chiniofon and benzimidazole

chiniofon has been researched along with benzimidazole* in 1 studies

Other Studies

1 other study(ies) available for chiniofon and benzimidazole

Article	Year
Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells. SLAS discovery : advancing life sciences R & D, 2017, Volume: 22, Issue:7 Human lysine demethylase (KDM) enzymes (KDM1-7) constitute an emerging class of therapeutic targets, with activities that support growth and development of metastatic disease. By interacting with and co-activating the androgen receptor, the KDM4 subfamily (KDM4A-E) promotes aggressive phenotypes of prostate cancer (PCa). Knockdown of KDM4 expression or inhibition of KDM4 enzyme activity reduces the proliferation of PCa cell lines and highlights inhibition of lysine demethylation as a possible therapeutic method for PCa treatment. To address this possibility, we screened the ChemBioNet small molecule library for inhibitors of the human KDM4E isoform and identified several compounds with IC Topics: Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Demethylation; Enzyme Inhibitors; Histone Demethylases; Histones; Humans; Hydroxyquinolines; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; PC-3 Cells; Prostatic Neoplasms; Pyrazolones; Receptors, Androgen; Transcription, Genetic	2017

Article

Year

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells.

SLAS discovery : advancing life sciences R & D, 2017, Volume: 22, Issue:7

Human lysine demethylase (KDM) enzymes (KDM1-7) constitute an emerging class of therapeutic targets, with activities that support growth and development of metastatic disease. By interacting with and co-activating the androgen receptor, the KDM4 subfamily (KDM4A-E) promotes aggressive phenotypes of prostate cancer (PCa). Knockdown of KDM4 expression or inhibition of KDM4 enzyme activity reduces the proliferation of PCa cell lines and highlights inhibition of lysine demethylation as a possible therapeutic method for PCa treatment. To address this possibility, we screened the ChemBioNet small molecule library for inhibitors of the human KDM4E isoform and identified several compounds with IC

Topics: Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Demethylation; Enzyme Inhibitors; Histone Demethylases; Histones; Humans; Hydroxyquinolines; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; PC-3 Cells; Prostatic Neoplasms; Pyrazolones; Receptors, Androgen; Transcription, Genetic

2017