chiniofon has been researched along with imidazole* in 1 studies
1 other study(ies) available for chiniofon and imidazole
| Article | Year |
|---|---|
Synthesis, biological evaluation, Structure - Activity relationship studies of quinoline-imidazole derivatives as potent antimalarial agents.
In our efforts to identify novel chemical scaffolds for the development of antimalarial agents, a series of quinoline - imidazole hybrid compounds were synthesized and their blood-stage antimalarial activity was evaluated in both drug-sensitive and -multi drug-resistant (MDR) P. falciparum strains. The new analogs possess sub-micromolar activities against Plasmodium falciparum. Among all synthesized derivatives, 11(xxxii) exhibited significant antimalarial efficacy in-vitro against both CQ-sensitive (IC Topics: 14-alpha Demethylase Inhibitors; Antimalarials; Antiprotozoal Agents; Cytochrome P-450 CYP3A Inhibitors; Hydroxyquinolines; Imidazoles; Nitroimidazoles; Plasmodium falciparum; Quinolines; Structure-Activity Relationship | 2022 |