-7 Cells; Methotrexate; Microscopy, Fluorescence; Nanoparticles; Surface-Active Agents | 2013 |
Polyamidoamine dendrimer conjugated chitosan nanoparticles for the delivery of methotrexate.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Cell Survival; Chitosan; Dendrimers; Drug Carriers; Fluorescein-5-isothiocyanate; Intracellular Space; Methotrexate; Mice; Nanoparticles; Platelet Aggregation | 2013 |
Methotrexate-loaded chitosan nanogels as 'Trojan Horses' for drug delivery to brain: preparation and in vitro/in vivo characterization.
Topics: Animals; Antineoplastic Agents; Brain; Chitosan; Drug Carriers; Drug Delivery Systems; Drug Stability; Hydrogel, Polyethylene Glycol Dimethacrylate; Kinetics; Male; Methotrexate; Nanoparticles; Particle Size; Rats | 2013 |
Methotrexate-loaded PEGylated chitosan nanoparticles: synthesis, characterization, and in vitro and in vivo antitumoral activity.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; HeLa Cells; Humans; Male; Methotrexate; Mice; Nanoparticles; Neoplasms; Particle Size; Polyethylene Glycols | 2014 |
Development of chitosan and polylactic acid based methotrexate intravitreal micro-implants to treat primary intraocular lymphoma: an in vitro study.
Topics: Absorption, Physicochemical; Animals; Capsules; Chitosan; Diffusion; Drug Implants; Humans; In Vitro Techniques; Intraocular Lymphoma; Intravitreal Injections; Lactic Acid; Materials Testing; Methotrexate; Polyesters; Polymers; Treatment Outcome | 2014 |
In vitro efficacy of polysaccharide-based nanoparticles containing disease-modifying antirheumatic drugs.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Chitosan; Dexamethasone; Drug Carriers; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-6; Interleukin-8; Methotrexate; Nanoparticles; Sialic Acids; Synovial Membrane | 2014 |
Development of both methotrexate and mitomycin C loaded PEGylated chitosan nanoparticles for targeted drug codelivery and synergistic anticancer effect.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Chitosan; Drug Delivery Systems; Drug Synergism; HeLa Cells; Humans; Methotrexate; Mice; Mitomycin; Nanoparticles; Neoplasms, Experimental; Polyethylene Glycols | 2014 |
pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate.
Topics: Antimetabolites, Antineoplastic; Cell Survival; Chitosan; Delayed-Action Preparations; HeLa Cells; Humans; Hydrogen-Ion Concentration; Methotrexate; Nanoparticles; Neoplasms; Oxidation-Reduction; Sulfhydryl Compounds | 2014 |
Synthesis and formulation of methotrexate (MTX) conjugated LaF3:Tb(3+)/chitosan nanoparticles for targeted drug delivery applications.
Topics: Apoptosis; Cell Survival; Chitosan; Dose-Response Relationship, Drug; Drug Delivery Systems; Humans; Inhibitory Concentration 50; Lanthanum; MCF-7 Cells; Methotrexate; Nanoparticles; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Static Electricity; Terbium; Time Factors; X-Ray Diffraction | 2015 |
Methotrexate-grafted-oligochitosan micelles as drug carriers: synthesis and biological evaluations.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chitosan; Diffusion; Drug Compounding; Humans; Materials Testing; Methotrexate; Micelles; Nanocapsules; Particle Size; Treatment Outcome | 2015 |
Biodegradable chitosan and polylactic acid-based intraocular micro-implant for sustained release of methotrexate into vitreous: analysis of pharmacokinetics and toxicity in rabbit eyes.
Topics: Absorbable Implants; Animals; Antimetabolites, Antineoplastic; Biocompatible Materials; Chitosan; Drug Delivery Systems; Drug Implants; Intravitreal Injections; Lactic Acid; Methotrexate; Models, Animal; Polyesters; Polymers; Rabbits; Retina; Vitreous Body | 2015 |
Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles.
Topics: Animals; Antimetabolites, Antineoplastic; BALB 3T3 Cells; Cell Survival; Chemistry, Pharmaceutical; Chitosan; CHO Cells; Chondroitin Sulfates; Cricetulus; Cross-Linking Reagents; Cryoprotective Agents; Dermatan Sulfate; Dose-Response Relationship, Drug; Drug Carriers; Female; Freeze Drying; Glucose; Glutathione; HeLa Cells; Humans; Kinetics; Methotrexate; Mice; Microscopy, Confocal; Nanomedicine; Nanoparticles; Polymethacrylic Acids; Polysaccharides; Solubility; Technology, Pharmaceutical; Uterine Cervical Neoplasms | 2015 |
Neuropharmacokinetic evaluation of methotrexate-loaded chitosan nanogels.
Topics: Animals; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Brain; Capillary Permeability; Chitosan; Drug Compounding; Drug Delivery Systems; Drug Liberation; Gels; Half-Life; Injections, Intravenous; Male; Methotrexate; Nanostructures; Particle Size; Rats; Rats, Sprague-Dawley; Surface Properties | 2015 |
Drug/Dye-Loaded, Multifunctional PEG-Chitosan-Iron Oxide Nanocomposites for Methotraxate Synergistically Self-Targeted Cancer Therapy and Dual Model Imaging.
Topics: Cell Line, Tumor; Cell Survival; Chitosan; Diagnostic Imaging; Drug Delivery Systems; Ferric Compounds; Humans; Methotrexate; Nanocomposites; Nanoparticles; Neoplasms; Polyethylene Glycols | 2015 |
Inclusion of a pH-responsive amino acid-based amphiphile in methotrexate-loaded chitosan nanoparticles as a delivery strategy in cancer therapy.
Topics: Amino Acids; Antineoplastic Agents; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Methotrexate; Nanoparticles | 2016 |
Chitosan-Fibrin Nanocomposites as Drug Delivering and Wound Healing Materials.
Topics: Animals; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; Escherichia coli; Fibrin; HeLa Cells; Humans; Male; Methotrexate; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanocomposites; Nanoparticles; Nanotechnology; Rats; Staphylococcus aureus; Tensile Strength; Wound Healing | 2015 |
Investigation of the cytokine response to NF-κB decoy oligonucleotide coated polysaccharide based nanoparticles in rheumatoid arthritis in vitro models.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Chitosan; Chromatography, High Pressure Liquid; Cytokines; Drug Carriers; Enzyme-Linked Immunosorbent Assay; Humans; In Vitro Techniques; Methotrexate; Nanoparticles; Oligodeoxyribonucleotides; Oligonucleotides; Polysaccharides; Sialic Acids | 2015 |
Characterization and biocompatibility of injectable microspheres-loaded hydrogel for methotrexate delivery.
Topics: Animals; Antimetabolites, Antineoplastic; Biocompatible Materials; Chitosan; Drug Delivery Systems; Drug Liberation; Hydrogels; Methotrexate; Mice; Microspheres; Rabbits | 2016 |
Effects of Incorporating Carboxymethyl Chitosan into PMMA Bone Cement Containing Methotrexate.
Topics: Animals; Biocompatible Materials; Bone Cements; Bone Neoplasms; Cell Line, Tumor; Chitosan; Compressive Strength; Femur; Guinea Pigs; Humans; Imaging, Three-Dimensional; Lab-On-A-Chip Devices; Materials Testing; Methotrexate; Microscopy, Electron, Scanning; Polymethyl Methacrylate; Tomography, Spiral Computed | 2015 |
Chitosan-based hydrogel nanoparticle amazing behaviors during transmission electron microscopy.
Topics: Antimetabolites, Antineoplastic; Chitosan; Drug Carriers; Drug Liberation; Hydrogel, Polyethylene Glycol Dimethacrylate; Methotrexate; Nanoparticles | 2016 |
Preparation, Characterization, and Optimization of Folic Acid-Chitosan-Methotrexate Core-Shell Nanoparticles by Box-Behnken Design for Tumor-Targeted Drug Delivery.
Topics: Cell Line; Cell Line, Tumor; Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Drug Delivery Systems; Folic Acid; HeLa Cells; Humans; Methotrexate; Nanoparticles; Particle Size | 2017 |
Ultrasonographical assessment of implanted biodegradable device for long-term slow release of methotrexate into the vitreous.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Chitosan; Delayed-Action Preparations; Disease Models, Animal; Drug Delivery Systems; Immunosuppressive Agents; Methotrexate; Polyesters; Rabbits; Retina; Ultrasonography; Vitreous Body | 2016 |
Methotrexate loading in chitosan nanoparticles at a novel pH: Response surface modeling, optimization and characterization.
Topics: Calorimetry, Differential Scanning; Chitosan; Dialysis; Drug Liberation; Freeze Drying; Hydrogen-Ion Concentration; Methotrexate; Nanoparticles; Spectroscopy, Fourier Transform Infrared; Statistics as Topic | 2016 |
Facile synthesis of magnetic-/pH-responsive hydrogel beads based on Fe3O4 nanoparticles and chitosan hydrogel as MTX carriers for controlled drug release.
Topics: Chemistry Techniques, Synthetic; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Hydrogels; Hydrogen-Ion Concentration; Kinetics; Magnetite Nanoparticles; Methotrexate; Microspheres | 2016 |
Noninvasive Electroretinography Assessment of Intravitreal Sustained-Release Methotrexate Microimplants in Rabbit Eyes.
Topics: Animals; Chitosan; Drug Delivery Systems; Electroretinography; Intravitreal Injections; Methotrexate; Polyesters; Rabbits; Retina | 2016 |
Pegylated and amphiphilic Chitosan coated manganese ferrite nanoparticles for pH-sensitive delivery of methotrexate: Synthesis and characterization.
Topics: Chitosan; Coated Materials, Biocompatible; Delayed-Action Preparations; Ferric Compounds; Humans; Manganese Compounds; MCF-7 Cells; Methotrexate; Nanoparticles; Polyethylene Glycols | 2017 |
Magnetic- and pH-responsive κ-carrageenan/chitosan complexes for controlled release of methotrexate anticancer drug.
Topics: Antineoplastic Agents; Carrageenan; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Hydrogen-Ion Concentration; Magnetite Nanoparticles; Methotrexate | 2017 |
Preparation and evaluation of biopolymeric nanoparticles as drug delivery system in effective treatment of rheumatoid arthritis.
Topics: Animals; Antioxidants; Antirheumatic Agents; Arthritis, Rheumatoid; Biocompatible Materials; Cell Culture Techniques; Cell Line; Chitosan; Dexamethasone; Drug Delivery Systems; Drug Stability; Excipients; Humans; Hydrogen-Ion Concentration; Methotrexate; Nanoparticles; Particle Size; Rats, Wistar; Surface Properties; Tissue Distribution | 2017 |
A green approach to dual-drug nanoformulations with targeting and synergistic effects for cancer therapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Camptothecin; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Combinations; Drug Compounding; Drug Stability; Drug Synergism; Female; Green Chemistry Technology; HeLa Cells; Humans; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Nanomedicine; Nanoparticles; Solubility; Technology, Pharmaceutical; Tissue Distribution; Tumor Burden; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Surface functionalization of methotrexate-loaded chitosan nanoparticles with hyaluronic acid/human serum albumin: Comparative characterization and in vitro cytotoxicity.
Topics: Antimetabolites; Cell Survival; Chitosan; Drug Liberation; Female; Humans; Hyaluronic Acid; MCF-7 Cells; Methotrexate; Molecular Weight; Nanoparticles; Particle Size; Serum Albumin | 2017 |
Structural and biological properties of thermosensitive chitosan-graphene hybrid hydrogels for sustained drug delivery applications.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Death; Cell Proliferation; Cell Survival; Chitosan; Drug Delivery Systems; Drug Liberation; Graphite; Hydrogels; Kinetics; Methotrexate; Mice; Spectroscopy, Fourier Transform Infrared; Temperature | 2017 |
Poloxamer surface modified trimethyl chitosan nanoparticles for the effective delivery of methotrexate in osteosarcoma.
Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; Endocytosis; Humans; Methotrexate; Nanoparticles; Osteosarcoma; Poloxamer | 2017 |
Developing single-entity theranostic: drug-based fluorescent nanoclusters with augmented cytotoxicity.
Topics: Apoptosis; Cell Proliferation; Cell Survival; Chitosan; Drug Delivery Systems; Gold; HeLa Cells; Humans; Metal Nanoparticles; Methotrexate; Neoplasms; Theranostic Nanomedicine | 2018 |
Fabrication and characterization of dual acting oleyl chitosan functionalised iron oxide/gold hybrid nanoparticles for MRI and CT imaging.
Topics: Animals; Cell Line, Tumor; Chitosan; Diagnostic Imaging; Drug Delivery Systems; Ferric Compounds; Gold; Humans; Magnetic Resonance Angiography; Magnetite Nanoparticles; Methotrexate; Mice; Tomography, X-Ray Computed | 2018 |
De-esterified tragacanth-chitosan nano-hydrogel for methotrexate delivery; optimization of the formulation by Taguchi design.
Topics: Biological Transport; Chitosan; Drug Carriers; Drug Compounding; Drug Liberation; Esterification; HT29 Cells; Humans; Hydrogels; MCF-7 Cells; Membrane Potential, Mitochondrial; Methotrexate; Nanoparticles; Tragacanth | 2018 |
Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chitosan; Drug Carriers; Female; Humans; Lung Neoplasms; Methotrexate; Mice; Mice, Inbred BALB C; Nanoparticles | 2018 |
Improved design and characterization of PLGA/PLA-coated Chitosan based micro-implants for controlled release of hydrophilic drugs.
Topics: Antimetabolites, Antineoplastic; Chitosan; Delayed-Action Preparations; Drug Design; Drug Implants; Drug Liberation; Hydrophobic and Hydrophilic Interactions; Lactic Acid; Methotrexate; Molecular Weight; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2018 |
Chemotherapeutic Efficacy of Implantable Antineoplastic-Treatment Protocols in an Optimal Mouse Model for Human Ovarian Carcinoma Cell Targeting.
Topics: Absorbable Implants; Acrylamides; Animals; Antineoplastic Agents; Antineoplastic Protocols; Carcinoma; Cell Line, Tumor; Chitosan; Female; Humans; Hydrogels; Methotrexate; Mice; Mice, Nude; Micelles; Nanoparticles; Ovarian Neoplasms; Povidone | 2018 |
Effects of PEG surface density and chain length on the pharmacokinetics and biodistribution of methotrexate-loaded chitosan nanoparticles.
Topics: Animals; Area Under Curve; Cell Line; Chitosan; Drug Carriers; Drug Delivery Systems; Drug Liberation; Endocytosis; Methotrexate; Mice, Inbred ICR; Nanoparticles; Particle Size; Polyethylene Glycols; Rats, Sprague-Dawley; Surface Properties; Tissue Distribution | 2018 |
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Topics: Chitosan; Drug Carriers; Methotrexate; Nanoparticles | 2018 |
Development of dual-drug-loaded stealth nanocarriers for targeted and synergistic anti-lung cancer efficacy.
Topics: A549 Cells; Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Cycle; Chitosan; Drug Carriers; Drug Design; Drug Liberation; Drug Synergism; Humans; Methotrexate; Mice, Inbred C57BL; Nanoparticles; Pemetrexed | 2018 |
Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Cell Line; Chitosan; Drug Delivery Systems; Humans; Methotrexate; Mice; Nanoparticles; Polysaccharides; Skin Absorption; Swine | 2019 |
A mechanistic investigation on methotrexate-loaded chitosan-based hydrogel nanoparticles intended for CNS drug delivery: Trojan horse effect or not?
Topics: Animals; Brain; Chitosan; Drug Carriers; Drug Delivery Systems; Hydrogels; Methotrexate; Nanoparticles; Particle Size; Rats; Verapamil | 2019 |
Chitosan-based nanomicelle as a novel platform for targeted delivery of methotrexate.
Topics: A549 Cells; Cell Survival; Chitosan; Drug Delivery Systems; Drug Liberation; Endocytosis; Fluorescein; Hemolysis; Humans; MCF-7 Cells; Methotrexate; Micelles; Nanoparticles; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared | 2019 |
Nuclear Factor kappa B (NF-κB) Targeted Self-Assembled Nanoparticles Loaded with Methotrexate for Treatment of Rheumatoid Arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chitosan; Drug Carriers; Male; Methotrexate; Mice; Nanoparticles; NF-kappa B; Particle Size; RAW 264.7 Cells | 2019 |
Methotrexate-conjugated chitosan-grafted pH- and thermo-responsive magnetic nanoparticles for targeted therapy of ovarian cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Liberation; Erlotinib Hydrochloride; Female; Humans; Magnetite Nanoparticles; Methotrexate; Ovarian Neoplasms | 2020 |
Redox response, antibacterial and drug package capacities of chitosan-α-lipoic acid conjugates.
Topics: Animals; Anti-Bacterial Agents; Cell Line, Tumor; Chitosan; Drug Carriers; Escherichia coli; Hydrogels; Methotrexate; Mice; Thioctic Acid | 2020 |
Role of folate-conjugated glycol-chitosan nanoparticles in modulating the activated macrophages to ameliorate inflammatory arthritis: in vitro and in vivo activities.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Survival; Chitosan; Drug Liberation; Female; Folic Acid; HEK293 Cells; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Methotrexate; Mice; Nanoparticles; Rats, Wistar; RAW 264.7 Cells | 2020 |
In Vitro Release of 5-Fluorouracil and Methotrexate from Different Thermosensitive Chitosan Hydrogel Systems.
Topics: Antimetabolites, Antineoplastic; Calorimetry, Differential Scanning; Chitosan; Drug Delivery Systems; Drug Liberation; Fluorouracil; Hydrogels; Methotrexate; Temperature | 2020 |
Evaluation of Encapsulated Eugenol by Chitosan Nanoparticles on the aggressive model of rheumatoid arthritis.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; Chemokine CCL2; Chitosan; Drug Carriers; Eugenol; Malondialdehyde; Methotrexate; Nanoparticles; Rats, Wistar; Transforming Growth Factor beta | 2020 |
Production, physicochemical characterization, and anticancer activity of methotrexate-loaded phytic acid-chitosan nanoparticles on HT-29 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Liberation; Gels; HT29 Cells; Humans; Methotrexate; Nanoparticles; Phytic Acid | 2020 |
Biodegradable nanocarriers based on chitosan-modified mesoporous silica nanoparticles for delivery of methotrexate for application in breast cancer treatment.
Topics: Breast Neoplasms; Chitosan; Drug Delivery Systems; Humans; Methotrexate; Nanoparticles; Porosity; Silicon Dioxide | 2021 |
Computational and experimental approaches for chitosan-based nano PECs design: Insights on a deeper comprehension of nanostructure formation.
Topics: Antimetabolites, Antineoplastic; Chitosan; Drug Carriers; Drug Compounding; Humans; Hyaluronic Acid; Hydrogen-Ion Concentration; Methotrexate; Methylcellulose; Nanostructures; Particle Size; Polyelectrolytes; Solutions; Static Electricity; Thermodynamics | 2021 |
Non-invasive evaluation of toxicity in vitreoretinal domain following insertion of sustained release methotrexate micro-implant.
Topics: Absorbable Implants; Animals; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Implants; Electroretinography; Immunosuppressive Agents; Intraocular Pressure; Intravitreal Injections; Methotrexate; Microscopy, Acoustic; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Retina; Slit Lamp Microscopy; Vitreous Body | 2021 |
Lactobionic acid-modified thymine-chitosan nanoparticles as potential carriers for methotrexate delivery.
Topics: Antimetabolites, Antineoplastic; Cell Proliferation; Cell Survival; Chitosan; Disaccharides; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Methotrexate; Molecular Conformation; Nanoparticles; Thymine | 2021 |
Chitosan/hyaluronan nanogels co-delivering methotrexate and 5-aminolevulinic acid: A combined chemo-photodynamic therapy for psoriasis.
Topics: Aminolevulinic Acid; Cell Line; Chitosan; Drug Therapy, Combination; Humans; Hyaluronic Acid; Levulinic Acids; Lipopolysaccharides; Methotrexate; Nanogels; Photosensitizing Agents; Psoriasis | 2022 |
Evaluation of the antiapoptotic and anti-inflammatory properties of chitosan in methotrexate-induced oral mucositis in rats.
Topics: Animals; Anti-Inflammatory Agents; Chitosan; Methotrexate; Mucositis; Rats; Rats, Wistar; Stomatitis | 2022 |
pH Responsive
Topics: Abelmoschus; Antineoplastic Agents; Chitosan; Drug Carriers; Drug Liberation; Hydrogen-Ion Concentration; Methotrexate; Nanoparticles; Particle Size | 2022 |
Methotrexate-loaded biodegradable nanoparticles exert anti-arthritic effect by downregulating pro-inflammatory cytokines in Freund's complete adjuvant-induced arthritic rats.
Topics: Animals; Arthritis, Experimental; Chitosan; Cytokines; Freund's Adjuvant; Methotrexate; Nanoparticles; Rats; Rats, Wistar | 2022 |
Influence of magnetite incorporation into chitosan on the adsorption of the methotrexate and in vitro cytotoxicity.
Topics: Adsorption; Chitosan; Ferrosoferric Oxide; Hydrogen-Ion Concentration; Iron; Kinetics; Methotrexate; Temperature; Thermodynamics; Water; Water Pollutants, Chemical | 2022 |
Core-shell Pluronic F127/chitosan based nanoparticles for effective delivery of methotrexate in the management of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Chitosan; Drug Carriers; Methotrexate; Nanoparticles; Particle Size; Poloxamer; Polymers; Rats | 2022 |
Preparation and evaluation of niosomal chitosan-based in situ gel formulation for direct nose-to-brain methotrexate delivery.
Topics: Brain; Chitosan; Drug Delivery Systems; Drug Liberation; Gels; Liposomes; Methotrexate; Particle Size | 2022 |
Chemo-photothermal therapeutic effect of chitosan-gelatin hydrogels containing methotrexate and melanin on a collagen-induced arthritis mouse model.
Topics: Animals; Arthritis, Experimental; Chitosan; Disease Models, Animal; Doxorubicin; Gelatin; Hydrogels; Infrared Rays; Melanins; Methotrexate; Mice; Phototherapy | 2022 |
A biodegradable pH and glutathione dual-triggered drug delivery system based on mesoporous silica, carboxymethyl chitosan and oxidized pullulan.
Topics: Chitosan; Drug Carriers; Drug Delivery Systems; Hydrogels; Hydrogen-Ion Concentration; Methotrexate; Nanoparticles; Silicon Dioxide | 2023 |
Synthesis and characterization of poly(3-hydroxybutyrate)/chitosan-graft poly (acrylic acid) conjugate hyaluronate for targeted delivery of methotrexate drug to colon cancer cells.
Topics: 3-Hydroxybutyric Acid; Caco-2 Cells; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Humans; Hyaluronic Acid; Methotrexate; Pharmaceutical Preparations; Polymers | 2023 |
In-vivo anticancer efficacy of self-targeted methotrexate-loaded polymeric nanoparticles in solid tumor-bearing rat.
Topics: Animals; Chitosan; Drug Carriers; Methotrexate; Nanoparticles; Neoplasms; Rats | 2023 |
Novel Chitosan Nanoparticles Loaded with Methotrexate for Topical Treatment of Psoriasis.
Topics: Animals; Chitosan; Methotrexate; Mice; Nanoparticles; Psoriasis; Rats; Skin | 2023 |
Transdermal Delivery of Methotrexate Loaded in Chitosan Nanoparticles to Treat Rheumatoid Arthritis.
Topics: Administration, Cutaneous; Animals; Arthritis, Rheumatoid; Chitosan; Cytokines; Humans; Methotrexate; Nanoparticles; Rats | 2024 |
A novel thermoresponsive nano carrier matrix of hyaluronic acid, methotrexate and chitosan to target the cluster of differentiation 44 receptors in tumors.
Topics: Chitosan; Humans; Hyaluronic Acid; Methotrexate; Nanoparticles; Neoplasms | 2023 |
Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Chitosan; Clove Oil; Drug-Related Side Effects and Adverse Reactions; Leflunomide; Methotrexate; Rats; Surface-Active Agents; Tumor Necrosis Factor-alpha | 2023 |
Wearable Microneedle-Based Array Patches for Continuous Electrochemical Monitoring and Drug Delivery: Toward a Closed-Loop System for Methotrexate Treatment.
Topics: Chitosan; Humans; Methotrexate; Needles; Neoplasms; Wearable Electronic Devices | 2023 |
Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascade.
Topics: Adenosine; Caffeine; Chitosan; Folic Acid; Humans; Immunotherapy; Methotrexate; Molecular Docking Simulation; Nanoparticles; Neoplasms; Receptor, Adenosine A2A; Tumor Microenvironment | 2023 |