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chitosan and hirudin

chitosan has been researched along with hirudin in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, MX; Hou, JL; Ma, CH; Wang, XL; Zhang, Q; Zhang, YJ1
Lu, WL; Ma, CH; Sun, JN; Wang, XL; Zhang, Q; Zhang, X; Zhang, YJ1
Chen, MX; Jiang, H; Sun, MJ; Wang, Q; Wang, XL; Yang, J; Zhang, Q; Zhang, YJ1
Chen, X; Huang, Y; Li, X; Liu, Y; Wang, F; Yang, J; Zhang, Y; Zhou, Y1
Chen, MX; Wei, BH; Ye, J; Yu, JP; Zhang, JB; Zhang, YJ1

Other Studies

5 other study(ies) available for chitosan and hirudin

ArticleYear
[Studies on the nasal epithelium toxicity of adjuvants and recombination hirudin (rHV2) nasal spary].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2005, Volume: 30, Issue:11

    Topics: Adjuvants, Pharmaceutic; Administration, Intranasal; Animals; Bufo bufo; Chitosan; Cilia; Epithelium; Female; Hirudins; Male; Nasal Mucosa; Palate; Rabbits; Recombinant Proteins

2005
Permeation-enhancing effects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo.
    Acta pharmacologica Sinica, 2005, Volume: 26, Issue:11

    Topics: Absorption; Administration, Intranasal; Animals; Area Under Curve; Biological Availability; Bufo bufo; Chitosan; Dose-Response Relationship, Drug; Drug Synergism; Fluorescein-5-isothiocyanate; Hirudins; Male; Nasal Mucosa; Rabbits; Rats; Rats, Sprague-Dawley; Recombinant Proteins

2005
[Promoting mechanism of enhancers and transport pathway of large hydrophilic molecular across nasal epithelium studied by ESR and CLSM technologies].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:11

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Absorption; Administration, Intranasal; Animals; Area Under Curve; beta-Cyclodextrins; Biological Availability; Biological Transport; Chitosan; Electron Spin Resonance Spectroscopy; Glycyrrhizic Acid; Hirudins; Male; Microscopy, Confocal; Nasal Cavity; Nasal Mucosa; Rabbits; Rats; Rats, Sprague-Dawley; Recombinant Proteins

2007
Nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer.
    Molecular pharmaceutics, 2010, Jun-07, Volume: 7, Issue:3

    Topics: Animals; Anticoagulants; Blood Platelets; Cations; Chitosan; Hirudin Therapy; Hirudins; Male; Micelles; Microscopy, Confocal; Molecular Structure; Oligopeptides; Platelet Aggregation; Polyethylene Glycols; Polymers; Rats; Rats, Sprague-Dawley; Recombinant Proteins

2010
[Preparation of freeze-dried powder of recombinate hirudin-2 nanoparticle for nasal delivery and permeability through nasal membrane in vitro].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2013, Volume: 36, Issue:6

    Topics: Absorption; Administration, Intranasal; Animals; Chitosan; Drug Delivery Systems; Drug Stability; Freeze Drying; Glucose; Hirudins; Male; Mannitol; Nanoparticles; Nasal Mucosa; Permeability; Powders; Rabbits; Recombinant Proteins; Technology, Pharmaceutical

2013